LOCUS AY082589 5886 bp mRNA linear HUM 03-NOV-2005 DEFINITION Homo sapiens deleted in liver cancer 2 alpha mRNA, complete cds. ACCESSION AY082589 VERSION AY082589.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5886) AUTHORS Ching,Y.P., Wong,C.M., Chan,S.F., Leung,T.H., Ng,D.C., Jin,D.Y. and Ng,I.O. TITLE Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma JOURNAL J. Biol. Chem. 278 (12), 10824-10830 (2003) PUBMED 12531887 REFERENCE 2 (bases 1 to 5886) AUTHORS Leung,T.H., Ching,Y.P., Yam,J.W., Wong,C.M., Yau,T.O., Jin,D.Y. and Ng,I.O. TITLE Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (42), 15207-15212 (2005) PUBMED 16217026 REFERENCE 3 (bases 1 to 5886) AUTHORS Ching,Y.-P., Chan,S.-F., Ng,I.O.L. and Jin,D.-Y. TITLE Direct Submission JOURNAL Submitted (06-MAR-2002) Department of Biochemistry, The University of Hong Kong, 3rd Floor, New Medical Complex, 21 Sassoon Road, Hong Kong, Hong Kong FEATURES Location/Qualifiers source 1..5886 /db_xref="H-InvDB:HIT000084257" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="13" /map="13q12.3; between RFC3 and KL" CDS 122..3463 /note="RhoGAP; DLC2alpha" /codon_start=1 /product="deleted in liver cancer 2 alpha" /protein_id="AAL91648.1" /translation="MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRI LARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDL VEPLCRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLY TLLPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTD NPVMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHK GSGRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESS PSEHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQEN LVVHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASC HRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVL PELQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGV RDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRL TAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQ ALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFR DLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVN LVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQG LAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLI QGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLR ERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLV SLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGH LCAAEVARIRNSFQPLIAEGPETKI" BASE COUNT 1659 a 1344 c 1415 g 1468 t ORIGIN 1 gcaagaatcg gcacgaggct gttgagctgt cctgggctgg gtgccttgct ctttgactga 61 gactggagac agacggcaac agccacaggc agactgaggt ggcaatagga aatctgccga 121 gatgttcagt caggtgccca ggaccccagc ctcaggctgc tactacctaa attccatgac 181 acctgagggc caggagatgt acttgcgatt tgatcagact acaagacgct ctccttacag 241 gatgagccgg attctagcac gccatcagct agtgactaaa attcaacaag aaattgaggc 301 aaaagaagca tgtgactggc tccgtgctgc cgggttcccg caatacgctc agttatatga 361 ggattcacaa tttcccatca acattgtggc tgtcaagaat gatcatgatt ttcttgaaaa 421 ggaccttgta gaacctcttt gcagacgact aaatacgttg aacaagtgtg cctcaatgaa 481 acttgatgtg aacttccaaa ggaaaaaggg tgacgactcc gatgaggaag atctttgtat 541 cagcaacaaa tggactttcc aaagaaccag tcgcaggtgg tctcgtgtgg acgacctcta 601 cacgctgctc cctcgaggag acagaaatgg gtcaccggga ggcacgggga tgaggaacac 661 gaccagcagt gagagcgtcc tcacagacct gagcgagcct gaggtctgct ccattcacag 721 cgaaagcagt ggaggcagcg acagtcgcag ccagccgggc cagtgctgta cagacaaccc 781 ggtcatgctg gatgccccac tcgtcagcag cagcctccca cagcccccca gagatgtcct 841 caaccacccc ttccacccca agaatgagaa gcccacgagg gctagggcca aatcattttt 901 gaaacgcatg gaaacactcc gagggaaggg agcccacggg aggcataagg ggtctgggcg 961 gacaggtggc ctggtgatca gtgggcccat gttgcagcag gagccagagt cctttaaggc 1021 tatgcagtgc atccaaatac caaatggaga tctccagaat tcgccgccac ctgcctgcag 1081 aaaagggctc ccatgctctg gcaagtcgag tggcgagagc agcccgtcgg agcacagcag 1141 cagcggggtg agcacgccct gcctgaagga acgcaagtgc cacgaggcca acaagcgcgg 1201 gggcatgtac ttggaggacc tagatgtgct ggcggggaca gcactgccgg atgcagggga 1261 ccaaagccgt atgcatgagt ttcactccca agagaatttg gtggtgcata ttcccaagga 1321 tcacaaacca ggaacattcc ccaaggcact ttctattgaa agcctctctc ccacagatag 1381 tagcaatggg gttaattgga ggaccggtag catctccctg ggcagagagc aggtccctgg 1441 tgccagggag ccccggctca tggcgtcctg ccacagagcc agccgagtca gtatctatga 1501 caatgtccct ggctcccatc tgtatgccag cacaggagat cttttggact tggagaaaga 1561 tgaccttttc cctcacttgg atgacattct gcagcatgtc aatgggctcc aagaggtagt 1621 cgatgactgg tccaaagatg tcttgcctga actgcaaact catgatacat tggttgggga 1681 acctggctta tccacctttc catctcctaa tcagatcacc ttagattttg aaggtaactc 1741 tgtctcagaa ggtcggacga cacccagtga tgtggaaaga gatgtaacat ctcttaatga 1801 atctgagcct cctggggtca gagacaggag ggattctggt gtaggggcct ctctgaccag 1861 gccaaacagg cgactccgat ggaacagttt ccagctgtcg caccagcccc ggccggcccc 1921 agcatcgccc cacatcagca gccagacggc cagccagctg agcctgctcc agcgcttctc 1981 actgctccgc ctcacggcca tcatggagaa gcactccatg tccaacaagc acggctggac 2041 atggtcagtt ccaaagttca tgaagaggat gaaagttccc gactacaaag acaaggctgt 2101 ctttggcgtt cctctcatag tccacgtcca aagaacggga cagcccctgc ctcaaagtat 2161 tcagcaagca ctgagatatc tacgcagcaa ctgcctcgat caggtgggtc tttttcgcaa 2221 atcaggagtg aagtctcgaa tccatgccct tcgccaaatg aatgaaaact tccctgagaa 2281 cgtcaactat gaagaccagt ctgcttatga tgtggcggat atggtgaaac agttcttccg 2341 ggacctccct gagcctcttt tcaccaacaa gctcagtgag acctttctcc atatctatca 2401 gtatgtctcc aaagagcagc ggctgcaggc cgtgcaggct gccatcctgc tactggccga 2461 tgagaacagg gaggtcctgc agacgctctt gtgtttcctg aacgacgtcg tcaacttggt 2521 ggaagagaat cagatgacgc ccatgaacct ggcagtgtgt ctggccccct ccctctttca 2581 tcttaattta ttgaagaaag aaagctctcc acgagtcata cagaagaaat atgccactgg 2641 gaagccagat caaaaggacc tcaacgagaa tctggcagca gctcaggggc tagcgcacat 2701 gatcatggaa tgcgacagac tttttgaggt tccacacgag ttggtggccc agtctcgtaa 2761 ctcgtatgtg gaggctgaga tccacgtgcc aaccctggaa gaattgggga cacagctgga 2821 ggagagtggg gcaactttcc acacttacct gaaccatctc atccagggcc tccagaaaga 2881 agccaaggag aagttcaaag gatgggtcac gtgctccagc acggacaata cagatcttgc 2941 tttcaaaaag gtgggcgacg ggaacccgct gaagctgtgg aaggcttctg tggaggtgga 3001 agcacccccc tcagtggtcc tgaaccgcgt gctgagagag cgccacctgt gggacgagga 3061 ctttgtgcag tggaaggttg tggaaactct agacaggcaa acagagatct accagtatgt 3121 gctgaacagc atggctcccc atccttccag agactttgtg gttctcagga cctggaaaac 3181 tgatttgccc aaaggaatgt gtaccctggt gtccctctcc gtggagcatg aggaagccca 3241 gctcctgggt ggtgtgcgag cagtggtgat ggactcgcag tacttgatag aaccgtgtgg 3301 ctctggcaag tcaagactga ctcacatctg caggatagac ctgaaaggtc actccccaga 3361 atggtacagc aaaggctttg gacatctgtg tgcagcagaa gttgccagga ttagaaactc 3421 tttccagccc ctcattgctg agggcccaga aactaaaatc tgagttttgc ccagtgtgac 3481 atcaaactca gggaagagga agctaaagtg acgagtgtgg cagagagtgt gcatgtgaga 3541 aagcgagaga aagaggaact gaaggacgcg gttaatgcct aaaaatggaa acgttaagaa 3601 gttggaatgt tggagatgca agaatttcca agaactttct tagccttcct ggagatggct 3661 acatccctac taatataatt ttaaaatgag aactttatat atattactta aaattaaatg 3721 gactattcct tgtgcattgc ctaatttgct atttaaaggc ttctaagaag cgtataccta 3781 actgtaaata aatgtatgta tagcatatgt acatatgtgt gtatatctcc atctttactg 3841 tatatatgta aaataccaat tttatataga attgtgtgtt ttgaaaatga cggtgtctga 3901 ctcagtgagt cccttcctca cacagttctt tccaagtggc tctgggcccc atctctccac 3961 tgtcctgtaa gctgtgcaga acctgctgct aacaccaagg tgtgaacatg ccctgatgcc 4021 taaccaaaga tgagttaacc aaaggaaaat aacattaaag gagacttatg tgttaacgct 4081 ttgtttctgc tattcaaaaa ctgagagtgg agatctggga taaagcaagg aaataataat 4141 tactcctcct taaagcaaat gggggggtga gaagtcatta ccaaatttaa agctagatga 4201 ggagttgcca ctgggcccag taagatggaa tttcagtgag atatggacca ccggagtcag 4261 cgagagtgac tgaaacagaa gcgatacctc tcgctcccat gcccatcact acagacccca 4321 agtcaagatg aatatcatag cctttacttc ttcacagcca aagggagccc ctgtgttgtc 4381 tcaagttttt ataaatacat ttcataatgt tattaaatgt cattctattt gaccagtggc 4441 ctatttggtc acagttaatt ggtgttttct tattgcactg aattcaactc cagacaccat 4501 acaaagggag atgatggcca ttccgttcaa atcctagatc gttacagctt cagggaattc 4561 atattttgtt atgtgtagga tactcttaaa atgtaattca ttaaactttt acaatctgaa 4621 agacagggtt tttaactaac atgagaccaa aactatgttc tttgattagt tttagatagt 4681 ataatcgggt ttattaattc ttctgtgttt cttcactagc cagtccaagc tacctatgca 4741 tttgacccaa ccttatttat tattgtacag atgaagcgaa ttgactccct ttagccaact 4801 gctaatggat cgaatgtgct ttttattgta attcaacagc tatagagaga aagataactt 4861 attgtgtgtt tgatttcagg gagagagatt ttctttggtc atccataata gagattgata 4921 agatttagca actggtgttg gagaaaaaaa gaaaagcaaa tgagtgtttt caggtttttt 4981 tgcattatat gcatttatgt aatgtttctg ttatcagcaa tgtgcaatta ttttattgag 5041 aggaataaaa aagctttcta tgagtttggt atggtgcgag gaaaatctta cagtttgaat 5101 tatgacctag aaatttttca ttcccatgtc tacctaagaa ggaagcagta aatccataat 5161 ttaccttttg ggcaatgctt tgtgagcaaa acaaagtcac ttctgccata acatcttgaa 5221 tgtaaccata tatgccagat tactttatat gcatcaacaa gatcaccagt gaagtttaat 5281 ctagctaaac actggtcctg ctcctgagat gggatcctat gtgtttggaa aacgtgatag 5341 gcacacgagg atgagtggct ttgtatcgcc cagagaggtg cttgtccaga tttcacatgc 5401 acatgaattg cctggggatc ttgtgaaact gcagactctg ctccaagtaa tctgggctgg 5461 gcctgagatt ctgcatttct aaggagtctc agggatgcct atgctgctgg cctaaaacca 5521 cactcagaaa cgaggaccta gaagatccct aaaacagaat aagaacaaat gtgattgtat 5581 ttctgattct ccctctcttc gaattatctg acttttttgt ttttgtgcac atagtaatca 5641 tatcaccgct gcataacaac acagtgcatc tttttaaaac aaggaaaagg gaaaaaaagg 5701 agaaaaaacg atgcatcaag cttgtttgtc aaataccaca gtattttatt cattgttatc 5761 ttgccaatgg aaataaagta tgatattgca tttaaatatt atatttatac ctcatgtata 5821 tttttacctc aattgttgat atcaatcatc aattgtaaat aaataattgc caaggcaaat 5881 aaattt //