LOCUS AY062002 2048 bp mRNA linear HUM 16-DEC-2001
DEFINITION Homo sapiens putative tumor suppressor RASSF3 isoform A (RASSF3)
mRNA, complete cds; alternatively spliced.
ACCESSION AY062002
VERSION AY062002.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2048)
AUTHORS Burbee,D.G., White,M.A. and Minna,J.D.
TITLE RASSF3 is regulated by methylation in lung and breast tumor cell
lines
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2048)
AUTHORS Burbee,D.G., White,M.A. and Minna,J.D.
TITLE Direct Submission
JOURNAL Submitted (13-NOV-2001) Hamon Center for Therapeutic Oncology
Research, University of Texas Southwestern Medical Center at
Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-8593, USA
FEATURES Location/Qualifiers
source 1..2048
/db_xref="H-InvDB:HIT000084044"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q31-q32"
gene 1..2048
/gene="RASSF3"
CDS 58..1314
/gene="RASSF3"
/note="RAS-binding protein; contains putative C1-membrane
binding domain, ATM phosphorylation site, and SH3-binding
domain; alternatively spliced; similar to the putative
tumor suppressor RASSF1A, mouse Nore1 and rat Maxp1 gene
products"
/codon_start=1
/product="putative tumor suppressor RASSF3 isoform A"
/protein_id="AAL40388.1"
/translation="MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRL
CVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRD
VRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHP
ECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSY
NTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDK
RTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQK
LSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKI
QQVQKKYDKFRQKLEEALRESQGKPG"
BASE COUNT 457 a 628 c 556 g 407 t
ORIGIN
1 cgggagtagc gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggcatg
61 gccatggcgt ccccggccat cgggcagcgc ccgtacccgc tactcttgga ccccgagccg
121 ccgcgctatc tacagagcct gagcggcccc gagctaccgc cgccgccccc cgaccggtcc
181 tcgcgcctct gtgtcccggc gcccctctcc actgcgcccg gggcgcgcga ggggcgcagc
241 gcccggaggg ctgcccgggg gaacctggag cccccgcccc gggcctcccg acccgctcgc
301 ccgctccggc ctggtctgca gcagagactg cggcggcggc ctggagcgcc ccgaccccgc
361 gacgtgcgga gcatcttcga gcagccgcag gatcccagag tcccggcgga gcgaggcgag
421 gggcactgct tcgccgagtt ggtgctgccg ggcggccccg gctggtgtga cctgtgcgga
481 cgagaggtgc tgcggcaggc gctgcgctgc actaactgta aattcacctg tcacccagaa
541 tgccgcagcc tgatccagtt ggactgcagt cagcaggagg gtttatcccg ggacagaccc
601 tctccagaaa gcaccctcac cgtgaccttc agccagaatg tctgtaaacc tgtggaggag
661 acacagcgcc cgcccacact gcaggagatc aagcagaaga tcgacagcta caacacgcga
721 gagaagaact gcctgggcat gaaactgagt gaagacggca cctacacggg tttcatcaaa
781 gtgcatctga aactccggcg gcctgtgacg gtgcctgctg ggatccggcc ccagtccatc
841 tatgatgcca tcaaggaggt gaacctggcg gctaccacgg acaagcggac atccttctac
901 ctgcccctag atgccatcaa gcagctgcac atcagcagca ccaccaccgt cagtgaggtc
961 atccaggggc tgctcaagaa gttcatggtt gtggacaatc cccagaagtt tgcacttttt
1021 aagcggatac acaaggacgg acaagtgctc ttccagaaac tctccattgc tgaccgcccc
1081 ctctacctgc gcctgcttgc tgggcctgac acggaggtcc tcagctttgt gctaaaggag
1141 aatgaaactg gagaggtaga gtgggatgcc ttctccatcc ctgaacttca gaacttccta
1201 acaatcctgg aaaaagagga gcaggacaaa atccaacaag tgcaaaagaa gtatgacaag
1261 tttaggcaga aactggagga ggccttaaga gaatcccagg gcaaacctgg gtaaccggtc
1321 ctgcttcctc tcctcctggt gcattcagat ttatttgtat tattaattat tattttgcaa
1381 cagacacttt ttctcaggac atctctggca ggtgcatttg tgcctgccca gcagttccag
1441 ctgtggcaaa agtctcttcc atggacaagt gtttgcacgg gggttcagct gtgcccgccc
1501 ccaggctgtg ccccaccaca gattctgcca aggatcagaa ctcatgtgaa acaaacagct
1561 gacgtcctct ctcgatctgc aagcctttca ccaaccaaat agttgcctct ctcgtcacca
1621 aactggaacc tcacaccagc cggcaaagga aggaagaaag gttttagagc tgtgtgttct
1681 ttctctggct ttgattcttc tttgagttct cttacttgcc acgtacagga ccattattta
1741 tgagtgaaaa gttgtagcac attccttttg caggtctgag ctaagcccct gaaagcaggg
1801 taatgctcat aaaaggactg ttcccgcggc cccaaggtgc ctgttgttca cacttaaggg
1861 aagtttataa agctactggc cccagatgct cagggtaagg agcaccaaag ctgaggctgg
1921 ctcagagatc tccagagaag ctgcagcctg ccctggccct ggctctggcc ctggcccaca
1981 ttgcacatgg aaacccaaag gcatatatct gcgtatgtgt ggtacttagt cacatctttg
2041 tcaacaaa
//