LOCUS AY212247 3792 bp mRNA linear HUM 03-MAR-2003 DEFINITION Homo sapiens Ste20 group protein kinase HGK mRNA, complete cds, alternatively spliced. ACCESSION AY212247 VERSION AY212247.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3792) AUTHORS Wright,J.H., Wang,X., Manning,G., LaMere,B.J., Le,P., Zhu,S., Khatry,D., Flanagan,P.M., Buckley,S.D., Whyte,D.B., Howlett,A.R., Bischoff,J.R., Lipson,K.E. and Jallal,B. TITLE The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion JOURNAL Mol. Cell. Biol. 23 (6), 2068-2082 (2003) PUBMED 12612079 REFERENCE 2 (bases 1 to 3792) AUTHORS Wright,J.H., Whyte,D., Plowman,G.D., Pugliese,R., Martinez,R. and Manning,G. TITLE Direct Submission JOURNAL Submitted (07-JAN-2003) SUGEN, Inc., 230 East Grand Ave., South San Francisco, CA 94080, USA FEATURES Location/Qualifiers source 1..3792 /db_xref="H-InvDB:HIT000085306" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q11.1-q11.2" /cell_line="SNB19" /cell_type="glioblastoma" /tissue_type="brain" /note="ZC1" CDS 1..3720 /note="tumor-associated splice form; similar to Mus musculus NIK, Drosophila misshapen (msn) and Caenorhabditis elegans mig-15; may function as a MAP kinase kinase kinase kinase (MAP4K); contains optional splice modules M1, M2, M3 and M8; alternatively spliced" /codon_start=1 /product="Ste20 group protein kinase HGK" /protein_id="AAO32626.1" /translation="MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRH VKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLW LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVL LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS CGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQ RPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVP EQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAE RLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRA REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVP VRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSG SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPA DLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRA ASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRRTQSASSTLQKHKSSSSF TPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDV LEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVK YERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIY GSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNT YGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK FLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW" BASE COUNT 1110 a 831 c 1047 g 804 t ORIGIN 1 atggcgaacg actcccctgc aaaaagtctg gtggacatcg acctctcctc cctgcgggat 61 cctgctggga tttttgagct ggtggaagtg gttggaaatg gcacctatgg acaagtctat 121 aagggtcgac atgttaaaac gggtcagttg gcagccatca aagttatgga tgtcactgag 181 gatgaagagg aagaaatcaa actggagata aatatgctaa agaaatactc tcatcacaga 241 aacattgcaa catattatgg tgctttcatc aaaaagagcc ctccaggaca tgatgaccaa 301 ctctggcttg ttatggagtt ctgtggggct gggtccatta cagaccttgt gaagaacacc 361 aaagggaaca cactcaaaga agactggatc gcttacatct ccagagaaat cctgagggga 421 ctggcacatc ttcacattca tcatgtgatt caccgggata tcaagggcca gaatgtgttg 481 ctgactgaga atgcagaggt gaaacttgtt gactttggtg tgagtgctca gctggacagg 541 actgtggggc ggagaaatac gttcataggc actccctact ggatggctcc tgaggtcatc 601 gcctgtgatg agaacccaga tgccacctat gattacagaa gtgatctttg gtcttgtggc 661 attacagcca ttgagatggc agaaggtgct ccccctctct gtgacatgca tccaatgaga 721 gcactgtttc tcattcccag aaaccctcct ccccggctga agtcaaaaaa atggtcgaag 781 aagtttttta gttttataga agggtgcctg gtgaagaatt acatgcagcg gccctctaca 841 gagcagcttt tgaaacatcc ttttataagg gatcagccaa atgaaaggca agttagaatc 901 cagcttaagg atcatataga tcgtaccagg aagaagagag gcgagaaaga tgaaactgag 961 tatgagtaca gtgggagtga ggaagaagag gaggaagtgc ctgaacagga aggagagcca 1021 agttccattg tgaacgtgcc tggtgagtct actcttcgcc gagatttcct gagactgcag 1081 caggagaaca aggaacgttc cgaggctctt cggagacaac agttactaca ggagcaacag 1141 ctccgggagc aggaagaata taaaaggcaa ctgctggcag agagacagaa gcggattgag 1201 cagcagaaag aacagaggcg acggctagaa gagcaacaaa ggagagagcg ggaagctaga 1261 aggcagcagg aacgtgaaca gcgaaggaga gaacaagaag aaaagaggcg tctagaggag 1321 ttggagagaa ggcgcaaaga agaagaggag aggagacggg cagaagaaga aaagaggaga 1381 gttgaaagag aacaggagta tatcaggcga cagctagaag aggagcagcg gcacttggaa 1441 gtccttcagc agcagctgct ccaggagcag gccatgttac tggagtgccg atggcgggag 1501 atggaggagc accggcaggc agagaggctc cagaggcagt tgcaacaaga acaagcatat 1561 ctcctgtctc tacagcatga ccataggagg ccgcacccgc agcactcgca gcagccgcca 1621 ccaccgcagc aggaaaggag caagccaagc ttccatgctc ccgagcccaa agcccactac 1681 gagcctgctg accgagcgcg agaggtggaa gatagattta ggaaaactaa ccacagctcc 1741 cctgaagccc agtctaagca gacaggcaga gtattggagc caccagtgcc ttcccgatca 1801 gagtcttttt ccaatggcaa ctccgagtct gtgcatcccg ccctgcagag accagcggag 1861 ccacaggttc ctgtgagaac aacatctcgc tcccctgttc tgtcccgtcg agattcccca 1921 ctgcagggca gtgggcagca gaatagccag gcaggacaga gaaactccac cagtattgag 1981 cccaggcttc tgtgggagag agtggagaag ctggtgccca gacctggcag tggcagctcc 2041 tcagggtcca gcaactcagg atcccagccc gggtctcacc ctgggtctca gagtggctcc 2101 ggggaacgct tcagagtgag atcatcatcc aagtctgaag gctctccatc tcagcgcctg 2161 gaaaatgcag tgaaaaaacc tgaagataaa aaggaagttt tcagacccct caagcctgct 2221 gatctgaccg cactggccaa agagcttcga gcagtggaag atgtacggcc acctcacaaa 2281 gtaacggact actcctcatc cagtgaggag tcggggacga cggatgagga ggacgacgat 2341 gtggagcagg aaggggctga cgagtccacc tcaggaccag aggacaccag agcagcgtca 2401 tctctgaatt tgagcaatgg tgaaacggaa tctgtgaaaa ccatgattgt ccatgatgat 2461 gtagaaagtg agccggccat gaccccatcc aaggagggca ctctaatcgt ccgccggact 2521 cagtccgcta gtagcacact ccagaaacac aaatcttcct cctcctttac accttttata 2581 gaccccagat tactacagat ttctccatct agcggaacaa cagtgacatc tgtggtggga 2641 ttttcctgtg atgggatgag accagaagcc ataaggcaag atcctacccg gaaaggctca 2701 gtggtcaatg tgaatcctac caacactagg ccacagagtg acaccccgga gattcgtaaa 2761 tacaagaaga ggtttaactc tgagattctg tgtgctgcct tatggggagt gaatttgcta 2821 gtgggtacag agagtggcct gatgctgctg gacagaagtg gccaagggaa ggtctatcct 2881 cttatcaacc gaagacgatt tcaacaaatg gacgtacttg agggcttgaa tgtcttggtg 2941 acaatatctg gcaaaaagga taagttacgt gtctactatt tgtcctggtt aagaaataaa 3001 atacttcaca atgatccaga agttgagaag aagcagggat ggacaaccgt aggggatttg 3061 gaaggatgtg tacattataa agttgtaaaa tatgaaagaa tcaaatttct ggtgattgct 3121 ttgaagagtt ctgtggaagt ctatgcgtgg gcaccaaagc catatcacaa atttatggcc 3181 tttaagtcat ttggagaatt ggtacataag ccattactgg tggatctcac tgttgaggaa 3241 ggccagaggt tgaaagtgat ctatggatcc tgtgctggat tccatgctgt tgatgtggat 3301 tcaggatcag tctatgacat ttatctacca acacatatcc agtgtagcat caaaccccat 3361 gcaatcatca tcctccccaa tacagatgga atggagcttc tggtgtgcta tgaagatgag 3421 ggggtttatg taaacacata tggaaggatc accaaggatg tagttctaca gtggggagag 3481 atgcctacat cagtagcata tattcgatcc aatcagacaa tgggctgggg agagaaggcc 3541 atagagatcc gatctgtgga aactggtcac ttggatggtg tgttcatgca caaaagggct 3601 caaagactaa aattcttgtg tgaacgcaat gacaaggtgt tctttgcctc tgttcggtct 3661 ggtggcagca gtcaggttta tttcatgacc ttaggcagga cttctcttct gagctggtag 3721 aagcagtgtg atccagggat tactggcctc cagagtcttc aagatcctga gaacttggaa 3781 ttccttgtaa ct //