LOCUS       AY168921                4183 bp    mRNA    linear   HUM 18-APR-2003
DEFINITION  Homo sapiens Est1p-like protein A mRNA, complete cds.
ACCESSION   AY168921
VERSION     AY168921.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4183)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr. Biol. 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   2  (bases 1 to 4183)
  AUTHORS   Snow,B.E., Gill,M. and Harrington,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2002) Medical Biophysics, University of Toronto,
            Ontario Cancer Institute, 620 University Avenue, Suite 706,
            Toronto, ON M5G 2C1, Canada
FEATURES             Location/Qualifiers
     source          1..4183
                     /db_xref="H-InvDB:HIT000084915"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     CDS             1..4167
                     /note="EST1A"
                     /codon_start=1
                     /product="Est1p-like protein A"
                     /protein_id="AAO17581.1"
                     /translation="MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFK
                     DEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLK
                     IIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEV
                     ANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDK
                     RRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDED
                     RIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPM
                     VRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAG
                     SPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD
                     EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVY
                     PGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSN
                     LLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKF
                     RQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKP
                     LRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQ
                     LALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFD
                     LSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSD
                     LNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTI
                     NMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPED
                     QDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTL
                     ADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDK
                     VIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLED
                     EEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQ
                     MRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETD
                     HRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLGN
                     NDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDI
                     PAFLTWAQVG"
     misc_feature    340..1509
                     /note="Region: DNA-binding domain"
     misc_feature    1747..2340
                     /note="Region: Est1p-like domain"
     misc_feature    2083..2247
                     /note="Region: tetratricopeptide repeats; TPRs"
     misc_feature    3643..4113
                     /note="PIN domains are similar to 5' exonucleases and
                     RNases and are thought to be involved in RNAi and
                     non-sense mediated mRNA decay (NMD); Region:
                     PilT-amino-terminal (PIN) domain"
BASE COUNT         1109 a         1037 c         1196 g          841 t
ORIGIN      
        1 atgaaggaat taaaggaggc caggccgcgc aaagataaca ggcgtccaga tctggaaatc
       61 tataagcctg gcctttctcg gctaaggaac aagcccaaaa tcaaggaacc ccctgggagt
      121 gaggaattca aagatgaaat tgttaatgac cgagattgct ctgctgttga aaatggtaca
      181 cagcccgtta aagatgtctg caaggaactg aacaaccaag agcagaatgg tcctatagac
      241 ccagaaaata atcggggaca agaatccttt cctaggactg ctggacaaga ggatcgtagt
      301 ctaaaaatta tcaaaagaac aaagaaaccc gacctgcaga tctatcagcc tggacgacgt
      361 ttgcagactg ttagcaaaga atccgccagt cgggtggagg aggaagaagt cctcaaccag
      421 gtagaacaac tgagagtaga ggaagatgag tgtaggggaa atgttgcgaa ggaggaagtt
      481 gcgaataaac cagacagggc tgagatagaa aagagcccag gtggtgggag agtaggggct
      541 gcaaaaggag aaaaaggaaa gaggatggga aaaggggagg gggtgaggga aacccacgac
      601 gacccagccc gcgggaggcc gggctccgca aagcgctact cccgctcaga caaacgaagg
      661 aatcgctacc gcacgcgcag caccagctca gctggcagca acaacagcgc tgagggagct
      721 ggcctgacgg ataatggatg tcgccgccgc cgacaggata ggaccaagga gaggccacga
      781 ctgaagaagc aagtgtctgt gtcctcaacc gattccttag acgaggacag aattgatgag
      841 cctgatggat taggacccag gagaagttca gaaaggaaga gacatttaga aagaaactgg
      901 tctggccgtg gggagggtga gcagaaaaac agtgctaaag aatatcgagg cactcttcgt
      961 gtcactttcg atgcagaagc catgaacaaa gagtctccca tggtgaggtc agccagggat
     1021 gatatggata gaggaaagcc tgacaaaggc ttgagcagtg ggggcaaagg ctctgagaag
     1081 caggagtcca aaaacccgaa acaagaactt cggggtcgtg gtcgtggcat tctgattttg
     1141 cctgcccata ccaccctatc tgtcaattca gcaggttctc cagagtccgc gcctttggga
     1201 cctcggcttt tgtttggatc tggtagtaag ggatctcgga gttggggccg tggaggcacc
     1261 acacgccgat tgtgggaccc aaacaatcct gatcagaaac ctgctctaaa gactcagacg
     1321 ccccagctac atttcttgga cactgatgat gaagtcagcc ctacatcttg gggtgactca
     1381 cgccaggctc aggcatctta ctataagttt caaaactctg acaaccccta ttattacccc
     1441 cggacaccag gccctgcctc ccagtatccc tatacgggct ataaccctct acagtaccca
     1501 gtgggcccta cgaatggtgt gtacccaggg ccttactacc caggctaccc gactccgtca
     1561 ggacagtatg tgtgtagccc tctacctacc agcaccatga gtcccgagga ggtagagcag
     1621 cacatgagga acctgcagca acaggagctg cacaggcttc tccgggtggc tgacaaccag
     1681 gaactgcagc tcagcaacct gctctccagg gaccgcatca gtccggaggg cctggagaag
     1741 atggcgcaac tcagagctga actgctgcag ctatatgagc gctgtattct attagatatt
     1801 gagttctctg ataatcagaa tgtggatcag atcctgtgga agaatgcttt ctatcaggtg
     1861 attgagaagt tcaggcaact tgtcaaggat ccgaatgttg agaacccaga acagattcgg
     1921 aacagacttt tggagctctt ggatgagggt agtgacttct ttgatagttt gcttcagaag
     1981 ctgcaggtta cttacaagtt caaactggaa gactacatgg atggtcttgc cattcgcagc
     2041 aagccattac gcaagacagt aaaatatgcc ttgatcagtg cccagcgatg catgatatgc
     2101 caaggagata ttgctaggta ccgggagcaa gccagtgata cagcgaatta tgggaaagca
     2161 cgcagttggt acctgaaggc ccagcacatt gctcccaaga atgggcgccc ctataaccag
     2221 ttggctttgc tggcagtgta tacgaggagg aagcttgacg ctgtctatta ctatatgcgc
     2281 agtttagctg ccagcaaccc tatcctgact gccaaggaga gtctcatgag cttgtttgaa
     2341 gagaccaagc ggaaggcaga acagatggaa aagaagcaac atgaggaatt tgacctgagc
     2401 cctgaccagt ggcggaaagg aaagaagtct actttccggc atgttggaga tgacaccact
     2461 cgcctggaga tctggattca tccatcccat ccacggtctt cccagggcac tgagtctggg
     2521 aaggattctg agcaagagaa tgggctgggc agcctgagtc ccagtgatct gaacaaaagg
     2581 ttcatcctca gttttctcca tgcccatggg aagctgttta cccggattgg gatggagaca
     2641 ttccctgcag tggctgagaa ggtcctcaag gagttccagg tgttactgca gcacagcccc
     2701 tctcccattg gaagtacccg catgctgcag cttatgacca tcaatatgtt tgcagtacac
     2761 aactcccagc tgaaagactg cttctcggag gagtgccgct ctgtgatcca ggaacaagcc
     2821 gcagctctgg gcttggccat gttttctcta ctggtccgcc gctgcacctg cttacttaag
     2881 gagtccgcca aagctcagct gtcctctcct gaggaccagg atgaccaaga cgacatcaag
     2941 gtgtcttcct ttgtcccgga cctgaaggag ctgctcccca gtgtcaaagt ctggtcagat
     3001 tggatgctcg gctacccgga cacctggaat cctcctccca catccctgga tctgccctcg
     3061 catgttgctg tggatgtatg gtcgacgctg gctgatttct gtaacatact gactgcagtg
     3121 aatcagtctg aggtgccact gtacaaggac ccggatgatg acctcaccct tcttatcctg
     3181 gaagaggatc ggcttctctc gggctttgtc cccttgctgg ctgcccctca ggacccctgc
     3241 tacgtggaga aaacctcgga taaggttatt gcagctgact gcaaaagggt cacagtgctg
     3301 aagtattttc tggaagccct ttgtggacaa gaagagcctc tgctggcatt caagggtgga
     3361 aagtatgtgt cagtggcacc cgtcccagac accatgggaa aggaaatggg aagccaagag
     3421 ggaacacgac tggaagatga ggaggaggat gtggtgattg aagactttga ggaagattca
     3481 gaggctgaag gcagcggagg cgaggatgac atcagggagc ttcgggccaa gaagctggct
     3541 ctggccagga agatagctga gcagcagcgt cgccaggaaa agatccaggc tgtcctggag
     3601 gaccacagtc agatgaggca gatggagctc gaaatcagac ctttgttcct cgtaccagac
     3661 accaacggct tcattgacca cctggccagt ctggcgcggc tgctggagag caggaagtac
     3721 atcctggtgg tgcccctcat cgtgatcaat gagctggacg gcctggccaa ggggcaggag
     3781 acagaccacc gggctggggg ctacgcccgt gtggtacaag agaaggcccg caagtccatc
     3841 gagttcctcg agcagcgatt cgagagtcgg gactcttgcc tgcgagccct gaccagccgt
     3901 ggcaatgaac tcgaatccat cgccttccgc agtgaggaca tcactggcca gctgggtaac
     3961 aacgatgatc tcatcctgtc ctgctgcctc cactactgca aagacaaggc taaggacttc
     4021 atgcccgcca gcaaagagga gccaatccgg ctactgcggg aggtggtgct gttgacggat
     4081 gaccggaacc tgcgtgtgaa ggcgctcaca aggaatgttc ctgtacggga catcccagcc
     4141 ttcctcacgt gggcccaggt gggctgaggg agccacactg ggg
//