LOCUS AY074797 16235 bp mRNA linear HUM 01-APR-2002
DEFINITION Homo sapiens polycystic kidney and hepatic disease 1 (PKHD1) mRNA,
complete cds.
ACCESSION AY074797
VERSION AY074797.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 16235)
AUTHORS Ward,C.J., Hogan,M.C., Rossetti,S., Walker,D., Sneddon,T., Wang,X.,
Kubly,V., Cunningham,J.M., Bacallao,R., Ishibashi,M.,
Milliner,D.S., Torres,V.E. and Harris,P.C.
TITLE The gene mutated in autosomal recessive polycystic kidney disease
encodes a large, receptor-like protein
JOURNAL Nat. Genet. 30 (3), 259-269 (2002)
PUBMED 11919560
REFERENCE 2 (bases 1 to 16235)
AUTHORS Harris,P.C.
TITLE Direct Submission
JOURNAL Submitted (22-JAN-2002) Nephrology Division, Mayo Clinic, 200 First
Street SW, Rochester, MN 55905, USA
FEATURES Location/Qualifiers
source 1..16235
/db_xref="H-InvDB:HIT000084190"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p12"
gene 1..16235
/gene="PKHD1"
CDS 277..12501
/gene="PKHD1"
/note="fibrocystin; cause of autosomal recessive
polycystic kidney disease (ARPKD)"
/codon_start=1
/product="polycystic kidney and hepatic disease 1"
/protein_id="AAL74290.1"
/translation="MTAWLISLMSIEVLLLAVRHLSLHIEPEEGSLAGGTWITVIFDG
LELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHE
GLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWII
TGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYPIQEDHGLGTLQCHVE
GDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTN
ITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEV
GDAVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNYTFWI
QADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLGGA
MYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNV
SGRGNFFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGP
EVSNSDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYRLDQYTHLCLAYKGHMNKI
LKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGDLQPPPANSP
VLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARPGGNLVESVSVVGSPPV
YSVTSWLAGCGTELPLITARSVPTEGTEEGSGLVLVTTQRRQRTSPPLGGHFRIQLPN
TVISDVPVQISAHHLHQLLQNNADDFTSRYLNASDFTVKEDLYTCYEHVWTLSWSTQI
GDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLGPIFGDMLATANQHTQVVVRVNDVP
AHCPGSCSFQYLQGSTPCVHSVWYSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCK
VIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVKPRLDMVEPSRAA
DIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVI
RGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQ
DALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPC
CGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGA
PTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVG
GSNLSNSVILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANM
SVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSL
GDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTN
TSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSV
FYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQ
QTCLTVNIGAELIRCIVPTGNGSVALEIEVDGLWYHIGVIGYNKAFTPELISISQSDD
ILTFAVAQISGAANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWA
SSALVFTSRVIITAVTENFGCLGGRLVHVFGAGFSPGNVSAAVCGAPCRVLANATVSA
FSCLVLPLDVSLAFLCGLKREEDSCEAARHTYVQCDLTVAMATEQLLESWPYLYICEE
SSQCLFVPDHWAESMFPSFSGLFISPKLERDEVLIYNSSCNITMETEAEMECETPNQP
ITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPERLPQDGDNVTVENGQLLLLDT
NTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRIGSEDKPFQGRAQITLYGS
SYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHALDTVLALEDAVDWNPGD
EVVIISGTGVKGAKPMEEIVTVETVQDTDLYLKSPLRYSHNFTENWVAGEHHILKATV
ALLSRSITIQGNLTNEREKLLVSCQEANAPEGNLQHCLYSMSEKMLGSRDMGARVIVQ
SFPEEPSQVQLKGVQFQVLGQAFHKHLSSLTLVGAMRESFIQGCTVRNSFSRGLSMCG
TLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDDWSGHGNIIRNNVIIQVS
GAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMTNQTSQAPLLSFTQNI
AHSCTRYGLFVYPKFQPPWDNVTGTTLFQSFTVWESAGGAQIFRSSNLRLKNFKVYSC
RDFGIDVLESDANTSVTDSLLLGHFAHKGSLCMSSGIKTPKRWELMVSNTTFVNFDLI
NCVAIRTCSDCSQGQGGFTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSH
ILASMETLSASCLVNSSFGRVVHGSACGGGVLFHRMSIGLANTPEVSYDLTMTDSRNK
TTTVNYVRDTLSNPRGWMALLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLV
HTDLPPYPDILLRCGSRVGLSFPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVI
LRVKEGMPPTISASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLILPNRT
VLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLEKEQKLLI
LLRASEGVFCDRMNGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGADIASGNERIIVED
AVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHHVRIYERLKHRHIGSVHVTEDGRHI
RLAAEVGLLTRNIQIQPDVSCRGRLFVGSFRKSSREEFSGVLQLLNVEIQNFGSPLYS
SVEFSNVSAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAYTV
TNNLVVLMTQPAWSTIWVAGIKVNQVKDINLHGNVVAGSERLGFHIRGHKCSSCELLW
SDNVAHSSLHGLHLYKESGLDNCTRISGFLAFKNFDYGAMLHVENSVEIENITLVDNT
IGLLAVVYVFSAPQNSVKKVQIVLRNSVIVATSSSFDCIQDKVKPHSANLTSTDRAPS
NPRGGRIGILWPVFTSEPNQWPQEPWHKVRNDHSISGIMKLQDVTFSSFVKSCYSDDL
DVCILPNAENSGIMHPITAERTRMLKIKDKNKFYFPSLQPRKDLGKVVCPELDCASPR
KYLFKDLDGRALGLPPPVSVFPKTEAEWTASFFNAGTFREEQKCTYQFLMQGFICKQT
DQVVLILDSADAIWAIQKLYPVVSVTSGFVDVFSSVNANIPCSTSGSVSTFYSILPIR
QITKVCFMDQTPQVLRFFLLGNKSTSKLLLAVFYHELQSPHVFLGESFIPPTLVQSAS
LLLNESIGANYFNIMDNLLYVVLQGEEPIEIRSGVSIHLALTVMVSVLEKGWEIVILE
RLTNFLQIGQNQIRFIHEMPGHEETLKAIADSRAKRKRNCPTVTCTSHYRRVGQRRPL
MMEMNSHRASPPMTVETISKVIVIEIGDSPTVRSTGMISSLSSNKLQNLAHRVITAQQ
TGVLENVLNMTIGALLVTQSKGVIGYGNTSSFKTGNLIYIRPYALSILVQPSDGEVGN
ELPVQPQLVFLDEQNRRVESLGPPSEPWTISASLEGASDSVLKGCTQAETQDGYVSFY
NLAVLISGSNWHFIFTVTSPPGVNFTARSKPFAVLPVTRKEKSTIILAASLSSVASWL
ALSCLVCCWLKRSKSRKTKPEEIPESQTNNQNIHIHISSKRRESQGPKKEDTVVGEDM
RMKVMLGKVNQCPHQLMNGVSRRKVSRHIVREEEAAVPAPGTTGITSHGHICAPGAPA
QQVYLQETGNWKEGQEQLLRYQLAGQNQLLLLCPDFRQERQQLPGQSRLSKQSGSLGL
SQEKKASCGATEAFCLHSVHPETIQEQL"
BASE COUNT 4328 a 3622 c 3795 g 4490 t
ORIGIN
1 acatttggct gggacacaaa cgagttaggt gagttatagt ctaacgtgag tgagttacct
61 gcgtggtggc tgcaggctga gctctaacca gataacatgt ccacggattc ttgacagaga
121 gaaataagat cacttagaaa gaaaggatca tttctccctt gagtcacaag gagacagaaa
181 cagaaaaaaa agcacaaaag ctatgctgct ccaatcaaaa ctgaaaatgc ttttaatgtc
241 tgagcaatct taagagtatt gatttaagtg gacagaatga ctgcctggct gatctctctg
301 atgagtattg aagtactact tttggcagta cgtcacctga gtttacatat tgaacctgaa
361 gaaggtagcc ttgcaggggg aacgtggatc acagtcattt ttgatggttt ggagttgggt
421 gttctttacc ccaacaatgg ctctcaattg gagatacacc tggtgaacgt gaacatggtg
481 gtgcccgcac tgcggagtgt tccctgtgac gtctttcctg ttttcttgga tttgcctgtg
541 gtgacatgcc ggaccagatc tgtgctgtct gaagcacatg agggtctgta cttcctggaa
601 gcatacttcg ggggacagct ggtaagcagt ccaaatccag gaccacgaga tagctgtact
661 ttcaagtttt ccaaggcgca gacacccatc gttcaccaag tttatccacc aagtggtgtt
721 ccaggaaaac taatacatgt atatggctgg attatcactg gaagattgga aacttttgat
781 tttgatgctg agtacattga tagcccagtg atcttggaag ctcaaggaga caaatgggtt
841 actccttgct ctcttataaa taggcagatg ggaagctgtt atcctattca ggaggaccat
901 ggtcttggga ctctgcagtg ccatgtggaa ggcgactaca tcggctccca gaatgttagc
961 ttctcagtat ttaacaaagg aaagtcaatg gtccacaaga aggcatggct gatcagtgct
1021 aaacaggatc ttttcctata ccagacacac tcagaaatat tatctgtgtt tccagaaact
1081 gggagccttg ggggaagaac aaacatcaca attacaggag acttttttga caattctgcc
1141 caggttacca ttgcaggcat tccatgtgat attagacacg tgtctcccag gaagattgag
1201 tgcaccactc gggctccagg aaaagatgtg aggctcacca cccctcagcc aggcaatcga
1261 gggcttcttt ttgaagttgg agatgctgtt gagggactgg aactgactga agccacccca
1321 gggtacaggt ggcagattgt ccctaatgcc agttctccat ttgggttttg gtcacaggaa
1381 ggacaacctt tcagagcacg gctcagtggg ttctttgtgg ctccagagac aaataattac
1441 actttctgga ttcaggcaga tagccaagct tccttgcatt tcagttggtc agaggaacca
1501 aggactaagg tgaaagtggc ctccatcagc gtcggcactg ctgactggtt tgactcctgg
1561 gagcagaata gggatgaagg gacctggcag cagaagactc ccaagttgga gctgttgggt
1621 ggagccatgt actacctgga agcagagcat catgggatag ccccaagcag ggggatgagg
1681 attggtgtcc agattcacaa cacctggctg aatcctgatg tggtcaccac ttacctacgg
1741 gagaagcacc agatccgagt ccgagcccag aggcttccag aagtacaggt gctgaatgta
1801 tcaggcagag gaaacttctt ccttacttgg gacaatgtct ctagtcagcc aatccctgca
1861 aatgccacag cccatctgat tcaaacaacc attgaggagt tacttgcagt aaaatgcaaa
1921 ctggaacccc tttggtctaa catccttctc cggcttggat ttgaacgagg cccagaagtt
1981 tccaactctg atggggacct caccagtggg acggagccct tctgtggcag gttcagcctc
2041 cgtcagcctc gacaccttgt ccttactccc ccggctgccc agaagggcta tcggctagat
2101 cagtatacac acctgtgtct tgcatacaaa ggccacatga acaagatcct gaagatgatt
2161 gtgtccttca caatcggctt tcaaaacatg gtaaagaata ccacctgtga ctggagtctc
2221 acgaggacca gccccgagag ctggcagttc gattgcactg acctctggga gacttgtgtg
2281 cgttgcttcg gggatctcca gccccctccg gcaaactccc cagtgctggt tcatcagatc
2341 aaccttctcc ctctggccca ggagacgggc ctgttctatg tggatgaaat tattattgca
2401 gacacaaacg taacagtttc tcaagctgat tctggaacgg ctcgcccagg gggcaatctg
2461 gtggaatcag tctctgtggt gggatcccct ccggtctaca gtgtcacctc ctggctggcg
2521 gggtgtggca cggagctccc gctcatcact gcacgctctg tgcccactga aggaacagaa
2581 gagggatctg gactggtcct ggtgacgaca cagagacgac agcggacaag tccacctcta
2641 ggaggacact ttcgcatcca gcttcctaat acagtgattt ctgatgtccc tgtacaaatt
2701 tctgctcatc accttcacca gctcttacag aataatgccg atgacttcac atccaggtac
2761 ctcaatgcca gtgacttcac tgtgaaggag gatctataca cttgctacga acacgtgtgg
2821 accttgtcct ggtccactca gattggggat ttgcccaatt ttatcagggt ctctgatgaa
2881 aaccttactg gagtgaatcc tgctgcagcc acgcgtgtgg tatatgatgg tggagttttt
2941 cttggaccca tatttggaga catgttggct actgccaacc agcatactca ggtggttgtg
3001 cgagtgaatg atgtaccagc tcattgccca ggttcctgct ctttccagta cctccaaggg
3061 tcaactccct gtgtccattc tgtgtggtac tccattgatg gtgacatcaa cctaatgatt
3121 tacattaccg gaactggttt ctctggtgac tcccagttct tgcaggttac agtgaacaaa
3181 acgagttgca aagttatttt ctcaaaccag accaatgtag tctgtcagac agatttgcta
3241 cctgttggaa tgcatcggat cttgatgttg gtgagaccct ctggtcttgc catcagtgcc
3301 actggagaag acctcttcct aaatgtgaaa cctagactgg atatggtgga gccttccaga
3361 gctgcggata ttggagggct ctgggccacc atccgaggct ctagtttgga aggtgttagc
3421 ctgatattat ttggatctta ctcgtgtgcc atcaatgtcg ctacaagcaa ttcaagcaga
3481 attcagtgca aagttccacc cagggggaaa gatggacgca ttgtgaatgt gactgtgatc
3541 agaggggact attctgcagt tcttcccaga gcatttacat atgtctcttc cttaaatcca
3601 gttattgtga ctctgagcag aaacataagc aatatagcag gcggtgagac cctggtcatt
3661 ggagtggcga ggctgatgaa ctatacggat ttggatgtgg aagtccacgt ccaggatgcc
3721 ttggctccgg ttcacacaca gtcggcttgg ggcctggagg tggcactgcc cccactgcca
3781 gctggtctcc acagaatttc cgtctctatc aatggggtca gcattcactc acaaggggtt
3841 gatctccaca tccagtacct cacagaagtt ttcagcatcg agccttgctg tgggtccctg
3901 ctgggaggga ccatcctcag catctcagga ataggcttca gcagggaccc agctttggtt
3961 tgggtacttg tgggcaatcg gtcctgtgac attgtgaact taacggaggc gagcatctgg
4021 tgtgaaaccc tgccagcccc ccagataccc gatgcgggcg ctcccactgt tccagctgcc
4081 gtggaggtct gggctggcaa caggttcttc gcccgtggtc cttcaccaag cttggtgggg
4141 aaaggcttca ccttcatgta tgaagcggca gcaacaccag tagtcactgc catgcaagga
4201 gaaatcacaa atagcagcct gagcctgcat gtgggaggaa gtaacctctc caactcagtc
4261 atccttctgg ggaacctgaa ctgtgatgtt gagacacagt ccttccaggg caacgtgagc
4321 ctgtctggat gctccatccc tcttcacagt ctggaggctg gcatctatcc tctccaagta
4381 cgtcagaagc agatgggatt tgctaatatg tctgtggtgc tccagcaatt tgcagtgatg
4441 cctcggataa tggccatctt cccatcgcag ggttcggcat gtggtgggac catacttact
4501 gtgagggggt tgcttcttaa ctctagaagg aggtcagttc gggttgacct ctcgggtcct
4561 tttacttgtg tgattttgag tttgggagac cacaccattc tctgccaggt tagcctggag
4621 ggtgacccct tgcctggagc ttccttctcc ctgaacgtca cagtcctggt caatgggcta
4681 accagcgagt gtcaggggaa ttgcactctt ttcataaggg aagaggcaag tcctgtcatg
4741 gatgccttgt ccacaaacac cagtgggtct ctgaccactg tgctgattag gggtcagagg
4801 ttagccacca cagctgatga gccgatggta tttgtggatg atcaacttcc ttgcaatgta
4861 acttttttta atgcaagcca cgttgtgtgc cagacaagag acttggcccc aggaccccac
4921 tacctgtcag ttttttatac aagaaatggg tatgcttgtt ctggtaatgt ttccagacac
4981 ttctacatta tgccccaagt gtttcattat tttcctaaga atttcagctt acatggtgga
5041 agcctcttga ccatagaggg cacaggcctg agaggacaga acaccacgtc agtctatatt
5101 gaccagcaga cctgcctgac ggtgaacatc ggtgctgagc tcatccggtg cattgttccc
5161 acagggaatg gctctgttgc cctggaaata gaggtagatg gactttggta tcacatagga
5221 gtcattggtt ataacaaggc ctttacccca gaattgatct ctatttctca gagcgatgac
5281 atcttaacct ttgcagtggc ccagatctca ggagctgcaa acattgacat ttttatagga
5341 atgtcaccct gtgtgggtgt ctctggtaac cacaccgttc ttcagtgcgt ggtcccttcc
5401 cttccggccg gggagtacca cgtcagaggc tatgactgca tcagagggtg ggcctcatct
5461 gccctggtgt tcacctcaag agttattatt acagcagtga cggagaactt cggctgcctg
5521 ggtggaaggc tggtgcatgt gtttggagcg ggattttctc cagggaatgt ctcagctgct
5581 gtgtgtggtg ctccctgccg agtcctggct aatgctacag tgtctgcctt cagctgcttg
5641 gttctgcccc tggatgtgtc cttggccttc ctgtgtggcc tgaagcgtga ggaggacagc
5701 tgtgaggctg ccagacacac ctatgtgcag tgtgatttga cagttgccat ggcgacagag
5761 caactgcttg aatcgtggcc ttacctctac atttgcgagg aaagttccca atgcctcttt
5821 gtgccagatc attgggcaga gtcaatgttt ccatcattct cgggcctctt tatcagccct
5881 aaattggaaa gagatgaagt tctcatctat aatagctcct gtaacattac catggaaact
5941 gaggcagaga tggagtgtga gacgcccaat cagccaatta ccgtcaagat tactgagata
6001 cggaaacgct ggggccagaa cactcagggc aacttttctt tacagttctg ccggagatgg
6061 tccaggactc acagctggtt tcctgaaagg ctgccacaag atggcgacaa cgtcacagtg
6121 gagaatggcc aattgcttct gctggacact aacacaagca tcctcaactt actgcacatt
6181 aaagggggca agctgatttt catggcccca ggacccatcg agctcagggc acacgccatc
6241 cttgtttctg atggtggaga gctccggatt ggatccgaag acaagccctt ccaaggcaga
6301 gctcagatca cactctacgg gagttcctac tcaactccct tctttcccta tggagtcaag
6361 ttcctggctg tgaggaatgg aactctttct ctgcacggtt cactaccaga agtaattgtc
6421 acctgtctta gagcaactgc ccatgcccta gacacagtgc tggctttaga agatgctgtg
6481 gactggaacc ctggggatga agttgtcatc atcagtggaa caggtgttaa aggtgccaaa
6541 ccgatggaag agattgtcac tgtggaaact gtgcaggata cagacctcta tcttaagtca
6601 cctttgagat attctcacaa ctttacagag aattgggtgg ctggagagca ccatatttta
6661 aaggccactg tggctctgct cagcaggagt attaccatac aaggaaatct cactaatgag
6721 agggagaagc tgcttgtttc atgccaggag gccaatgctc cagaaggtaa tctgcagcac
6781 tgtttgtatt ccatgagtga gaagatgcta ggatccaggg atatgggagc cagagtgatc
6841 gttcagtcct tcccagaaga gcccagccag gtccagttga agggagtgca gtttcaagtc
6901 ttggggcaag ccttccataa gcatctgagc tcactcactc tggtgggagc tatgagagag
6961 tctttcatac agggctgcac agtgaggaac tccttcagta gaggcctcag catgtgcggg
7021 accttgggcc tgaaggtgga cagtaatgta ttctacaata ttttaggtca tgcgctgcta
7081 gttgggacat gcacggagat gagatatatc tcctgggagg caattcatgg aaggaaagat
7141 gactggtcag gacatggaaa tataataaga aacaacgtga tcatccaggt ttctggtgcc
7201 gagggactct ccaatcctga aatgttgaca ccatctggca tctatatctg cagtcccacc
7261 aatgttatag aggggaacag agtgtgtggt gctggctatg gctacttttt ccatctcatg
7321 accaaccaaa catcacaagc tccgcttctt tccttcactc agaacattgc acattcttgt
7381 accaggtatg gtctctttgt ataccctaaa tttcagccac cttgggataa tgtcactggc
7441 accactctgt tccagagctt cacagtttgg gaaagtgcag gtggtgccca gatttttaga
7501 agtagcaatc ttcgcctgaa aaacttcaaa gtttattcat gcagagattt tggaattgac
7561 gtcttggaaa gtgatgcaaa tacttcagtt actgacagct tattacttgg tcattttgcc
7621 cacaagggaa gtctgtgtat gtcatctggg attaaaactc ctaaaagatg ggaactgatg
7681 gtgtctaaca caacctttgt taattttgat ctcatcaact gtgtggccat tagaacctgt
7741 tcagactgtt cccaaggaca aggtggattt actgtgaaga ccagccagtt gaagtttaca
7801 aactcttcaa acttagtggc atttccattt cctcatgcag caattttgga agacttggat
7861 gggtctctgt ctgggaaaaa cagaagtcac attcttgctt ctatggaaac cctttcagct
7921 tcttgtttgg tcaattcaag ctttggtcgg gttgtccatg gcagtgcctg tggaggaggt
7981 gttctttttc atcgtatgtc tattggttta gcgaatactc ctgaagtttc ttatgattta
8041 accatgactg acagcagaaa taaaacaacc actgtcaatt atgtacgtga tacattgtct
8101 aaccctcgtg gctggatggc tctgctcttg gaccaagaga cctactcatt gcaatctgag
8161 aacctttgga tcaacagatc tctgcagtac tcagcaacct ttgacaactt tgctcctggt
8221 aattacctac tgctggtgca cacagatttg ccgccttacc ctgacatcct cctaagatgt
8281 gggagtcgag tgggtctgtc ttttccattt cttccatcac caggtcagaa ccaaggctgt
8341 gactggttct tcaatagcca gctgaggcaa ctcacctatc tggtttcagg tgaaggccaa
8401 gttcaagtca ttctccgggt gaaggaaggt atgcccccaa ctatttcagc ttctacctct
8461 gcccctgaat cagctttaaa atggtccctc cctgaaacat ggcaaggtgt tgaagaaggc
8521 tggggaggat acaacaatac cattccaggc cctggggatg acgttctcat tttacccaac
8581 agaactgtcc ttgtggatac agatcttcca ttcttcaaag ggctgtatgt gatggggacc
8641 ttagacttcc ctgtggacag aagcaatgtt ctgagtgtgg catgcatggt cattgcaggc
8701 ggggagctga aagttggtac tttagaaaat cccttagaaa aggaacaaaa gcttctgatt
8761 ctccttagag cctcagaggg agtcttttgt gaccgtatga atggaattca tattgaccca
8821 ggaacaattg gggtttatgg gaaagttcat ctttacagtg cttatcctaa gaactcctgg
8881 acacatcttg gagctgatat tgcctcagga aatgagagaa ttatagtaga agatgcagtg
8941 gattggcgcc cccatgacaa aatagtcctt agctcctctt cttatgagcc tcatgaagca
9001 gaggtcctca ctgtgaaaga agtcaagggc caccatgtga ggatctatga acggctcaaa
9061 caccggcata ttggaagtgt acatgtcacg gaggatggcc gacacattcg tttggctgct
9121 gaggttggac tgttgacccg aaatatacaa attcagcctg acgtatcatg tagggggaga
9181 ctgtttgtgg ggtccttcag gaagtccagc cgagaagaat tttcaggtgt ccttcaactt
9241 cttaatgtgg aaattcagaa cttcgggtca ccattgtact catctgttga attcagtaat
9301 gtgtcagcag gatcctggat catatcatct actctgcacc agagctgtgg cgggggcatt
9361 catgcagctg ccagtcatgg agtactttta aatgacaata ttgtgtttgg cacagctggc
9421 catggcatag atttagaggg tcaggcctat actgtcacta ataaccttgt ggttctgatg
9481 acacagccag cgtggtccac catttgggtg gcgggaatca aagtgaacca ggtaaaggac
9541 atcaacctcc atggcaacgt tgtggcagga tcagagagac ttggctttca catccgaggc
9601 cacaagtgct cctcttgtga actgctttgg tctgacaatg tggcgcattc aagtcttcat
9661 ggccttcatc tctataagga aagtggactt gacaactgta ccagaatctc tggcttcttg
9721 gctttcaaga actttgacta tggtgccatg ttacatgtag agaacagcgt ggagatagag
9781 aacattactc tggtagacaa tactattggt cttttggcag tagtgtatgt attttctgct
9841 ccacaaaatt ccgtcaaaaa agtgcagatt gtgcttagga attcagtcat tgtggccacc
9901 agctcttctt ttgactgcat tcaggacaaa gtgaagccgc actcagccaa cttgacatca
9961 acagatagag ctccctccaa tccaagagga ggtcgaattg gtattctgtg gcctgtattc
10021 acctcagaac caaatcagtg gcctcaggag ccatggcaca aagtgaggaa tgatcattca
10081 atttcaggaa tcatgaaact tcaagatgtt accttttcta gttttgtgaa gagttgctat
10141 agcgatgacc tggatgtctg cattctacca aatgcagaga acagtggaat tatgcaccca
10201 ataacagcag agaggaccag gatgctaaag ataaaagata aaaacaagtt ctactttcct
10261 tcattacaac ccaggaaaga tttaggaaaa gtagtctgtc ctgaattaga ctgtgcaagt
10321 ccaagaaaat atctcttcaa ggatctggat gggagagccc tgggtctgcc tccaccagtt
10381 tctgtatttc ctaaaacaga ggcagaatgg actgcatcct tcttcaacgc aggtacattt
10441 agagaagaac agaaatgtac ataccaattt ctgatgcaag gattcatctg caaacagact
10501 gaccaagtgg tcctaattct tgatagcgct gatgccattt gggcaattca gaagttatat
10561 ccagttgtat ctgtgactag tggttttgtt gatgtcttta gcagtgtaaa tgccaatatt
10621 ccctgctcta cttctgggtc agtgtctact ttctattcta tcttacccat caggcaaatc
10681 accaaagtct gcttcatgga tcaaactcct caagttttgc gcttttttct attggggaac
10741 aaaagtacct ccaagcttct cttggctgta ttctaccatg agctccagag cccccacgtc
10801 ttcttagggg aaagttttat tccacccact ctggttcagt cagcttcctt attgctgaat
10861 gaatctattg gtgccaacta tttcaacatc atggataacc tcttgtatgt tgtcctacaa
10921 ggagaggagc ccattgaaat acgctcaggt gtttccattc acttggccct cactgtgatg
10981 gtttcagtct tagaaaaagg ctgggaaata gtaatactcg aaagactaac taacttctta
11041 cagattggcc aaaaccaaat caggtttatt cacgagatgc ctggccatga agagacctta
11101 aaggccattg ctgacagtag agcaaaaaga aagcgcaatt gccctactgt gacttgcact
11161 agtcattata gaagagttgg tcaacgtagg cctctcatga tggaaatgaa ctcacatagg
11221 gcttcacccc caatgactgt ggaaactatc tcaaaagtga ttgtcattga aattggtgat
11281 tcgccaacag taaggagcac tggaatgatt tcatccttat caagtaacaa attacagaat
11341 ttggctcatc gagtcatcac tgctcaacag actggggtac tagagaatgt tctgaatatg
11401 actatcgggg ccttactagt tactcagtca aagggagtca ttggctatgg aaatacaagc
11461 agttttaaaa ctgggaactt gatatatatt cggccctatg cactttccat cctagtccag
11521 ccttcagatg gagaagtggg aaatgagctt ccagtgcagc cacaattggt atttttggat
11581 gagcagaatc gaagagtaga gtccctggga cctccttcag agccatggac aatttcagct
11641 tccctggaag gagcatcaga ctcagtgcta aaagggtgca cccaggcaga aactcaagat
11701 ggttatgtta gcttctacaa cttggcagtc ttgatctctg ggtcaaactg gcactttatt
11761 tttactgtca cttctcctcc aggagtcaat tttacagctc gatccaagcc atttgctgtc
11821 ttgcctgtga ctaggaagga gaagtcgacc atcatcctgg ctgcttccct gtcctctgtg
11881 gcctcatggc tggctctgag ctgtctggtg tgctgttggc ttaaaagaag caaaagcaga
11941 aaaacaaaac ctgaagagat tcctgaatcc cagactaata atcaaaatat tcatatccac
12001 atctcatcca aacgccgaga atcacaaggg cccaaaaaag aagacactgt ggtgggagaa
12061 gatatgagaa tgaaggtcat gctgggcaag gtgaaccagt gcccccacca gttgatgaat
12121 ggagtgtcca gaaggaaagt tagccgccac attgtccgag aggaagaggc tgctgtgcct
12181 gctcctggta ctactggcat cacatcccat gggcacatct gtgctccagg tgctcctgct
12241 cagcaggtgt acctgcaaga gactgggaac tggaaggagg gccaagagca gttgctcaga
12301 taccagctgg caggccaaaa tcagctgctg ctgctatgcc cagacttcag acaagagagg
12361 cagcagttgc cagggcaaag tcggctgagt aagcaaagtg gcagcttggg gctttcccaa
12421 gagaagaaag cctcctgcgg ggccactgag gcattctgcc ttcattcagt acacccggaa
12481 actattcagg agcaactgtg atcagggaag ttgggggcat ttggcctgaa aggcagaatg
12541 ttcccagtat ttctggataa taagctgggg aagtgaggac tgtcctgctg ggacaactaa
12601 gaagagagaa tgtggactct gaatcccttt ttcaacttta aaatggaaaa cagtcatata
12661 aatgcttaca gactgaaaaa tgtctcatac atattttgca gctatcatga tcctagttca
12721 atgctaggca aataatggca cttgttaatt atttaccagt ttttaactta agcctgattt
12781 taacaacttg ataatggtgt aatactgact tataccagca ggggttatta ttaagcattc
12841 tctggattga ccacccacaa tgctttgagc ttcttttata gaagggatca tgaaaaggtc
12901 tggtcagcta cagtttaatt ccacactgtt acagaaaagc atttctttat cctgtagtag
12961 catttgaagg gacagttcaa caccctgctc cctgatctgt cagagcttac cttccaacca
13021 caaggcaact tcctggcttt ttacaagtgg attttatttc atggtttaaa ttcaatcatt
13081 attgagaacc tacagtagtg tgagcgtatc aaatttgcac ttcatgagga tttacacatg
13141 aaaattgata ttctcatggg ctttgctgag agtttagtta aggacaaaga tgtaaaaatg
13201 ccaaatttgg gaaaggaaat tttgtatgac cactgttcta tttttcagtg attctctctg
13261 ttagtagctg ggtcacattt acaactggaa aagaactaca ttgggagatc agagaaagcc
13321 aagtggccaa gtcctttatc aaaaagctgc tttttggaga agatgatgca taaagctgtg
13381 atactaagga gaggagagat tatgtcatat gcaactgctc taggctgtgc agggggttta
13441 aatggagatc agaacaaagg ctcacctggt attgatacat ttggtaaggt tgttaaaggc
13501 aatttcacca aattcacaca tttgtacggg gcccatttct tttcaaactg aagaatactt
13561 taaacagcct gactgtgtcc ttggctctgg atccagaagg ccttatgctc caagcatgta
13621 aagaaaagat cgcaggaatg tggagagctt ccaaaaagag attgctctca gattttcctg
13681 aaaatcctga aaaccaggat tttccaatct ctacaatgtt aaggggttgt tgtgtagttg
13741 cattggaaga gagaaaggaa acacactctt tcattgctga attctaaata atgatgccct
13801 gaattagttc tatgagaagt actggcagac agctgttatg tctgcagggc atcaaggggc
13861 aggtgtgtct caccctacta agaattggca gaaatgtttt aacctcttct ttaggcatct
13921 ggtgagtatt gcagatcttc aggctgtccc taaaaggagg taggtagcct tctctgtggt
13981 cactgtgttg gatttggaag aaaatataag tagatgttaa ggtcagtgct ctccaggaga
14041 tttcaatcca ggctatctgt gttcagggaa tgatttgcaa gaagttggtt tatagacgtt
14101 tactctggag gcacaagctg gctgccatgc tgagtaagtc ctctttgtag atgatgtatt
14161 ttgcttgggc accaacagaa ttaaaaacga aaaacaaaaa aaaactcgaa tgacttaggc
14221 agaacatgcc ttccctagtt taattagtcc ctgttataac cagttattta tctttttttg
14281 tagattctcg gtcttgaagt catttgcctt tgcaatctct actttagtat actcattgga
14341 tcctcaaaga gccgtaagct ttttggaaaa aaacatttca gaagtgaagg cttttgaggt
14401 ttataaaatg gtagcagtct tagtccttgc cctgcctcag tttacctgca catgctttct
14461 ttcatttcct cggattcttt caccactttt taagtttttt ttccacaggt atttttcctg
14521 agctctatac catgcattta gctgcctagt gagaatatcc agtaggttat cctatagtta
14581 ctatgaagtt aacacagccc aaaaacctac ttctccttgt gtttttttcc aactcaatga
14641 atgacatcac tgcactcaga ccagaaatct agaagtcagt catgactctt cattctattt
14701 cgcccttcac aaagagttag ctgccagctc tgttatttct gccccttctt tacccttctt
14761 ccaattttta ttatcttctt atttatcctc tatgtgtcac aagaccagtc tttctgggag
14821 gcatgtttta tcctatccct ctgcgtagga ataaccataa ttatcttact aattccatcc
14881 cagaaaagcc tgtgatccct gaggccagaa ttgactcttt gggcctaaat agcagctata
14941 aacatcttca gtaacttgcc aggctctagc atgtggcatg gaattttggc atctagctaa
15001 aattcctcaa cccatagtta agctactcct ctttctccta aaaaaaaaaa aaaatgagag
15061 aattagggaa acaccaaaag caaagagagc agctctatgt tcattcatgt ctggagatga
15121 gccaatttga gcaccactgt aggccaactc taaatttatt cagatcgtta acatgggtaa
15181 cccagcaaat atttcccagc agtgacaatc tacacccttt atctaaataa atattgagat
15241 gtgctttttt cctgtgttag ttcaaagaat ctcttcttgc ctcccattgc tgattttctg
15301 tattgatgga ctcatttctc tcaagagatt ggacaagcta aaattctaga gagttcaaaa
15361 gtgtttgaaa gtacatttta agtgttctca ccacaaaaaa tgctagtgtg tgaggtgata
15421 catatgttaa ttagttcaac tgatccattc cacaatgtat acatatttca aactatcgag
15481 ttgtacatga taaatatata caatttttat ttgtcaaata aagaacatct ataaatattt
15541 atagatttca aaattgagaa agaagtatat atggagccac ggttgttttg accatttctc
15601 catgcttttt gtttggggag ggggacattt tttggggggc agggactgtg ttcagggaaa
15661 gtacctgacc aacagaactt caagtctctt ccagagtgcg agactcagct tatctgatca
15721 aggtgaactt gcccttcaat agacttgccc ttgttactgc ccagtgaggc caccaaggac
15781 caagaacagt tgagctctct cagggccttc ccctttcaac aatttagttg aatgactccc
15841 ttccatctat cagtcttact ccaaatatat gaaattacta tacattgaaa tgcctgcaaa
15901 ctatatgcaa aaatgagtat gaggaaatca aatgtaaatc atatgcaaat attattcaac
15961 caagcttcta taaaattgta cgtgtcaata acagtaaaga attttaatta attctgtcat
16021 ttaaaattca tgcattccat attttgcttt cagaacttat agtctatgcc aattttgaaa
16081 aaactataag cacaaggaat taaatactat tgagtataga actgttgatt tcaacataca
16141 ctatagcact ttgactaatt acagatatat ttgatagaaa agtcacattt ctacaaggta
16201 attttcaaaa agaaataaaa catttctgta aactt
//