LOCUS AY081219 5759 bp mRNA linear HUM 07-OCT-2002
DEFINITION Homo sapiens multidrug resistance-associated protein (ABCC4) mRNA,
complete cds.
ACCESSION AY081219
VERSION AY081219.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5759)
AUTHORS Adachi,M., Sampath,J., Lan,L.B., Sun,D., Hargrove,P., Flatley,R.,
Tatum,A., Edwards,M.Z., Wezeman,M., Matherly,L., Drake,R. and
Schuetz,J.
TITLE Expression of MRP4 confers resistance to ganciclovir and
compromises bystander cell killing
JOURNAL J. Biol. Chem. 277 (41), 38998-39004 (2002)
PUBMED 12105214
REFERENCE 2 (bases 1 to 5759)
AUTHORS Adachi,M., Sampath,J., Sun,D. and Schuetz,J.D.
TITLE Direct Submission
JOURNAL Submitted (22-FEB-2002) Pharmaceutical Sciences, St. Jude
Children's Research Hospital, 332 North Lauderdale St., Memphis, TN
38105-2794, USA
FEATURES Location/Qualifiers
source 1..5759
/db_xref="H-InvDB:HIT000084242"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5759
/gene="ABCC4"
/gene_synonym="MRP4"
CDS 22..3999
/gene="ABCC4"
/gene_synonym="MRP4"
/note="ATP-binding cassette sub-family C (CFTR/MRP) member
4"
/codon_start=1
/product="multidrug resistance-associated protein"
/protein_id="AAL88745.1"
/translation="MLPVYQEVKPNPLQDANICSRVFFWWLNPLFKIGHKRRLEEDDM
YSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIE
ESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ
CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG
PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM
NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFV
TFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLL
DEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI
KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD
AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG
IDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENV
PVTLSEENRSEGKVGFQAYKSYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWAN
KQSMLNVTVNGGGNVTGKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLH
NKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSV
AVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLGSTTRSPVFSHLSSSLQGLWTI
RAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK
TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKR
PPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISAL
FRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEEL
WNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEAT
ANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL
QNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
FETAL"
BASE COUNT 1669 a 1134 c 1274 g 1682 t
ORIGIN
1 gcgcccgccc cgcccggcaa gatgctgccc gtgtaccagg aggtgaagcc caacccgctg
61 caggacgcga acatctgctc acgcgtgttc ttctggtggc tcaatccctt gtttaaaatt
121 ggccataaac ggagattaga ggaagatgat atgtattcag tgctgccaga agaccgctca
181 cagcaccttg gagaggagtt gcaagggttc tgggataaag aagttttaag agctgagaat
241 gacgcacaga agccttcttt aacaagagca atcataaagt gttactggaa atcttattta
301 gttttgggaa tttttacgtt aattgaggaa agtgccaaag taatccagcc catatttttg
361 ggaaaaatta ttaattattt tgaaaattat gatcccatgg attctgtggc tttgaacaca
421 gcgtacgcct atgccacggt gctgactttt tgcacgctca ttttggctat actgcatcac
481 ttatattttt atcacgttca gtgtgctggg atgaggttac gagtagccat gtgccatatg
541 atttatcgga aggcacttcg tcttagtaac atggccatgg ggaagacaac cacaggccag
601 atagtcaatc tgctgtccaa tgatgtgaac aagtttgatc aggtgacagt gttcttacac
661 ttcctgtggg caggaccact gcaggcgatc gcagtgactg ccctactctg gatggagata
721 ggaatatcgt gccttgctgg gatggcagtt ctaatcattc tcctgccctt gcaaagctgt
781 tttgggaagt tgttctcatc actgaggagt aaaactgcaa ctttcacgga tgccaggatc
841 aggaccatga atgaagttat aactggtata aggataataa aaatgtacgc ctgggaaaag
901 tcattttcaa atcttattac caatttgaga aagaaggaga tttccaagat tctgagaagt
961 tcctgcctca gagggatgaa tttggcttca tttttcagtg caagcaaaat catcgtgttt
1021 gtgaccttca ccacctacgt gctcctcggc agtgtgatca cagccagccg cgtgttcgtg
1081 gcagtgacgc tgtatggggc tgtgcggctg acggttaccc tcttcttccc ctcagccatt
1141 gagagggtgt cagaggcaat cgtcagcatc cgaagaatcc agaccttttt gctacttgat
1201 gagatatcac agcgcaaccg tcagctgccg tcagatggta aaaagatggt gcatgtgcag
1261 gattttactg ctttttggga taaggcatca gagaccccaa ctctacaagg cctttccttt
1321 actgtcagac ctggcgaatt gttagctgtg gtcggccccg tgggagcagg gaagtcatca
1381 ctgttaagtg ccgtgctcgg ggaattggcc ccaagtcacg ggctggtcag cgtgcatgga
1441 agaattgcct atgtgtctca gcagccctgg gtgttctcgg gaactctgag gagtaatatt
1501 ttatttggga agaaatacga aaaggaacga tatgaaaaag tcataaaggc ttgtgctctg
1561 aaaaaggatt tacagctgtt ggaggatggt gatctgactg tgataggaga tcggggaacc
1621 acgctgagtg gagggcagaa agcacgggta aaccttgcaa gagcagtgta tcaagatgct
1681 gacatctatc tcctggacga tcctctcagt gcagtagatg cggaagttag cagacacttg
1741 ttcgaactgt gtatttgtca aattttgcat gagaagatca caattttagt gactcatcag
1801 ttgcagtacc tcaaagctgc aagtcagatt ctgatattga aagatggtaa aatggtgcag
1861 aaggggactt acactgagtt cctaaaatct ggtatagatt ttggctccct tttaaagaag
1921 gataatgagg aaagtgaaca acctccagtt ccaggaactc ccacactaag gaatcgtacc
1981 ttctcagagt cttcggtttg gtctcaacaa tcttctagac cctccttgaa agatggtgct
2041 ctggagagcc aagatacaga gaatgtccca gttacactat cagaggagaa ccgttctgaa
2101 ggaaaagttg gttttcaggc ctataagagt tacttcagag ctggtgctca ctggattgtc
2161 ttcattttcc ttattctcct aaacactgca gctcaggttg cctatgtgct tcaagattgg
2221 tggctttcat actgggcaaa caaacaaagt atgctaaatg tcactgtaaa tggaggagga
2281 aatgtaaccg ggaagctaga tcttaactgg tacttaggaa tttattcagg tttaactgta
2341 gctaccgttc tttttggcat agcaagatct ctattggtat tctacgtcct tgttaactct
2401 tcacaaactt tgcacaacaa aatgtttgag tcaattctga aagctccggt attattcttt
2461 gatagaaatc caataggaag aattttaaat cgtttctcca aagacattgg acacttggat
2521 gatttgctgc cgctgacgtt tttagatttc atccagacat tgctacaagt ggttggtgtg
2581 gtctctgtgg ctgtggccgt gattccttgg atcgcaatac ccttggttcc ccttggaatc
2641 attttcattt ttcttcggcg atattttttg gaaacgtcaa gagatgtgaa gcgcctggga
2701 tctacaactc ggagtccagt gttttcccac ttgtcatctt ctctccaggg gctctggacc
2761 atccgggcat acaaagcaga agagaggtgt caggaactgt ttgatgcaca ccaggattta
2821 cattcagagg cttggttctt gtttttgaca acgtcccgct ggttcgccgt ccgtctggat
2881 gccatctgtg ccatgtttgt catcatcgtt gcctttgggt ccctgattct ggcaaaaact
2941 ctggatgccg ggcaggttgg tttggcactg tcctatgccc tcacgctcat ggggatgttt
3001 cagtggtgtg ttcgacaaag tgctgaagtt gagaatatga tgatctcagt agaaagggtc
3061 attgaataca cagaccttga aaaagaagca ccttgggaat atcagaaacg cccaccacca
3121 gcctggcccc atgaaggagt gataatcttt gacaatgtga acttcatgta cagtccaggt
3181 gggcctctgg tactgaagca tctgacagca ctcattaaat cacaagaaaa ggttggcatt
3241 gtgggaagaa ccggagctgg aaaaagttcc ctcatctcag ccctttttag attgtcagaa
3301 cccgaaggta aaatttggat tgataagatc ttgacaactg aaattggact tcacgattta
3361 aggaagaaaa tgtcaatcat acctcaggaa cctgttttgt tcactggaac aatgaggaaa
3421 aacctggatc cctttaatga gcacacggat gaggaactgt ggaatgcctt acaagaggta
3481 caacttaaag aaaccattga agatcttcct ggtaaaatgg atactgaatt agcagaatca
3541 ggatccaatt ttagtgttgg acaaagacaa ctggtgtgcc ttgccagggc aattctcagg
3601 aaaaatcaga tattgattat tgatgaagcg acggcaaatg tggatccaag aactgatgag
3661 ttaatacaaa aaaaaatccg ggagaaattt gcccactgca ccgtgctaac cattgcacac
3721 agattgaaca ccattattga cagcgacaag ataatggttt tagattcagg aagactgaaa
3781 gaatatgatg agccgtatgt tttgctgcaa aataaagaga gcctatttta caagatggtg
3841 caacaactgg gcaaggcaga agccgctgcc ctcactgaaa cagcaaaaca ggtatacttc
3901 aaaagaaatt atccacatat tggtcacact gaccacatgg ttacaaacac ttccaatgga
3961 cagccctcga ccttaactat tttcgagaca gcactgtgaa tccaaccaaa atgtcaagtc
4021 cgttccgaag gcattttcca ctagtttttg gactatgtaa accacattgt actttttttt
4081 actttggcaa caaatattta tacatacaag atgctagttc atttgaatat ttctcccaac
4141 ttatccaagg atctccagct ctaacaaaat ggtttatttt tatttaaatg tcaatagttg
4201 ttttttaaaa tccaaatcag aggtgcaggc caccagttaa atgccgtcta tcaggttttg
4261 tgccttaaga gactacagag tcaaagctca tttttaaagg agtaggacaa agttgtcaca
4321 ggtttttgtt gttgttttta ttgcccccaa aattacatgt taatttccat ttatatcagg
4381 gattctattt acttgaagac tgtgaagttg ccattttgtc tcattgtttt ctttgacata
4441 actaggatcc attatttccc ctgaaggctt cttgttagaa aatagtacag ttacaaccaa
4501 taggaacaac aaaaagaaaa agtttgtgac attgtagtag ggagtgtgta ccccttactc
4561 cccatcaaaa aaaaaatgga tacatggtta aaggatagaa gggcaatatt ttatcatatg
4621 ttctaaaaga gaaggaagag aaaatactac tttctcaaaa tggaagccct taaagggctt
4681 tgatactgaa agacacaaat gtgaccgtcc atcctccttt agagttgcat gacttggaca
4741 cggtaactgg tgcagtttta gactcagcat tgtgacactt accaagaagg ccaaacctct
4801 aaccgacatt cctgaaatac gtggcattat tcttttttgg atttctcatt tatggaaggc
4861 taaccctctg ttgaccgtaa gccttttggt ttgggctatt taaaatcctt tctaaattgg
4921 catgaatagg ctcttgctaa cgggatgaga caaactgaaa attattgcaa gcattgacta
4981 taattatgca gtacgttctc aggatgcatc caggggttca tttttatgga gctgtccagg
5041 ttagtttact cctgaccact aatagcattg tcatttgggc tttctgttga atgaatcaac
5101 aaaccacaat acttcctggg accttttgta ctttatttga actatgagtc tttaattttt
5161 cctgatgatg gtggctgtaa tatgttgagt tcagtttact aaaggtttta ctattatggt
5221 ttgaagtgga gtctcatgac ctctcagaat aaggtgtcac ctccctgaaa ttgcatatat
5281 gtatatagac atgcacacgt gtgcatttgt ttgtatacat atatttgtcc ttcgtatagc
5341 aagttttttg ctcatcagca gagagcaaca gatgttttat tgagtgaagc cttaaaaagc
5401 acacaccaca cacagctaac tgccaaaata cattgaccgt agtagctgtt caactcctag
5461 tacttagaaa tacacgtatg gttaatgttc agtccaacaa accacacaca gtaaatgttt
5521 attaatagtc atggttcgta ttttaggtga ctgaaattgc aacagtgatc ataatgaggt
5581 ttgttaaaac gatagctata ttcaaaatgt ctatatgttt atttggactt ttgaggttaa
5641 agacagtcat ataaacgtcc tgtttctgtt ttaatgttat catagaattt tttaatgaaa
5701 ctaaattcaa ttgaaataaa tgatagtttt catctccaaa aaaaaaaaaa aaaaaaaaa
//