LOCUS AY082591 5784 bp mRNA linear HUM 03-NOV-2005
DEFINITION Homo sapiens deleted in liver cancer 2 gamma mRNA, complete cds.
ACCESSION AY082591
VERSION AY082591.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5784)
AUTHORS Leung,T.H., Ching,Y.P., Yam,J.W., Wong,C.M., Yau,T.O., Jin,D.Y. and
Ng,I.O.
TITLE Deleted in liver cancer 2 (DLC2) suppresses cell transformation by
means of inhibition of RhoA activity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (42), 15207-15212 (2005)
PUBMED 16217026
REFERENCE 2 (bases 1 to 5784)
AUTHORS Ching,Y.-P., Wong,C.-M., Chan,S.-F., Lau,T., Kung,H.-F., Fan,S.-T.,
Jin,D.-Y. and Ng,I.O.L.
TITLE DLC2 is frequently deleted in hepatocellular carcinoma and encodes
a RhoGAP protein with growth suppressor function
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 5784)
AUTHORS Ching,Y.-P., Chan,S.-F., Ng,I.O.L. and Jin,D.-Y.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-2002) Department of Biochemistry, The University
of Hong Kong, 3rd Floor, New Medical Complex, 21 Sassoon Road, Hong
Kong, Hong Kong
FEATURES Location/Qualifiers
source 1..5784
/db_xref="H-InvDB:HIT000084259"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q12.3; between RFC3 and KL"
CDS 374..3361
/note="RhoGAP; DLC2gamma"
/codon_start=1
/product="deleted in liver cancer 2 gamma"
/protein_id="AAL91650.1"
/translation="MKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTL
LPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNP
VMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGS
GRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPS
EHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLV
VHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASCHR
ASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVLPE
LQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGVRD
RRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRLTA
IMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQAL
RYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFRDL
PEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLV
EENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLA
HMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLIQG
LQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRER
HLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSL
SVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLC
AAEVARIRNSFQPLIAEGPETKI"
BASE COUNT 1656 a 1301 c 1381 g 1446 t
ORIGIN
1 ctcacagaca acagccaagc acagaggaaa tattagctgg cagagataac gaagagaaaa
61 cactcggtga cagatgcacc atctgtcagt ttctgaggag cagttttcaa gaaagctgaa
121 aatgaattga agaagagagg ggttttgttt gaaaggtaca gcacagccta aggacaattt
181 taaacaaaaa attgaggcaa aagaagcatg tgactggctc cgtgctgccg ggttcccgca
241 atacgctcag ttatatgagg attcacaatt tcccatcaac attgtggctg tcaagaatga
301 tcatgatttt cttgaaaagg accttgtaga acctctttgc agacgactaa atacgttgaa
361 caagtgtgcc tcaatgaaac ttgatgtgaa cttccaaagg aaaaagggtg acgactccga
421 tgaggaagat ctttgtatca gcaacaaatg gactttccaa agaaccagtc gcaggtggtc
481 tcgtgtggac gacctctaca cgctgctccc tcgaggagac agaaatgggt caccgggagg
541 cacggggatg aggaacacga ccagcagtga gagcgtcctc acagacctga gcgagcctga
601 ggtctgctcc attcacagcg aaagcagtgg aggcagcgac agtcgcagcc agccgggcca
661 gtgctgtaca gacaacccgg tcatgctgga tgccccactc gtcagcagca gcctcccaca
721 gccccccaga gatgtcctca accacccctt ccaccccaag aatgagaagc ccacgagggc
781 tagggccaaa tcatttttga aacgcatgga aacactccga gggaagggag cccacgggag
841 gcataagggg tctgggcgga caggtggcct ggtgatcagt gggcccatgt tgcagcagga
901 gccagagtcc tttaaggcta tgcagtgcat ccaaatacca aatggagatc tccagaattc
961 gccgccacct gcctgcagaa aagggctccc atgctctggc aagtcgagtg gcgagagcag
1021 cccgtcggag cacagcagca gcggggtgag cacgccctgc ctgaaggaac gcaagtgcca
1081 cgaggccaac aagcgcgggg gcatgtactt ggaggaccta gatgtgctgg cggggacagc
1141 actgccggat gcaggggacc aaagccgtat gcatgagttt cactcccaag agaatttggt
1201 ggtgcatatt cccaaggatc acaaaccagg aacattcccc aaggcacttt ctattgaaag
1261 cctctctccc acagatagta gcaatggggt taattggagg accggtagca tctccctggg
1321 cagagagcag gtccctggtg ccagggagcc ccggctcatg gcgtcctgcc acagagccag
1381 ccgagtcagt atctatgaca atgtccctgg ctcccatctg tatgccagca caggagatct
1441 tttggacttg gagaaagatg accttttccc tcacttggat gacattctgc agcatgtcaa
1501 tgggctccaa gaggtagtcg atgactggtc caaagatgtc ttgcctgaac tgcaaactca
1561 tgatacattg gttggggaac ctggcttatc cacctttcca tctcctaatc agatcacctt
1621 agattttgaa ggtaactctg tctcagaagg tcggacgaca cccagtgatg tggaaagaga
1681 tgtaacatct cttaatgaat ctgagcctcc tggggtcaga gacaggaggg attctggtgt
1741 aggggcctct ctgaccaggc caaacaggcg actccgatgg aacagtttcc agctgtcgca
1801 ccagccccgg ccggccccag catcgcccca catcagcagc cagacggcca gccagctgag
1861 cctgctccag cgcttctcac tgctccgcct cacggccatc atggagaagc actccatgtc
1921 caacaagcac ggctggacat ggtcagttcc aaagttcatg aagaggatga aagttcccga
1981 ctacaaagac aaggctgtct ttggcgttcc tctcatagtc cacgtccaaa gaacgggaca
2041 gcccctgcct caaagtattc agcaagcact gagatatcta cgcagcaact gcctcgatca
2101 ggtgggtctt tttcgcaaat caggagtgaa gtctcgaatc catgcccttc gccaaatgaa
2161 tgaaaacttc cctgagaacg tcaactatga agaccagtct gcttatgatg tggcggatat
2221 ggtgaaacag ttcttccggg acctccctga gcctcttttc accaacaagc tcagtgagac
2281 ctttctccat atctatcagt atgtctccaa agagcagcgg ctgcaggccg tgcaggctgc
2341 catcctgcta ctggccgatg agaacaggga ggtcctgcag acgctcttgt gtttcctgaa
2401 cgacgtcgtc aacttggtgg aagagaatca gatgacgccc atgaacctgg cagtgtgtct
2461 ggccccctcc ctctttcatc ttaatttatt gaagaaagaa agctctccac gagtcataca
2521 gaagaaatat gccactggga agccagatca aaaggacctc aacgagaatc tggcagcagc
2581 tcaggggcta gcgcacatga tcatggaatg cgacagactt tttgaggttc cacacgagtt
2641 ggtggcccag tctcgtaact cgtatgtgga ggctgagatc cacgtgccaa ccctggaaga
2701 attggggaca cagctggagg agagtggggc aactttccac acttacctga accatctcat
2761 ccagggcctc cagaaagaag ccaaggagaa gttcaaagga tgggtcacgt gctccagcac
2821 ggacaataca gatcttgctt tcaaaaaggt gggcgacggg aacccgctga agctgtggaa
2881 ggcttctgtg gaggtggaag cacccccctc agtggtcctg aaccgcgtgc tgagagagcg
2941 ccacctgtgg gacgaggact ttgtgcagtg gaaggttgtg gaaactctag acaggcaaac
3001 agagatctac cagtatgtgc tgaacagcat ggctccccat ccttccagag actttgtggt
3061 tctcaggacc tggaaaactg atttgcccaa aggaatgtgt accctggtgt ccctctccgt
3121 ggagcatgag gaagcccagc tcctgggtgg tgtgcgagca gtggtgatgg actcgcagta
3181 cttgatagaa ccgtgtggct ctggcaagtc aagactgact cacatctgca ggatagacct
3241 gaaaggtcac tccccagaat ggtacagcaa aggctttgga catctgtgtg cagcagaagt
3301 tgccaggatt agaaactctt tccagcccct cattgctgag ggcccagaaa ctaaaatctg
3361 agttttgccc agtgtgacat caaactcagg gaagaggaag ctaaagtgac gagtgtggca
3421 gagagtgtgc atgtgagaaa gcgagagaaa gaggaactga aggacgcggt taatgcctaa
3481 aaatggaaac gttaagaagt tggaatgttg gagatgcaag aatttccaag aactttctta
3541 gccttcctgg agatggctac atccctacta atataatttt aaaatgagaa ctttatatat
3601 attacttaaa attaaatgga ctattccttg tgcattgcct aatttgctat ttaaaggctt
3661 ctaagaagcg tatacctaac tgtaaataaa tgtatgtata gcatatgtac atatgtgtgt
3721 atatctccat ctttactgta tatatgtaaa ataccaattt tatatagaat tgtgtgtttt
3781 gaaaatgacg gtgtctgact cagtgagtcc cttcctcaca cagttctttc caagtggctc
3841 tgggccccat ctctccactg tcctgtaagc tgtgcagaac ctgctgctaa caccaaggtg
3901 tgaacatgcc ctgatgccta accaaagatg agttaaccaa aggaaaataa cattaaagga
3961 gacttatgtg ttaacgcttt gtttctgcta ttcaaaaact gagagtggag atctgggata
4021 aagcaaggaa ataataatta ctcctcctta aagcaaatgg gggggtgaga agtcattacc
4081 aaatttaaag ctagatgagg agttgccact gggcccagta agatggaatt tcagtgagat
4141 atggaccacc ggagtcagcg agagtgactg aaacagaagc gatacctctc gctcccatgc
4201 ccatcactac agaccccaag tcaagatgaa tatcatagcc tttacttctt cacagccaaa
4261 gggagcccct gtgttgtctc aagtttttat aaatacattt cataatgtta ttaaatgtca
4321 ttctatttga ccagtggcct atttggtcac agttaattgg tgttttctta ttgcactgaa
4381 ttcaactcca gacaccatac aaagggagat gatggccatt ccgttcaaat cctagatcgt
4441 tacagcttca gggaattcat attttgttat gtgtaggata ctcttaaaat gtaattcatt
4501 aaacttttac aatctgaaag acagggtttt taactaacat gagaccaaaa ctatgttctt
4561 tgattagttt tagatagtat aatcgggttt attaattctt ctgtgtttct tcactagcca
4621 gtccaagcta cctatgcatt tgacccaacc ttatttatta ttgtacagat gaagcgaatt
4681 gactcccttt agccaactgc taatggatcg aatgtgcttt ttattgtaat tcaacagcta
4741 tagagagaaa gataacttat tgtgtgtttg atttcaggga gagagatttt ctttggtcat
4801 ccataataga gattgataag atttagcaac tggtgttgga gaaaaaaaga aaagcaaatg
4861 agtgttttca ggtttttttg cattatatgc atttatgtaa tgtttctgtt atcagcaatg
4921 tgcaattatt ttattgagag gaataaaaaa gctttctatg agtttggtat ggtgcgagga
4981 aaatcttaca gtttgaatta tgacctagaa atttttcatt cccatgtcta cctaagaagg
5041 aagcagtaaa tccataattt accttttggg caatgctttg tgagcaaaac aaagtcactt
5101 ctgccataac atcttgaatg taaccatata tgccagatta ctttatatgc atcaacaaga
5161 tcaccagtga agtttaatct agctaaacac tggtcctgct cctgagatgg gatcctatgt
5221 gtttggaaaa cgtgataggc acacgaggat gagtggcttt gtatcgccca gagaggtgct
5281 tgtccagatt tcacatgcac atgaattgcc tggggatctt gtgaaactgc agactctgct
5341 ccaagtaatc tgggctgggc ctgagattct gcatttctaa ggagtctcag ggatgcctat
5401 gctgctggcc taaaaccaca ctcagaaacg aggacctaga agatccctaa aacagaataa
5461 gaacaaatgt gattgtattt ctgattctcc ctctcttcga attatctgac ttttttgttt
5521 ttgtgcacat agtaatcata tcaccgctgc ataacaacac agtgcatctt tttaaaacaa
5581 ggaaaaggga aaaaaaggag aaaaaacgat gcatcaagct tgtttgtcaa ataccacagt
5641 attttattca ttgttatctt gccaatggaa ataaagtatg atattgcatt taaatattat
5701 atttatacct catgtatatt tttacctcaa ttgttgatat caatcatcaa ttgtaaataa
5761 ataattgcca aggcaaataa attt
//