LOCUS AY176045 5959 bp mRNA linear HUM 20-AUG-2003
DEFINITION Homo sapiens Grb10 interacting GYF protein 2 mRNA, complete cds.
ACCESSION AY176045
VERSION AY176045.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5959)
AUTHORS Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
Smith,R.J.
TITLE Two novel proteins that are linked to insulin-like growth factor
(IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
JOURNAL J. Biol. Chem. 278 (34), 31564-31573 (2003)
PUBMED 12771153
REFERENCE 2 (bases 1 to 5959)
AUTHORS Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
Smith,R.J.
TITLE Direct Submission
JOURNAL Submitted (07-NOV-2002) Endocrinology, Brown University, 55
Claverick St., Providence, RI 02903, USA
FEATURES Location/Qualifiers
source 1..5959
/db_xref="H-InvDB:HIT000250901"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q36.1"
/tissue_type="kidney"
CDS 312..4211
/note="GIGYF2"
/codon_start=1
/product="Grb10 interacting GYF protein 2"
/protein_id="AAO46889.1"
/translation="MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYG
REEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVL
RLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQS
WEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDG
GWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSG
SIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEEC
SDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEAS
QFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLI
LPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALD
DERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMS
LLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQH
LQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRS
VSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQE
RREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQR
EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE
AQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQ
QQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELM
KALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGP
RNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHAL
NTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQR
QQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGK
KKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY"
BASE COUNT 1746 a 1274 c 1540 g 1399 t
ORIGIN
1 atcttgtgtt gttgaggctg aggactgact ggggttctga gactccctgt cccggaccgc
61 agattatagt gggaccagtc tcattaggtt gaatctacag cctatgttgg tgttaaccca
121 ggtctcttag agcgttaaaa ggatctgaac aaagtctgct caaatctcct gctgtgaacc
181 agcagaattt ttgaacagag accacgtctc cacctcctgg gctccaacga ttctcccatc
241 ttggcctccc aaagcgctgg atttacaggt ttcttcacat ataaaaatct attgtaaaaa
301 tacggaaaag aatggcagcg gaaacgcaga cactgaactt tgggcctgaa tggctccgag
361 ctctgtccag tggtgggagt attacatccc ctcctctttc tccagcattg ccgaagtata
421 aattagcaga ttatcgttac ggcagagaag aaatgttagc acttttcctt aaagacaaca
481 agataccttc agaccttctg gataaagaat ttctgcctat cctccaggag gaaccccttc
541 caccattggc tctggtaccc tttacagaag aagaacagag aaacttttcc atgtctgtaa
601 atagtgctgc tgtcctgcga ttgacaggac gaggaggagg aggaacagtg gtgggggctc
661 ctagaggtcg aagttcttca agagggcgag gcagaggcag aggtgaatgt ggtttctacc
721 aaagaagttt tgatgaagta gagggtgttt ttggtcgagg aggtggcaga gaaatgcata
781 gatcgcagag ctgggaggaa aggggtgaca gacgttttga aaaaccagga cgaaaagatg
841 tagggagacc aaattttgag gaaggtggac caacatcagt agggagaaag catgaattta
901 tacgctcaga aagtgaaaat tggcgcatct ttagagagga acaaaatgga gaagatgaag
961 atggaggttg gcgactagct ggatcaagga gggatggaga gaggtggcga cctcacagtc
1021 ctgatggccc tcgttctgca ggctggcggg aacacatgga acgacgtcgg aggtttgagt
1081 ttgattttcg agatagagat gatgaacggg gttaccgaag ggttcgctct ggcagtggga
1141 gcatagatga tgacagggat agcttgcccg aatggtgctt agaggatgct gaagaagaaa
1201 tgggtacatt tgactcatct ggagcattcc tttctctaaa aaaagtacag aaagagccta
1261 ttccagaaga gcaggagatg gacttccggc ctgtggacga aggggaggag tgctctgact
1321 ctgagggtag ccataatgaa gaggccaaag aacccgataa gacaaataag aaagaaggag
1381 agaaaacaga tagagtagga gttgaagcta gtgaggaaac tccccagacc tcatcatcat
1441 ctgctagacc aggtactcct tcagaccatc agtctcagga agcatcacag tttgagagga
1501 aagatgaacc aaaaactgag caaacggaaa aagctgaaga ggagactcgg atggaaaata
1561 gtctaccagc caaagtgccc agcagagggg atgaaatggt tgctgatgtc cagcagcccc
1621 tgtcgcagat tccttcagat acagcctctc ctcttctcat acttccacct cctgttccca
1681 atcctagtcc tactctccgg ccagttgaaa caccagttgt aggtgctcct ggtatgggca
1741 gtgtttccac agaacctgat gatgaagaag gtctcaaaca tttggagcag caagctgaga
1801 aaatggtggc ttatctccaa gacagtgcac tagatgatga aagattggca tcaaaactgc
1861 aagagcacag agctaaagga gtgtcgattc cattgatgca tgaagcaatg cagaagtggt
1921 attacaaaga tcctcaggga gaaattcaag gtcccttcaa taatcaggag atggcagaat
1981 ggtttcaggc gggctatttt actatgtctt tattggtgaa gagagcgtgt gatgaaagct
2041 tccaacctct tggcgatatc atgaaaatgt ggggaagggt tcccttttct ccaggtccag
2101 ctccccctcc tcatatggga gagctggacc aggaacgact gaccaggcag caagaactca
2161 cagccttata ccagatgcag cacctgcagt accagcagtt tttaatacaa caacaatatg
2221 cacaggtttt ggcccaacag cagaaagcag cactgtcttc ccagcagcag cagcagttgg
2281 cacttcttct tcaacagttt cagaccttga agatgagaat atctgatcag aacatcattc
2341 cctcagtaac taggtctgtg tccgtgccag atactggctc tatctgggag cttcagccaa
2401 cagcttcaca gcctacagtt tgggaaggtg gtagtgtatg ggatcttcct ctggacacca
2461 cgacaccagg ccctgccctg gaacagcttc agcagctaga gaaggccaaa gctgcaaagc
2521 tagagcaaga gagaagagag gcagaaatga gggcaaaacg ggaagaggaa gagcgaaaga
2581 ggcaggaaga actccgaaga caacaggagg aaattcttcg gcgacagcag gaagaagaaa
2641 ggaaaaggcg agaggaagaa gaacttgccc gaaggaaaca ggaagaggct ctgcgtcgcc
2701 agcgggagca agaaattgca ttaaggcgac agcgagaaga ggaagaaaga cagcagcaag
2761 aagaagctct tagaagactg gaagagagga gaagagaaga ggaagaaagg cggaagcagg
2821 aagaattgtt acgcaaacag gaagaggagg ctgcaaaatg ggcccgggaa gaagaagaag
2881 cccagcgtcg attagaggag aaccggctgc ggatggaaga ggaggcagcc agactccggc
2941 atgaggaaga agaacggaag agaaaggagc tggaggtcca gcggcagaag gagttaatgc
3001 gccagaggca acagcagcaa gaggctctcc ggaggttgca gcagcagcag cagcaacaac
3061 agctggcgca gatgaagctt ccttcttctt caacgtgggg ccagcagtcc aatacaacag
3121 catgtcagtc ccaggccacg ctgtcgttgg ctgaaatcca aaaactagag gaagaacgag
3181 aacggcagct tcgagaagag caaaggcgcc agcagaggga gttgatgaaa gctcttcagc
3241 agcagcagca acagcaacag cagaaactct caggttgggg gaatgtcagc aaaccttcag
3301 gtaccacgaa atctcttctg gagatccagc aggaagaggc caggcaaatg caaaagcagc
3361 agcagcagca gcagcaacac cagcaaccaa acagagctcg taacaatacg cattccaacc
3421 tgcacaccag cattgggaat tctgtttggg gctctataaa tactggtcct cctaaccagt
3481 gggcatctga cctagtcagt agtatttgga gtaatgctga cactaaaaac tccaacatgg
3541 gattctggga tgatgcagtg aaagaggtgg gacctaggaa ttcaacaaat aaaaataaaa
3601 acaacgccag tctcagtaaa tctgtaggtg tgtctaaccg gcagaataag aaagtagaag
3661 aagaagaaaa gttgctgaag ctctttcagg gagtaaataa agcccaagat ggatttacgc
3721 agtggtgtga acagatgctt catgccctta atacggcaaa taacttggat gttcccacat
3781 ttgtttcttt cctgaaagaa gtagaatctc cttatgaggt ccatgattat atcagggcct
3841 atttaggaga tacttctgag gccaaggagt ttgccaagca gttccttgag cgccgtgcca
3901 aacagaaagc caaccagcag cgtcagcagc agcagctgcc acagcagcag cagcagcagc
3961 cgccacagca gccgccacag cagccacaac agcaggactc tgtgtggggg atgaaccaca
4021 gtacactcca ttcagtattt cagaccaatc aaagcaacaa ccaacaatcc aattttgagg
4081 ctgtgcagag tggcaagaag aagaaaaagc agaagatggt ccgagcagat cccagtttat
4141 taggattttc agtcaatgca tcatcggagc gactcaacat gggtgaaatc gagacgttgg
4201 atgactactg agcacctgcc agtggactgg ccatccctct cctgtctgcc gactatggag
4261 tctccacctt tggacacaac acttactcac catttactct ttatcactct gcaacaaatc
4321 acagaaccga tcatctcagg ctttttcttc tggccctttg tgtccaagat tctttaatcc
4381 atttttgttg gtgaacatct cagactatag ataagtggac tggaccctgt gtcttggggg
4441 tggcagttgg gattactccc caacaaggct gattttaggc agcatgtgtt cactgtgctg
4501 tgatttcatc tactgtctcc cagaaagtgt gttgggatcg gccattagca gcttgctttc
4561 tcttgtcact ttttttcttc tattttgttt tttcttcttc tttttccccc catcagggca
4621 aatggtctaa ctggtgcaat catgaagaga gttaatggtt aacagacatt ggccaataac
4681 aaaacacccc atggactgtg actcgagtat ccaacaggca gtcagagctc tcccggtctg
4741 aaagttgcat tgccactgct aactttggga ttgcatcaga gaggccctga gtggggttga
4801 gatgaggttg gtttggtttg atgttacaca ctcctcacct gttctttctg agtgtccttt
4861 ctctgaaagg atttatgttt ttcttcgtta gatagtgact tctgagcaag ctgatctccc
4921 ctggcatgct ccaacctgat tggacaaagg aagctctatg gcctgggaga gagactattc
4981 ttaatttttc tttcttacaa aaactgattt ttcccataaa tatttttact tcagaggact
5041 aggaccattt tgttttgggc ccttctgctg aaaatttgtc tcgtttaaga ggcagctaga
5101 atctttacca tatgtatgaa tttgtataat ttcatttttg gatagggata aacttttgct
5161 tctgataaaa gcctggaatt tcatctggtc ctcagagcat tgcgtgtgtg tcttgctgta
5221 gcccggaaaa ggttttgtgt aaagattctg ggatggcaag ttgtttgcct tttctgaaaa
5281 gagaacatac agaacctgtc catctttaag accttcatcc atggaatcta ctatacagga
5341 ggatgcagtg ggctggaggg gatgggcgaa aatgggagca ggaagcctgg cctggcttct
5401 ggtcatggcc tcctaaaacc ttaaacttca agtagaaatg tactcaagcc ctatttataa
5461 acaaatactt ttcctgcctc caccaaaccc ctacagaaca tcacctggaa ttgccactca
5521 cactgggttg gagtcattgg gcagctgtgc ctgtgcgaga ggtgctgtgg tctgggcagc
5581 ccctggaaaa gcacctttgc tgcctgtcat tgttgcctga agaaggctgg agttgctctg
5641 agagcagttt gggtttggag tattatattt ggcttctatt tttattattt tggatcacca
5701 ttctccctat cccttcttgc ctccctccct tctaaacatg tgtaataact atacagagac
5761 tgctacaaaa ttgtatatag tttttggatc aaatagcatg aggggagagg aaaccattaa
5821 aagttggggc tcctactctc ctttgctttg taaattcaaa agttgggggt gggtaagagg
5881 gatagttaaa atgtttacaa aactttaggc tccctcggaa cttttgccag tgtggaggaa
5941 aataaaaaag aacttaaat
//