LOCUS AY177664 3579 bp mRNA linear HUM 12-FEB-2004 DEFINITION Homo sapiens desmoglein 4 preproprotein (DSG4) mRNA, complete cds. ACCESSION AY177664 VERSION AY177664.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3579) AUTHORS Whittock,N.V. and Bower,C. TITLE Genetic evidence for a novel human desmosomal cadherin, desmoglein 4 JOURNAL J. Invest. Dermatol. 120 (4), 523-530 (2003) PUBMED 12648213 REFERENCE 2 (bases 1 to 3579) AUTHORS Whittock,N.V. TITLE Direct Submission JOURNAL Submitted (10-NOV-2002) Center for Molecular Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Old Pathology Building, Barrack Road, Exeter EX2 5DW, England FEATURES Location/Qualifiers source 1..3579 /db_xref="H-InvDB:HIT000084989" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="18" /map="18q12" gene 1..3579 /gene="DSG4" 5'UTR 1..135 /gene="DSG4" CDS 136..3258 /gene="DSG4" /note="desmosomal cadherin" /codon_start=1 /product="desmoglein 4 preproprotein" /protein_id="AAO47078.1" /db_xref="GI:29335956" /translation="MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTV RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTI NPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQS VYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA SIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVV KMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAF SVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSR EFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS PSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPI LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWR IEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGT AVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRP ANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFP SHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNA DPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASP GVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVT RYSNIHYTQQ" sig_peptide 136..198 /gene="DSG4" misc_feature 199..3255 /gene="DSG4" /note="encodes desmoglein 4 proprotein" mat_peptide 283..3255 /gene="DSG4" /product="desmoglein 4" 3'UTR 3259..3579 /gene="DSG4" BASE COUNT 1067 a 729 c 834 g 949 t ORIGIN 1 caccacagtt atcacccatg ccctcctaaa agggtgtctc aaagcatatc tttctgtaga 61 gcagaattcg gaactgagaa gacgagggct caaattgaat ctcacaggat ttgcgtgcaa 121 gagaaaccca aaggaatgga ttggctcttc ttcagaaaca tttgcctttt gatcattcta 181 atggtggtga tggaagtaaa cagtgaattt attgttgagg tgaaggaatt tgacattgaa 241 aatggcacta caaaatggca aacagtcaga agacaaaagc gggagtggat caagtttgcc 301 gcagcctgtc gagaaggaga ggacaactcg aagaggaacc ccattgccaa aattcgatca 361 gactgcgaat cgaaccagaa gataacatac cggatttctg gagtagggat tgatcgacca 421 ccatatgggg tattcaccat taatcctcgc actggggaaa ttaacatcac ttcagtggta 481 gacagagaaa taactccact tttcttgatc tattgccggg ctctgaattc acggggtgaa 541 gatttagaaa ggcctcttga gcttagagtc aaagttatgg acataaatga taacgctcca 601 gtcttttcgc aaagtgtata cacagccagc attgaagaaa atagtgatgc caatacattg 661 gtagtaaagt tatgtgccac agatgcagat gaagaaaatc atctgaattc taaaattgcc 721 tacaagatcg tctctcagga gccatcaggt gcacccatgt tcattctgaa taggtacact 781 ggagaagtct gcaccatgtc cagtttcttg gacagagagc aacacagtat gtacaacctg 841 gttgtgagag gctcagatcg ggatggagct gcagatggac tgtcttctga gtgtgactgt 901 agaatcaagg ttttagacgt caacgataat ttccccacct tagagaaaac ttcatactca 961 gccagtattg aagagaattg tttaagttcg gaactgatac gattacaagc aattgatctt 1021 gatgaagaag gcactgataa ctggttggct caatatttaa ttctctctgg aaatgatggg 1081 aattggttcg atattcaaac agatccacaa accaatgaag gcattttgaa agttgtcaag 1141 atgctggatt atgaacaagc acctaacatt cagcttagta tcggagttaa aaaccaagct 1201 gattttcact actccgttgc ttctcaattc caaatgcacc caacccctgt gagaattcaa 1261 gttgttgatg tgagagaagg acctgcattt catccaagta ctatggcttt tagtgtgcgg 1321 gaaggaataa aaggaagttc cttattgaat tatgtgcttg gcacatatac agccatagat 1381 ttggacacag gaaaccctgc aacagatgtc agatatatca tagggcatga tgcaggcagc 1441 tggttaaaaa ttgattcaag aactggtgag atacaatttt ctagagaatt tgataagaag 1501 tcaaaatata ttatcaatgg gatatacaca gcagagatcc tggctataga tgatggctct 1561 ggaaaaacag ctacaggaac catatgtatt gaggttcctg atatcaatga ttattgtcca 1621 aacatttttc ctgaaagaag aaccatctgc attgactctc catcagtcct tatctctgtt 1681 aatgaacatt cttatgggtc tccgtttact ttctgtgttg ttgatgagcc accaggaata 1741 gctgacatgt gggatgtcag atcaacaaat gctacctcgg caatccttac ggctaagcag 1801 gttttatctc caggatttta tgaaatccca atcctggtga aggacagcta taacagagca 1861 tgtgaattgg cacaaatggt gcagttatat gcctgtgatt gcgatgacaa ccacatgtgc 1921 ctggactctg gtgccgcggg catctacaca gaggacataa ctggtgacac gtatgggcct 1981 gtcactgaag accaagctgg agtttcaaat gttggtcttg gaccagcagg gattggcatg 2041 atggttctgg gcatcctgct actgattttg gctccactct tgctgctcct gtgttgctgc 2101 aaacagagac agccagaagg cctgggaaca agatttgctc ctgtgcctga gggcggagaa 2161 ggagtgatgc agtcttggag aattgaaggg gcccatcccg aggacaggga tgtgtcaaat 2221 atatgtgcac ccatgacagc ctcaaatacc caggatcgga tggattcctc tgaaatctac 2281 accaacacct atgcagccgg gggcacggtg gaaggaggtg tatcgggagt ggagctcaac 2341 acaggtatgg ggacagccgt tggcctcatg gccgcagggg ccgcaggagc ctcaggggcc 2401 gcaaggaaga ggagctctac catgggaacc ctgcgggact acgctgacgc agacatcaac 2461 atggctttct tggacagcta cttctcggag aaagcgtatg cttatgcaga tgaagatgaa 2521 ggtcgaccag ccaatgactg cttgctcatt tatgaccacg agggagtcgg gtctcccgta 2581 ggctctattg gttgttgcag ttggattgtg gatgacttag atgaaagctg catggaaact 2641 ttagatccaa aatttaggac tcttgctgag atctgcttaa acacagaaat tgaaccattt 2701 ccttcacacc aggcttgtat accaatcagt actgacctcc ctttgctcgg acctaattac 2761 tttgttaatg aatcttcagg attgactccc tcagaagttg aattccaaga agaaatggca 2821 gcatctgaac ccgtggtcca tggggatatt attgtgactg agacttacgg taatgctgat 2881 ccatgtgtgc aacccactac aattattttt gatcctcagc ttgcacccaa tgttgtagta 2941 accgaagcag taatggcacc tgtctatgat attcaaggga atatttgtgt acctgctgag 3001 ttagcagatt acaacaatgt aatctatgct gagagagtac tggctagtcc tggtgtgcct 3061 gacatgagca atagtagcac gactgagggt tgtatgggac ctgtgatgag cggcaatatt 3121 ttagtagggc cagaaattca agtgatgcaa atgatgagtc cagaccttcc cataggccaa 3181 accgttggct ccacatcccc catgacatct cgacacagag taacacgata cagtaacata 3241 cattacaccc aacagtaagt gctttatggt cagtattcta tgtggagacc ttgcaccttg 3301 taatcatcaa tacatccacc aaaaatatat aatgtaccat atatattaat agtcaacaaa 3361 tactcagata ttctaaggtc aatgccatta tttgattata ccattttgag ggtgaatatg 3421 gctaggcact ttagataagc ctttttaaaa ttctttctga ttttaaataa tgcgtcaaaa 3481 aatgtgcaga aaatgtattg catcccttga tactgtctaa cgaatagcac ataactcata 3541 ttgtgaatcc tatgggtctt gaggcctgta gaaccaatc // LOCUS AY168788 3531 bp mRNA linear HUM 01-MAY-2004 DEFINITION Homo sapiens desmoglein 4 (DSG4) mRNA, complete cds. ACCESSION AY168788 VERSION AY168788.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3531) AUTHORS Nguyen,V.T. TITLE Experimental Mouse Model-Passive Transfer of Nondesmoglein 1 and 3 Antibodies for Pemphigus Vulgaris JOURNAL (in) Chan,L.S. (Ed.); ANIMAL MODELS OF HUMAN INFLAMMATORY SKIN DISEASES; CRC Press LLC, FL, USA (2003) REFERENCE 2 (bases 1 to 3531) AUTHORS Nguyen,V.T. TITLE Novel Pemphigus Vulgaris Antigen Desmoglein 4 has an Important Role in Mediating Keratinocyte Adhesion JOURNAL Unpublished REFERENCE 3 (bases 1 to 3531) AUTHORS Nguyen,V.T. TITLE Direct Submission JOURNAL Submitted (25-OCT-2002) Dermatology, University of California, Davis, Neuroscience Building, 1515 Newton Court, Davis, CA 95616, USA FEATURES Location/Qualifiers source 1..3531 /db_xref="H-InvDB:HIT000250885" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="18" /map="18q12" /cell_type="epidermal keratinocyte" gene 1..3531 /gene="DSG4" CDS 30..3209 /gene="DSG4" /note="cadherin; keratinocyte adhesion molecule; recombinant protein is recognized by Homo sapiens pemphigus vulgaris antibody to desmoglein 3, a classical autoimmune skin blistering disease antigen encoded by GenBank Accession Number M76482; may have a role in mediating keratinocyte adhesion" /codon_start=1 /product="desmoglein 4" /protein_id="AAO43657.1" /db_xref="GI:37727191" /translation="MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTV RRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTI NPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQS VYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSA SIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVV KMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAF SVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSR EFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDS PSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPI LVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVS NVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWR IEGAHPEDRLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAA GGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFL DSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLD PKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMA ASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVP AELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDL PIGQTVGSTSPMTSRHRVTRYSNIHYTQQ" BASE COUNT 1035 a 722 c 835 g 939 t ORIGIN 1 ggatttgcgt gcaagagaaa cccaaaggaa tggattggct cttcttcaga aacatttgcc 61 ttttgatcat tctaatggtg gtgatggaag taaacagtga atttattgtt gaggtgaagg 121 aatttgacat tgaaaatggc actacaaaat ggcaaacagt cagaagacaa aagcgggagt 181 ggatcaagtt tgccgcagcc tgtcgagaag gagaggacaa ctcgaagagg aaccccattg 241 ccaaaattcg atcagactgc gaatcgaacc agaagataac ataccgaatt tctggagtag 301 ggattgatcg accaccatat ggggtattca ccattaatcc tcgcactggg gaaattaaca 361 tcacttcagt ggtagacaga gaaataactc cacttttctt gatctattgc cgggctctga 421 attcacgggg tgaagattta gaaaggcctc ttgagcttag agtcaaagtt atggacataa 481 atgataacgc tccagtcttt tcgcaaagtg tatacacagc cagtattgaa gaaaatagtg 541 atgccaatac attggtagta aagttatgtg ccacagatgc agatgaagaa aatcatctga 601 attctaaaat tgcctacaag atcgtctctc aggagccatc aggtgcaccc atgttcattc 661 tgaataggta cactggagaa gtctgcacca tgtccagttt cttggacaga gagcaacaca 721 gtatgtacaa cctggttgtg agaggctcag atcgggatgg agctgcagat ggactgtctt 781 ctgagtgtga ctgtagaatc aaggttttag acgtcaacga taatttcccc accttagaga 841 aaacttcata ctcagccagt attgaagaga attgtttaag ttcggaactg atacgattac 901 aagcaattga tcttgatgaa gaaggcactg ataactggtt ggctcaatat ttaattctct 961 ctggaaatga tgggaattgg ttcgatattc aaacagatcc acaaaccaat gaaggcattt 1021 tgaaagttgt caagatgctg gattatgaac aagcacctaa cattcagctt agtatcggag 1081 ttaaaaacca agctgatttt cactactccg ttgcttctca attccaaatg cacccaaccc 1141 ctgtgagaat tcaagttgtt gatgtgagag aaggacctgc atttcatcca agtactatgg 1201 cttttagtgt gcgggaagga ataaaaggaa gttccttatt gaattatgtg cttggcacat 1261 atacagccat agatttggac acaggaaacc ctgcaacaga tgtcagatat atcatagggc 1321 atgatgcagg cagctggtta aaaattgatt caagaactgg tgagatacaa ttttctagag 1381 aatttgataa gaagtcaaaa tatattatca atgggatata cacagcagag atcctggcta 1441 tagatgatgg ctctggaaaa acagctacag gaaccatatg tattgaggtt cctgatatca 1501 atgattattg tccaaacatt tttcctgaaa gaagaaccat ctgcattgac tctccatcag 1561 tccttatctc tgttaatgaa cattcttatg ggtctccgtt tactttctgt gttgttgatg 1621 agccaccagg aatagctgac atgtgggatg tcagatcaac aaatgctacc tcggcaatcc 1681 ttacggctaa gcaggtttta tctccaggat tttatgaaat cccaatcctg gtgaaggaca 1741 gctataacag agcatgtgaa ttggcacaaa tggtgcagtt atatgcctgt gattgcgatg 1801 acaaccacat gtgcctggac tctggtgccg cgggcatcta cacagaggac ataactggtg 1861 acacgtatgg gcctgtcact gaagaccaag ctggagtttc aaatgttggt cttggaccag 1921 cagggattgg catgatggtt ctgggcatcc tgctactgat tttggctcca ctcttgctgc 1981 tcctgtgttg ctgcaaacag agacagccag aaggcctggg aacaagattt gctcctgtgc 2041 ctgagggcgg agaaggagtg atgcagtctt ggagaattga aggggcccat cccgaggaca 2101 ggctttttag cgcctacgcc ttgccgggtg gtggtggcac cgcagacggc ggcggcagcg 2161 ttttaggcag atgcgcgctg caggcaactc cagcgctgtt aaaccaacat cctccctttt 2221 cagaaatcta caccaacacc tatgcagccg ggggcacggt ggaaggaggt gtatcgggag 2281 tggagctcaa cacaggtatg gggacagccg ttggcctcat ggccgcaggg gccgcaggag 2341 cctcaggggc cgcaaggaag aggagctcta ccatgggaac cctgcgggac tacgctgacg 2401 cagacatcaa catggctttc ttggacagct acttctcgga gaaagcgtat gcttatgcag 2461 atgaagatga aggtcgacca gccaatgact gcttgctcat ttatgaccac gagggagtcg 2521 ggtctcccgt aggctctatt ggttgttgca gttggattgt ggatgactta gatgaaagct 2581 gcatggaaac tttagatcca aaatttagga ctcttgctga gatctgctta aacacagaaa 2641 ttgaaccatt tccttcacac caggcttgta taccaatcag tactgacctc cctttgctcg 2701 gacctaatta ctttgttaat gaatcttcag gattgactcc ctcagaagtt gaattccaag 2761 aagaaatggc agcatctgaa cccgtggtcc atggggatat tattgtgact gagacttacg 2821 gtaatgctga tccatgtgtg caacccacta caattatttt tgatcctcag cttgcaccca 2881 atgttgtagt aaccgaagca gtaatggcac ctgtctatga tattcaaggg aatatttgtg 2941 tacctgctga gttagcagat tacaacaatg taatctatgc tgagagagta ctggctagtc 3001 ctggtgtgcc tgacatgagc aatagtagca cgactgaggg ttgtatggga cctgtgatga 3061 gcggcaatat tttagtaggg ccagaaattc aagtgatgca aatgatgagt ccagaccttc 3121 ccataggcca aaccgttggc tccacatccc ccatgacatc tcgacacaga gtaacacgat 3181 acagtaacat acattacacc caacagtaag tgctttatgg tcagtattct atgtggagat 3241 cttgcacctt gtaatcatca atacatccac caaaaatata taatgtacca tatatattaa 3301 tagtcaacaa atactcagat attctaaggt caatgccatt atttgattat accattttga 3361 gggtgaatat ggctaggcac tttagataag cctttttaaa attctttctg attttaaata 3421 atgcgtcaaa aaatgtgcag aaaatgtatt gcatcccttg atactgtcta acgaatagca 3481 cataactcgt attgtgaatc ctatgggtct tgaggcctgt agaaccaatc t //