LOCUS AY044164 4281 bp mRNA linear HUM 28-AUG-2001
DEFINITION Homo sapiens lymphocyte alpha-kinase (LAK) mRNA, complete cds.
ACCESSION AY044164
VERSION AY044164.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4281)
AUTHORS Ryazanov,A.G., Pavur,K.S. and Dorovkov,M.V.
TITLE Alpha-kinases: a new class of protein kinases with a novel
catalytic domain
JOURNAL Curr. Biol. 9 (2), R43-R45 (1999)
PUBMED 10021370
REFERENCE 2 (bases 1 to 4281)
AUTHORS Ryazanova,L.V., Pavur,K.S., Petrov,A.N., Dorovkov,M.V. and
Ryazanov,A.G.
TITLE Novel type of signaling molecules: protein kinases covalently
linked with ion channels
JOURNAL Mol. Biol. (N.Y.) 35, 271-283 (2001)
REFERENCE 3 (bases 1 to 4281)
AUTHORS Ryazanov,A.G.
TITLE Direct Submission
JOURNAL Submitted (06-JUL-2001) Department of Pharmacology,
UMDNJ-R.W.Johnson Medical School, 675 Hoes Lane, Piscataway, NJ
08854, USA
FEATURES Location/Qualifiers
source 1..4281
/db_xref="H-InvDB:HIT000083762"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q25"
gene 1..4281
/gene="LAK"
CDS 83..3817
/gene="LAK"
/note="protein kinase"
/codon_start=1
/product="lymphocyte alpha-kinase"
/protein_id="AAK94675.1"
/translation="MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLP
SELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILAR
DCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGK
LLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIW
ASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLL
SAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEI
GLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNF
STSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQG
DFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQE
KPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNDE
GAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTA
LSEELENDREGRAMHSLRSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGI
FLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNIGTHPSVQK
EEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDA
PLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQ
LLDSTDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQP
GNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEA
RTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQET
IVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTA
QHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTK
VVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKV
FTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT"
BASE COUNT 1229 a 956 c 1046 g 1050 t
ORIGIN
1 ggctccttta ttgagaatca atgtcttctc ctaggtaatt gatcacccta gacccaggga
61 cacccaattc atcgtaatca tcatgaataa tcaaaaagtg gtagctgtgc tactgcaaga
121 gtgcaagcaa gtgctggatc agctcttgtt ggaagcgcca gatgtgtcgg aagaggacaa
181 gagcgaggac cagcgctgca gagctttact ccccagcgag ttaaggaccc tgatccagga
241 ggcaaaggaa atgaagtggc ccttcgtgcc tgaaaagtgg cagtacaaac aagccgtggg
301 cccagaggac aaaacaaacc tgaaggatgt gattggcgcc gggttgcagc agttactggc
361 gtccctgagg gcctccatcc tcgctcggga ctgtgcggct gcggcggcta ttgtgttctt
421 ggtggaccgg ttcctgtatg ggctcgacgt ctctggaaaa cttctgcagg tcgccaaagg
481 tctccacaag ttgcagccag ccacgccaat tgccccgcag gtggttattc gccaagcccg
541 aatctccgtg aactcaggaa aacttttaaa agcagagtat attctgagca gtctaataag
601 caacaatgga gcaacgggta cctggctgta cagaaatgaa agtgacaagg tcctggtgca
661 gtcggtctgt atacagatca gagggcagat tctgcaaaag ctgggtatgt ggtacgaagc
721 agcagagtta atatgggcct ccattgtagg atatttggca cttcctcagc cggataaaaa
781 gggcctctcc acgtcgctag gtatactggc agacatcttt gtttccatga gcaagaacga
841 ttatgaaaag tttaaaaaca atccacaaat taatttgagc ctgctgaagg agtttgacca
901 ccatttgctg tccgctgcag aagcctgcaa gctggcagct gccttcagtg cctatacgcc
961 gctcttcgtg ctcacagctg tgaatatccg tggcacgtgt ttattgtcct acagtagttc
1021 aaatgactgt cctccagaat tgaaaaactt acatctgtgt gaagccaaag aggcctttga
1081 gattggcctc ctcaccaaga gagatgatga gcctgttact ggaaaacagg agcttcacag
1141 ctttgtcaaa gctgctttcg gtctcaccac agtgcacaga aggctccatg gggagacagg
1201 gacggtccat gcagcaagtc agctctgtaa ggaagcaatg gggaagctgt acaatttcag
1261 cacttcctcc agaagtcagg acagagaagc tctgtctcaa gaagttatgt ctgtgattgc
1321 ccaggtgaag gaacatttac aagttcaaag cttctcaaat gtagatgaca gatcttatgt
1381 tcccgagagt ttcgagtgca ggttggataa acttatcttg catgggcaag gggatttcca
1441 aaaaatcctt gacacctatt cacagcacca tacttcggtg tgtgaagtat ttgaaagtga
1501 ttgtggaaac aacaaaaatg aacagaaaga tgcaaaaaca ggagtctgca tcactgctct
1561 aaaaacagaa ataaaaaaca tagatactgt gagtactact caagaaaagc cacattgtca
1621 aagagacaca ggaatatctt cctccctaat gggtaagaat gttcagaggg aactcagaag
1681 gggaggaagg agaaactgga cccattctga tgcatttcga gtctccttgg atcaagatgt
1741 ggagactgag actgagccat cggactacag caatgatgag ggagctgttt tcaacaagtc
1801 tctgagtggc agccagactt ccagtgcttg gagcaactta tcagggttta gttcctctgc
1861 aagctgggag gaagtgaatt atcacgttga cgacaggtca gccagaaaag agcctggcaa
1921 agaacatctg gtggacactc agtgttccac tgccttgtct gaggagctag agaatgacag
1981 ggaaggcaga gctatgcatt cattgcgttc acagcttcat gatctctctc ttcaggaacc
2041 caacaatgac aatttggagc cttctcaaaa tcagccacag caacagatgc ccttgacacc
2101 cttctcgcct cataataccc caggcatttt cttggcccct ggtgcagggc ttctagaagg
2161 agctccagaa ggtatccagg aagtcagaaa tatgggaccc agaaatactt ctgctcactc
2221 cagaccctca tatcgttctg cttcttggtc ttctgattct ggtaggccca agaatatagg
2281 cacacatcct tcagtccaaa aagaagaagc ctttgaaata attgttgagt ttccagaaac
2341 caactgcgat gtcaaagaca ggcaggggaa agagcaggga gaagaaatta gtgaaagagg
2401 cgcaggccct acatttaaag ctagtccctc ctgggttgac ccagaaggag aaacagcaga
2461 aagcactgaa gatgcaccct tagactttca cagggtcctg cacaattctc tgggaaacat
2521 ttccatgctg ccatgtagct ccttcacccc taattggcct gttcaaaatc ctgactccag
2581 aaaaagtggt ggcccagtcg cagagcaggg catcgaccct gatgcctcca cagtggatga
2641 ggaggggcaa ctgctcgaca gcacggatgt tccctgcaca aatgggcacg gctctcatag
2701 actgtgcatt ctgagacagc cgcctggtca gagggcggag acccccaatt cctctgtaag
2761 cggtaacatc ctcttccctg tcctcagcga ggactgcact accacagagg aaggaaatca
2821 gcctggaaac atgctaaact gcagccagaa ctccagctca tcctcagtgt ggtggctgaa
2881 atcacctgca ttttccagtg gttcttctga gggggacagc ccttggtcct atctgaattc
2941 cagtgggagt tcttgggttt cattgccggg aaagatgagg aaagagatcc ttgaggctcg
3001 caccttgcaa cctgatgact ttgaaaagct gttggcagga gtgaggcatg attggctgtt
3061 tcagagacta gagaatacgg gggtttttaa gcccagtcaa ctccaccgag cacatagtgc
3121 tcttttgtta aaatattcaa aaaaatctga actgtggacg gcccaggaaa ctattgtcta
3181 tttgggggac tacttgactg tgaagaaaaa aggcagacaa agaaatgctt tttgggttca
3241 tcatcttcat caagaagaaa ttctggggag gtatgttggg aaagactata aggagcagaa
3301 ggggctctgg caccacttca ctgatgtgga gcggcagatg accgcacagc actatgtgac
3361 agaatttaac aagagactct atgaacaaaa cattcccacc cagatattct acatcccatc
3421 cacaatacta ctgattttag aggacaagac aataaaggga tgtatcagtg tggagcctta
3481 catactggga gaatttgtaa aattgtcaaa taacacgaaa gtggtgaaaa cagaatacaa
3541 agccacagaa tatggcttgg cctatggcca tttttcttat gagttttcta atcatagaga
3601 tgttgtggtc gatttacaag gttgggtaac cggtaatgga aaaggactca tctacctcac
3661 agatccccag attcactccg ttgatcagaa agttttcact accaattttg gaaagagagg
3721 aattttttac ttctttaata accagcatgt ggaatgtaat gaaatctgcc atcgtctttc
3781 tttgactaga ccttcaatgg agaaaccatg cacatagaat acggcacagt ctggtccttt
3841 ggggcttggg cagggccgtg acacaggttc tggccaatga tttgcaagag gaattgatca
3901 gtatcacttt aagtcctgca tttaattggc agcacaagat cctgcagagc ctctttccct
3961 ctgccacagt tatcaagaat gggtcaggag accgctgctt ctgggcataa gtcctgcaag
4021 gaaagcaaca tggaaaacag ccccaactca cccatgaggg atgaaaagca ctcttgagaa
4081 aggcatgtgt tgtttaagcc attgagattt tagagctttt tgtcactatc tgtcaagact
4141 gatactactg gggcttttcc tattgatttg ggagttcttt acatattaaa aaaatgtgag
4201 cctttgtgat acgaattcaa tttgttttcc tgtcttttga catttgactt tgcataaaag
4261 tttatctgtg cataatttta a
//