LOCUS AY102279 4789 bp mRNA linear HUM 23-SEP-2003
DEFINITION Homo sapiens RTN4 isoform A (RTN4) mRNA, complete cds;
alternatively spliced.
ACCESSION AY102279
VERSION AY102279.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4789)
AUTHORS Oertle,T., Huber,C., van der Putten,H. and Schwab,M.E.
TITLE Genomic structure and functional characterisation of the promoters
of human and mouse nogo/rtn4
JOURNAL J. Mol. Biol. 325 (2), 299-323 (2003)
PUBMED 12488097
REFERENCE 2 (bases 1 to 4789)
AUTHORS Oertle,T. and Schwab,M.E.
TITLE Direct Submission
JOURNAL Submitted (07-MAY-2002) Brain Research Institute, University of
Zurich and ETH Zurich, Winterthurerstr.190, Zuerich 8057,
Switzerland
REFERENCE 3 (bases 1 to 4789)
AUTHORS Van der Putten,H.
TITLE Direct Submission
JOURNAL Submitted (07-MAY-2002) Nervous System Research, Novartis Pharma
Inc., Basel, Switzerland
FEATURES Location/Qualifiers
source 1..4789
/db_xref="H-InvDB:HIT000084443"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16"
gene 1..4789
/gene="RTN4"
/gene_synonym="NOGO"
5'UTR 1..244
/gene="RTN4"
/gene_synonym="NOGO"
/experiment="experimental evidence, no additional details
recorded"
CDS 245..3823
/gene="RTN4"
/gene_synonym="NOGO"
/note="NOGO-A; RTN4-A; alternatively spliced"
/codon_start=1
/product="RTN4 isoform A"
/protein_id="AAM64248.1"
/translation="MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEED
EDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAP
ERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWT
PPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTIS
AGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEV
SEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKL
VSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFER
VWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPST
PEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEK
NTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV
TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAV
PSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN
INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSP
DSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKP
YLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRET
ETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTE
LPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKV
LVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLS
LTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELV
QKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALI
SLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE"
3'UTR 3824..4789
/gene="RTN4"
/gene_synonym="NOGO"
BASE COUNT 1422 a 1052 c 1075 g 1240 t
ORIGIN
1 gctggcctca ctcctagctc atctgggcgg cggcggcaag tggggacagg gcgggtggcg
61 catcaccggc gcggaggcag gaggagcagt ctcattgttc cgggagccgt caccacagta
121 ggtccctcgg ctcagtcggc ccagcccctc tcagtcctcc ccaaccccca caaccgcccg
181 cggctctgag acgcggcccc ggcggcggcg gcagcagctg cagcatcatc tccaccctcc
241 agccatggaa gacctggacc agtctcctct ggtctcgtcc tcggacagcc caccccggcc
301 gcagcccgcg ttcaagtacc agttcgtgag ggagcccgag gacgaggagg aagaagagga
361 ggaggaagag gaggacgagg acgaagacct ggaggagctg gaggtgctgg agaggaagcc
421 cgccgccggg ctgtccgcgg ccccagtgcc caccgcccct gccgccggcg cgcccctgat
481 ggacttcgga aatgacttcg tgccgccggc gccccgggga cccctgccgg ccgctccccc
541 cgtcgccccg gagcggcagc cgtcttggga cccgagcccg gtgtcgtcga ccgtgcccgc
601 gccatccccg ctgtctgctg ccgcagtctc gccctccaag ctccctgagg acgacgagcc
661 tccggcccgg cctccccctc ctcccccggc cagcgtgagc ccccaggcag agcccgtgtg
721 gaccccgcca gccccggctc ccgccgcgcc cccctccacc ccggccgcgc ccaagcgcag
781 gggctcctcg ggctcagtgg atgagaccct ttttgctctt cctgctgcat ctgagcctgt
841 gatacgctcc tctgcagaaa atatggactt gaaggagcag ccaggtaaca ctatttcggc
901 tggtcaagag gatttcccat ctgtcctgct tgaaactgct gcttctcttc cttctctgtc
961 tcctctctca gccgcttctt tcaaagaaca tgaatacctt ggtaatttgt caacagtatt
1021 acccactgaa ggaacacttc aagaaaatgt cagtgaagct tctaaagagg tctcagagaa
1081 ggcaaaaact ctactcatag atagagattt aacagagttt tcagaattag aatactcaga
1141 aatgggatca tcgttcagtg tctctccaaa agcagaatct gccgtaatag tagcaaatcc
1201 tagggaagaa ataatcgtga aaaataaaga tgaagaagag aagttagtta gtaataacat
1261 ccttcataat caacaagagt tacctacagc tcttactaaa ttggttaaag aggatgaagt
1321 tgtgtcttca gaaaaagcaa aagacagttt taatgaaaag agagttgcag tggaagctcc
1381 tatgagggag gaatatgcag acttcaaacc atttgagcga gtatgggaag tgaaagatag
1441 taaggaagat agtgatatgt tggctgctgg aggtaaaatc gagagcaact tggaaagtaa
1501 agtggataaa aaatgttttg cagatagcct tgagcaaact aatcacgaaa aagatagtga
1561 gagtagtaat gatgatactt ctttccccag tacgccagaa ggtataaagg atcgttcagg
1621 agcatatatc acatgtgctc cctttaaccc agcagcaact gagagcattg caacaaacat
1681 ttttcctttg ttaggagatc ctacttcaga aaataagacc gatgaaaaaa aaatagaaga
1741 aaagaaggcc caaatagtaa cagagaagaa tactagcacc aaaacatcaa acccttttct
1801 tgtagcagca caggattctg agacagatta tgtcacaaca gataatttaa caaaggtgac
1861 tgaggaagtc gtggcaaaca tgcctgaagg cctgactcca gatttagtac aggaagcatg
1921 tgaaagtgaa ttgaatgaag ttactggtac aaagattgct tatgaaacaa aaatggactt
1981 ggttcaaaca tcagaagtta tgcaagagtc actctatcct gcagcacagc tttgcccatc
2041 atttgaagag tcagaagcta ctccttcacc agttttgcct gacattgtta tggaagcacc
2101 attgaattct gcagttccta gtgctggtgc ttccgtgata cagcccagct catcaccatt
2161 agaagcttct tcagttaatt atgaaagcat aaaacatgag cctgaaaacc ccccaccata
2221 tgaagaggcc atgagtgtat cactaaaaaa agtatcagga ataaaggaag aaattaaaga
2281 gcctgaaaat attaatgcag ctcttcaaga aacagaagct ccttatatat ctattgcatg
2341 tgatttaatt aaagaaacaa agctttctgc tgaaccagct ccggatttct ctgattattc
2401 agaaatggca aaagttgaac agccagtgcc tgatcattct gagctagttg aagattcctc
2461 acctgattct gaaccagttg acttatttag tgatgattca atacctgacg ttccacaaaa
2521 acaagatgaa actgtgatgc ttgtgaaaga aagtctcact gagacttcat ttgagtcaat
2581 gatagaatat gaaaataagg aaaaactcag tgctttgcca cctgagggag gaaagccata
2641 tttggaatct tttaagctca gtttagataa cacaaaagat accctgttac ctgatgaagt
2701 ttcaacattg agcaaaaagg agaaaattcc tttgcagatg gaggagctca gtactgcagt
2761 ttattcaaat gatgacttat ttatttctaa ggaagcacag ataagagaaa ctgaaacgtt
2821 ttcagattca tctccaattg aaattataga tgagttccct acattgatca gttctaaaac
2881 tgattcattt tctaaattag ccagggaata tactgaccta gaagtatccc acaaaagtga
2941 aattgctaat gccccggatg gagctgggtc attgccttgc acagaattgc cccatgacct
3001 ttctttgaag aacatacaac ccaaagttga agagaaaatc agtttctcag atgacttttc
3061 taaaaatggg tctgctacat caaaggtgct cttattgcct ccagatgttt ctgctttggc
3121 cactcaagca gagatagaga gcatagttaa acccaaagtt cttgtgaaag aagctgagaa
3181 aaaacttcct tccgatacag aaaaagagga cagatcacca tctgctatat tttcagcaga
3241 gctgagtaaa acttcagttg ttgacctcct gtactggaga gacattaaga agactggagt
3301 ggtgtttggt gccagcctat tcctgctgct ttcattgaca gtattcagca ttgtgagcgt
3361 aacagcctac attgccttgg ccctgctctc tgtgaccatc agctttagga tatacaaggg
3421 tgtgatccaa gctatccaga aatcagatga aggccaccca ttcagggcat atctggaatc
3481 tgaagttgct atatctgagg agttggttca gaagtacagt aattctgctc ttggtcatgt
3541 gaactgcacg ataaaggaac tcaggcgcct cttcttagtt gatgatttag ttgattctct
3601 gaagtttgca gtgttgatgt gggtatttac ctatgttggt gccttgttta atggtctgac
3661 actactgatt ttggctctca tttcactctt cagtgttcct gttatttatg aacggcatca
3721 ggcacagata gatcattatc taggacttgc aaataagaat gttaaagatg ctatggctaa
3781 aatccaagca aaaatccctg gattgaagcg caaagctgaa tgaaaacgcc caaaataatt
3841 agtaggagtt catctttaaa ggggatattc atttgattat acgggggagg gtcagggaag
3901 aacgaacctt gacgttgcag tgcagtttca cagatcgttg ttagatcttt atttttagcc
3961 atgcactgtt gtgaggaaaa attacctgtc ttgactgcca tgtgttcatc atcttaagta
4021 ttgtaagctg ctatgtatgg atttaaaccg taatcatatc tttttcctat ctgaggcact
4081 ggtggaataa aaaacctgta tattttactt tgttgcagat agtcttgccg catcttggca
4141 agttgcagag atggtggagc tagaaaaaaa aaaaaaaaag cccttttcag tttgtgcact
4201 gtgtatggtc cgtgtagatt gatgcagatt ttctgaaatg aaatgtttgt ttagacgaga
4261 tcataccggt aaagcaggaa tgacaaagct tgcttttctg gtatgttcta ggtgtattgt
4321 gacttttact gttatattaa ttgccaatat aagtaaatat agattatata tgtatagtgt
4381 ttcacaaagc ttagaccttt accttccagc caccccacag tgcttgatat ttcagagtca
4441 gtcattggtt atacatgtgt agttccaaag cacataagct agaagaagaa atatttctag
4501 gagcactacc atctgttttc aacatgaaat gccacacaca tagaactcca acaacatcaa
4561 tttcattgca cagactgact gtagttaatt ttgtcacaga atctatggac tgaatctaat
4621 gcttccaaaa atgttgtttg tttgcaaata tcaaacattg ttatgcaaga aattattaat
4681 tacaaaatga agatttatac cattgtggtt taagctgtac tgaactaaat ctgtggaatg
4741 cattgtgaac tgtaaaagca aagtatcaat aaagcttata gacttaaaa
//