LOCUS AY057989 4731 bp mRNA linear HUM 31-DEC-2001
DEFINITION Homo sapiens GAB3 mRNA, complete cds.
ACCESSION AY057989
VERSION AY057989.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4731)
AUTHORS Wolf,I., Jenkins,B.J., Liu,Y., Seiffert,M., Custodio,J.M., Young,P.
and Rohrschneider,L.R.
TITLE Gab3, a new DOS/Gab family member, facilitates macrophage
differentiation
JOURNAL Mol. Cell. Biol. 22 (1), 231-244 (2002)
PUBMED 11739737
REFERENCE 2 (bases 1 to 4731)
AUTHORS Wolf,I., Liu,Y., Young,P. and Rohrschneider,L.R.
TITLE Direct Submission
JOURNAL Submitted (08-OCT-2001) Basic Sciences Division, Fred Hutchinson
Cancer Research Center, 1100 Fairview Ave. North - Mailstop B2-152,
Seattle, WA 98109-1024, USA
FEATURES Location/Qualifiers
source 1..4731
/db_xref="H-InvDB:HIT000083971"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq28"
CDS 33..1793
/function="differentiation signaling"
/note="DOS/Gab family; scaffolding protein; signal
transduction protein; similar to Drosophila melanogaster
DOS"
/codon_start=1
/product="GAB3"
/protein_id="AAL25825.1"
/translation="MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDV
LEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTE
QEMQVWVHSISQVCNLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDD
PNTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASF
DDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLL
ESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKP
ECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDS
YVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSRP
PPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIE
MEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQ
KTQALQSTKQEWTDERQSKV"
BASE COUNT 1303 a 1140 c 1106 g 1182 t
ORIGIN
1 cccagctgga ggaagcggcg gcggcggcca cgatgagtgc gggcgacgca gtgtgcaccg
61 gctggctcgt taagtcgccc cccgagagga agctacagcg ctacgcctgg cgcaagcgct
121 ggtttgtcct ccggcgaggc cgcatgagcg gcaaccccga tgtcttggag tactacagga
181 acaagcactc cagcaagccc atccgggtga tagacctcag cgagtgtgca gtgtggaagc
241 atgtgggccc cagctttgtt cggaaggaat ttcagaataa tttcgtgttc attgtcaaga
301 ctacttcccg tacattctac ctggtggcca aaactgagca agaaatgcag gtgtgggtgc
361 acagcatcag tcaggtctgc aaccttggcc acctggagga tggtgcagat tccatggaga
421 gcctctctta cacgccctcc tccctgcagc catcctctgc cagctccctt cttaccgccc
481 atgctgccag ctcctctttg ccaagagatg acccaaacac taatgccgta gccactgagg
541 aaaccagaag tgagtcagag cttctcttcc ttccagatta tctggttttg tccaactgcg
601 agactggaag actgcaccat accagtctac ccaccagatg tgatagctgg tcaaactcag
661 accgttcatt ggaacaggct tcatttgatg atgtttttgt tgactgcctg cagccgctcc
721 cctccagtca tttggtccac ccctcatgcc atggcagtgg agctcaggag gtgccatcct
781 cgaggcctca ggctgccctg atctggagta gagaaatcaa tgggccaccc agggaccact
841 tgtcttcttc accattgctg gaaagttcct taagttccac cattcaggta gataaaaatc
901 aaggttcctt accctgtgga gcaaaagaac tagacattat gtccaacact ccacctcccc
961 gcccccctaa gccaagccat ctgtctgaac ggcgccaaga ggagtggagt acacacagtg
1021 gtagcaagaa gccagaatgc actctggttc caagaagaat ctccctctct ggtttagaca
1081 acatgagaac ctggaaagct gatgtagaag gccaatcctt aagacaccga gacaagcggc
1141 ttagtttgaa tttgccatgc aggttctccc cgatgtaccc cacagcttca gccagtatcg
1201 aagacagcta tgtgcccatg agcccccagg ctggtgcctc tggtcttgga ccccactgca
1261 gccctgatga ctacattcca atgaactcag gaagcatctc aagcccgttg cctgagctgc
1321 ctgcaaacct ggaacctccc ccagtgaata gagatctcaa gcctcagagg aaatcacggc
1381 cacctcctct ggacctgaga aacctctcga tcatccggga acatgcatct cttaccagga
1441 cccgcactgt gccttgcagt cgaaccagct ttctctctcc agaaagaaat ggtattaatt
1501 ctgcaagatt ttttgctaat cctgtttcca gagaagacga agaaagctac atcgaaatgg
1561 aggagcaccg aacagccagt tccctgagca gtggtgccct tacgtggaca aagaaattca
1621 gcctagatta tttggccctg gacttcaatt cagcatcacc agcccccatg cagcagaaac
1681 ttctcctttc agaagaacaa agagtagact atgtccaagt ggatgagcag aagacacagg
1741 ctctccagag cacaaaacag gagtggacgg atgaaaggca atccaaagta tgagaggtgc
1801 gggcttgtgc catgtgtgaa acagggaagc ttggggctca gtttgagttt tttctttttt
1861 tttttttttt gtccactaaa aacacactga tggtcaacac aggtcaaaac caagagagaa
1921 tgtgtagttt tcaaggtctt ggccagaacc tttaggaaag aagacctgtt tatacattga
1981 aggaagaaaa gaaggaagca gttgccttcc ggagggggct ctgagagaat ctagcctccc
2041 ctctgtccta ttggagcaaa gattggagtg agtgttgcca ccaacaggat tttatcgttt
2101 gactccaata cctgaaattc tgacttctct cctgtgcttc aatgagaatg ataaattatc
2161 ctagcaaagg ggcctctgga gaccatcttg ttccagcctc tgaagacagt tgaggagatc
2221 aagcccagca atggtggcag aatcttactc cacagacttc agcagactag tcatttcaat
2281 acccaaagaa agacaagtga caggggcaat ggatctcagg ctctgagata agtatatcag
2341 atgacactgg tggctctaag gatattgcaa ttaagcagct acctgtagcc aggtattctg
2401 ctgctcttgg ccttttccca cgcatcgtct cgtgtcttct ccgaaagacc ttggaagata
2461 ggcctggaag agactgttga tgccactttg aagaaaagaa cactgagaac tagaggaggg
2521 aacactttgc ccaagattac tcacaaagcc aagacccaga gtccagctta gagaatagag
2581 ttgttcaggc tgccaattgc aagctcattc ctctacctca tacttcctct gaggattttg
2641 acaaaatgga ttaattgggt gagccttgga gacatgtggg aaacacctgc agacacaaaa
2701 tgagtagtca tcctgtctcc ctttcaatag ggatctgaac aggtgttttg atacttgaaa
2761 gatgtgcatg tcaagtgagg gtttctttct gcgatgttca actggaactc tcccatcagt
2821 agttacaatt agaaatacct actgatggtt agtctgaagg ccattctcat ggtcacctat
2881 acagtgtgtt tccctgtgag ctagcagaca caatgaccag gaaaaaacct atgaattcca
2941 ttcttaggtt tcccagccaa ttgctccctt ctgctttaga agtgactagg tactgagagt
3001 acaaacactc ccactttata atgaaggcgt catgtcaccc cttcctttac aggtcctggg
3061 gtccaggaga cccagaatga aggtgtcagt tgggcatgaa gtgttattta gtgtccattc
3121 ttgatccttc tgagcaccta cagctggaaa ctaagcagat actggtcctg cattctgact
3181 gagattgtgt cttctttatg aggatagatc aaattggcag tcaggcccat gatagtcagt
3241 gcagttgggg cagttgtaga ctttgctaca ggatttcagg gtttccaatc accccacagg
3301 taagtgaatg ccaaagtctt cttttttcag accatacaag aagtcatttt gattttcaaa
3361 gaagccgttt tgattttcaa agaagcaggt tctggtgaca ttattttctt ccttggacaa
3421 agtgggggga aatttctaag tattttaact gagttcaggg tccttagtga gcctggacag
3481 agcaaggaga gggctcccca ctccctaagc cccacagcca gttctgcatc accacacaca
3541 gccagagcct gtgaggagct gccttcttcc ccatgtgact tgcaaagagt ctcaggcaag
3601 aaaccagggc ttcaaactgc tagttcccat ggagggtagt tccctcgtgt ggagcacttg
3661 tgttaggatc actgattatc tgacaaaggc tggtgcagaa aaaaaattgt aggcccaagt
3721 gtcaagaacc acaccagatt ggagatagaa aagaatagct gaaattatgt cagtggtgaa
3781 atgtcactcc attgacccac cgaaaaaaga aaagaaatct gtttctacca aacatttcca
3841 gaaacgtatt tatagcatga agaaacacac atgggtagtg tgacctgttt ggatgtgatt
3901 acttaaaaat ggaatgctct gaataggcac tctctacatt aaaggtatgg aaggcgatag
3961 gggtcagaat tttaaaaatt taattttgaa aaaggtgact cacccctcat ttccagagtg
4021 taggcaatta tgtcctgctt tgataaaact gctagaggat ggctatgcaa aagcataacg
4081 attcaaggaa acaaagtaca ggtagttttt gagctgacag cagcaaaggc accataagtc
4141 aaaatattgg ttttggtgga gatgatcgat gtgtgtgtgt gagagagagc tatgtttcta
4201 accaagggcc taatgtttgt tacagaaatg atcccagaga cctacaagat gtgggaatca
4261 gcataacagg gcaatgcagc aattaacccc acatcgtttt ctgtagttcc tttttgtttc
4321 attttcttct gtctcacctc gttagaaaat tcctcccagt caggggtcgt ccagtgcagg
4381 acgggggacc caagggtctc aagcctgcaa gtccagaagg tgacaaaccc aggagcactg
4441 ggagttaagc tttccttggg gagggaagag ccttgatgtc cagcacacag cctggctata
4501 aagacacgaa gcgacctacc cactgtacag tccacttcac aggatcagct gaatcatgac
4561 ctttaaaagt tccgagttga aactgaaggc tctcctcaga cctggctttt tcctcagtcc
4621 ctgttcatac catctctgca cccacaatca cactgatttt tcaaattcat tttgtttttg
4681 ctgtttcatt tctggcatta ataaaagtct tataaggaaa aaaaaaaaaa a
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