LOCUS       AY216713                1519 bp    mRNA    linear   HUM 24-MAR-2003
DEFINITION  Homo sapiens putative tumor suppressor RASSF4 isoform A (RASSF4)
            mRNA, complete cds; alternatively spliced.
ACCESSION   AY216713
VERSION     AY216713.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Burbee,D.G., White,M.A., Miller,D.S., Muller,C.Y. and Minna,J.D.
  TITLE     RASSF4 (AD037) is transcriptionally repressed by an epigenetic
            mechanism in ovarian cancer cell lines
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Burbee,D.G., White,M.A., Miller,D.S., Muller,C.Y. and Minna,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2003) Hamon Center for Therapeutic Oncology
            Research, University of Texas SW Medical Center, 5323 Harry Hines
            Blvd., Dallas, TX 75390-8593, USA
FEATURES             Location/Qualifiers
     source          1..1519
                     /db_xref="H-InvDB:HIT000085317"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11-q11"
     gene            1..1519
                     /gene="RASSF4"
     CDS             135..1100
                     /gene="RASSF4"
                     /note="putative RAS-binding protein; alternatively
                     spliced; AD037; contains amino terminal domain common to
                     RASSF2, RASSF4, and RASSF6; potential ATM phosphorylation
                     domain and potential RAS-binding domain; similar to the
                     tumor suppressor RASSF1A, mouse Nore1 and rat Maxp1 gene
                     products"
                     /codon_start=1
                     /product="putative tumor suppressor RASSF4 isoform A"
                     /protein_id="AAO61138.1"
                     /translation="MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRH
                     REEEGTLIIEGLLNIAWGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNG
                     NITAKGPSIQPVHKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQ
                     RIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSE
                     FALYIVHESGERTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKF
                     EMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK"
BASE COUNT          361 a          447 c          430 g          281 t
ORIGIN      
        1 ctgaagcccg gggtcagcag gcgctgcggg cgcagctccg gtgcaagcga ggacacgaca
       61 catgcagtgg cttctggact gcgcgatgac tggacgcaag taacttctag gtctgcagac
      121 aagaggaaga gaagatgaag gaagactgtc tgccgagttc tcacgtgccc atcagtgaca
      181 gcaagtccat tcagaagtcg gagctcttag gcctgctgaa aacctacaac tgctaccatg
      241 agggcaagag cttccagctg agacaccgtg aggaagaagg gactctgatc atcgaggggc
      301 tcctcaacat tgcctggggg ctgaggcggc ccatccggct gcagatgcag gatgaccggg
      361 agcaggtgca cctcccctcc acctcatgga tgcccagacg gcctagctgc cctctaaagg
      421 agccatcgcc ccagaacggg aacatcacag ccaaggggcc aagcattcag ccagtgcaca
      481 aggctgagag ttccacagac agctcggggc ccctggagga ggcagaggag gccccccagc
      541 tgatgcggac caagagcgac gccagttgca tgagccagag gaggcccaag tgccgcgccc
      601 ccggtgaggc ccagcgcatc cggcgacacc ggttctctat caacggccac ttctacaatc
      661 ataagacctc cgtgtttact ccagcctatg gatccgtgac caatgtgagg gtcaacagca
      721 ccatgacaac cctgcaggtg ctcaccctgc tgctgaacaa atttagggtg gaagatggcc
      781 ccagtgagtt cgcactctac atcgttcacg agtctgggga gcggacaaaa ttaaaagact
      841 gcgagtaccc gctgatttcc agaatcctgc atgggccatg tgagaagatc gccaggatct
      901 tcctgatgga agctgacttg ggcgtggaag tcccccatga agtcgctcag tacattaagt
      961 ttgaaatgcc ggtgctggac agttttgttg aaaaattaaa agaagaggaa gaaagagaaa
     1021 taatcaaact gaccatgaag ttccaagccc tgcgtctgac gatgctgcag cgcctggagc
     1081 agctggtgga ggccaagtaa ctggccaaca cctgcctctt ccaaagtccc cagcagtggc
     1141 aggtgtacac tgagccctgg ttgctggccc cggccggtca cattgactga tggccaccgc
     1201 ctgacgaatc gagtgcctgt gtgtctacct ctctgaagcc tgagcaccat gattcccaca
     1261 gccagctctt ggctccaaga tgagcaccca caggaagccg accaggcctg aggggccagg
     1321 aacttgctgg gtcagatctg tgtggccagc cctgtccaca accatgcctc tcctgcactg
     1381 gagagcagtg ctggcccagc ccctgcggct taggcttcat ctgcttgaca ttgcctgtcc
     1441 cagagcccct gtgggtcaca agcccctgtc ctcttcctca tatgagaact tgtctgcctc
     1501 atatacgctg cccacagga
//