LOCUS AY157990 5337 bp mRNA linear HUM 07-DEC-2002
DEFINITION Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 5 (MLL5)
mRNA, complete cds, alternatively spliced.
ACCESSION AY157990
VERSION AY157990.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5337)
AUTHORS Dohner,K., Obermiller,R.T., Lipka,D.B., Hofmann,K., Fazekash,G.,
Frohling,S., Lichter,P., Scherer,S.W. and Dohner,H.
TITLE Identification and Characterization of a Novel Gene Located in the
Commonly Deleted Region 7q22-q31.1 in Myeloid Leukemias
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 5337)
AUTHORS Dohner,K., Obermiller,R.T., Lipka,D.B., Hofmann,K., Fazekas,G.,
Frohling,S., Lichter,P., Scherer,S.W. and Dohner,H.
TITLE Direct Submission
JOURNAL Submitted (02-OCT-2002) Internal Medicine III, University Hospital
of Ulm, Robert-Koch-Strasse 8, Ulm D-89077, Germany
FEATURES Location/Qualifiers
source 1..5337
/db_xref="H-InvDB:HIT000084844"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22"
gene 1..5337
/gene="MLL5"
CDS 1..5337
/gene="MLL5"
/note="similar to Drosophila trithorax; exon 12 is skipped
completely and exon 13 is skipped partially; alternatively
spliced"
/codon_start=1
/product="myeloid/lymphoid or mixed-lineage leukemia 5"
/protein_id="AAN76325.1"
/translation="MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQ
LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSS
ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
ERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTAS
RVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETK
IKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVES
HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
MCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDY
GNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKMTREERKMEAILQAF
ARLEKREKRREQALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVN
RTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPET
ETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITT
DPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWL
KQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQ
LLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTP
VTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQE
IKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDRAEPNSQ
LDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQD
DTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNCTPQNPPQKKKVSLLEYRKRQRE
ARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNA
TSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGE
SPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPD
TSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQ
QKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHT
PVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSG
TLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKG
SLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPP
PPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHH
HPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPP
LFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTP
TASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH"
BASE COUNT 1712 a 1320 c 1032 g 1273 t
ORIGIN
1 atgagcatag tgatcccatt gggggttgat acagcagaga cgtcatactt ggaaatggct
61 gcaggttcag aaccagaatc cgtagaagct agccctgtgg tagttgagaa atccaacagt
121 tatccccacc agttatatac cagcagctca catcattcac acagttacat tggtttgccc
181 tatgcggacc ataattatgg tgctcgtcct cctccgacac ctccggcttc ccctcctcca
241 tcagtcctta ttagcaaaaa tgaagtaggc atatttacca ctcctaattt tgatgaaact
301 tccagtgcta ctacaatcag cacatctgag gatggaagtt atggtactga tgtaaccagg
361 tgcatatgtg gttttacaca tgatgatgga tacatgatct gttgtgacaa atgcagcgtt
421 tggcaacata ttgactgcat ggggattgat aggcagcata ttcctgatac atatctatgt
481 gaacgttgtc agcctaggaa tttggataaa gagagggcag tgctactaca acgccggaaa
541 agggaaaata tgtcagatgg tgataccagt gcaactgaga gtggtgatga ggttcctgtg
601 gaattatata ctgcatttca gcatactcca acatcaatta ctttaactgc ttcaagagtt
661 tccaaagtta atgataaaag aaggaaaaaa agcggggaga aagaacaaca catttcaaaa
721 tgtaaaaagg catttcgtga aggatctagg aagtcatcaa gagttaaggg ttcagctcca
781 gagattgatc cttcatctga tggttcaaat tttggatggg agacaaagat caaagcatgg
841 atggatcgat atgaagaagc aaataacaac cagtacagtg agggtgttca gagggaggca
901 caaagaatag ctctgagatt aggcaatgga aatgacaaaa aagagatgaa taaatccgat
961 ttgaatacca acaatttgct cttcaaacct cctgtagaga gccatataca aaagaataag
1021 aaaattctta aatctgcaaa agatttgcct cctgatgcac ttatcattga atacagaggg
1081 aagtttatgc tgagagaaca gtttgaagca aatgggtatt tctttaaaag accataccct
1141 tttgtgttat tctactctaa atttcatggg ctagaaatgt gtgttgatgc aaggactttt
1201 gggaatgagg ctcgattcat caggcggtct tgtacaccca atgcagaggt gaggcatgaa
1261 attcaagatg gaaccataca tctttatatt tattctatac acagtattcc aaagggaact
1321 gaaattacta ttgcctttga ttttgactat ggaaattgta agtacaaggt ggactgtgca
1381 tgcctcaaag aaaacccaga gtgccctgtt ctaaaacgta gttctgaatc catggaaaat
1441 atcaatagtg gttatgagac cagacggaaa aaaggaaaga tgacaagaga agaaagaaaa
1501 atggaagcaa ttttgcaagc ttttgccaga cttgaaaaga gagagaaaag aagagaacaa
1561 gctttggaaa ggatcagcac agccaaaact gaagttaaaa ctgaatgtaa agatacacag
1621 attgtcagtg atgctgaagt tattcaggaa caagcaaaag aagaaaatgc tagcaagcca
1681 acccctgcca aagtaaatag aactaaacag agaaaaagtt tttctcggag taggactcac
1741 attggacagc agcgtcggag acacagaact gtcagcatgt gttcagatat ccagccatct
1801 tctcctgata tagaagttac ttcacaacaa aatgatattg aaaatactgt acttacaata
1861 gaaccagaaa ctgaaactgc actagcagaa ataattactg aaactgaagt tccagcactt
1921 aataaatgtc ctaccaagta ccccaaaaca aagaagcact tggttaatga atggttaagt
1981 gagaagaatg agaagacagg aaaaccttca gatggccttt cagaaaggcc tctacgcata
2041 actacagatc ctgaagtgtt agctacacaa ctcaattctt taccaggtct cacttacagc
2101 ccccatgtat actccactcc taagcattat attagattta cttcaccatt cctttcagaa
2161 aaaaggagaa gaaaagaacc tactgaaaac atttctggtt catgcaagaa gcgatggttg
2221 aaacaagctc tggaagaaga aaattcagca attttacata gatttaattc accctgtcaa
2281 gaaagatcca gaagtcctgc agtcaatggt gaaaataaaa gtccactact attaaatgac
2341 agctgttccc ttccagattt aactacacca ctaaaaaaac gaagatttta tcagttgcta
2401 gattcggttt actcagaaac ctccacacct actccttccc cgtatgctac accaactcac
2461 accgatatta ctcctatgga cccatctttt gccacgcctc cacggataaa atcagatgat
2521 gaaacttgta gaaatggtta taaacccata tattcaccag ttaccccagt aactcctggt
2581 acaccaggaa ataccatgca ctttgagaat atttcttccc cagaaagttc tccagaaata
2641 aagagacgca cttatagtca agagggatat gacagatctt caaccatgtt aacattgggg
2701 ccttttagaa attctaattt aactgaactg ggtctgcaag aaataaagac tattggttat
2761 acgagcccta ggagtaggac tgaagtcaac aggcagtgtc ctggagaaaa ggaacctgtg
2821 tcagaccttc agctaggact cgatgcagtt gagccaactg ccctacataa aaccctggaa
2881 acgcctgcac atgacagggc tgagcccaac agccaactgg actcgactca ctctggacgg
2941 ggcacaatgt attcttcctg ggtaaagagc cctgacagaa caggagttaa cttctcagtg
3001 aactccaact tgagggacct gacaccctcg catcagttgg aggttggagg aggcttccga
3061 ataagtgagt caaagtgcct gatgcaggat gatactagag gcatgtttat ggaaacaact
3121 gtgttttgta cttccgaaga tgggcttgta tctggtttcg gacggactgt taatgacaat
3181 ttgatcgacg ggaattgcac accccagaat ccaccacaaa agaaaaaggt ttctctatta
3241 gaataccgta agagacaacg tgaagctagg aaaagtggct ctaagacaga gaactttcca
3301 ctcattagtg tatcacccca tgcaagtgga agcttgagca acaatggtga tggctgtgcc
3361 agcagtaatg acaatgggga gcaggtggac cacactgcta gcctaccttt accaacacca
3421 gctacagttt ataatgccac ttctgaagaa actagcaata actgccctgt taaggatgct
3481 actgctagtg agaagaatga accagaagtt caatggactg cctcaacttc agtggaacaa
3541 gtcagagaaa ggagttatca gagagcttta cttctcagtg atcaccgaaa agataaagat
3601 agtgggggag aatcaccatg tgtctcatgt tcaccgagtc atgttcagtc ttcaccttca
3661 tctcattcaa atcacatacc ccagttgcaa gctaagggcc cagtcccttc tttcagtgaa
3721 cttatggaag accctgatcc tgaaaatcca gaacccacaa ctacgaatga atgtccatcc
3781 ccagatactt ctcaaaatac ttgtaaaagt cctccaaaaa tgagcaagcc tggttcacct
3841 ggatctgtaa ttcctgctca agcacacggg aaaatattca caaaaccaga tccccaatgg
3901 gactccacag ttagtgcatc cgaagctgaa aatggtgttc acctaaaaac agagctccaa
3961 caaaaacagc tatcaaataa caaccaagca ctttcaaaga atcatcctcc tcagacacac
4021 gttcgtaatt catctgagca actttcacaa aagctgcctt ctgtgccaac aaagttgcac
4081 tgtcctccat cacctcacct agaaaatcct ccaaagtcat ccacgcctca cacacctgta
4141 cagcatggtt atctttcacc aaagcctcct tcacagcagt taggatctcc ctacaggcct
4201 catcattcac agtcacctca agttggaaca cctcagcgag agcctcaaag aaacttttat
4261 ccagcagcac agaaccttcc agccaatact cagcaggcaa cttctggaac attatttaca
4321 cagacaccct caggacaatc ttcagcaaca tacagtcagt ttaaccaaca aagtctgaac
4381 agcacggcac caccccctcc acctcctcca cctccttctt cgtcttacta tcaaaaccag
4441 cagccctctg caaactttca gaattataat cagctcaaag gtagtctttc tcaacaaact
4501 gtgtttacat caggaccaaa tcaagcactt cctggcacca caagccagca aacagttcca
4561 ggacaccacg tgactccagg gcattttttg ccctctcaga accctaccat tcaccatcaa
4621 actgctgctg ccgtagtccc ccctcctcct ccaccaccac ctgctccagg accgcacctt
4681 gtacaacagc cgaattccca tcagcaacac tctgtagcac atgtagtagg gcctgttcat
4741 gcggtcaccc ctgggtcgca tattcattct caaactgctg gacaccactt acccccaccc
4801 ccaccccctc ctggtcctgc ccctcatcac catccaccac cccatccatc cacaggactc
4861 caaggtctac aagcacaaca ccagcatgtt gtaaattcag cacccccacc accccctccg
4921 ccgccacctt ccagtgtttt ggcttctggg catcatacca catcagctca agccttacac
4981 cacccacctc atcaaggacc tccacttttt ccttcgagtg ctcatccaac tgtaccaccg
5041 tatccctcac aagctacaca tcataccact ttgggaccgg gaccccagca ccagccttct
5101 ggaacagggc cacattgtcc attacctgtc acaggtcctc atctccagcc ccaaggacca
5161 aacagtattc caacacctac tgcttcaggg ttctgtcctc atcctggctc tgtggccctg
5221 ccacatgggg ttcaaggacc tcagcaggca tctccagtgc ctggacagat tccaattcac
5281 agagcacagg tgccaccaac atttcaaaac aattaccatg ggtcagggtg gcattaa
//