LOCUS AY112670 2601 bp mRNA linear HUM 26-JUL-2004
DEFINITION Homo sapiens transcriptional coactivator tubedown-100 (TBDN100)
mRNA, complete cds.
ACCESSION AY112670
VERSION AY112670.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2601)
AUTHORS Willis,D.M., Loewy,A.P., Charlton-Kachigian,N., Shao,J.S.,
Ornitz,D.M. and Towler,D.A.
TITLE Regulation of osteocalcin gene expression by a novel Ku antigen
transcription factor complex
JOURNAL J. Biol. Chem. 277 (40), 37280-37291 (2002)
PUBMED 12145306
REFERENCE 2 (bases 1 to 2601)
AUTHORS Willis,D.M., Loewy,A.P., Charlton-Kachigian,N., Shao,J.-S.,
Ornitz,D.M. and Towler,D.A.
TITLE Direct Submission
JOURNAL Submitted (15-MAY-2002) Bone and Mineral Diseases, Washington
University School of Medicine, 216 South Kingshighway, Saint Louis,
MO 63110, USA
FEATURES Location/Qualifiers
source 1..2601
/db_xref="H-InvDB:HIT000084451"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2601
/gene="TBDN100"
CDS 1..2601
/gene="TBDN100"
/note="nuclear localization verified by western blot;
binds Ku70 and Ku80; expressed in osteoblasts"
/codon_start=1
/product="transcriptional coactivator tubedown-100"
/protein_id="AAM48746.1"
/translation="MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAE
HGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKC
YRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHL
LEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEK
QICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLER
LKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYK
DKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSI
ALEYINTAIESTPTLIELFLVKAKIYKHAGNIREAARWMDEAQALDTADRFINSKCAK
YMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKC
HEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYL
KLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQ
KKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIY
FRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNR
LFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRN
LQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSS
AEAEELANEI"
misc_feature 136..543
/gene="TBDN100"
/note="Region: tetratricopeptide repeat; TPR"
misc_feature 568..771
/gene="TBDN100"
/note="Region: tetratricopeptide repeat; TPR"
misc_feature 1120..1425
/gene="TBDN100"
/note="Region: tetratricopeptide repeat; TPR"
misc_feature 1834..1884
/gene="TBDN100"
/note="Region: putative nuclear localization signal"
BASE COUNT 922 a 425 c 572 g 682 t
ORIGIN
1 atgccggccg tgagcctccc gcccaaggag aatgcgctct tcaagcggat cttgaggtgt
61 tatgaacata aacagtatag aaatggattg aaattctgta aacaaatact ttctaatccc
121 aaatttgcag agcatggaga aaccttggct atgaaaggat taacattgaa ctgtttgggg
181 aaaaaggaag aagcttatga attggttcgt agaggtttga gaaatgactt gaagagtcat
241 gtgtgttggc acgtttatgg ccttcttcag aggtcagaca agaagtatga tgaagccatt
301 aagtgttaca gaaatgcact aaaatgggat aaagacaatc ttcaaatctt aagggacctt
361 tccttactac agattcaaat gcgagatctt gagggttaca gggaaacgag gtatcagtta
421 cttcagcttc gacctgcgca gagagcatca tggattggtt atgctattgc ttaccattta
481 ttagaagatt atgaaatggc agcaaagatt ttagaagaat ttaggaaaac acaacagaca
541 tcccctgaca aggtggatta tgaatatagt gaactactct tatatcagaa tcaagttctt
601 cgggaagcag gtctctatag agaagctttg gaacatcttt gtacctatga aaagcagatt
661 tgtgataaac ttgctgtaga agaaaccaaa ggggaacttc tgttgcaact atgtcgtttg
721 gaagatgctg cagatgttta tagaggattg caagagagaa atcctgaaaa ctgggcctat
781 tacaaaggct tggaaaaagc actcaagcca gctaatatgt tagaacggct aaaaatttat
841 gaggaagcct ggactaaata tcccagggga ctggtgccaa gaaggctgcc gttaaacttt
901 ttatctggtg agaagtttaa agaatgtttg gataagttcc taaggatgaa tttcagcaag
961 ggttgcccac cagtcttcaa tactttaaga tcattataca aagacaaaga aaaggtggca
1021 atcatagaag agttagtagt aggttatgaa acctctctaa aaagctgccg gttatttaac
1081 cccaatgatg atggaaagga ggaaccacca accacattac tttgggtcca gtactacttg
1141 gcacaacatt atgacaaaat tggtcagcca tctattgctt tggagtacat aaatactgct
1201 attgaaagta cacctacatt aatagaactc tttctcgtga aagctaaaat ctataagcat
1261 gctggaaata ttagagaagc tgcaaggtgg atggatgagg cccaggcctt ggacacagca
1321 gacagattta tcaactccaa atgtgcaaaa tacatgctaa aagccaacct gattaaagaa
1381 gctgaagaaa tgtgctcaaa gtttacaagg gaaggaacat cagcggtaga gaatttgaat
1441 gaaatgcagt gcatgtggtt ccaaacagaa tgtgcccagg cttataaagc aatgaataaa
1501 tttggtgaag cacttaagaa atgtcatgag attgagagac attttataga aatcactgat
1561 gaccagtttg actttcatac atactgtatg aggaagatta cccttagatc atatgtggac
1621 ttattaaaac tagaagatgt acttcgacag catccatttt acttcaaggc agcaagaatt
1681 gctatagaga tctatttgaa gcttcatgac aaccccctta cagatgagaa taaagaacac
1741 gaagctgata cagcaaacat gtctgacaaa gagctaaaga agctacgtaa taaacaaaga
1801 agagctcaaa agaaagccca gatagaagaa gagaaaaaaa atgcagaaaa agaaaagcag
1861 cagagaaatc agaaaaagaa gaaggatgat gatgatgagg agataggagg tccaaaagaa
1921 gaacttattc cagagaaact ggccaaggtt gaaactccat tggaagaagc tattaaattt
1981 ttaacaccgt tgaagaactt ggtgaagaac aagatagaga ctcatctttt tgcctttgag
2041 atttacttta ggaaagaaaa gtttcttttg atgctacaat cagtaaagag ggcatttgct
2101 attgattcta gtcatccctg gcttcatgag tgtatgattc gtctctttaa tactgcagtg
2161 tgtgaaagta aagatttatc tgatacagtt agaacagtat taaaacaaga aatgaatcgt
2221 ctttttggag caacgaatcc aaagaatttt aatgaaactt ttctgaaaag gaattctgat
2281 tcattgccac acagattatc agctgccaaa atggtatatt acttagatcc ttctagtcag
2341 aagcgagcta tagagttggc aacaacactt gatgaatctc tcactaacag aaacctccag
2401 acatgtatgg aggtattgga agccttgtat gatggtagcc taggagactg taaagaagct
2461 gctgaaattt atagagcaaa ttgtcataag cttttccctt atgctttggc tttcatgcct
2521 cctggatatg aagaggatat gaagatcaca gttaatggag atagttctgc agaagctgaa
2581 gaactggcca atgaaatctg a
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