LOCUS       AY212247                3792 bp    mRNA    linear   HUM 03-MAR-2003
DEFINITION  Homo sapiens Ste20 group protein kinase HGK mRNA, complete cds,
            alternatively spliced.
ACCESSION   AY212247
VERSION     AY212247.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3792)
  AUTHORS   Wright,J.H., Wang,X., Manning,G., LaMere,B.J., Le,P., Zhu,S.,
            Khatry,D., Flanagan,P.M., Buckley,S.D., Whyte,D.B., Howlett,A.R.,
            Bischoff,J.R., Lipson,K.E. and Jallal,B.
  TITLE     The STE20 kinase HGK is broadly expressed in human tumor cells and
            can modulate cellular transformation, invasion, and adhesion
  JOURNAL   Mol. Cell. Biol. 23 (6), 2068-2082 (2003)
   PUBMED   12612079
REFERENCE   2  (bases 1 to 3792)
  AUTHORS   Wright,J.H., Whyte,D., Plowman,G.D., Pugliese,R., Martinez,R. and
            Manning,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JAN-2003) SUGEN, Inc., 230 East Grand Ave., South San
            Francisco, CA 94080, USA
FEATURES             Location/Qualifiers
     source          1..3792
                     /db_xref="H-InvDB:HIT000085306"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1-q11.2"
                     /cell_line="SNB19"
                     /cell_type="glioblastoma"
                     /tissue_type="brain"
                     /note="ZC1"
     CDS             1..3720
                     /note="tumor-associated splice form; similar to Mus
                     musculus NIK, Drosophila misshapen (msn) and
                     Caenorhabditis elegans mig-15; may function as a MAP
                     kinase kinase kinase kinase (MAP4K); contains optional
                     splice modules M1, M2, M3 and M8; alternatively spliced"
                     /codon_start=1
                     /product="Ste20 group protein kinase HGK"
                     /protein_id="AAO32626.1"
                     /translation="MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRH
                     VKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLW
                     LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVL
                     LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS
                     CGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQ
                     RPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVP
                     EQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL
                     AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE
                     RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAE
                     RLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRA
                     REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVP
                     VRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSG
                     SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPA
                     DLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRA
                     ASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRRTQSASSTLQKHKSSSSF
                     TPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD
                     TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDV
                     LEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVK
                     YERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIY
                     GSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNT
                     YGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK
                     FLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW"
BASE COUNT         1110 a          831 c         1047 g          804 t
ORIGIN      
        1 atggcgaacg actcccctgc aaaaagtctg gtggacatcg acctctcctc cctgcgggat
       61 cctgctggga tttttgagct ggtggaagtg gttggaaatg gcacctatgg acaagtctat
      121 aagggtcgac atgttaaaac gggtcagttg gcagccatca aagttatgga tgtcactgag
      181 gatgaagagg aagaaatcaa actggagata aatatgctaa agaaatactc tcatcacaga
      241 aacattgcaa catattatgg tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa
      301 ctctggcttg ttatggagtt ctgtggggct gggtccatta cagaccttgt gaagaacacc
      361 aaagggaaca cactcaaaga agactggatc gcttacatct ccagagaaat cctgagggga
      421 ctggcacatc ttcacattca tcatgtgatt caccgggata tcaagggcca gaatgtgttg
      481 ctgactgaga atgcagaggt gaaacttgtt gactttggtg tgagtgctca gctggacagg
      541 actgtggggc ggagaaatac gttcataggc actccctact ggatggctcc tgaggtcatc
      601 gcctgtgatg agaacccaga tgccacctat gattacagaa gtgatctttg gtcttgtggc
      661 attacagcca ttgagatggc agaaggtgct ccccctctct gtgacatgca tccaatgaga
      721 gcactgtttc tcattcccag aaaccctcct ccccggctga agtcaaaaaa atggtcgaag
      781 aagtttttta gttttataga agggtgcctg gtgaagaatt acatgcagcg gccctctaca
      841 gagcagcttt tgaaacatcc ttttataagg gatcagccaa atgaaaggca agttagaatc
      901 cagcttaagg atcatataga tcgtaccagg aagaagagag gcgagaaaga tgaaactgag
      961 tatgagtaca gtgggagtga ggaagaagag gaggaagtgc ctgaacagga aggagagcca
     1021 agttccattg tgaacgtgcc tggtgagtct actcttcgcc gagatttcct gagactgcag
     1081 caggagaaca aggaacgttc cgaggctctt cggagacaac agttactaca ggagcaacag
     1141 ctccgggagc aggaagaata taaaaggcaa ctgctggcag agagacagaa gcggattgag
     1201 cagcagaaag aacagaggcg acggctagaa gagcaacaaa ggagagagcg ggaagctaga
     1261 aggcagcagg aacgtgaaca gcgaaggaga gaacaagaag aaaagaggcg tctagaggag
     1321 ttggagagaa ggcgcaaaga agaagaggag aggagacggg cagaagaaga aaagaggaga
     1381 gttgaaagag aacaggagta tatcaggcga cagctagaag aggagcagcg gcacttggaa
     1441 gtccttcagc agcagctgct ccaggagcag gccatgttac tggagtgccg atggcgggag
     1501 atggaggagc accggcaggc agagaggctc cagaggcagt tgcaacaaga acaagcatat
     1561 ctcctgtctc tacagcatga ccataggagg ccgcacccgc agcactcgca gcagccgcca
     1621 ccaccgcagc aggaaaggag caagccaagc ttccatgctc ccgagcccaa agcccactac
     1681 gagcctgctg accgagcgcg agaggtggaa gatagattta ggaaaactaa ccacagctcc
     1741 cctgaagccc agtctaagca gacaggcaga gtattggagc caccagtgcc ttcccgatca
     1801 gagtcttttt ccaatggcaa ctccgagtct gtgcatcccg ccctgcagag accagcggag
     1861 ccacaggttc ctgtgagaac aacatctcgc tcccctgttc tgtcccgtcg agattcccca
     1921 ctgcagggca gtgggcagca gaatagccag gcaggacaga gaaactccac cagtattgag
     1981 cccaggcttc tgtgggagag agtggagaag ctggtgccca gacctggcag tggcagctcc
     2041 tcagggtcca gcaactcagg atcccagccc gggtctcacc ctgggtctca gagtggctcc
     2101 ggggaacgct tcagagtgag atcatcatcc aagtctgaag gctctccatc tcagcgcctg
     2161 gaaaatgcag tgaaaaaacc tgaagataaa aaggaagttt tcagacccct caagcctgct
     2221 gatctgaccg cactggccaa agagcttcga gcagtggaag atgtacggcc acctcacaaa
     2281 gtaacggact actcctcatc cagtgaggag tcggggacga cggatgagga ggacgacgat
     2341 gtggagcagg aaggggctga cgagtccacc tcaggaccag aggacaccag agcagcgtca
     2401 tctctgaatt tgagcaatgg tgaaacggaa tctgtgaaaa ccatgattgt ccatgatgat
     2461 gtagaaagtg agccggccat gaccccatcc aaggagggca ctctaatcgt ccgccggact
     2521 cagtccgcta gtagcacact ccagaaacac aaatcttcct cctcctttac accttttata
     2581 gaccccagat tactacagat ttctccatct agcggaacaa cagtgacatc tgtggtggga
     2641 ttttcctgtg atgggatgag accagaagcc ataaggcaag atcctacccg gaaaggctca
     2701 gtggtcaatg tgaatcctac caacactagg ccacagagtg acaccccgga gattcgtaaa
     2761 tacaagaaga ggtttaactc tgagattctg tgtgctgcct tatggggagt gaatttgcta
     2821 gtgggtacag agagtggcct gatgctgctg gacagaagtg gccaagggaa ggtctatcct
     2881 cttatcaacc gaagacgatt tcaacaaatg gacgtacttg agggcttgaa tgtcttggtg
     2941 acaatatctg gcaaaaagga taagttacgt gtctactatt tgtcctggtt aagaaataaa
     3001 atacttcaca atgatccaga agttgagaag aagcagggat ggacaaccgt aggggatttg
     3061 gaaggatgtg tacattataa agttgtaaaa tatgaaagaa tcaaatttct ggtgattgct
     3121 ttgaagagtt ctgtggaagt ctatgcgtgg gcaccaaagc catatcacaa atttatggcc
     3181 tttaagtcat ttggagaatt ggtacataag ccattactgg tggatctcac tgttgaggaa
     3241 ggccagaggt tgaaagtgat ctatggatcc tgtgctggat tccatgctgt tgatgtggat
     3301 tcaggatcag tctatgacat ttatctacca acacatatcc agtgtagcat caaaccccat
     3361 gcaatcatca tcctccccaa tacagatgga atggagcttc tggtgtgcta tgaagatgag
     3421 ggggtttatg taaacacata tggaaggatc accaaggatg tagttctaca gtggggagag
     3481 atgcctacat cagtagcata tattcgatcc aatcagacaa tgggctgggg agagaaggcc
     3541 atagagatcc gatctgtgga aactggtcac ttggatggtg tgttcatgca caaaagggct
     3601 caaagactaa aattcttgtg tgaacgcaat gacaaggtgt tctttgcctc tgttcggtct
     3661 ggtggcagca gtcaggttta tttcatgacc ttaggcagga cttctcttct gagctggtag
     3721 aagcagtgtg atccagggat tactggcctc cagagtcttc aagatcctga gaacttggaa
     3781 ttccttgtaa ct
//