LOCUS AY123223 3535 bp mRNA linear HUM 06-MAY-2003
DEFINITION Homo sapiens sestrin 2 mRNA, complete cds.
ACCESSION AY123223
VERSION AY123223.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3535)
AUTHORS Budanov,A.V., Shoshani,T., Faerman,A., Zelin,E., Kamer,I.,
Kalinski,H., Gorodin,S., Fishman,A., Chajut,A., Einat,P.,
Skaliter,R., Gudkov,A.V., Chumakov,P.M. and Feinstein,E.
TITLE Identification of a novel stress-responsive gene Hi95 involved in
regulation of cell viability
JOURNAL Oncogene 21 (39), 6017-6031 (2002)
PUBMED 12203114
REFERENCE 2 (bases 1 to 3535)
AUTHORS Feinstein,E. and Kalinski,H.
TITLE Direct Submission
JOURNAL Submitted (17-JUN-2002) Quark Biotech Inc./QBI Enterprises Ltd.,
Weizmann Science Park, POB 4071, Ness Ziona 70400, Israel
FEATURES Location/Qualifiers
source 1..3535
/db_xref="H-InvDB:HIT000084564"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p35.3"
CDS 323..1765
/note="Hi95; hypoxia-responsive p53 target"
/codon_start=1
/product="sestrin 2"
/protein_id="AAM92261.1"
/translation="MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGP
SAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLH
TDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLS
EINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILP
EGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDE
GTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAP
PTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRA
IWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHS
EKVHVNLLLLEARMQAALLYALRAITRYMT"
BASE COUNT 752 a 1054 c 1000 g 726 t
ORIGIN
1 ctccgcggcg gggatgctga ggagcgctgg gtccgggagc agccctggcc cctgcggact
61 tccgaggccg tgaaaacccc tgcgctgcgg cccttcccag gcccccgagg ccgttcgccg
121 ttcccgaagc ccgactgggg gaagagtcca gcaccaaagc ggccgttctc ggattccgga
181 gcgttctgga gccccgagag acgccccggg gttctagaag ctccccggcg gcgcccagtc
241 ccggcttcat tcgggcgtcc ctccgaaacc cactcgggtg cacgggtcgt cggcgagccg
301 cgaccgggtc ctggcgcgca ccatgatcgt ggcggactcc gagtgccgcg cagagctcaa
361 ggactacctg cggttcgccc cgggcggcgt cggcgactcg ggccccggag aggagcagag
421 ggagagccgg gctcggcgag gccctcgagg gcccagcgcc ttcatccccg tggaggaggt
481 ccttcgggag ggggctgaga gcctcgagca gcacctgggg ctggaggcac tgatgtcctc
541 tgggcgagta gacaacctgg cagtggtgat gggcctgcac cctgactact ttaccagctt
601 ctggcgcctg cactacctgc tgctgcacac ggatggtccc ttggccagct cctggcgcca
661 ctacattgcc atcatggctg ccgcccgcca tcagtgttct tacctggtag gctcccacat
721 ggccgagttt ctgcagactg gtggtgaccc tgagtggctg ctgggcctcc accgggcccc
781 cgagaagctg cgcaaactca gcgagatcaa caagttgctg gcgcatcggc catggctcat
841 caccaaggaa cacatccagg ccttgctgaa gaccggcgag cacacttggt ccctggccga
901 gctcattcag gctctggtcc tgctcaccca ctgccactcg ctctcctcct tcgtgtttgg
961 ctgtggcatc ctccctgagg gggatgcaga tggcagccct gccccccagg cacctacacc
1021 ccctagtgaa cagagcagcc ccccaagcag ggacccgttg aacaactctg ggggctttga
1081 gtctgcccgc gacgtggagg cgctgatgga gcgcatgcag cagctgcagg agagcctgct
1141 gcgggatgag gggacgtccc aggaggagat ggagagccgc tttgagctgg agaagtcaga
1201 gagcctgctg gtgaccccct cagctgacat cctggagccc tctccacacc cagacatgct
1261 gtgctttgtg gaagacccta ctttcggata tgaggacttc actcggagag gggctcaggc
1321 accccctacc ttccgggccc aggattatac ctgggaagac catggctact cgctgatcca
1381 gcggctttac cctgagggtg ggcagctgct ggatgagaag ttccaggcag cctatagcct
1441 cacctacaat accatcgcca tgcacagtgg tgtggacacc tccgtgctcc gcagggccat
1501 ctggaactat atccactgcg tctttggcat cagatatgat gactatgatt atggggaggt
1561 gaaccagctc ctggagcgga acctcaaggt ctatatcaag acagtggcct gctacccaga
1621 gaagaccacc cgaagaatgt acaacctctt ctggaggcac ttccgccact cagagaaggt
1681 ccacgtgaac ttgctgctcc tggaggcgcg catgcaagcc gctctgctgt acgccctccg
1741 tgccatcacc cgctacatga cctgactcct gagcaggacc tgggcccggt tcagctcccc
1801 acaaggactt ctctgtctgg agacagcccc agaccctttt gtgtcccatg cccaccctcc
1861 ccacgctgca gtgggcttgt gtgtgatgtg cagtcccgaa gccacaccct cccttttcct
1921 cactggaatg gacagttcat tgcactgact ctgggatctc agccctgctc ctgggagctg
1981 gaagagcact tggagatcct aagggaccac acccttcctc cttcccctgc ccacagaggc
2041 agagggcaca ggaaagaagc cgggccaagc tcggaattaa tgtgccacaa gtgttgtggc
2101 cttcctgaac tgggaagtcc ctggctggcc cccgggggag aggggcaaat gcctccggga
2161 ctgacactcc aggcagcttt gccttctctc ccctgtcatt tccagatttc attacctcct
2221 acttgccatt cacccatcaa tgtgaaagtc agggtcacag ctggtctgtg tgtccagttc
2281 cctaaaagcc tgttctgttg ggcagcctga ggctgttgcc cgaatcctag ttcagttttt
2341 tgacttcctt tgcccttttt cccttttctc catgcttaat ggtgtgaggc gtcaggagag
2401 aggccaagta cataaaaaaa aaaaaaagca gattatctct agagagtttg agcctttgct
2461 ggtcacattg ccttctgaag aggagggagt attagattat aaatcctctt tattttggtc
2521 ctttatgctt gaggttccaa cctggagcca cagtgtgtga naggaggagg agagggagaa
2581 ttctgttctc ccanagctgc acctgcctcg canaggccag caccccactc tcctgcctcc
2641 agtggccctg ccgcagatgt ctcccaaaaa gttgagcctt tctagatggc ttaggtggca
2701 ccatggctca gcaggagggg cgggaggcac cagggttctt gtttggaccc tgcccctggg
2761 ccatggccag gtgaccatgg ctacattgcc aaacctctga ctgccacagc tgcagactga
2821 gagggtgggt ctgagtcccc acaatgtctg aagctgcccc tgggattctc aggccaacct
2881 gccaacagca agcggatttt cttgcaagat cagggacccc atttctgcag ccagtgtctc
2941 ctgggtgcct tctgaggact cccaccccca tcccagtatc tcatctgtcc cctctcctgg
3001 ggcttaagtg ggttgcttcc aggcagaagc agccaaggac cgattccagg cactttctgt
3061 agcaaatgac tgtgaattac gacttctctt gcccttcttc tagcagtctg tgcctcctct
3121 ctgaccagtt tggagggcac tgaagaaagg caagggccgt gctgctgctg ggcggggcag
3181 gagaggagcc tggccagtgt gccacattaa atacccgtgc aggcgcggag aagcaaccgg
3241 cacccccttc cggcctgaaa gccctccctg caagaaggtg tgcaggagag aagaggcccc
3301 ggcatgggga tctgggttct agagggcatg tgatgactgt aaatgttcac tgggtgggta
3361 gggagtggta tccagtgttc aagtgcagaa atctttggct ttgctaccag ttccatatga
3421 tgagaaataa acgttcgctg aggttttgtt tcataaaaaa aaaaaaaaaa aaaaaaaaaa
3481 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
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