LOCUS       AY044450                5375 bp    mRNA    linear   HUM 04-SEP-2001
DEFINITION  Homo sapiens heart alpha-kinase (HAK) mRNA, complete cds.
ACCESSION   AY044450
VERSION     AY044450.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5375)
  AUTHORS   Ryazanov,A.G., Pavur,K.S. and Dorovkov,M.V.
  TITLE     Alpha-kinases: a new class of protein kinases with a novel
            catalytic domain
  JOURNAL   Curr. Biol. 9 (2), R43-R45 (1999)
   PUBMED   10021370
REFERENCE   2  (bases 1 to 5375)
  AUTHORS   Ryazanova,L.V., Pavur,K.S., Petrov,A.N., Dorovkov,M.V. and
            Ryazanov,A.G.
  TITLE     Novel type of signaling molecules: protein kinases covalently
            linked with ion channels
  JOURNAL   Mol. Biol. (Mosk.) 35, 271-283 (2001)
REFERENCE   3  (bases 1 to 5375)
  AUTHORS   Ryazanov,A.G.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2001) Department of Pharmacology,
            UMDNJ-R.W.Johnson Medical School, 675 Hoes Lane, Piscataway, NJ
            08854, USA
FEATURES             Location/Qualifiers
     source          1..5375
                     /db_xref="H-InvDB:HIT000083776"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
     gene            1..5375
                     /gene="HAK"
     CDS             199..4794
                     /gene="HAK"
                     /note="expressed predominantly in heart"
                     /codon_start=1
                     /product="heart alpha-kinase"
                     /protein_id="AAK95952.1"
                     /translation="MQVNTLFETSQVPDWSDPPQVQVQETVRETISCSQMPAFSEPAG
                     EESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQQEEKQDRDGNIPDNFRED
                     LKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPEPTDTALTLENVCDE
                     PRDREAVCAMECFEASDQGTCFDTIDSLVGTPVDNYSPQEICSVDTELAEGQNKVSDL
                     CSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFISTFTLNISHTASEGATGEN
                     LAKVEKSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSA
                     ADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETVTIATEVHPAKYLAVSIPEDK
                     HAGGTEERFPRASHEKVSQFPSQVQVDHILSGATIKSTKELLCRAPSVPGVPHHVLQL
                     PEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQSLSQQGS
                     LSAPDFQQSLPTTSAAQEERNLVPTAPSPASSREGAGQRSGWGTRVSVVAETAGEEDS
                     QALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESKASD
                     GGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPTI
                     SVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEK
                     QLKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSN
                     DGNMGHEAEIQSAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVL
                     QPSEGGERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHSSL
                     GVDTHNSTGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCT
                     SSPEGNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLL
                     QDPCQKGTLGCAKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGV
                     KKKILSRVAALRLKLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRA
                     PVLLKKIQAEMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSF
                     AIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFK
                     EDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNA
                     IAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLI
                     HRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGC
                     LLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSL
                     QNNNQKQKQPSIGKSKVQTNSMTVKKAGPETPGEKKT"
BASE COUNT         1641 a         1269 c         1285 g         1180 t
ORIGIN      
        1 gaatctgctg agcccccact aacccagagt gataaaagag agacttctca caccacagca
       61 gcagcgactg gtcggagttc ccatgctgat gcaagagaat gtgctatttc aacccaggca
      121 gagcaagaag caaaaaccct tcaaacttca acagactcag tctccaaaga aggcaacaca
      181 aattgcaagg gagaaggcat gcaagttaat actctatttg aaacaagcca ggttccagac
      241 tggagtgatc ctcctcaggt acaagttcag gaaacagtca gagagacaat ctcttgcagc
      301 cagatgccag ctttctcaga gcctgctggg gaggagtccc cattcactgg gaccacaaca
      361 atttccttct caaacttagg aggggtccac aaggaaaatg catcattagc tcaacactcg
      421 gaggtcaaac cctgtacctg tggtccacag caggaagaaa aacaagacag agatggcaac
      481 atacctgaca atttcaggga agacctaaaa tatgagcaga gcatctcaga agccaatgat
      541 gagactatgt ccccaggtgt gttctcaagg catctcccca aggatgctcg tgctgacttc
      601 agggagcctg tggctgtctc tgttgcttcc cctgaaccca cagatactgc cctcaccctg
      661 gaaaatgtgt gtgatgagcc aagggacaga gaagcagtgt gtgcaatgga gtgttttgag
      721 gctagtgacc aaggaacatg ttttgatacc atagattctc ttgttgggac accagttgat
      781 aactattcgc ctcaagaaat ttgctctgta gatacggaac tggcagaagg tcaaaacaaa
      841 gtatctgatt tatgttcttc taatgacaag acactggaag tcttttttca gacacaagtg
      901 tctgagactt cagtgtctac gtgcaaaagc agcaaggacg gcaactcagt catgtcccct
      961 ctttttatca gtactttcac cttgaacatt tcacacacag ctagtgaagg tgccacagga
     1021 gaaaatctag ccaaggtgga gaaatccacc tacccactgg cctccacagt acatgctggc
     1081 caggagcagc caagccccag caactcagga gggcttgatg aaacacagct cctttcttct
     1141 gagaacaatc ctttagtgca atttaaagaa ggaggtgaca agagccccag tcctagtgcc
     1201 gcagacacca cagccacacc agccagttat agttcaattg tgagttttcc ttgggagaag
     1261 ccaacaacat taactgctaa taatgagtgc tttcaagcga ccagagagac tgttaccatt
     1321 gccaccgaag tccacccagc caaatacctt gctgtgtcaa ttcctgagga caagcatgca
     1381 ggtggcactg aggagaggtt ccctcgtgca tcccatgaaa aggtttccca atttccttcc
     1441 caagtgcagg tggatcatat tttaagtggt gctaccatca aatctacaaa agagctactt
     1501 tgcagggcac ccagtgtgcc aggagtccca caccatgtcc tgcagctccc agagggagag
     1561 ggtttctgca gtaattcccc tcttcaggtt gataacctgt ctggagataa gagccagact
     1621 gtggacagag cagactttag gagctatgaa gagaatttcc aagaaagagg aagtgaaaca
     1681 aagcaggggg tccagcagca gagcctgtcc cagcagggtt ctctttctgc acctgatttc
     1741 caacaaagtt tgcctacgac atctgctgca caagaggaaa gaaacttggt gcccacggcc
     1801 ccctcaccag caagctctag ggaaggagca gggcagcgct caggttgggg gacgagggtc
     1861 tccgtggtgg ctgaaactgc tggggaagaa gacagtcagg ctctgagcaa cgttccatct
     1921 ctctctgata tccttttgga agagtctaaa gaatatagac ctggaaattg ggaggcaggc
     1981 aacaagctga agattataac tctagaggct tccgcttctg aaatctggcc accacgacaa
     2041 ctgacaaatt ctgagagcaa ggcatcagac ggtggtctca taattcctga caaggtctgg
     2101 gctgtacctg atagtctaaa ggcagatgct gttgtgcctg aattggcccc ctctgaaata
     2161 gcagcattgg ctcacagtcc agaggatgct gagtcagccc ttgctgatag cagagaaagc
     2221 cataaaggcg aagagcccac catcagtgta cactggagaa gtctttcttc ccggggtttc
     2281 agccaaccga gactcctgga gtcatccgtg gaccctgtag atgaaaagga gttatctgtc
     2341 acagattcac tgtcagcggc ttctgaaact ggagggaagg aaaatgttaa caatgtgagt
     2401 caagaccagg aggaaaaaca actcaagatg gatcacactg ccttctttaa aaagtttctg
     2461 acctgcccta aaatcctaga gtcctctgta gatcccattg atgagataag tgtgatagag
     2521 tacaccaggg ctggaaaacc agagccctct gaaaccacac cacagggcgc cagagaagga
     2581 ggtcaatcaa atgacggaaa catgggccac gaagcggaaa tccagtcggc cattttgcaa
     2641 gttccatgtc tccagggaac cattctgagt gaaaatagaa tcagcagaag ccaagaaggc
     2701 agtatgaagc aggaggcaga acaaattcaa cctgaggagg caaaaactgc catttggcaa
     2761 gtcctgcaac ccagcgaagg cggtgaaaga attccaagtg gatgtagcat aggccaaata
     2821 caagaaagca gtgatgggag cttaggggag gctgagcaaa gcaaaaagga caaagcagaa
     2881 ttgatttccc ccacttcacc tctttctagt tgtcttccaa taatgactca ctcttctctt
     2941 ggggttgaca cgcacaactc cacaggccaa attcatgacg tccctgaaaa tgacatagtt
     3001 gagcccagaa agcgtcagta tgtgtttcct gtttcacaga aaaggggaac tattgagaat
     3061 gagcgtggga aacctttgcc ctcttctcct gatcttacca ggttcccttg tacttcatct
     3121 cctgaaggaa atgtcacaga ctttttgata agccacaaaa tggaggaacc taaaatagag
     3181 gtgcttcaaa ttggggaaac caaaccccca agctcatcta gctcctcagc gaagaccttg
     3241 gcatttattt caggagaacg tgagttagag aaagccccta agttactgca ggatccatgt
     3301 caaaagggca ccctgggctg tgcgaaaaag tccagggaga gagagaagtc cctggaagcc
     3361 cgagcaggca aatcgccagg gaccctcaca gcagtgacgg ggtcagagga ggtcaagagg
     3421 aagccagaag ccccaggcag tggacattta gctgagggag taaagaagaa aattttgtcc
     3481 agggtggcag cactgaggct gaaactggaa gaaaaggaaa atatcagaaa gaactcagcc
     3541 tttcttaaaa agatgcccaa actcgaaaca tcattatcac acacagaaga gaaacaagac
     3601 ccaaaaaagc catcttgcaa aagagaagga agagctccag tattactgaa aaaaatccaa
     3661 gctgagatgt tccctgaaca ctctggaaat gtaaaattaa gctgccaatt tgcagaaatt
     3721 catgaagatt ctactatctg ctggacaaaa gattcaaagt ccatagccca agtgcagaga
     3781 agtgcagggg acaactccac tgtttccttt gccatcgtgc aagccagtcc gaaggaccag
     3841 ggactctatt actgctgcat caagaacagc tacggaaaag tgactgctga atttaacctc
     3901 acagctgaag ttctcaaaca gctgtcaagt cgccaggata ctaaaggatg tgaagagatt
     3961 gaattcagcc aactcatctt caaagaagac ttcctccatg acagctactt tgggggccgc
     4021 ctgcgtggtc agatcgccac ggaggagctg cactttggag aaggggttca ccgcaaagcc
     4081 ttccgcagca cagtgatgca cggcctcatg cctgtcttca aacctggcca tgcctgtgtg
     4141 cttaaggtgc acaatgccat tgcctatggg accagaaata atgatgagct catccaaagg
     4201 aactacaaac tcgctgccca ggaatgctat gttcaaaata ctgccaggta ttatgccaag
     4261 atctacgctg ctgaagcaca gcctctggaa ggctttggag aagtacctga gatcattcct
     4321 atttttctta tccatcggcc tgagaacaat atcccgtatg ctacagtgga ggaggagctg
     4381 attggagaat ttgtgaagta ttccatcagg gatgggaaag aaataaactt cttgagaaga
     4441 gaatcagaag ctggtcagaa atgttgcacc ttccagcact gggtgtacca gaaaacaagt
     4501 ggctgcctcc tggtgacgga catgcaaggt gtaggaatga agctaactga cgttggcata
     4561 gcaacgctgg ctaaagggta caagggattt aaaggcaact gttccatgac cttcattgat
     4621 cagtttaaag cactacacca gtgtaacaag tattgcaaaa tgctgggact gaaatccctt
     4681 caaaacaaca accagaaaca gaagcagccg agcattggga aaagcaaagt tcaaacaaac
     4741 tctatgacag taaagaaggc agggcctgag accccaggcg aaaagaaaac ctaacgtccc
     4801 tgggtaacct aatggccact ggctagcagc acacaatctc gccagggaaa atctgaggcc
     4861 acacaggaga gaatatacag cctgcagaga gtgcgtggca atccttaccc ccagccgact
     4921 gtgcgccaag atgcttctaa acccatcacc tgctgtcttc actcaaatga tttcagaaca
     4981 ggatttgcga ccaggtttat ggggagattg aatcaacgat tggtctcaaa gacaggccat
     5041 tctttatata cacgtttagc atttttacca acctcacatc atgtgtatat ttgtgtattt
     5101 gcacatggtt gtgctgtcga ggacctggtg ctgagaagag tctgttcaca gccaaaattc
     5161 ttcccactgt cattcctaac ctgggatttc tagacacatc ctgctgtgat gtaaacagaa
     5221 atcacgaatt cgctcactgg atcaagttgt tccactggtg tctaatacgc tattgttgcc
     5281 ggaggtgggt tctgtgacgt gaagccattt cccatcattc aacagccagt tacaattttc
     5341 tgtttaatta aattcatatt taaacaaaaa aaaaa
//