LOCUS       AY184374                 591 bp    mRNA    linear   HUM 18-APR-2006
DEFINITION  Homo sapiens interferon-lambda3 mRNA, complete cds.
ACCESSION   AY184374
VERSION     AY184374.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat. Immunol. 4 (1), 69-77 (2003)
   PUBMED   12483210
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Lasfar,A., Lewis-Antes,A., Smirnov,S.V., Anantha,S., Abushahba,W.,
            Tian,B., Reuhl,K., Dickensheets,H., Sheikh,F., Donnelly,R.P.,
            Raveche,E. and Kotenko,S.V.
  TITLE     Characterization of the mouse IFN-lambda ligand-receptor system:
            IFN-lambdas exhibit antitumor activity against B16 melanoma
  JOURNAL   Cancer Res. 66 (8), 4468-4477 (2006)
   PUBMED   16618774
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Kotenko,S.V. and Gallagher,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-NOV-2002) Biochemistry & Molecular Biology,
            University of Medicine and Dentistry of New Jersey, New Jersey
            Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
FEATURES             Location/Qualifiers
     source          1..591
                     /db_xref="H-InvDB:HIT000085074"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.13"
     CDS             1..591
                     /function="mediates antiviral protection through a unique
                     class II cytokine receptor complex composed of CRF2-12
                     (IFN-lambdaR1) and CRF2-4 (IL-10R2) subunits"
                     /note="IFN-lambda3; cytokine"
                     /codon_start=1
                     /product="interferon-lambda3"
                     /protein_id="AAN86127.1"
                     /translation="MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKS
                     LSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTL
                     KVLEASADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLYRLQE
                     APKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV"
BASE COUNT           99 a          202 c          178 g          112 t
ORIGIN      
        1 atgaccgggg actgcatgcc agtgctggtg ctgatggccg cagtgctgac cgtgactgga
       61 gcagttcctg tcgccaggct ccgcggggct ctcccggatg caaggggctg ccacatagcc
      121 cagttcaagt ccctgtctcc acaggagctg caggccttta agagggccaa agatgcctta
      181 gaagagtcgc ttctgctgaa ggactgcaag tgccgctccc gcctcttccc caggacctgg
      241 gacctgaggc agctgcaggt gagggagcgc cccgtggctt tggaggctga gctggccctg
      301 acgctgaagg ttctggaggc ctccgctgac actgacccag ccctggggga tgtcttggac
      361 cagccccttc acaccctgca ccatatcctc tcccagctcc gggcctgtat ccagcctcag
      421 cccacggcag ggcccaggac ccggggccgc ctccaccatt ggctgtaccg gctccaggag
      481 gccccaaaaa aggagtcccc tggctgcctc gaggcctctg tcaccttcaa cctcttccgc
      541 ctcctcacgc gagacctgaa ttgtgttgcc agcggggacc tgtgtgtctg a
//