LOCUS AY035376 1173 bp mRNA linear HUM 12-SEP-2001
DEFINITION Homo sapiens peptidoglycan recognition protein-I-alpha precursor
(PGLYRPIalpha) mRNA, complete cds.
ACCESSION AY035376
VERSION AY035376.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1173)
AUTHORS Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
TITLE Peptidoglycan recognition proteins: a novel family of four human
innate immunity pattern recognition molecules
JOURNAL J. Biol. Chem. 276 (37), 34686-34694 (2001)
PUBMED 11461926
REFERENCE 2 (bases 1 to 1173)
AUTHORS Liu,C., Xu,Z., Gupta,D. and Dziarski,R.
TITLE Direct Submission
JOURNAL Submitted (14-MAY-2001) Northwest Center for Medical Education,
Indiana University School of Medicine, 3400 Broadway, Gary, IN
46408, USA
FEATURES Location/Qualifiers
source 1..1173
/db_xref="H-InvDB:HIT000083504"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21; BAC 236c22"
gene 1..1173
/gene="PGLYRPIalpha"
/note="PGRPIalpha"
CDS 54..1079
/gene="PGLYRPIalpha"
/note="PGRP-I-alpha; member of PGRP family; innate
immunity pattern recognition molecule; contains 2
transmembrane domains, 2 extracellular domains, and 1
cytoplasmic domain"
/codon_start=1
/product="peptidoglycan recognition protein-I-alpha
precursor"
/protein_id="AAK72484.1"
/translation="MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPV
AYIITDQLPGMQCQQQSVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWN
IQGLHTQGYNNISLGIAFFGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLL
KEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVST
DCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIA
FIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIIS
TWPHFKH"
sig_peptide 54..104
/gene="PGLYRPIalpha"
misc_feature 294..377
/gene="PGLYRPIalpha"
/note="Region: conserved PGRP domain IV"
misc_feature 642..686
/gene="PGLYRPIalpha"
/note="Region: conserved PGRP domain III"
misc_feature 762..848
/gene="PGLYRPIalpha"
/note="Region: conserved PGRP domain II"
misc_feature 921..1070
/gene="PGLYRPIalpha"
/note="Region: conserved PGRP domain I"
BASE COUNT 250 a 364 c 297 g 262 t
ORIGIN
1 cctctcttcc agggctgccg tccacactct cccggtcaga gtcctgggac cacatgggga
61 cgctgccatg gcttcttgcc ttcttcattc tgggtctcca ggcttgggat actcccacca
121 tcgtctcccg caaggagtgg ggggcaagac cgctcgcctg cagggccctg ctgaccctgc
181 ctgtggccta catcatcaca gaccagctcc cagggatgca gtgccagcag cagagcgttt
241 gcagccagat gctgcggggg ttgcagtccc attccgtcta caccataggc tggtgcgacg
301 tggcgtacaa cttcctggtt ggggatgatg gcagggtgta tgaaggtgtt ggctggaaca
361 tccaaggctt gcacacccag ggctacaaca acatttccct gggcatcgcc ttctttggca
421 ataagatagg cagcagtccc agccctgctg ccttatcagc tgcagagggt ctgatctcct
481 atgccatcca gaagggtcac ctgtcgccca ggtatattca gccacttctt ctgaaagaag
541 agacctgcct ggaccctcaa catccagtga tgcccaggaa ggtttgcccc aacatcatca
601 aacgatctgc ttgggaagcc agagagacac actgccctaa aatgaacctc ccagccaaat
661 atgtcatcat catccacacc gctggcacaa gctgcactgt atccacagac tgccagactg
721 tcgtccgaaa catacagtcc tttcacatgg acacacggaa cttttgtgac attggatatc
781 acttcctggt gggccaggat ggtggcgtgt atgaaggggt tggatggcac atccaaggct
841 ctcacactta tggattcaac gatattgccc taggaattgc cttcatcggc tactttgtag
901 aaaagcctcc aaatgctgca gcgctggagg cggcccagga cctgatccag tgtgccgtgg
961 ttgaggggta cctgactcca aactacctgc tgatgggcca cagtgacgtg gtcaacatcc
1021 tgtcccctgg gcaggctttg tataacatca tcagcacctg gcctcatttc aagcactgaa
1081 ggaggcccca ctccctttga gactgccctc cctcccctgc tgggtctctc caaccctcac
1141 cagccaagct ggctcagcac cttgtgtccc cct
//