LOCUS       AY078404                3606 bp    mRNA    linear   HUM 27-DEC-2002
DEFINITION  Homo sapiens up-regulated gene 4 (URG4) mRNA, complete cds.
ACCESSION   AY078404
VERSION     AY078404.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
            Clayton,M.M., Zhu,M. and Feitelson,M.A.
  TITLE     Hepatitis Bx antigen stimulates expression of a novel cellular
            gene, URG4, that promotes hepatocellular growth and survival
  JOURNAL   Neoplasia 4 (4), 355-368 (2002)
   PUBMED   12082552
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   Tufan,N.L.S., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
            Clayton,M.M., Zhu,M. and Feitelson,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2002) Pathology, Anatomy and Cell Biology, Thomas
            Jefferson University, 1020 Locust Street, Philadelphia, PA 19107,
            USA
FEATURES             Location/Qualifiers
     source          1..3606
                     /db_xref="H-InvDB:HIT000084221"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="short arm"
     gene            1..3606
                     /gene="URG4"
     5'UTR           1..13
                     /gene="URG4"
     CDS             14..2782
                     /gene="URG4"
                     /note="oncoprotein; up-regulated by Hepatitis B virus X
                     protein in hepatocarcinogenesis; promotes hepatocellular
                     growth and survival; contains non-functional ATP/GTP
                     binding site motif"
                     /codon_start=1
                     /product="up-regulated gene 4"
                     /protein_id="AAL83710.1"
                     /translation="MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRY
                     GDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVP
                     KDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIY
                     SFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTF
                     LLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSP
                     GHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGS
                     HWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFL
                     NKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLG
                     LKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWA
                     VDPPEKHRAELRRRLLELRMQQNGHDSSSGVQEFISGISSPSLSEKQYFLRWMEWGLA
                     RVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEA
                     GRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSR
                     LVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHIL
                     VIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLE
                     KTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGL
                     AFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQ
                     LIELVRRL"
     3'UTR           2783..3606
                     /gene="URG4"
BASE COUNT          875 a          938 c         1057 g          736 t
ORIGIN      
        1 cctcgctgcg ctcatggcgt cgcccgggca ttcagatttg ggagaagtag ccccagaaat
       61 aaaagcatca gagagacgaa cagctgtggc cattgcagat ttggaatgga gagaaatgga
      121 aggagatgat tgcgagttcc gttatggaga tggtacaaat gaggctcagg acaatgattt
      181 tccaacagtg gagagaagca ggcttcaaga aatgctgtca cttttgggcc tagagacgta
      241 ccaggtccag aaactcagcc tccaggactc tctgcagatc agttttgaca gtatgaagaa
      301 ctgggcccct caggttccca aagacttgcc ctggaatttc ctcaggaagt tgcaggccct
      361 caatgctgat gccaggaata ccactatggt gctggacgtg ctcccagacg ccaggcctgt
      421 ggagaaggag agccagatgg aagaggagat catctactgg gacccagctg atgaccttgc
      481 tgccgacatt tattcctttt ctgagctgcc cacccctgat acgccagtga accccttaga
      541 ccttctctgt gccctgctgc tctcctcaga cagtttcctg caacaagaaa tagcgttgaa
      601 aatggccctc tgccagtttg cactcccact cgtgttgcct gactcggaga accactacca
      661 tacatttctg ctgtgggcca tgcggggcat tgtgaggaca tggtggtccc agcccccaag
      721 gggcatgggg agcttccggg aagacagcgt ggtcttgtcc agggcgcccg ccttcgcctt
      781 cgtgcgcatg gacgtcagta gcaactccaa gtcccagctt ctcaacgccg tcctcagccc
      841 gggccacagg cagtgggact gcttctggca tcgggacctc aacttgggca ccaatgcccg
      901 ggagatttcg gatgggttgg tagaaatttc ctggtttttt cccagcggaa gggaggactt
      961 ggacattttc ccagaacctg tggcctttct gaacctgaga ggtgacatcg ggtctcactg
     1021 gctgcagttt aagctcttga cagaaatctc ctccgctgtg tttatattga ctgacaatat
     1081 cagtaagaag gaatacaaat tgctgtactc catgaaggag tcaaccacaa aatactactt
     1141 catcctgagt ccctaccgtg ggaagcgcaa cacaaacctg agatttctga ataagttaat
     1201 tcctgtgctg aaaatagacc actcacatgt cctggtaaag gtcagcagca ctgacagcga
     1261 cagcttcgtg aagaggatcc gggccatcgt tgggaatgtg ctgcgggcac cctgcaggcg
     1321 ggtatctgtg gaggacatgg cgcacgcagc ccgcaaactg ggcctaaagg tcgacgagga
     1381 ctgtgaggag tgtcagaaag cgaaagaccg gatggagagg attaccagga aaatcaaaga
     1441 ctcggatgcc tacagaaggg acgagctgag gctgcagggg gacccctgga gaaaggcagc
     1501 ccaagtggag aaggagttct gccagctcca gtgggccgtg gacccccctg agaagcacag
     1561 ggctgagctg aggcggcggc tgctagaact tcgaatgcag cagaacggcc atgattcctc
     1621 ctcgggggtg caggagttca tctcggggat cagcagcccc tccttgagtg agaagcagta
     1681 cttcctgagg tggatggagt ggggcctggc acgggtggcc cagccgcgac tgagacagcc
     1741 tccggagacg cttctcaccc tgagaccaaa gcacgggggc accacagacg tgggggagcc
     1801 gctctggcct gagcccctag gggtggaaca cttcttgcgg gagatgggac agttttatga
     1861 ggctgagagc tgtcttgtgg aggcagggag gctgccggca ggccagaggc gttttgccca
     1921 cttcccaggc ttggcctcgg agctgctgct gacagggctg cctctggagc taatcgatgg
     1981 gagcacgctg agcatgcccg tccgctgggt cacagggctc ctgaaggagc tgcacgtccg
     2041 actggagaga cggtcaaggc tggtggttct gtcaaccgtc ggggtgccag gcacgggcaa
     2101 gtccacactc ctcaacacca tgtttgggct gcggtttgcc acagggaaga gctgcggtcc
     2161 tcgaggggcc ttcatgcagc tcatcacagt ggctgagggc ttcagccagg acctgggctg
     2221 tgaccacatc ctggtgatag actccggggg cttgataggt ggggccttga cgtcagctgg
     2281 ggacagattt gagctggagg cttccttggc cactctgctc atgggactga gcaatgtcac
     2341 cgtgatcagt ctagctgaaa ccaaggacat tccagcagct attctgcatg catttctgag
     2401 gttagaaaaa acggggcaca tgcccaacta ccagtttgta taccagaacc ttcatgatgt
     2461 atctgttccc ggccctaggc ccagagacaa gagacagctc ctggatccac ctggtgacct
     2521 gagcagggct gcagcccaga tggagaaaca gggcgacggc ttccgggcac tggcaggcct
     2581 ggccttctgc gaccctgaga agcagcacat ctggcacatc ccaggcctgt ggcacggagc
     2641 acctcccatg gccgcagtga gcttggccta cagtgaagcc atatttgaat tgaagagatg
     2701 cctactcgaa aacatcagga acggcttgtc gaaccaaaac aaaaacatcc agcagctcat
     2761 tgagctggtg agacggctgt gagtgtgcag agaaacccag ttcaggtgta ggaggctgct
     2821 gtgggcagcc ctgtctgatg gggcacccgt gtggggctgt gctctggtgc ctgagaatgg
     2881 ctggtgccca atcgacatga gaagacgagc agaagacaga gggtttggag tctcctcaac
     2941 agtgttaaaa gaggaagtga cctcacagac cagctcagag atgttaccaa gaatatcaca
     3001 gcccccaggg tagggagaca agcagcagtt tgttctgtct cagctcctgt caaggatcct
     3061 gcggggtggg ccctctgtat agctgctctc tgtcactggc ccctggagtg ggagcagcgt
     3121 ccttagtcac tgcaggccca ggcgggcagg tggtcccagg acagaggtgg ggaagttgtc
     3181 ctgaggaagc agaagtaggc cttgctcccg cccaacccaa gggcctccag tggaccagca
     3241 ttcaagatgt gagtgcccgt ggtgtgcaag gcactcccat ggcaccgtat ttattgactg
     3301 atctgtgaag gcttccctga cccctgccca ggaagagttc actggtcgct ctgttgtgcc
     3361 ccacagcact ttgttatacc tctgccacac acttcacgca gcgcgttgta actcatgtgt
     3421 ttacatgtct gtccccccag actgtgagct ccttgagggc agggactgta cattctccag
     3481 ctctgtgtcc ccagggcctg gcacattgta gacgcttaat aaatgtctgt taaatgaaaa
     3541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3601 aaaaaa
//