LOCUS AY147037 7139 bp mRNA linear HUM 29-SEP-2002
DEFINITION Homo sapiens MLL5 (MLL5) mRNA, complete cds; alternatively spliced.
ACCESSION AY147037
VERSION AY147037.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7139)
AUTHORS Dohner,K., Obermiller,R.T., Lipka,D.B., Hofmann,K., Fazekas,G.,
Frohling,S., Lichter,P., Scherer,S.W. and Dohner,H.
TITLE Identification and Characterization of a Novel Gene Located in the
Commonly Deleted Region 7q22-q31.1 in Myeloid Leukemias
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7139)
AUTHORS Dohner,K., Obermiller,R.T., Lipka,D.B., Hofmann,K., Fazekas,G.,
Frohling,S., Lichter,P., Scherer,S.W. and Dohner,H.
TITLE Direct Submission
JOURNAL Submitted (03-SEP-2002) Internal Medicine III, University Hospital
of Ulm, Robert-Koch-Strasse 8, Ulm D-89081, Germany
FEATURES Location/Qualifiers
source 1..7139
/db_xref="H-InvDB:HIT000084754"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22"
gene 1..7139
/gene="MLL5"
5'UTR 1..534
/gene="MLL5"
CDS 535..6111
/gene="MLL5"
/note="contains PHD finger and SET domains; similar to
Drosophila trithorax; alternatively spliced"
/codon_start=1
/product="MLL5"
/protein_id="AAN17675.1"
/translation="MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQ
LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSS
ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
ERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTAS
RVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETK
IKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVES
HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
MCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDY
GNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQN
ITLDCEGTTNKMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQ
IAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSD
AEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSP
DIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLS
EKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFL
SEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPL
LLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPP
RIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDR
SSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAV
EPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLT
PSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNC
TPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSND
NGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVR
ERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDP
QWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVP
TKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQRE
PQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPP
SSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFL
PSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHI
HSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV
LASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGP
HCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRA
QVPPTFQNNYHGSGWH"
3'UTR 6112..7139
/gene="MLL5"
BASE COUNT 2211 a 1640 c 1430 g 1858 t
ORIGIN
1 cgccgccatt ttcccagagc gagaggcagt gacactgagc gggcgcaggg ggccgagtcg
61 gagaccgtgc cggagttcgg gagcggcaac agagtgggca tagacactcc gagcagcctc
121 gccgtcgtct ctgcgttcct gttgactgcc tggctgcccc ctcccctact cctcggttcc
181 tggtgaagag gctgcgcgct gctgtttggg gagggggtgt gtggagccgg gtcctgtgtc
241 cgcagtggct gctgtcgggg ggtcgcctgt tcgcggaggt gcggagagac tccttggggg
301 tcgagcacat aacggggttc gggtgtctcg tgtgtgaaca tcacaggtct attctggata
361 agcaggtttt gtgaagacat ttattctttc ttggacctca gatttaccag acatctcatg
421 ggtttgtgga tgcacttaga tgtttgcaat gagcactgtg gctggcatgc cccagtgttt
481 tggataccaa tgcataggac tccatagtaa tcgaatttac cagaggcgaa cgtcatgagc
541 atagtgatcc cattgggggt tgatacagca gagacgtcat acttggaaat ggctgcaggt
601 tcagaaccag aatccgtaga agctagccct gtggtagttg agaaatccaa cagttatccc
661 caccagttat ataccagcag ctcacatcat tcacacagtt acattggttt gccctatgcg
721 gaccataatt atggtgctcg tcctcctccg acacctccgg cttcccctcc tccatcagtc
781 cttattagca aaaatgaagt aggcatattt accactccta attttgatga aacttccagt
841 gctactacaa tcagcacatc tgaggatgga agttatggta ctgatgtaac caggtgcata
901 tgtggtttta cacatgatga tggatacatg atctgttgtg acaaatgcag cgtttggcaa
961 catattgact gcatggggat tgataggcag catattcctg atacatatct atgtgaacgt
1021 tgtcagccta ggaatttgga taaagagagg gcagtgctac tacaacgccg gaaaagggaa
1081 aatatgtcag atggtgatac cagtgcaact gagagtggtg atgaggttcc tgtggaatta
1141 tatactgcat ttcagcatac tccaacatca attactttaa ctgcttcaag agtttccaaa
1201 gttaatgata aaagaaggaa aaaaagcggg gagaaagaac aacacatttc aaaatgtaaa
1261 aaggcatttc gtgaaggatc taggaagtca tcaagagtta agggttcagc tccagagatt
1321 gatccttcat ctgatggttc aaattttgga tgggagacaa agatcaaagc atggatggat
1381 cgatatgaag aagcaaataa caaccagtac agtgagggtg ttcagaggga ggcacaaaga
1441 atagctctga gattaggcaa tggaaatgac aaaaaagaga tgaataaatc cgatttgaat
1501 accaacaatt tgctcttcaa acctcctgta gagagccata tacaaaagaa taagaaaatt
1561 cttaaatctg caaaagattt gcctcctgat gcacttatca ttgaatacag agggaagttt
1621 atgctgagag aacagtttga agcaaatggg tatttcttta aaagaccata cccttttgtg
1681 ttattctact ctaaatttca tgggctagaa atgtgtgttg atgcaaggac ttttgggaat
1741 gaggctcgat tcatcaggcg gtcttgtaca cccaatgcag aggtgaggca tgaaattcaa
1801 gatggaacca tacatcttta tatttattct atacacagta ttccaaaggg aactgaaatt
1861 actattgcct ttgattttga ctatggaaat tgtaagtaca aggtggactg tgcatgcctc
1921 aaagaaaacc cagagtgccc tgttctaaaa cgtagttctg aatccatgga aaatatcaat
1981 agtggttatg agaccagacg gaaaaaagga aaaaaagaca aagatatttc aaaagaaaaa
2041 gatacacaaa atcagaatat tactttggat tgtgaaggaa cgaccaacaa aatgaagagc
2101 ccagaaacta aacaaagaaa gctttctcca ctgagactat cagtatcaaa taatcaggaa
2161 ccagatttta ttgatgatat agaagaaaaa actcctatta gtaatgaagt agaaatggaa
2221 tcagaggagc agattgcaga aaggaaaagg aagatgacaa gagaagaaag aaaaatggaa
2281 gcaattttgc aagcttttgc cagacttgaa aagagagaga aaagaagaga acaagctttg
2341 gaaaggatca gcacagccaa aactgaagtt aaaactgaat gtaaagatac acagattgtc
2401 agtgatgctg aagttattca ggaacaagca aaagaagaaa atgctagcaa gccaacccct
2461 gccaaagtaa atagaactaa acagagaaaa agtttttctc ggagtaggac tcacattgga
2521 cagcagcgtc ggagacacag aactgtcagc atgtgttcag atatccagcc atcttctcct
2581 gatatagaag ttacttcaca acaaaatgat attgaaaata ctgtacttac aatagaacca
2641 gaaactgaaa ctgcactagc agaaataatt actgaaactg aagttccagc acttaataaa
2701 tgtcctacca agtaccccaa aacaaagaag cacttggtta atgaatggtt aagtgagaag
2761 aatgagaaga caggaaaacc ttcagatggc ctttcagaaa ggcctctacg cataactaca
2821 gatcctgaag tgttagctac acaactcaat tctttaccag gtctcactta cagcccccat
2881 gtatactcca ctcctaagca ttatattaga tttacttcac cattcctttc agaaaaaagg
2941 agaagaaaag aacctactga aaacatttct ggttcatgca agaagcgatg gttgaaacaa
3001 gctctggaag aagaaaattc agcaatttta catagattta attcaccctg tcaagaaaga
3061 tccagaagtc ctgcagtcaa tggtgaaaat aaaagtccac tactattaaa tgacagctgt
3121 tcccttccag atttaactac accactaaaa aaacgaagat tttatcagtt gctagattcg
3181 gtttactcag aaacctccac acctactcct tccccgtatg ctacaccaac tcacaccgat
3241 attactccta tggacccatc ttttgccacg cctccacgga taaaatcaga tgatgaaact
3301 tgtagaaatg gttataaacc catatattca ccagttaccc cagtaactcc tggtacacca
3361 ggaaatacca tgcactttga gaatatttct tccccagaaa gttctccaga aataaagaga
3421 cgcacttata gtcaagaggg atatgacaga tcttcaacca tgttaacatt ggggcctttt
3481 agaaattcta atttaactga actgggtctg caagaaataa agactattgg ttatacgagc
3541 cctaggagta ggactgaagt caacaggcag tgtcctggag aaaaggaacc tgtgtcagac
3601 cttcagctag gactcgatgc agttgagcca actgccctac ataaaaccct ggaaacgcct
3661 gcacatgaca gggctgagcc caacagccaa ctggactcga ctcactctgg acggggcaca
3721 atgtattctt cctgggtaaa gagccctgac agaacaggag ttaacttctc agtgaactcc
3781 aacttgaggg acctgacacc ctcgcatcag ttggaggttg gaggaggctt ccgaataagt
3841 gagtcaaagt gcctgatgca ggatgatact agaggcatgt ttatggaaac aactgtgttt
3901 tgtacttccg aagatgggct tgtatctggt ttcggacgga ctgttaatga caatttgatc
3961 gacgggaatt gcacacccca gaatccacca caaaagaaaa aggtttctct attagaatac
4021 cgtaagagac aacgtgaagc taggaaaagt ggctctaaga cagagaactt tccactcatt
4081 agtgtatcac cccatgcaag tggaagcttg agcaacaatg gtgatggctg tgccagcagt
4141 aatgacaatg gggagcaggt ggaccacact gctagcctac ctttaccaac accagctaca
4201 gtttataatg ccacttctga agaaactagc aataactgcc ctgttaagga tgctactgct
4261 agtgagaaga atgaaccaga agttcaatgg actgcctcaa cttcagtgga acaagtcaga
4321 gaaaggagtt atcagagagc tttacttctc agtgatcacc gaaaagataa agatagtggg
4381 ggagaatcac catgtgtctc atgttcaccg agtcatgttc agtcttcacc ttcatctcat
4441 tcaaatcaca taccccagtt gcaagctaag ggcccagtcc cttctttcag tgaacttatg
4501 gaagaccctg atcctgaaaa tccagaaccc acaactacga atgaatgtcc atccccagat
4561 acttctcaaa atacttgtaa aagtcctcca aaaatgagca agcctggttc acctggatct
4621 gtaattcctg ctcaagcaca cgggaaaata ttcacaaaac cagatcccca atgggactcc
4681 acagttagtg catccgaagc tgaaaatggt gttcacctaa aaacagagct ccaacaaaaa
4741 cagctatcaa ataacaacca agcactttca aagaatcatc ctcctcagac acacgttcgt
4801 aattcatctg agcaactttc acaaaagctg ccttctgtgc caacaaagtt gcactgtcct
4861 ccatcacctc acctagaaaa tcctccaaag tcatccacgc ctcacacacc tgtacagcat
4921 ggttatcttt caccaaagcc tccttcacag cagttaggat ctccctacag gcctcatcat
4981 tcacagtcac ctcaagttgg aacacctcag cgagagcctc aaagaaactt ttatccagca
5041 gcacagaacc ttccagccaa tactcagcag gcaacttctg gaacattatt tacacagaca
5101 ccctcaggac aatcttcagc aacatacagt cagtttaacc aacaaagtct gaacagcacg
5161 gcaccacccc ctccacctcc tccacctcct tcttcgtctt actatcaaaa ccagcagccc
5221 tctgcaaact ttcagaatta taatcagctc aaaggtagtc tttctcaaca aactgtgttt
5281 acatcaggac caaatcaagc acttcctggc accacaagcc agcaaacagt tccaggacac
5341 cacgtgactc cagggcattt tttgccctct cagaacccta ccattcacca tcaaactgct
5401 gctgccgtag tcccccctcc tcctccacca ccacctgctc caggaccgca ccttgtacaa
5461 cagccgaatt cccatcagca acactctgta gcacatgtag tagggcctgt tcatgcggtc
5521 acccctgggt cgcatattca ttctcaaact gctggacacc acttaccccc acccccaccc
5581 cctcctggtc ctgcccctca tcaccatcca ccaccccatc catccacagg actccaaggt
5641 ctacaagcac aacaccagca tgttgtaaat tcagcacccc caccaccccc tccgccgcca
5701 ccttccagtg ttttggcttc tgggcatcat accacatcag ctcaagcctt acaccaccca
5761 cctcatcaag gacctccact ttttccttcg agtgctcatc caactgtacc accgtatccc
5821 tcacaagcta cacatcatac cactttggga ccgggacccc agcaccagcc ttctggaaca
5881 gggccacatt gtccattacc tgtcacaggt cctcatctcc agccccaagg accaaacagt
5941 attccaacac ctactgcttc agggttctgt cctcatcctg gctctgtggc cctgccacat
6001 ggggttcaag gacctcagca ggcatctcca gtgcctggac agattccaat tcacagagca
6061 caggtgccac caacatttca aaacaattac catgggtcag ggtggcatta aaatggactc
6121 caaaaacatt tttttaaatg ttctgtaaga taaactgtat atttcatatg tacctgttaa
6181 ggtacttttt aaagcttgta catgaacctt tgtataaaaa acaccagtgc tctttcgttg
6241 tatttttctc atttttgctt tttaaaattc ctttaaaaaa tgtgctgtta agccagtatt
6301 aggtatcttt attttgtaag tgaacattcc agctgttttt ttctggcaga tctgatgctg
6361 atttgatgct gtatgatctt tttttttttt ttagttaaat tcatttagtg aatgttctat
6421 tattttatac atacacatta agtactcagc taagtaatgg cactatgagg attttttttt
6481 tctttcctgt cagcagcagt tctgtgaatg catcttaggt ataaaaatgc aatacagatt
6541 tttatatttt ggtgtggaca tggctcattt tgttttacca gttatttgca agcaaaatgt
6601 aatttaatgt atagatgatt tctaatgtct cctgacaaac tgtaaatact gcatttcttt
6661 tgcgtatata attgcttaca gcttttctca tttgatatat agcattgtac atatgacaag
6721 tcttttgcaa aactgtgtga tctttgtgaa agtagtacag tatatgacct ttaatttctt
6781 ttttatttta aatatactgt cacactgaag cactggttgg gcattttaat tcatgttaat
6841 aaatcacaat tatgtcagtt ttaccagatt gtcctgtaca acttctaaga tcgggatctg
6901 tgtgtttcta cagaagttct agttttcaaa tatagattgt aaggagcctt caattttctt
6961 tagcgactac tacctcagca acaggaggca gcaaggggct gttcctgtgg tggtttctgt
7021 ttgcattttt gcaggagcca taggaaacta ctgaaatgat tgtgctgggt aaattaagga
7081 tctggcatca tacaaaatga agccagacca ctaatgcatt acagtagttc ttgaataca
//