LOCUS AY168921 4183 bp mRNA linear HUM 18-APR-2003 DEFINITION Homo sapiens Est1p-like protein A mRNA, complete cds. ACCESSION AY168921 VERSION AY168921.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4183) AUTHORS Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M., Robinson,M.O. and Harrington,L. TITLE Functional conservation of the telomerase protein Est1p in humans JOURNAL Curr. Biol. 13 (8), 698-704 (2003) PUBMED 12699629 REFERENCE 2 (bases 1 to 4183) AUTHORS Snow,B.E., Gill,M. and Harrington,L. TITLE Direct Submission JOURNAL Submitted (25-OCT-2002) Medical Biophysics, University of Toronto, Ontario Cancer Institute, 620 University Avenue, Suite 706, Toronto, ON M5G 2C1, Canada FEATURES Location/Qualifiers source 1..4183 /db_xref="H-InvDB:HIT000084915" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17p13.3" CDS 1..4167 /note="EST1A" /codon_start=1 /product="Est1p-like protein A" /protein_id="AAO17581.1" /translation="MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFK DEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLK IIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEV ANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDK RRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDED RIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPM VRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAG SPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVY PGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSN LLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKF RQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKP LRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQ LALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFD LSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSD LNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTI NMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPED QDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTL ADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDK VIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLED EEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQ MRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETD HRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGN NDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDI PAFLTWAQVG" misc_feature 340..1509 /note="Region: DNA-binding domain" misc_feature 1747..2340 /note="Region: Est1p-like domain" misc_feature 2083..2247 /note="Region: tetratricopeptide repeats; TPRs" misc_feature 3643..4113 /note="PIN domains are similar to 5' exonucleases and RNases and are thought to be involved in RNAi and non-sense mediated mRNA decay (NMD); Region: PilT-amino-terminal (PIN) domain" BASE COUNT 1109 a 1037 c 1196 g 841 t ORIGIN 1 atgaaggaat taaaggaggc caggccgcgc aaagataaca ggcgtccaga tctggaaatc 61 tataagcctg gcctttctcg gctaaggaac aagcccaaaa tcaaggaacc ccctgggagt 121 gaggaattca aagatgaaat tgttaatgac cgagattgct ctgctgttga aaatggtaca 181 cagcccgtta aagatgtctg caaggaactg aacaaccaag agcagaatgg tcctatagac 241 ccagaaaata atcggggaca agaatccttt cctaggactg ctggacaaga ggatcgtagt 301 ctaaaaatta tcaaaagaac aaagaaaccc gacctgcaga tctatcagcc tggacgacgt 361 ttgcagactg ttagcaaaga atccgccagt cgggtggagg aggaagaagt cctcaaccag 421 gtagaacaac tgagagtaga ggaagatgag tgtaggggaa atgttgcgaa ggaggaagtt 481 gcgaataaac cagacagggc tgagatagaa aagagcccag gtggtgggag agtaggggct 541 gcaaaaggag aaaaaggaaa gaggatggga aaaggggagg gggtgaggga aacccacgac 601 gacccagccc gcgggaggcc gggctccgca aagcgctact cccgctcaga caaacgaagg 661 aatcgctacc gcacgcgcag caccagctca gctggcagca acaacagcgc tgagggagct 721 ggcctgacgg ataatggatg tcgccgccgc cgacaggata ggaccaagga gaggccacga 781 ctgaagaagc aagtgtctgt gtcctcaacc gattccttag acgaggacag aattgatgag 841 cctgatggat taggacccag gagaagttca gaaaggaaga gacatttaga aagaaactgg 901 tctggccgtg gggagggtga gcagaaaaac agtgctaaag aatatcgagg cactcttcgt 961 gtcactttcg atgcagaagc catgaacaaa gagtctccca tggtgaggtc agccagggat 1021 gatatggata gaggaaagcc tgacaaaggc ttgagcagtg ggggcaaagg ctctgagaag 1081 caggagtcca aaaacccgaa acaagaactt cggggtcgtg gtcgtggcat tctgattttg 1141 cctgcccata ccaccctatc tgtcaattca gcaggttctc cagagtccgc gcctttggga 1201 cctcggcttt tgtttggatc tggtagtaag ggatctcgga gttggggccg tggaggcacc 1261 acacgccgat tgtgggaccc aaacaatcct gatcagaaac ctgctctaaa gactcagacg 1321 ccccagctac atttcttgga cactgatgat gaagtcagcc ctacatcttg gggtgactca 1381 cgccaggctc aggcatctta ctataagttt caaaactctg acaaccccta ttattacccc 1441 cggacaccag gccctgcctc ccagtatccc tatacgggct ataaccctct acagtaccca 1501 gtgggcccta cgaatggtgt gtacccaggg ccttactacc caggctaccc gactccgtca 1561 ggacagtatg tgtgtagccc tctacctacc agcaccatga gtcccgagga ggtagagcag 1621 cacatgagga acctgcagca acaggagctg cacaggcttc tccgggtggc tgacaaccag 1681 gaactgcagc tcagcaacct gctctccagg gaccgcatca gtccggaggg cctggagaag 1741 atggcgcaac tcagagctga actgctgcag ctatatgagc gctgtattct attagatatt 1801 gagttctctg ataatcagaa tgtggatcag atcctgtgga agaatgcttt ctatcaggtg 1861 attgagaagt tcaggcaact tgtcaaggat ccgaatgttg agaacccaga acagattcgg 1921 aacagacttt tggagctctt ggatgagggt agtgacttct ttgatagttt gcttcagaag 1981 ctgcaggtta cttacaagtt caaactggaa gactacatgg atggtcttgc cattcgcagc 2041 aagccattac gcaagacagt aaaatatgcc ttgatcagtg cccagcgatg catgatatgc 2101 caaggagata ttgctaggta ccgggagcaa gccagtgata cagcgaatta tgggaaagca 2161 cgcagttggt acctgaaggc ccagcacatt gctcccaaga atgggcgccc ctataaccag 2221 ttggctttgc tggcagtgta tacgaggagg aagcttgacg ctgtctatta ctatatgcgc 2281 agtttagctg ccagcaaccc tatcctgact gccaaggaga gtctcatgag cttgtttgaa 2341 gagaccaagc ggaaggcaga acagatggaa aagaagcaac atgaggaatt tgacctgagc 2401 cctgaccagt ggcggaaagg aaagaagtct actttccggc atgttggaga tgacaccact 2461 cgcctggaga tctggattca tccatcccat ccacggtctt cccagggcac tgagtctggg 2521 aaggattctg agcaagagaa tgggctgggc agcctgagtc ccagtgatct gaacaaaagg 2581 ttcatcctca gttttctcca tgcccatggg aagctgttta cccggattgg gatggagaca 2641 ttccctgcag tggctgagaa ggtcctcaag gagttccagg tgttactgca gcacagcccc 2701 tctcccattg gaagtacccg catgctgcag cttatgacca tcaatatgtt tgcagtacac 2761 aactcccagc tgaaagactg cttctcggag gagtgccgct ctgtgatcca ggaacaagcc 2821 gcagctctgg gcttggccat gttttctcta ctggtccgcc gctgcacctg cttacttaag 2881 gagtccgcca aagctcagct gtcctctcct gaggaccagg atgaccaaga cgacatcaag 2941 gtgtcttcct ttgtcccgga cctgaaggag ctgctcccca gtgtcaaagt ctggtcagat 3001 tggatgctcg gctacccgga cacctggaat cctcctccca catccctgga tctgccctcg 3061 catgttgctg tggatgtatg gtcgacgctg gctgatttct gtaacatact gactgcagtg 3121 aatcagtctg aggtgccact gtacaaggac ccggatgatg acctcaccct tcttatcctg 3181 gaagaggatc ggcttctctc gggctttgtc cccttgctgg ctgcccctca ggacccctgc 3241 tacgtggaga aaacctcgga taaggttatt gcagctgact gcaaaagggt cacagtgctg 3301 aagtattttc tggaagccct ttgtggacaa gaagagcctc tgctggcatt caagggtgga 3361 aagtatgtgt cagtggcacc cgtcccagac accatgggaa aggaaatggg aagccaagag 3421 ggaacacgac tggaagatga ggaggaggat gtggtgattg aagactttga ggaagattca 3481 gaggctgaag gcagcggagg cgaggatgac atcagggagc ttcgggccaa gaagctggct 3541 ctggccagga agatagctga gcagcagcgt cgccaggaaa agatccaggc tgtcctggag 3601 gaccacagtc agatgaggca gatggagctc gaaatcagac ctttgttcct cgtaccagac 3661 accaacggct tcattgacca cctggccagt ctggcgcggc tgctggagag caggaagtac 3721 atcctggtgg tgcccctcat cgtgatcaat gagctggacg gcctggccaa ggggcaggag 3781 acagaccacc gggctggggg ctacgcccgt gtggtacaag agaaggcccg caagtccatc 3841 gagttcctcg agcagcgatt cgagagtcgg gactcttgcc tgcgagccct gaccagccgt 3901 ggcaatgaac tcgaatccat cgccttccgc agtgaggaca tcactggcca gctgggtaac 3961 aacgatgatc tcatcctgtc ctgctgcctc cactactgca aagacaaggc taaggacttc 4021 atgcccgcca gcaaagagga gccaatccgg ctactgcggg aggtggtgct gttgacggat 4081 gaccggaacc tgcgtgtgaa ggcgctcaca aggaatgttc ctgtacggga catcccagcc 4141 ttcctcacgt gggcccaggt gggctgaggg agccacactg ggg //