LOCUS AY098914 2350 bp mRNA linear HUM 04-JAN-2003
DEFINITION Homo sapiens neuronal tryptophan hydroxylase (TPH) mRNA, complete
cds.
ACCESSION AY098914
VERSION AY098914.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2350)
AUTHORS Walther,D.J., Peter,J.U., Bashammakh,S., Hortnagl,H., Voits,M.,
Fink,H. and Bader,M.
TITLE Synthesis of serotonin by a second tryptophan hydroxylase isoform
JOURNAL Science 299 (5603), 76 (2003)
PUBMED 12511643
REFERENCE 2 (bases 1 to 2350)
AUTHORS Walther,D.J., Peter,J.-U. and Bader,M.
TITLE Direct Submission
JOURNAL Submitted (23-APR-2002) Hypertension Research, Max-Delbrueck-Center
for Molecular Medicine, Robert-Roessle-Strasse 10, Berlin-Buch,
Berlin D-13092, Germany
FEATURES Location/Qualifiers
source 1..2350
/db_xref="H-InvDB:HIT000084391"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
gene 1..2350
/gene="TPH"
CDS 142..1614
/gene="TPH"
/note="HSNTPH"
/codon_start=1
/product="neuronal tryptophan hydroxylase"
/protein_id="AAM28946.1"
/translation="MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKN
DDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRR
SSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISE
LDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETK
TWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVR
PVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQ
FSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALS
DKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPY
TQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI"
BASE COUNT 700 a 503 c 510 g 637 t
ORIGIN
1 cattgctctt cagcaccagg gttctggaca gcgccccaag caggcagctg atcgcacgcc
61 ccttcctctc aatctccgcc agcgctgcta ctgcccctct agtaccccct gctgcagaga
121 aagaatatta caccgggatc catgcagcca gcaatgatga tgttttccag taaatactgg
181 gcacggagag ggttttccct ggattcagca gtgcccgaag agcatcagct acttggcagc
241 tcaacactaa ataaacctaa ctctggcaaa aatgacgaca aaggcaacaa gggaagcagc
301 aaacgtgaag ctgctaccga aagtggcaag acagcagttg ttttctcctt gaagaatgaa
361 gttggtggat tggtaaaagc actgaggctc tttcaggaaa aacgtgtcaa catggttcat
421 attgaatcca ggaaatctcg gcgaagaagt tctgaggttg aaatctttgt ggactgtgag
481 tgtgggaaaa cagaattcaa tgagctcatt cagttgctga aatttcaaac cactattgtg
541 acgctgaatc ctccagagaa catttggaca gaggaagaag agctagagga tgtgccctgg
601 ttccctcgga agatctctga gttagacaaa tgctctcaca gagttctcat gtatggttct
661 gagcttgatg ctgaccaccc aggatttaag gacaatgtct atcgacagag aagaaagtat
721 tttgtggatg tggccatggg ttataaatat ggtcagccca ttcccagggt ggagtatact
781 gaagaagaaa ctaaaacttg gggtgttgta ttccgggagc tctccaaact ctatcccact
841 catgcttgcc gagagtattt gaaaaacttc cctctgctga ctaaatactg tggctacaga
901 gaggacaatg tgcctcaact cgaagatgtc tccatgtttc tgaaagaaag gtctggcttc
961 acggtgaggc cggtggctgg atacctgagc ccacgagact ttctggcagg actggcctac
1021 agagtgttcc actgtaccca gtacatccgg catggctcag atcccctcta caccccagaa
1081 ccagacacat gccatgaact cttgggacat gttccactac ttgcggatcc taagtttgct
1141 cagttttcac aagaaatagg tctggcgtct ctgggagcat cagatgaaga tgttcagaaa
1201 ctagccacgt gctatttctt cacaatcgag tttggccttt gcaagcaaga agggcaactg
1261 cgggcatatg gagcaggact cctttcctcc attggagaat taaagcacgc cctttctgac
1321 aaggcatgtg tgaaagcctt tgacccaaag acaacttgct tacaggaatg ccttatcacc
1381 accttccagg aagcctactt tgtttcagaa agttttgaag aagccaaaga aaagatgagg
1441 gactttgcaa agtcaattac ccgtcccttc tcagtatact tcaatcccta cacacagagt
1501 attgaaattc tgaaagacac cagaagtatt gaaaatgtgg tgcaggacct tcgcagcgac
1561 ttgaatacag tgtgtgatgc tttaaacaaa atgaaccaat atctggggat ttgatgcctg
1621 gaactatgtt gttgccagca tgatcttttt ggggcttagc agcagttcag tcaatgtcat
1681 ataacgcaaa taaccttctg tgtcatggct tggctaataa gcatgcaatt ccatatatct
1741 ataccatctt gtaactcact gtgttagtat ataaagcacc ataagaaatc caatggcaga
1801 taacctgaaa taacgtatta tgtttaaaca tcttaaaaag atttgacatt cctgcttagt
1861 gtccttaacc aaactgcatc tagttaaaat ttgtaacaaa tagccctctt atgagtctca
1921 tttatgccct tttctttttc agatctaagc ctttcctctg tgttcattag ataaaatgaa
1981 aaaaagcagt gaagctgttt ccattttcaa tagtatcagt gttttcacgc attatttgag
2041 ataaacccag aattgtagga aacttcccat cacaataaca aaggttcaat attctatttc
2101 aaaaattgtt gaggtaacac agcagttgga atgattttta ggttgagtat ttacacaatg
2161 caagaaaaca cctttttaca aatggaatta tgtaggttgc gttgaccttg tagaacctga
2221 gttatgacaa gcttcctgaa gtattttgga agatagtact tccggaaagg acattaggaa
2281 agactaaaca gtggacaatc aatcttggga ctatgaattt tatgctggaa taaagtaaat
2341 tatcatgttc
//