LOCUS AY168922 3060 bp mRNA linear HUM 18-APR-2003
DEFINITION Homo sapiens Est1p-like protein B mRNA, complete cds.
ACCESSION AY168922
VERSION AY168922.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3060)
AUTHORS Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
Robinson,M.O. and Harrington,L.
TITLE Functional conservation of the telomerase protein Est1p in humans
JOURNAL Curr. Biol. 13 (8), 698-704 (2003)
PUBMED 12699629
REFERENCE 2 (bases 1 to 3060)
AUTHORS Snow,B.E., Gill,M. and Harrington,L.
TITLE Direct Submission
JOURNAL Submitted (25-OCT-2002) Medical Biophysics, University of Toronto,
Ontario Cancer Institute, 620 University Avenue, Suite 706,
Toronto, ON M5G 2C1, Canada
FEATURES Location/Qualifiers
source 1..3060
/db_xref="H-InvDB:HIT000084916"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.2"
CDS 4..3054
/note="EST1B"
/codon_start=1
/product="Est1p-like protein B"
/protein_id="AAO17582.1"
/translation="MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAY
QEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIH
SRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSAS
GKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQL
GTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLS
LASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLV
NHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKS
RKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAF
DAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASN
LQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGS
ESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSL
WNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPL
RAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQ
SEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPY
LVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFK
KGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTI
ITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG"
misc_feature 160..774
/note="Region: Est1p-like domain"
misc_feature 517..681
/note="Region: tetratricopeptide repeats; TPRs"
misc_feature 2566..2961
/note="PIN domains are similar to 5' exonucleases and
RNases and are thought to be involved in RNAi and
non-sense mediated mRNA decay (NMD); Region:
PilT-amino-terminal (PIN) domain"
BASE COUNT 727 a 872 c 825 g 636 t
ORIGIN
1 accatgagcc aaggcccccc cacaggggag agcagcgagc ccgaagcaaa agtcctccac
61 actaagcggc tttaccgggc tgtggtggag gctgtgcatc gacttgacct catcctttgc
121 aacaaaactg cttatcaaga agtattcaaa ccagaaaaca ttagcctgag gaacaagctg
181 cgtgagctct gcgtcaagct tatgttcctg cacccagtgg actatgggag aaaggctgag
241 gagctgctgt ggagaaaggt atactatgaa gttatccagc ttatcaagac taacaaaaag
301 cacatccaca gccggagcac tttggaatgt gcctacagga cgcacctggt tgctggtatt
361 ggcttctacc agcatctcct tctctatatc cagtcccact accagctgga actgcagtgc
421 tgcatcgact ggacccatgt cactgacccc ctcataggat gcaagaagcc agtgtctgcc
481 tcagggaagg agatggattg ggcacagatg gcatgtcacc gatgtctggt gtatctgggg
541 gatttgtccc gatatcagaa tgaattagct ggcgtagata ccgagctgct agccgagaga
601 ttttactacc aagccctgtc agtagctcct cagattggaa tgcccttcaa tcagctgggc
661 accctggcag gcagcaagta ctataatgtg gaagccatgt attgctacct gcgctgcatc
721 cagtcagaag tgtcctttga gggagcctat gggaacctca agcggctgta tgacaaggca
781 gccaaaatgt accaccaact gaagaagtgt gagactcgga aactgtctcc tggcaaaaag
841 cgatgtaaag acattaaaag gttgctagtg aactttatgt atctgcaaag cctcctacag
901 cccaaaagca gctccgtgga ctcagagctg acctcacttt gccagtcagt cctggaggac
961 ttcaacctct gcctcttcta cctgccctcc tcacccaacc tcagcctggc cagtgaggat
1021 gaggaggagt atgagagtgg atatgctttc ctcccggacc ttctcatctt tcaaatggtc
1081 atcatctgcc ttatgtgtgt gcacagcttg gagagagcag gatccaagca gtacagtgca
1141 gccattgcct tcaccctggc cctcttttcc cacctcgtca atcatgtcaa catacggctg
1201 caggctgagc tggaagaggg cgagaatccc gtcccggcat tccagagtga tggcacagat
1261 gaaccagagt ccaaggaacc tgtggagaaa gaggaggagc cagatcctga gcctcctcct
1321 gtaacacccc aagtgggtga gggcagaaag agccgtaagt tctctcgcct ctcctgtctc
1381 cgccgtcgcc gccacccacc caaagttggt gatgacagtg acctgagtga aggctttgaa
1441 tcggactcaa gccatgactc agcccgggcc agtgagggct cagacagtgg ctctgacaag
1501 agtcttgaag gtgggggaac ggcctttgat gctgaaacag actcggaaat gaatagccag
1561 gagtcccgat cagacttgga agatatggag gaagaggagg ggacacggtc accaaccctg
1621 gagccccctc ggggcagatc agaggctccc gattccctca atggcccact gggccccagt
1681 gaggctagca ttgccagcaa tctacaagcc atgtccaccc agatgttcca gactaagcgc
1741 tgcttccgac tggcccccac ctttagcaac ctgctcctcc agcccaccac caaccctcat
1801 acctcggcca gccacaggcc ttgcgtcaat ggggatgtag acaagccttc agagccagcc
1861 tctgaggagg gctctgagtc ggaggggagt gagtccagtg gacgctcctg tcggaatgag
1921 cgcagcatcc aggagaagct tcaggtcctg atggccgaag gtctgcttcc tgctgtgaaa
1981 gtcttcctgg actggcttcg gaccaacccc gacctcatca tcgtgtgtgc acagagctct
2041 caaagtctgt ggaaccgcct gtctgtgttg ctgaatctgt tgcctgctgc tggtgaactc
2101 caggagtctg gcctggcctt gtgtcctgag gtccaagatc ttcttgaagg ttgtgaactg
2161 cctgacctcc cctctagcct tctgctccca gaggacatgg ctcttcgtaa cctgcccccg
2221 ctccgagctg cccacagacg ctttaacttt gacacggatc ggcccctgct cagcacctta
2281 gaggagtcag tggtgcgcat ctgctgcatc cgcagctttg gtcatttcat cgcccgcctg
2341 caaggcagca tcctgcagtt caacccagag gttggcatct tcgtcagcat tgcccagtct
2401 gagcaggaga gcctgctgca gcaggcccag gcacagttcc gaatggcaca ggaggaagct
2461 cgtcggaaca ggctcatgag agacatggct cagctacgac ttcagctcga agtgtctcag
2521 ctggagggca gcctgcagca gcccaaggcc cagtcagcca tgtctcccta cctcgtccct
2581 gacacccagg ccctctgcca ccatctccct gtcatccgcc aactggccac cagtggccgc
2641 ttcattgtca tcatcccaag gacagtgatc gatggcctgg atttgctgaa gaaggaacac
2701 ccaggggccc gggatgggat tcggtacctg gaggcagagt ttaaaaaagg aaacaggtac
2761 attcgctgcc agaaagaggt gggaaagagc tttgagcggc ataagctgaa gaggcaggat
2821 gcagatgcct ggactctcta taagatccta gacagctgca aacagctgac tctggcccag
2881 ggggcaggtg aggaggatcc gagtggcatg gtgaccatca tcacaggcct tccactggac
2941 aaccccagcg tgctttcagg ccccatgcag gcagccctgc aggccgctgc ccacgccagt
3001 gtggacatca agaatgttct ggacttctac aagcagtgga aggaaattgg ttgatactga
//