LOCUS       AY150309                6659 bp    mRNA    linear   HUM 11-AUG-2004
DEFINITION  Homo sapiens rhotekin-2 (RTKN2) mRNA, complete cds.
ACCESSION   AY150309
VERSION     AY150309.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6659)
  AUTHORS   Gregorio-King,C.C., Gough,T., Van Der Meer,G.J., Hosking,J.B.,
            Waugh,C.M., McLeod,J.L., Collier,F.M. and Kirkland,M.A.
  TITLE     Mechanisms of resistance to the cytotoxic effects of oxysterols in
            human leukemic cells
  JOURNAL   J. Steroid Biochem. Mol. Biol. 88 (3), 311-320 (2004)
   PUBMED   15120425
REFERENCE   2  (bases 1 to 6659)
  AUTHORS   Gough,T.J., Collier,F.M., Gregorio-King,C.C., Hosking,J.B., Van Der
            Meer,G.J., McLeod,J.L. and Kirkland,M.A.
  TITLE     Identification of a Novel Rhotekin-like Gene and its Expression in
            Human Hematopoietic Cells
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 6659)
  AUTHORS   Gough,T.J., Collier,F.M., Gregorio-King,C.C., Hosking,J.B., Van Der
            Meer,G.J., McLeod,J.L. and Kirkland,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-2002) Douglas Hocking Research Institute, Geelong
            Hospital, Ryrie Street, Geelong, Victoria 3220, Australia
FEATURES             Location/Qualifiers
     source          1..6659
                     /db_xref="H-InvDB:HIT000084774"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
                     /cell_type="promyelocytic leukemia"
     gene            1..6659
                     /gene="RTKN2"
     CDS             98..1927
                     /gene="RTKN2"
                     /note="rhotekin-like protein; contains Rho-binding domain
                     and pleckstrin homology domain"
                     /codon_start=1
                     /product="rhotekin-2"
                     /protein_id="AAN71738.1"
                     /translation="MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSL
                     STQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKI
                     AISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENV
                     TIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDD
                     EMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCR
                     LVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPAL
                     VVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHF
                     FDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKI
                     EETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPP
                     SDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPAR
                     RNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV"
BASE COUNT         2159 a         1170 c         1187 g         2143 t
ORIGIN      
        1 ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt
       61 gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg
      121 tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat
      181 agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa
      241 agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta
      301 tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt
      361 gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg
      421 aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta
      481 tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt
      541 ggataaaaca atcacagata tatgttttga aaatgtaacc atatttaatg aagcagggcc
      601 agactttcag ataaaggtgg aagtgtatag ttgctgtaca gaagaatctt ctataaccaa
      661 cacaccaaaa aagctagcta agaaactcaa gacatctata agtaaagcta caggaaagaa
      721 aataagttca gtgcttcaag aagaggatga tgaaatgtgc ttgctcctca gctctgctgt
      781 ttttggtgta aagtataatt tgctagctca cactacccta accttggaaa gtgctgagga
      841 tagtttcaag acccataatc tgtctattaa tggaaatgag gagtcttcat tttggcttcc
      901 cctgtatggc aacatgtgct gccgactagt tgcccagcca gcttgtatgg ctgaggatgc
      961 atttgcagga tttcttaatc agcagcaaat ggtagaaggt ctgattagtt ggagaaggtt
     1021 gtattgtgtt ttgcgaggag gtaaactcta ttgtttttac agtccagagg aaattgaagc
     1081 taaagtggaa ccagctttgg tagtacccat taacaaggaa accagaatcc gggcaatgga
     1141 taaggatgcc aagaaaagaa tccataattt ctctgtcatc aatcctgttc ctggacaagc
     1201 tataactcag atttttgcag ttgacaatag agaagatctt cagaagtgga tggaagcctt
     1261 ctggcagcat ttctttgatc ttagccaatg gaagcactgt tgtgaagaac ttatgaaaat
     1321 tgagattatg tcaccacgga aaccaccttt gttcttgaca aaagaggcaa cctcagtcta
     1381 ccatgatatg agcattgatt cacctatgaa acttgaaagt ttaacggata taatacaaaa
     1441 aaaaattgaa gagacaaatg ggcagttcct tattggtcag catgaagaat ccttaccacc
     1501 tccttgggcc acactctttg atggtaacca tcaaatggtc atccagaaaa aggtactgta
     1561 tcctgcaagt gagccattac atgatgaaaa agggaaaaag agacaagctc cccttcctcc
     1621 ttctgataaa cttccattca gcttaaaatc acagagtaac acagatcaat tggttaagga
     1681 caactgggga aaaacaagtg tatctcagac atcgtctttg gataccaaac tatcaactct
     1741 aatgcatcac ttacagaaac caatggctgc tcctcgaaaa cttctgcctg ccaggagaaa
     1801 tagattaagt gatggtgagc acacagacac taaaaccaat tttgaagcca agccagtgcc
     1861 agctccaagg cagaaatcca tcaaagacat tctggaccct agatcatggc tgcaggcaca
     1921 agtatagaaa actcttaatg ataaaacatt taacaaaatc tataactgtg aagcttaatt
     1981 cagaggcatt atagaataat gtgtaattat ataggtaaat atagtgattt ataccaataa
     2041 ttaataagct attaggtata gaaaaacatt ttataatgaa gaagtggatt tctcttttac
     2101 tcctgatttg cagaatgtaa gtgatttctc cagcagtgtg caagaggcag tttctagaca
     2161 atatcctaat tgttggaagg gttaatttat tcctgaatta gtaccaggca gtgaataagc
     2221 cctaggcaga ataaagcatt aaaatttctt ttggggagag actgtctagt aatttaaaat
     2281 gtgttaaata tgaaccatat tctcattgtg agaattttaa tactaatgga atgtttcaaa
     2341 ggttttattc aaaccacaaa ttatagaatc cacccaagaa aattttctta gcattctgga
     2401 attctcatct aatggttcac tggctctcat ctattgttta actcactagt ttataggcct
     2461 gaccttttaa attcctggga taaattttag aatattaaat tcttcatctt taaagggaat
     2521 ttgtaatgtg ctattcaaac ttgtttcctt gatgagccct gaaatactgt tgacattaac
     2581 tttcataaat gaagcataac acttactagt ttagagaaat ggtagatgaa atgctcttta
     2641 cattcaattt tctgtgtgtg gtgctaattt ccattgtgac tttggaattt agggaagtga
     2701 gtagctgatc aacaccttaa aattcattta atacttattt aaaaagaaga tgagagattc
     2761 aaaaatatca gaaaagttgg ccatggtaaa taattttcag aattcttttt taaaatttta
     2821 attagatttc cttttcctag taagagttga tgtctgctag tggtattttt cattaaatgt
     2881 catattctta caacagtgac attggaatca tttccatagg aggtaatttc catagcaact
     2941 aatcatagtg acccaaacag gattataaag tcaagtgagg aataaatagc agaaaaatac
     3001 cttaaaggaa caaaaaatcc attttttata ataatgcttt ttgtaaacaa gagcagaaca
     3061 gttttaaaaa tctaattaga atttccaaat aaaacagttt ccataaggtg tcagcaacag
     3121 cactaaaaat ctcaaatcac actgaaccct aaatgtcatt gcaagaaata aaaatttaag
     3181 aattaaattg ctgccctgtg tataatctct tgagatcttt ttaaagctag caagaactct
     3241 atttggatca gaactacatt attacaaaac aaaatgaaca cttgaccaaa aaaccacatt
     3301 aatttaaatg gagcctttca ttattttcag atagcggggt cttttccatt tatagagaat
     3361 gatgtaactg ccaggacact tttgtgtttg cccaggactc ctagtaagaa ttgaatcttg
     3421 agggagtaat gataacaaaa ggtttcttgt gactggtaac atcaggacag acagagtttt
     3481 tggtgagaag aaagtactat atgcctgctt gatagcatgt agagatcatc acatgtatgg
     3541 aaaccttaaa aagtaaactt attttttcta actagaaggc tctcataagt ttctgttatg
     3601 attgccattt caataaatga cattaaaaat ctaaaggata ttattgtttg aatttttggg
     3661 ttatttttta aaacttcatt gctgtttttg acagcatttg tgactgtcat tgccactaaa
     3721 ttattgagct agaagatgct gcagggaaaa ttgttttgaa gctggcatct aagcattctt
     3781 ttttttttcc tagttgatgc cttcctttat tacaaatcag tattaaaact tccagattat
     3841 attcttgtca tttttcctca tgcagataac agcaggaagg acttaaggtg tataagaaaa
     3901 agaaagtatt catacagaaa ttacctagca gttgtgccct cagagtagaa ctttgaaaca
     3961 ggactgaagc cctttttacc tagaaccatt taaaagcctg agcaaggacc accaccccct
     4021 ccccaccaaa ttattcggtc tctttctggg gggcccagct tactgtatgt tacaagtctt
     4081 tgaaatgggt ctggtgtctt cagctcctga aatgctaatt taccccttac ctaaggagtg
     4141 tagttataat acagagttgg tttccttcct tccttccttc cttccttcct tccttccttc
     4201 cttccttcct tccttccttc cttccttcat tccctctgtc cgtctctcct tccctccttc
     4261 cctccttcct tcctttttgt ctttgtttct ttctctggcc ccctgtcctc tctctctgtc
     4321 tcatcccctt ttcccacttt ccttctgtct ctccttcctc ccttccttta cagtttaaaa
     4381 aaaaaatcta aaaatagtta agcactgtgt caaagagtgt ttcaaaagaa ttgtttgttt
     4441 tctcatttct taaaccagaa gtttatgaca aataaatatg ccatgtaata tgaaagctgc
     4501 ttcagctttt tatgagcttt cacattcctt gtttgtcctt ttaatttgtt tcttgatata
     4561 tgaagactat aaacttgaaa caaagagtta gctgtcagct cttgataata taattgggga
     4621 aacagaatag atattttatg atatgataat tctgatgatc taaagataat gtcttagaca
     4681 attaccttta catttcaagc tctgggatat aaattacgta gtcagcatta agatagtatt
     4741 atttttaatt gctactaagt ggtaactttt gtattttaat atcttgcaag ggcaaagaag
     4801 gcatttttaa aattctaaat gcacacctcc taaggtaaat agtctttcaa aaatatcagg
     4861 cgtgccaact cttgctgagt tttgttaaat cctccttaac tgtctgcagt gccccctgac
     4921 ttcttttaaa tggatgtgaa tatatgtgga aaactaaatc catttattat aaatgcctta
     4981 tctttaccct ttgggatctt actaaatgca ttttacctgc tactatttat taaaaatgga
     5041 agctgtcttg aattagagat acctcacgta aggtaggtta agcagtcaag tatttcttta
     5101 ggcttatgtt cagcacctca gccccctact gagaagttaa ttaattcagt ccaaaatgaa
     5161 attatagggc agtttggtgc aatttatgtt aaatgccatt tgaatgtaat cacctgtgtt
     5221 accacgaatg aggcacaact atactacatg gacagagtac tgcattgcac catgagcaag
     5281 aactgctctg caagaaaaat atctgtccct gtggtctgaa tttatcaaaa ctcattttct
     5341 tgttaaagag tgaattattg aatagtaatt aaactttaac tgatgaccat ttatattcta
     5401 gtagccatct tcactgttag tcttaaatta taatgtaaag ttgacatttt ccccttacat
     5461 ttcaaaggca tcactatttt taaatgttta catatgttta catgtttgtg tgcaactgct
     5521 tcattgctat taatagttaa atgaaatctg catattctgg atcatagatg ttcttagtta
     5581 actctgggaa agatgttacc tttgggtttt taaaagacaa gtcatcattt gaaaatatat
     5641 tagggtgtgt tgattttctg acatgcttgt gtaattggct ttgtttataa tttttatttt
     5701 ttaatatggg tcagactttt ggattaaaaa gtattatatc atggacatac attttttaaa
     5761 gtaccaaagg tatttggtaa gcgagcccaa gtcatgtaat tgaaacttct gtacattaaa
     5821 agaactgatt catgaagacg ttttctaact ttttctcttt aagtgctcct ctagactaga
     5881 ctgattgaag tagacagtgt ggtggaatca gtttaatcag aaaaagacat accaagtagc
     5941 tggtgctaat tattataaga ctaacattct gataagccat ggtataatta acattattaa
     6001 aatgtttaca tataatcctt cttaaagtat actcttttaa aaatccattg acataacctt
     6061 acttttagtt tagtgatcca gaatttcccc agagcttaag ccactgcagt aaattaggta
     6121 cgtaggatat tcagtcgcta ctagccacaa ggagtctcct tattttaatg tacctccctc
     6181 agtactttat tcctgcagag cgcctcagag tgggggagag aaatgagcaa tcctggctca
     6241 gttggattat ttcagcattt tatttctaaa tctgtagtgt gatcagaaat atttaaaatt
     6301 aaaaaaatac tttacagaga gaggcctact aatcaatgtg cttagagaaa caaactacct
     6361 ttacattcaa ttaacaacaa aaaaagttac agaaatttta acaaacattt ttctttatct
     6421 gagtatggga gaaaatacta atgctgacac gtttaataat tagaaaagat cattccagat
     6481 cttatggaaa attgtgtttt aaattccagc agtttgctct tgagacatgg taatctctta
     6541 atgtaactac taaaggagag gtagattgaa aagatcttgt atatacataa ttatgtcaga
     6601 tggttcaaga tatcaaaata aattgttttg ttgaaaatga aaaaaaaaaa aaaaaaaaa
//