LOCUS AY150309 6659 bp mRNA linear HUM 11-AUG-2004 DEFINITION Homo sapiens rhotekin-2 (RTKN2) mRNA, complete cds. ACCESSION AY150309 VERSION AY150309.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6659) AUTHORS Gregorio-King,C.C., Gough,T., Van Der Meer,G.J., Hosking,J.B., Waugh,C.M., McLeod,J.L., Collier,F.M. and Kirkland,M.A. TITLE Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells JOURNAL J. Steroid Biochem. Mol. Biol. 88 (3), 311-320 (2004) PUBMED 15120425 REFERENCE 2 (bases 1 to 6659) AUTHORS Gough,T.J., Collier,F.M., Gregorio-King,C.C., Hosking,J.B., Van Der Meer,G.J., McLeod,J.L. and Kirkland,M.A. TITLE Identification of a Novel Rhotekin-like Gene and its Expression in Human Hematopoietic Cells JOURNAL Unpublished REFERENCE 3 (bases 1 to 6659) AUTHORS Gough,T.J., Collier,F.M., Gregorio-King,C.C., Hosking,J.B., Van Der Meer,G.J., McLeod,J.L. and Kirkland,M.A. TITLE Direct Submission JOURNAL Submitted (13-SEP-2002) Douglas Hocking Research Institute, Geelong Hospital, Ryrie Street, Geelong, Victoria 3220, Australia FEATURES Location/Qualifiers source 1..6659 /db_xref="H-InvDB:HIT000084774" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q22.1" /cell_type="promyelocytic leukemia" gene 1..6659 /gene="RTKN2" CDS 98..1927 /gene="RTKN2" /note="rhotekin-like protein; contains Rho-binding domain and pleckstrin homology domain" /codon_start=1 /product="rhotekin-2" /protein_id="AAN71738.1" /translation="MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSL STQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKI AISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENV TIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDD EMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCR LVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPAL VVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHF FDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKI EETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPP SDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPAR RNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV" BASE COUNT 2159 a 1170 c 1187 g 2143 t ORIGIN 1 ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt 61 gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg 121 tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat 181 agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa 241 agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta 301 tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt 361 gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg 421 aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta 481 tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt 541 ggataaaaca atcacagata tatgttttga aaatgtaacc atatttaatg aagcagggcc 601 agactttcag ataaaggtgg aagtgtatag ttgctgtaca gaagaatctt ctataaccaa 661 cacaccaaaa aagctagcta agaaactcaa gacatctata agtaaagcta caggaaagaa 721 aataagttca gtgcttcaag aagaggatga tgaaatgtgc ttgctcctca gctctgctgt 781 ttttggtgta aagtataatt tgctagctca cactacccta accttggaaa gtgctgagga 841 tagtttcaag acccataatc tgtctattaa tggaaatgag gagtcttcat tttggcttcc 901 cctgtatggc aacatgtgct gccgactagt tgcccagcca gcttgtatgg ctgaggatgc 961 atttgcagga tttcttaatc agcagcaaat ggtagaaggt ctgattagtt ggagaaggtt 1021 gtattgtgtt ttgcgaggag gtaaactcta ttgtttttac agtccagagg aaattgaagc 1081 taaagtggaa ccagctttgg tagtacccat taacaaggaa accagaatcc gggcaatgga 1141 taaggatgcc aagaaaagaa tccataattt ctctgtcatc aatcctgttc ctggacaagc 1201 tataactcag atttttgcag ttgacaatag agaagatctt cagaagtgga tggaagcctt 1261 ctggcagcat ttctttgatc ttagccaatg gaagcactgt tgtgaagaac ttatgaaaat 1321 tgagattatg tcaccacgga aaccaccttt gttcttgaca aaagaggcaa cctcagtcta 1381 ccatgatatg agcattgatt cacctatgaa acttgaaagt ttaacggata taatacaaaa 1441 aaaaattgaa gagacaaatg ggcagttcct tattggtcag catgaagaat ccttaccacc 1501 tccttgggcc acactctttg atggtaacca tcaaatggtc atccagaaaa aggtactgta 1561 tcctgcaagt gagccattac atgatgaaaa agggaaaaag agacaagctc cccttcctcc 1621 ttctgataaa cttccattca gcttaaaatc acagagtaac acagatcaat tggttaagga 1681 caactgggga aaaacaagtg tatctcagac atcgtctttg gataccaaac tatcaactct 1741 aatgcatcac ttacagaaac caatggctgc tcctcgaaaa cttctgcctg ccaggagaaa 1801 tagattaagt gatggtgagc acacagacac taaaaccaat tttgaagcca agccagtgcc 1861 agctccaagg cagaaatcca tcaaagacat tctggaccct agatcatggc tgcaggcaca 1921 agtatagaaa actcttaatg ataaaacatt taacaaaatc tataactgtg aagcttaatt 1981 cagaggcatt atagaataat gtgtaattat ataggtaaat atagtgattt ataccaataa 2041 ttaataagct attaggtata gaaaaacatt ttataatgaa gaagtggatt tctcttttac 2101 tcctgatttg cagaatgtaa gtgatttctc cagcagtgtg caagaggcag tttctagaca 2161 atatcctaat tgttggaagg gttaatttat tcctgaatta gtaccaggca gtgaataagc 2221 cctaggcaga ataaagcatt aaaatttctt ttggggagag actgtctagt aatttaaaat 2281 gtgttaaata tgaaccatat tctcattgtg agaattttaa tactaatgga atgtttcaaa 2341 ggttttattc aaaccacaaa ttatagaatc cacccaagaa aattttctta gcattctgga 2401 attctcatct aatggttcac tggctctcat ctattgttta actcactagt ttataggcct 2461 gaccttttaa attcctggga taaattttag aatattaaat tcttcatctt taaagggaat 2521 ttgtaatgtg ctattcaaac ttgtttcctt gatgagccct gaaatactgt tgacattaac 2581 tttcataaat gaagcataac acttactagt ttagagaaat ggtagatgaa atgctcttta 2641 cattcaattt tctgtgtgtg gtgctaattt ccattgtgac tttggaattt agggaagtga 2701 gtagctgatc aacaccttaa aattcattta atacttattt aaaaagaaga tgagagattc 2761 aaaaatatca gaaaagttgg ccatggtaaa taattttcag aattcttttt taaaatttta 2821 attagatttc cttttcctag taagagttga tgtctgctag tggtattttt cattaaatgt 2881 catattctta caacagtgac attggaatca tttccatagg aggtaatttc catagcaact 2941 aatcatagtg acccaaacag gattataaag tcaagtgagg aataaatagc agaaaaatac 3001 cttaaaggaa caaaaaatcc attttttata ataatgcttt ttgtaaacaa gagcagaaca 3061 gttttaaaaa tctaattaga atttccaaat aaaacagttt ccataaggtg tcagcaacag 3121 cactaaaaat ctcaaatcac actgaaccct aaatgtcatt gcaagaaata aaaatttaag 3181 aattaaattg ctgccctgtg tataatctct tgagatcttt ttaaagctag caagaactct 3241 atttggatca gaactacatt attacaaaac aaaatgaaca cttgaccaaa aaaccacatt 3301 aatttaaatg gagcctttca ttattttcag atagcggggt cttttccatt tatagagaat 3361 gatgtaactg ccaggacact tttgtgtttg cccaggactc ctagtaagaa ttgaatcttg 3421 agggagtaat gataacaaaa ggtttcttgt gactggtaac atcaggacag acagagtttt 3481 tggtgagaag aaagtactat atgcctgctt gatagcatgt agagatcatc acatgtatgg 3541 aaaccttaaa aagtaaactt attttttcta actagaaggc tctcataagt ttctgttatg 3601 attgccattt caataaatga cattaaaaat ctaaaggata ttattgtttg aatttttggg 3661 ttatttttta aaacttcatt gctgtttttg acagcatttg tgactgtcat tgccactaaa 3721 ttattgagct agaagatgct gcagggaaaa ttgttttgaa gctggcatct aagcattctt 3781 ttttttttcc tagttgatgc cttcctttat tacaaatcag tattaaaact tccagattat 3841 attcttgtca tttttcctca tgcagataac agcaggaagg acttaaggtg tataagaaaa 3901 agaaagtatt catacagaaa ttacctagca gttgtgccct cagagtagaa ctttgaaaca 3961 ggactgaagc cctttttacc tagaaccatt taaaagcctg agcaaggacc accaccccct 4021 ccccaccaaa ttattcggtc tctttctggg gggcccagct tactgtatgt tacaagtctt 4081 tgaaatgggt ctggtgtctt cagctcctga aatgctaatt taccccttac ctaaggagtg 4141 tagttataat acagagttgg tttccttcct tccttccttc cttccttcct tccttccttc 4201 cttccttcct tccttccttc cttccttcat tccctctgtc cgtctctcct tccctccttc 4261 cctccttcct tcctttttgt ctttgtttct ttctctggcc ccctgtcctc tctctctgtc 4321 tcatcccctt ttcccacttt ccttctgtct ctccttcctc ccttccttta cagtttaaaa 4381 aaaaaatcta aaaatagtta agcactgtgt caaagagtgt ttcaaaagaa ttgtttgttt 4441 tctcatttct taaaccagaa gtttatgaca aataaatatg ccatgtaata tgaaagctgc 4501 ttcagctttt tatgagcttt cacattcctt gtttgtcctt ttaatttgtt tcttgatata 4561 tgaagactat aaacttgaaa caaagagtta gctgtcagct cttgataata taattgggga 4621 aacagaatag atattttatg atatgataat tctgatgatc taaagataat gtcttagaca 4681 attaccttta catttcaagc tctgggatat aaattacgta gtcagcatta agatagtatt 4741 atttttaatt gctactaagt ggtaactttt gtattttaat atcttgcaag ggcaaagaag 4801 gcatttttaa aattctaaat gcacacctcc taaggtaaat agtctttcaa aaatatcagg 4861 cgtgccaact cttgctgagt tttgttaaat cctccttaac tgtctgcagt gccccctgac 4921 ttcttttaaa tggatgtgaa tatatgtgga aaactaaatc catttattat aaatgcctta 4981 tctttaccct ttgggatctt actaaatgca ttttacctgc tactatttat taaaaatgga 5041 agctgtcttg aattagagat acctcacgta aggtaggtta agcagtcaag tatttcttta 5101 ggcttatgtt cagcacctca gccccctact gagaagttaa ttaattcagt ccaaaatgaa 5161 attatagggc agtttggtgc aatttatgtt aaatgccatt tgaatgtaat cacctgtgtt 5221 accacgaatg aggcacaact atactacatg gacagagtac tgcattgcac catgagcaag 5281 aactgctctg caagaaaaat atctgtccct gtggtctgaa tttatcaaaa ctcattttct 5341 tgttaaagag tgaattattg aatagtaatt aaactttaac tgatgaccat ttatattcta 5401 gtagccatct tcactgttag tcttaaatta taatgtaaag ttgacatttt ccccttacat 5461 ttcaaaggca tcactatttt taaatgttta catatgttta catgtttgtg tgcaactgct 5521 tcattgctat taatagttaa atgaaatctg catattctgg atcatagatg ttcttagtta 5581 actctgggaa agatgttacc tttgggtttt taaaagacaa gtcatcattt gaaaatatat 5641 tagggtgtgt tgattttctg acatgcttgt gtaattggct ttgtttataa tttttatttt 5701 ttaatatggg tcagactttt ggattaaaaa gtattatatc atggacatac attttttaaa 5761 gtaccaaagg tatttggtaa gcgagcccaa gtcatgtaat tgaaacttct gtacattaaa 5821 agaactgatt catgaagacg ttttctaact ttttctcttt aagtgctcct ctagactaga 5881 ctgattgaag tagacagtgt ggtggaatca gtttaatcag aaaaagacat accaagtagc 5941 tggtgctaat tattataaga ctaacattct gataagccat ggtataatta acattattaa 6001 aatgtttaca tataatcctt cttaaagtat actcttttaa aaatccattg acataacctt 6061 acttttagtt tagtgatcca gaatttcccc agagcttaag ccactgcagt aaattaggta 6121 cgtaggatat tcagtcgcta ctagccacaa ggagtctcct tattttaatg tacctccctc 6181 agtactttat tcctgcagag cgcctcagag tgggggagag aaatgagcaa tcctggctca 6241 gttggattat ttcagcattt tatttctaaa tctgtagtgt gatcagaaat atttaaaatt 6301 aaaaaaatac tttacagaga gaggcctact aatcaatgtg cttagagaaa caaactacct 6361 ttacattcaa ttaacaacaa aaaaagttac agaaatttta acaaacattt ttctttatct 6421 gagtatggga gaaaatacta atgctgacac gtttaataat tagaaaagat cattccagat 6481 cttatggaaa attgtgtttt aaattccagc agtttgctct tgagacatgg taatctctta 6541 atgtaactac taaaggagag gtagattgaa aagatcttgt atatacataa ttatgtcaga 6601 tggttcaaga tatcaaaata aattgttttg ttgaaaatga aaaaaaaaaa aaaaaaaaa //