LOCUS       AY082589                5886 bp    mRNA    linear   HUM 03-NOV-2005
DEFINITION  Homo sapiens deleted in liver cancer 2 alpha mRNA, complete cds.
ACCESSION   AY082589
VERSION     AY082589.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5886)
  AUTHORS   Ching,Y.P., Wong,C.M., Chan,S.F., Leung,T.H., Ng,D.C., Jin,D.Y. and
            Ng,I.O.
  TITLE     Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with
            growth suppressor function and is underexpressed in hepatocellular
            carcinoma
  JOURNAL   J. Biol. Chem. 278 (12), 10824-10830 (2003)
   PUBMED   12531887
REFERENCE   2  (bases 1 to 5886)
  AUTHORS   Leung,T.H., Ching,Y.P., Yam,J.W., Wong,C.M., Yau,T.O., Jin,D.Y. and
            Ng,I.O.
  TITLE     Deleted in liver cancer 2 (DLC2) suppresses cell transformation by
            means of inhibition of RhoA activity
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 102 (42), 15207-15212 (2005)
   PUBMED   16217026
REFERENCE   3  (bases 1 to 5886)
  AUTHORS   Ching,Y.-P., Chan,S.-F., Ng,I.O.L. and Jin,D.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2002) Department of Biochemistry, The University
            of Hong Kong, 3rd Floor, New Medical Complex, 21 Sassoon Road, Hong
            Kong, Hong Kong
FEATURES             Location/Qualifiers
     source          1..5886
                     /db_xref="H-InvDB:HIT000084257"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3; between RFC3 and KL"
     CDS             122..3463
                     /note="RhoGAP; DLC2alpha"
                     /codon_start=1
                     /product="deleted in liver cancer 2 alpha"
                     /protein_id="AAL91648.1"
                     /translation="MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRI
                     LARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDL
                     VEPLCRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLY
                     TLLPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTD
                     NPVMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHK
                     GSGRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESS
                     PSEHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQEN
                     LVVHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASC
                     HRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVL
                     PELQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGV
                     RDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRL
                     TAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQ
                     ALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFR
                     DLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVN
                     LVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQG
                     LAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLI
                     QGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLR
                     ERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLV
                     SLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGH
                     LCAAEVARIRNSFQPLIAEGPETKI"
BASE COUNT         1659 a         1344 c         1415 g         1468 t
ORIGIN      
        1 gcaagaatcg gcacgaggct gttgagctgt cctgggctgg gtgccttgct ctttgactga
       61 gactggagac agacggcaac agccacaggc agactgaggt ggcaatagga aatctgccga
      121 gatgttcagt caggtgccca ggaccccagc ctcaggctgc tactacctaa attccatgac
      181 acctgagggc caggagatgt acttgcgatt tgatcagact acaagacgct ctccttacag
      241 gatgagccgg attctagcac gccatcagct agtgactaaa attcaacaag aaattgaggc
      301 aaaagaagca tgtgactggc tccgtgctgc cgggttcccg caatacgctc agttatatga
      361 ggattcacaa tttcccatca acattgtggc tgtcaagaat gatcatgatt ttcttgaaaa
      421 ggaccttgta gaacctcttt gcagacgact aaatacgttg aacaagtgtg cctcaatgaa
      481 acttgatgtg aacttccaaa ggaaaaaggg tgacgactcc gatgaggaag atctttgtat
      541 cagcaacaaa tggactttcc aaagaaccag tcgcaggtgg tctcgtgtgg acgacctcta
      601 cacgctgctc cctcgaggag acagaaatgg gtcaccggga ggcacgggga tgaggaacac
      661 gaccagcagt gagagcgtcc tcacagacct gagcgagcct gaggtctgct ccattcacag
      721 cgaaagcagt ggaggcagcg acagtcgcag ccagccgggc cagtgctgta cagacaaccc
      781 ggtcatgctg gatgccccac tcgtcagcag cagcctccca cagcccccca gagatgtcct
      841 caaccacccc ttccacccca agaatgagaa gcccacgagg gctagggcca aatcattttt
      901 gaaacgcatg gaaacactcc gagggaaggg agcccacggg aggcataagg ggtctgggcg
      961 gacaggtggc ctggtgatca gtgggcccat gttgcagcag gagccagagt cctttaaggc
     1021 tatgcagtgc atccaaatac caaatggaga tctccagaat tcgccgccac ctgcctgcag
     1081 aaaagggctc ccatgctctg gcaagtcgag tggcgagagc agcccgtcgg agcacagcag
     1141 cagcggggtg agcacgccct gcctgaagga acgcaagtgc cacgaggcca acaagcgcgg
     1201 gggcatgtac ttggaggacc tagatgtgct ggcggggaca gcactgccgg atgcagggga
     1261 ccaaagccgt atgcatgagt ttcactccca agagaatttg gtggtgcata ttcccaagga
     1321 tcacaaacca ggaacattcc ccaaggcact ttctattgaa agcctctctc ccacagatag
     1381 tagcaatggg gttaattgga ggaccggtag catctccctg ggcagagagc aggtccctgg
     1441 tgccagggag ccccggctca tggcgtcctg ccacagagcc agccgagtca gtatctatga
     1501 caatgtccct ggctcccatc tgtatgccag cacaggagat cttttggact tggagaaaga
     1561 tgaccttttc cctcacttgg atgacattct gcagcatgtc aatgggctcc aagaggtagt
     1621 cgatgactgg tccaaagatg tcttgcctga actgcaaact catgatacat tggttgggga
     1681 acctggctta tccacctttc catctcctaa tcagatcacc ttagattttg aaggtaactc
     1741 tgtctcagaa ggtcggacga cacccagtga tgtggaaaga gatgtaacat ctcttaatga
     1801 atctgagcct cctggggtca gagacaggag ggattctggt gtaggggcct ctctgaccag
     1861 gccaaacagg cgactccgat ggaacagttt ccagctgtcg caccagcccc ggccggcccc
     1921 agcatcgccc cacatcagca gccagacggc cagccagctg agcctgctcc agcgcttctc
     1981 actgctccgc ctcacggcca tcatggagaa gcactccatg tccaacaagc acggctggac
     2041 atggtcagtt ccaaagttca tgaagaggat gaaagttccc gactacaaag acaaggctgt
     2101 ctttggcgtt cctctcatag tccacgtcca aagaacggga cagcccctgc ctcaaagtat
     2161 tcagcaagca ctgagatatc tacgcagcaa ctgcctcgat caggtgggtc tttttcgcaa
     2221 atcaggagtg aagtctcgaa tccatgccct tcgccaaatg aatgaaaact tccctgagaa
     2281 cgtcaactat gaagaccagt ctgcttatga tgtggcggat atggtgaaac agttcttccg
     2341 ggacctccct gagcctcttt tcaccaacaa gctcagtgag acctttctcc atatctatca
     2401 gtatgtctcc aaagagcagc ggctgcaggc cgtgcaggct gccatcctgc tactggccga
     2461 tgagaacagg gaggtcctgc agacgctctt gtgtttcctg aacgacgtcg tcaacttggt
     2521 ggaagagaat cagatgacgc ccatgaacct ggcagtgtgt ctggccccct ccctctttca
     2581 tcttaattta ttgaagaaag aaagctctcc acgagtcata cagaagaaat atgccactgg
     2641 gaagccagat caaaaggacc tcaacgagaa tctggcagca gctcaggggc tagcgcacat
     2701 gatcatggaa tgcgacagac tttttgaggt tccacacgag ttggtggccc agtctcgtaa
     2761 ctcgtatgtg gaggctgaga tccacgtgcc aaccctggaa gaattgggga cacagctgga
     2821 ggagagtggg gcaactttcc acacttacct gaaccatctc atccagggcc tccagaaaga
     2881 agccaaggag aagttcaaag gatgggtcac gtgctccagc acggacaata cagatcttgc
     2941 tttcaaaaag gtgggcgacg ggaacccgct gaagctgtgg aaggcttctg tggaggtgga
     3001 agcacccccc tcagtggtcc tgaaccgcgt gctgagagag cgccacctgt gggacgagga
     3061 ctttgtgcag tggaaggttg tggaaactct agacaggcaa acagagatct accagtatgt
     3121 gctgaacagc atggctcccc atccttccag agactttgtg gttctcagga cctggaaaac
     3181 tgatttgccc aaaggaatgt gtaccctggt gtccctctcc gtggagcatg aggaagccca
     3241 gctcctgggt ggtgtgcgag cagtggtgat ggactcgcag tacttgatag aaccgtgtgg
     3301 ctctggcaag tcaagactga ctcacatctg caggatagac ctgaaaggtc actccccaga
     3361 atggtacagc aaaggctttg gacatctgtg tgcagcagaa gttgccagga ttagaaactc
     3421 tttccagccc ctcattgctg agggcccaga aactaaaatc tgagttttgc ccagtgtgac
     3481 atcaaactca gggaagagga agctaaagtg acgagtgtgg cagagagtgt gcatgtgaga
     3541 aagcgagaga aagaggaact gaaggacgcg gttaatgcct aaaaatggaa acgttaagaa
     3601 gttggaatgt tggagatgca agaatttcca agaactttct tagccttcct ggagatggct
     3661 acatccctac taatataatt ttaaaatgag aactttatat atattactta aaattaaatg
     3721 gactattcct tgtgcattgc ctaatttgct atttaaaggc ttctaagaag cgtataccta
     3781 actgtaaata aatgtatgta tagcatatgt acatatgtgt gtatatctcc atctttactg
     3841 tatatatgta aaataccaat tttatataga attgtgtgtt ttgaaaatga cggtgtctga
     3901 ctcagtgagt cccttcctca cacagttctt tccaagtggc tctgggcccc atctctccac
     3961 tgtcctgtaa gctgtgcaga acctgctgct aacaccaagg tgtgaacatg ccctgatgcc
     4021 taaccaaaga tgagttaacc aaaggaaaat aacattaaag gagacttatg tgttaacgct
     4081 ttgtttctgc tattcaaaaa ctgagagtgg agatctggga taaagcaagg aaataataat
     4141 tactcctcct taaagcaaat gggggggtga gaagtcatta ccaaatttaa agctagatga
     4201 ggagttgcca ctgggcccag taagatggaa tttcagtgag atatggacca ccggagtcag
     4261 cgagagtgac tgaaacagaa gcgatacctc tcgctcccat gcccatcact acagacccca
     4321 agtcaagatg aatatcatag cctttacttc ttcacagcca aagggagccc ctgtgttgtc
     4381 tcaagttttt ataaatacat ttcataatgt tattaaatgt cattctattt gaccagtggc
     4441 ctatttggtc acagttaatt ggtgttttct tattgcactg aattcaactc cagacaccat
     4501 acaaagggag atgatggcca ttccgttcaa atcctagatc gttacagctt cagggaattc
     4561 atattttgtt atgtgtagga tactcttaaa atgtaattca ttaaactttt acaatctgaa
     4621 agacagggtt tttaactaac atgagaccaa aactatgttc tttgattagt tttagatagt
     4681 ataatcgggt ttattaattc ttctgtgttt cttcactagc cagtccaagc tacctatgca
     4741 tttgacccaa ccttatttat tattgtacag atgaagcgaa ttgactccct ttagccaact
     4801 gctaatggat cgaatgtgct ttttattgta attcaacagc tatagagaga aagataactt
     4861 attgtgtgtt tgatttcagg gagagagatt ttctttggtc atccataata gagattgata
     4921 agatttagca actggtgttg gagaaaaaaa gaaaagcaaa tgagtgtttt caggtttttt
     4981 tgcattatat gcatttatgt aatgtttctg ttatcagcaa tgtgcaatta ttttattgag
     5041 aggaataaaa aagctttcta tgagtttggt atggtgcgag gaaaatctta cagtttgaat
     5101 tatgacctag aaatttttca ttcccatgtc tacctaagaa ggaagcagta aatccataat
     5161 ttaccttttg ggcaatgctt tgtgagcaaa acaaagtcac ttctgccata acatcttgaa
     5221 tgtaaccata tatgccagat tactttatat gcatcaacaa gatcaccagt gaagtttaat
     5281 ctagctaaac actggtcctg ctcctgagat gggatcctat gtgtttggaa aacgtgatag
     5341 gcacacgagg atgagtggct ttgtatcgcc cagagaggtg cttgtccaga tttcacatgc
     5401 acatgaattg cctggggatc ttgtgaaact gcagactctg ctccaagtaa tctgggctgg
     5461 gcctgagatt ctgcatttct aaggagtctc agggatgcct atgctgctgg cctaaaacca
     5521 cactcagaaa cgaggaccta gaagatccct aaaacagaat aagaacaaat gtgattgtat
     5581 ttctgattct ccctctcttc gaattatctg acttttttgt ttttgtgcac atagtaatca
     5641 tatcaccgct gcataacaac acagtgcatc tttttaaaac aaggaaaagg gaaaaaaagg
     5701 agaaaaaacg atgcatcaag cttgtttgtc aaataccaca gtattttatt cattgttatc
     5761 ttgccaatgg aaataaagta tgatattgca tttaaatatt atatttatac ctcatgtata
     5821 tttttacctc aattgttgat atcaatcatc aattgtaaat aaataattgc caaggcaaat
     5881 aaattt
//