LOCUS AY194287 6480 bp mRNA linear HUM 02-SEP-2003
DEFINITION Homo sapiens rac GTPase activating protein mRNA, complete cds.
ACCESSION AY194287
VERSION AY194287.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6480)
AUTHORS Zhao,C., Ma,H., Bossy-Wetzel,E., Lipton,S.A., Zhang,Z. and
Feng,G.S.
TITLE GC-GAP, a Rho family GTPase-activating protein that interacts with
signaling adapters Gab1 and Gab2
JOURNAL J. Biol. Chem. 278 (36), 34641-34653 (2003)
PUBMED 12819203
REFERENCE 2 (bases 1 to 6480)
AUTHORS Zhao,C. and Feng,G.-S.
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2002) The Burnham Institute, 10901 N. Torrey
Pines Road, La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..6480
/db_xref="H-InvDB:HIT000085183"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
CDS 304..5520
/note="Rho family GAP; GC-GAP; similar to KIAA0712;
GAB-associated CDC42"
/codon_start=1
/product="rac GTPase activating protein"
/protein_id="AAO43677.1"
/translation="MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCT
AFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFR
ELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLAD
YCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF
SGRISMAMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVG
EGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESE
PSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNG
EMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAEDVDLSPPDIGVASLDFDPMS
FQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSP
LQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMSISEPISVTL
PPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYESE
VQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSSVSLIP
PPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATTEDNLSSSYS
AVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDL
TGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPP
RFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTATMTY
MTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVV
GQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQ
PGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSS
SNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFN
MTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCS
RVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPA
YCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCD
VDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVV
SMPPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLG
GIYVIHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHG
GHGSTQPEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGA
GQLDYGSKGIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAP
EKHSRDCYKEEEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSV
TVVSQYDNLEDYHSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAEL
SLQHPETQIHAE"
BASE COUNT 1766 a 1702 c 1436 g 1576 t
ORIGIN
1 ctccactgac tggactgaaa acagggccaa gaaaactgct gctgcagggg gtcctgaaaa
61 cagctggaac ccggcagtga tgtgggacct aacttgaagt taacctgtgg tggtgaggtt
121 ggaaccagtt ggattatgat ttattttcta cactcttgta cggaatgcag agctgttgta
181 tcctgatgaa tctactgcta aatatagtca tttggaataa ttttaagtat tgatcttaaa
241 acttgtacca caacaagagt gtctaaaaag cacggcaagc tcattacgtt cttacgaaca
301 ttcatgaagt ctcgtccaac aaaacagaag ctgaagcagc ggggaatctt gaaagagagg
361 gtgtttggtt gtgacctggg ggagcacctt ctaaattctg gttttgaagt gccgcaggtt
421 cttcaaagct gcacagcatt cattgagaga tatggcatcg tggatggaat ctatcgcctt
481 tctggtgttg cctccaatat ccagagacta cgccatgaat ttgactctga gcacgtcccc
541 gacctgacga aagaaccgta tgttcaggac atccattctg tgggttccct atgtaagctg
601 tacttccggg aactcccaaa ccctctgctt acctaccagc tgtatgagaa attttctgat
661 gcagtttcag cagcaacaga tgaagaaagg ctgataaaaa tccacgatgt catccagcag
721 ctccccccac cacactacag aacactggag ttcctgatga gacacttgtc tcttctagct
781 gactattgtt ccatcacaaa tatgcatgca aaaaatctag caattgtttg ggctccaaac
841 ctgttaagat caaaacagat agaatctgcc tgcttcagtg gaacagcagc tttcatggaa
901 gtgaggattc agtctgtggt tgttgagttc atcctgaatc acgttgatgt gctgttcagc
961 ggcagaatca gcatggccat gcaagagggg gcagcttctc tatcaaggcc caagtccctc
1021 ctggtatcct ctccatccac caaactgctg acattggaag aggcccaggc acgaacacaa
1081 gctcaggtca attctccaat tgtgacggaa aataaatata tcgaagtagg agaaggacct
1141 gctgcacttc aggggaaatt tcataccata attgagttcc cacttgaaag aaagaggcct
1201 caaaataaga tgaaaaagtc tcctgtgggt agctggcgtt cctttttcaa cttggggaaa
1261 tcatcatctg tttctaaacg aaagctgcag cggaatgaga gtgagccttc agagatgaaa
1321 gccatggctc tgaaaggtgg cagggcagaa ggaaccctcc gttcagctaa aagtgaggag
1381 tctcttacat ctctccatgc agttgatggt gattctaagc tcttccgacc cagaagaccc
1441 agatcttcca gtgatgcact gtctgcctct tttaatggag aaatgctggg gaaccgctgt
1501 aactcctatg ataatctgcc tcatgacaat gagagtgagg aggaaggagg gctgcttcat
1561 atcccagccc ttatgtctcc tcattcagct gaggatgttg acttgagccc accagacatt
1621 ggagtagcca gcctggattt tgatccaatg tcatttcaat gtagtcctcc taaggccgaa
1681 tcagaatgtc tggagagtgg tgcttccttt ttagattcac caggatactc caaggataaa
1741 ccaagtgcca ataaaaagga tgcagaaaca ggtagtagcc aatgtcagac tccaggaagc
1801 acagcaagct ctgaacctgt ctctcctctt caggagaaac tgagtccatt ctttaccctg
1861 gacttgagcc caactgaaga taaatcatct aagccatcct cctttactga aaaggtcgtc
1921 tatgctttct ctccgaagat aggacggaaa ttaagcaaat caccttctat gagcatatct
1981 gagccaattt cagtgaccct accaccacgg gtgtcagaag tcattggtac agtctcaaat
2041 accacagctc agaatgcatc atcttcaacc tgggacaaat gcgttgaaga aagggatgcc
2101 acaaatagat cccccaccca gatagtaaag atgaaaacaa atgagacagt tgcccaagaa
2161 gcatatgaat ctgaagtcca gcccctggac caggtggctg ctgaagaagt agaattgcca
2221 gggaaagagg atcagtctgt ctcaagcagt cagagtaagg ctgtagcttc tggacagact
2281 cagacaggag cagttaccca tgacccccct caggattccg ttcctgtcag ttcagtctct
2341 cttatcccac caccaccgcc tccgaaaaat gttgcccgaa tgttggcgct agcattagct
2401 gagtccgcac agcaagcctc aactcagtca ttgaagagac cagggacctc tcaggctggg
2461 tatacaaatt atggagacat agcggtggct acaactgaag ataatctgtc cagttcttac
2521 tctgcagttg ctctagataa ggcctatttc caaaccgatc gaccagcaga gcagttccac
2581 ctccagaata atgcaccagg aaactgtgac catcctctac cagagacaac agctactggg
2641 gatcctaccc attccaacac aactgaatct ggggagcaac atcaccaagt agacttaaca
2701 gggaatcagc cacatcaagc atatttatct ggggacccag aaaaggccag aattacttca
2761 gttcccttag actcagagaa gtctgatgat catgtaagtt tccctgaaga ccagtctggg
2821 aagaacagta tgccaactgt ctccttcttg gatcaggacc agtctccacc ccgtttctac
2881 agtggagatc agcctccttc ttatcttggt gcaagtgtgg ataaactcca tcacccttta
2941 gaatttgcag acaaatctcc cacacctcct aatttaccta gcgataaaat ctaccctcct
3001 tctgggtccc ccgaagagaa taccagcaca gccaccatga cttacatgac aactactcca
3061 gcaacagccc aaatgagcac caaggaagcc agctgggatg tggctgaaca acccaccact
3121 gctgattttg ctgctgccac acttcagcgc acgcacagaa ctaatcgtcc ccttccccct
3181 ccgccttccc agagatctgc agagcagcca ccagttgtgg ggcaggtaca agcagcaacc
3241 aatataggat taaataattc ccacaaggtt caaggagtag ttccagttcc agagaggcca
3301 cctgaacctc gagccatgga tgaccctgcg tctgccttca tcagtgacag tggtgctgct
3361 gctgctcagt gtcccatggc tacagctgtc cagccaggcc tgcctgagaa agtgcgggac
3421 ggtgcccggg tcccgctgct gcacctgcgc gccgagtctg tccctgcgca tccctgtggc
3481 tttcctgcac cactgccccc caccaggatg atggagagta agatgattgc tgccatacac
3541 tccagcagtg cagatgccac cagcagttca aattatcatt cctttgtcac tgcttcatcc
3601 acctctgtgg acgatgcatt gcctttacca cttcctgtcc cacaacctaa gcatgcttct
3661 cagaaaacag tttactcctc ctttgctagg cccgatgtca ccactgaacc ctttggtcca
3721 gataactgtt tgcatttcaa tatgactcca aactgccagt accgtcccca gagtgtacct
3781 ccccatcaca ataaattgga gcagcaccaa gtgtatggtg ccaggtcaga gccaccagcc
3841 tccatgggtc ttcgttataa cacatatgtg gccccaggaa gaaacgcatc tggacaccac
3901 tccaagccat gcagccgggt cgagtatgtg tcttctttga gctcctctgt caggaatacc
3961 tgttaccccg aagacattcc accgtaccct accatccgga gagtgcagtc tctccatgct
4021 ccgccgtctt ccatgattcg ctctgttccc atttcacgga cagaagttcc cccagatgat
4081 gagccagcct actgcccaag acctctgtac caatataagc catatcagtc ctcccaggcc
4141 cgctcagatt atcatgtcac tcagcttcag ccttactttg agaatggccg ggtccactac
4201 aggtatagcc catattccag ttcttctagt tcctattaca gtccagatgg ggccctgtgt
4261 gatgtggatg cctatggcac agtccagttg agaccccttc accgccttcc caatcgagac
4321 tttgctttct acaatcctag gctgcaagga aagagcttgt acagttatgc tggtttggct
4381 ccacgtcccc gggccaacgt gactggctat ttctctccca acgaccataa tgtagtcagc
4441 atgcctccgg ctgctgatgt gaagcacacc tacacctcat gggatcttga ggacatggaa
4501 aaataccgca tgcagtccat ccggagagag agccgtgctc ggcagaaggt gaaagggcct
4561 gtcatgtccc aatatgataa catgaccccg gcggtgcagg acgacttggg tgggatctat
4621 gtcatccatc tgcgtagtaa atcagatcct gggaaaactg gacttctctc agtggcagaa
4681 ggaaaggaga gccgccatgc agccaaggcc atcagtcccg agggagagga ccgcttctat
4741 aggaggcatc ccgaggcaga gatggacaga gcccaccatc acggaggcca tggtagcacg
4801 cagccggaga agccatccct gcctcagaag cagagcagcc tgaggagcag gaagcttcct
4861 gacatgggct gcagtcttcc tgagcacagg gcacaccaag aagcaagcca taggcagttc
4921 tgtgagtcaa agaatgggcc cccttatccc cagggagctg gccagttaga ttatgggtcc
4981 aaagggattc cagacacttc tgagccagtc agctaccaca actctggagt aaaatatgct
5041 gcatccgggc aagaatcttt aagactgaac cacaaagagg taaggctctc caaagagatg
5101 gagcgaccct gggttaggca gccttctgcc ccagagaaac actccagaga ctgctacaag
5161 gaggaagaac acctcactca gtcaatcgtc ccacccccta aaccagagag gagtcatagc
5221 ctcaaactcc atcataccca gaacgtggag agggacccca gtgtgctgta ccagtaccaa
5281 ccacacggca agcgccagag cagtgtgact gttgtgtccc agtatgataa cctggaagat
5341 taccactccc tgcctcagca ccagcgagga gtctttggag ggggcggcat ggggacgtat
5401 gtgccccctg gctttcccca tccacagagc aggacctatg ctacagcgtt gggtcaaggg
5461 gccttcctgc ccgcagagtt gtccttgcag catcctgaaa cacagatcca tgcagaatga
5521 gccctgcgag caatagagtt gaagcagcct ctgctggaca gtggactgtt ctattttttt
5581 caataaccaa aaagattaaa caaaaaatac tataaaaccc ctgaccacat ttaaaaaatg
5641 ataataaaag taaacaaatc agcatctttt tccccttccc tgcttcatta ccccctcttc
5701 catctataga ctttgtcatt tttgtcttta gaaaagatct gaaggatggt aaagccccgt
5761 gctgaaaccc agtagagaaa cctgtctcag gacacacttg ccatctaggg ctagcttgaa
5821 agagcctgag gactgccttt aactgaattt gaattcagca ttgtcctttc ttcttagtat
5881 ttgctgcata attgagagca gttcacatcg atttcctggt aggcgtctgc attccctgtt
5941 gtgttcctgc ttctccttca gtagctgcac aacttgcgca gatcgacaca ctgttgtcac
6001 ttcattctcc ccgtctgaga aggatcttgt gttcagttag agtcgtggaa aaatccctga
6061 tccttcaagg tcagtcagac agttggcaac attataatta aaaataagaa attaagactt
6121 taaattaaac atttggtaga gtcatcataa aacaccagac cacttagact caggctgaac
6181 catactcttt ctattcttat ttttcatcct tgttcctcac ggttcagtga acaggctcat
6241 atcatgacag aatggacttt taaaagttag tacttaagga aacttcttta ggtggaagaa
6301 agtaaagttc ttattgtcag tgaactttat tagcaccaga aatctctatt gatgctttta
6361 atgcattgcc tgccttcagg ttttcttctt accccacccc tcaataagat ttggtgaatt
6421 gtaattctag taaaacatgt cataccattg gttttcctaa attatcaact ttctttcatt
//