LOCUS AY082590 5810 bp mRNA linear HUM 03-NOV-2005
DEFINITION Homo sapiens deleted in liver cancer 2 beta mRNA, complete cds.
ACCESSION AY082590
VERSION AY082590.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5810)
AUTHORS Leung,T.H., Ching,Y.P., Yam,J.W., Wong,C.M., Yau,T.O., Jin,D.Y. and
Ng,I.O.
TITLE Deleted in liver cancer 2 (DLC2) suppresses cell transformation by
means of inhibition of RhoA activity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (42), 15207-15212 (2005)
PUBMED 16217026
REFERENCE 2 (bases 1 to 5810)
AUTHORS Ching,Y.-P., Wong,C.-M., Chan,S.-F., Lau,T., Kung,H.-F., Fan,S.-T.,
Jin,D.-Y. and Ng,I.O.L.
TITLE DLC2 is frequently deleted in hepatocellular carcinoma and encodes
a RhoGAP protein with growth suppressor function
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 5810)
AUTHORS Ching,Y.-P., Chan,S.-F., Ng,I.O.L. and Jin,D.-Y.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-2002) Department of Biochemistry, The University
of Hong Kong, 3rd Floor, New Medical Complex, 21 Sassoon Road, Hong
Kong, Hong Kong
FEATURES Location/Qualifiers
source 1..5810
/db_xref="H-InvDB:HIT000084258"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q12.3; between RFC3 and KL"
CDS 70..3387
/note="RhoGAP; DLC2beta"
/codon_start=1
/product="deleted in liver cancer 2 beta"
/protein_id="AAL91649.1"
/translation="MLEPSSVLHANVNQAPLWCLVLRWCRECKDTVCGGKQKSRVNHT
FQRREIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRL
NTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDR
NGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAP
LVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGL
VISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSG
VSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKD
HKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSI
YDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDT
LVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGV
GASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRLTAIMEKHS
MSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSN
CLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFRDLPEPLFT
NKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMT
PMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMEC
DRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLIQGLQKEAK
EKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDED
FVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEE
AQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVAR
IRNSFQPLIAEGPETKI"
BASE COUNT 1634 a 1325 c 1394 g 1457 t
ORIGIN
1 cggacgcgtg ggcggaaaca tgagagagga ctatcatctg ctccttgctc tgaatttctt
61 tgaacctcca tgctggaacc ctcctcagtt ctccatgcaa acgttaacca ggcccctttg
121 tggtgcttgg tgctgcgctg gtgcagagaa tgcaaagaca ctgtctgtgg tgggaaacag
181 aaaagcagag tgaaccacac attccagcgc cgggaaattg aggcaaaaga agcatgtgac
241 tggctccgtg ctgccgggtt cccgcaatac gctcagttat atgaggattc acaatttccc
301 atcaacattg tggctgtcaa gaatgatcat gattttcttg aaaaggacct tgtagaacct
361 ctttgcagac gactaaatac gttgaacaag tgtgcctcaa tgaaacttga tgtgaacttc
421 caaaggaaaa agggtgacga ctccgatgag gaagatcttt gtatcagcaa caaatggact
481 ttccaaagaa ccagtcgcag gtggtctcgt gtggacgacc tctacacgct gctccctcga
541 ggagacagaa atgggtcacc gggaggcacg gggatgagga acacgaccag cagtgagagc
601 gtcctcacag acctgagcga gcctgaggtc tgctccattc acagcgaaag cagtggaggc
661 agcgacagtc gcagccagcc gggccagtgc tgtacagaca acccggtcat gctggatgcc
721 ccactcgtca gcagcagcct cccacagccc cccagagatg tcctcaacca ccccttccac
781 cccaagaatg agaagcccac gagggctagg gccaaatcat ttttgaaacg catggaaaca
841 ctccgaggga agggagccca cgggaggcat aaggggtctg ggcggacagg tggcctggtg
901 atcagtgggc ccatgttgca gcaggagcca gagtccttta aggctatgca gtgcatccaa
961 ataccaaatg gagatctcca gaattcgccg ccacctgcct gcagaaaagg gctcccatgc
1021 tctggcaagt cgagtggcga gagcagcccg tcggagcaca gcagcagcgg ggtgagcacg
1081 ccctgcctga aggaacgcaa gtgccacgag gccaacaagc gcgggggcat gtacttggag
1141 gacctagatg tgctggcggg gacagcactg ccggatgcag gggaccaaag ccgtatgcat
1201 gagtttcact cccaagagaa tttggtggtg catattccca aggatcacaa accaggaaca
1261 ttccccaagg cactttctat tgaaagcctc tctcccacag atagtagcaa tggggttaat
1321 tggaggaccg gtagcatctc cctgggcaga gagcaggtcc ctggtgccag ggagccccgg
1381 ctcatggcgt cctgccacag agccagccga gtcagtatct atgacaatgt ccctggctcc
1441 catctgtatg ccagcacagg agatcttttg gacttggaga aagatgacct tttccctcac
1501 ttggatgaca ttctgcagca tgtcaatggg ctccaagagg tagtcgatga ctggtccaaa
1561 gatgtcttgc ctgaactgca aactcatgat acattggttg gggaacctgg cttatccacc
1621 tttccatctc ctaatcagat caccttagat tttgaaggta actctgtctc agaaggtcgg
1681 acgacaccca gtgatgtgga aagagatgta acatctctta atgaatctga gcctcctggg
1741 gtcagagaca ggagggattc tggtgtaggg gcctctctga ccaggccaaa caggcgactc
1801 cgatggaaca gtttccagct gtcgcaccag ccccggccgg ccccagcatc gccccacatc
1861 agcagccaga cggccagcca gctgagcctg ctccagcgct tctcactgct ccgcctcacg
1921 gccatcatgg agaagcactc catgtccaac aagcacggct ggacatggtc agttccaaag
1981 ttcatgaaga ggatgaaagt tcccgactac aaagacaagg ctgtctttgg cgttcctctc
2041 atagtccacg tccaaagaac gggacagccc ctgcctcaaa gtattcagca agcactgaga
2101 tatctacgca gcaactgcct cgatcaggtg ggtctttttc gcaaatcagg agtgaagtct
2161 cgaatccatg cccttcgcca aatgaatgaa aacttccctg agaacgtcaa ctatgaagac
2221 cagtctgctt atgatgtggc ggatatggtg aaacagttct tccgggacct ccctgagcct
2281 cttttcacca acaagctcag tgagaccttt ctccatatct atcagtatgt ctccaaagag
2341 cagcggctgc aggccgtgca ggctgccatc ctgctactgg ccgatgagaa cagggaggtc
2401 ctgcagacgc tcttgtgttt cctgaacgac gtcgtcaact tggtggaaga gaatcagatg
2461 acgcccatga acctggcagt gtgtctggcc ccctccctct ttcatcttaa tttattgaag
2521 aaagaaagct ctccacgagt catacagaag aaatatgcca ctgggaagcc agatcaaaag
2581 gacctcaacg agaatctggc agcagctcag gggctagcgc acatgatcat ggaatgcgac
2641 agactttttg aggttccaca cgagttggtg gcccagtctc gtaactcgta tgtggaggct
2701 gagatccacg tgccaaccct ggaagaattg gggacacagc tggaggagag tggggcaact
2761 ttccacactt acctgaacca tctcatccag ggcctccaga aagaagccaa ggagaagttc
2821 aaaggatggg tcacgtgctc cagcacggac aatacagatc ttgctttcaa aaaggtgggc
2881 gacgggaacc cgctgaagct gtggaaggct tctgtggagg tggaagcacc cccctcagtg
2941 gtcctgaacc gcgtgctgag agagcgccac ctgtgggacg aggactttgt gcagtggaag
3001 gttgtggaaa ctctagacag gcaaacagag atctaccagt atgtgctgaa cagcatggct
3061 ccccatcctt ccagagactt tgtggttctc aggacctgga aaactgattt gcccaaagga
3121 atgtgtaccc tggtgtccct ctccgtggag catgaggaag cccagctcct gggtggtgtg
3181 cgagcagtgg tgatggactc gcagtacttg atagaaccgt gtggctctgg caagtcaaga
3241 ctgactcaca tctgcaggat agacctgaaa ggtcactccc cagaatggta cagcaaaggc
3301 tttggacatc tgtgtgcagc agaagttgcc aggattagaa actctttcca gcccctcatt
3361 gctgagggcc cagaaactaa aatctgagtt ttgcccagtg tgacatcaaa ctcagggaag
3421 aggaagctaa agtgacgagt gtggcagaga gtgtgcatgt gagaaagcga gagaaagagg
3481 aactgaagga cgcggttaat gcctaaaaat ggaaacgtta agaagttgga atgttggaga
3541 tgcaagaatt tccaagaact ttcttagcct tcctggagat ggctacatcc ctactaatat
3601 aattttaaaa tgagaacttt atatatatta cttaaaatta aatggactat tccttgtgca
3661 ttgcctaatt tgctatttaa aggcttctaa gaagcgtata cctaactgta aataaatgta
3721 tgtatagcat atgtacatat gtgtgtatat ctccatcttt actgtatata tgtaaaatac
3781 caattttata tagaattgtg tgttttgaaa atgacggtgt ctgactcagt gagtcccttc
3841 ctcacacagt tctttccaag tggctctggg ccccatctct ccactgtcct gtaagctgtg
3901 cagaacctgc tgctaacacc aaggtgtgaa catgccctga tgcctaacca aagatgagtt
3961 aaccaaagga aaataacatt aaaggagact tatgtgttaa cgctttgttt ctgctattca
4021 aaaactgaga gtggagatct gggataaagc aaggaaataa taattactcc tccttaaagc
4081 aaatgggggg gtgagaagtc attaccaaat ttaaagctag atgaggagtt gccactgggc
4141 ccagtaagat ggaatttcag tgagatatgg accaccggag tcagcgagag tgactgaaac
4201 agaagcgata cctctcgctc ccatgcccat cactacagac cccaagtcaa gatgaatatc
4261 atagccttta cttcttcaca gccaaaggga gcccctgtgt tgtctcaagt ttttataaat
4321 acatttcata atgttattaa atgtcattct atttgaccag tggcctattt ggtcacagtt
4381 aattggtgtt ttcttattgc actgaattca actccagaca ccatacaaag ggagatgatg
4441 gccattccgt tcaaatccta gatcgttaca gcttcaggga attcatattt tgttatgtgt
4501 aggatactct taaaatgtaa ttcattaaac ttttacaatc tgaaagacag ggtttttaac
4561 taacatgaga ccaaaactat gttctttgat tagttttaga tagtataatc gggtttatta
4621 attcttctgt gtttcttcac tagccagtcc aagctaccta tgcatttgac ccaaccttat
4681 ttattattgt acagatgaag cgaattgact ccctttagcc aactgctaat ggatcgaatg
4741 tgctttttat tgtaattcaa cagctataga gagaaagata acttattgtg tgtttgattt
4801 cagggagaga gattttcttt ggtcatccat aatagagatt gataagattt agcaactggt
4861 gttggagaaa aaaagaaaag caaatgagtg ttttcaggtt tttttgcatt atatgcattt
4921 atgtaatgtt tctgttatca gcaatgtgca attattttat tgagaggaat aaaaaagctt
4981 tctatgagtt tggtatggtg cgaggaaaat cttacagttt gaattatgac ctagaaattt
5041 ttcattccca tgtctaccta agaaggaagc agtaaatcca taatttacct tttgggcaat
5101 gctttgtgag caaaacaaag tcacttctgc cataacatct tgaatgtaac catatatgcc
5161 agattacttt atatgcatca acaagatcac cagtgaagtt taatctagct aaacactggt
5221 cctgctcctg agatgggatc ctatgtgttt ggaaaacgtg ataggcacac gaggatgagt
5281 ggctttgtat cgcccagaga ggtgcttgtc cagatttcac atgcacatga attgcctggg
5341 gatcttgtga aactgcagac tctgctccaa gtaatctggg ctgggcctga gattctgcat
5401 ttctaaggag tctcagggat gcctatgctg ctggcctaaa accacactca gaaacgagga
5461 cctagaagat ccctaaaaca gaataagaac aaatgtgatt gtatttctga ttctccctct
5521 cttcgaatta tctgactttt ttgtttttgt gcacatagta atcatatcac cgctgcataa
5581 caacacagtg catcttttta aaacaaggaa aagggaaaaa aaggagaaaa aacgatgcat
5641 caagcttgtt tgtcaaatac cacagtattt tattcattgt tatcttgcca atggaaataa
5701 agtatgatat tgcatttaaa tattatattt atacctcatg tatattttta cctcaattgt
5761 tgatatcaat catcaattgt aaataaataa ttgccaaggc aaataaattt
//