LOCUS AY032952 3500 bp mRNA linear HUM 28-SEP-2006
DEFINITION Homo sapiens nGAP-like protein (AF9q34) mRNA, complete cds.
ACCESSION AY032952
VERSION AY032952.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3500)
AUTHORS von Bergh,A.R., Wijers,P.M., Groot,A.J., van Zelderen-Bhola,S.,
Falkenburg,J.H., Kluin,P.M. and Schuuring,E.
TITLE Identification of a novel RAS GTPase-activating protein (RASGAP)
gene at 9q34 as an MLL fusion partner in a patient with de novo
acute myeloid leukemia
JOURNAL Genes Chromosomes Cancer 39 (4), 324-334 (2004)
PUBMED 14978793
REFERENCE 2 (bases 1 to 3500)
AUTHORS von Bergh,A.R.M., Wijers-Koster,P.M., Groot,A.J., Kluin,P.M. and
Schuuring,E.
TITLE Direct Submission
JOURNAL Submitted (23-APR-2001) Department of Pathology, Leiden University
Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
FEATURES Location/Qualifiers
source 1..3500
/db_xref="H-InvDB:HIT000083382"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
/note="acute myeloid leukemia patient"
gene 1..3500
/gene="AF9q34"
CDS 148..3345
/gene="AF9q34"
/note="MLL fusion partner"
/codon_start=1
/product="nGAP-like protein"
/protein_id="AAK50336.1"
/translation="MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQD
YCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLP
AKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKK
KERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPM
EMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSE
VDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK
CSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERL
ISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYM
SFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLE
QSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIEND
LSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSM
VDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQT
PTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSE
ELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPP
PPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPE
LKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQA
EKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKD
IQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQ
LKERYSMQARNGISPTNPTKLQITENGEFRNSSNC"
BASE COUNT 769 a 1109 c 1057 g 565 t
ORIGIN
1 tgttcctctt ctttcgtgtt gtgtcagaag ccatgatttc cagtcttctc atctggaaga
61 tgaaggaaaa gatagacccg accccacagg gttctgaggc tcaaactgaa agcctggtgg
121 tggggcacct gtgacaggtc ccatctgatg ccgaggctga aggagtctcg ctcccacgag
181 tccctgctca gccccagcag tgcggtggag gcgctggacc tcagcatgga ggaagaggtg
241 gtcatcaagc ccgtgcacag cagcatcctt ggccaggact actgcttcga ggtgacgacg
301 tcatcaggaa gcaagtgctt ttcctgccgg tctgcagctg agcgggataa gtggatggag
361 aacctccggc gagcggtgca tcccaacaag gacaacagcc ggcgtgtgga gcacatcctg
421 aagctgtggg tgatcgaggc caaggacctg ccagccaaga agaagtacct gtgcgagctg
481 tgcctggacg atgtgctcta tgcccgcacc acgggcaagc tcaagacgga caatgttttc
541 tggggcgagc acttcgagtt ccacaacttg ccgcctctgc gcacggtcac tgtccacctg
601 taccgggaga ccgacaagaa gaagaagaag gagcgcaaca gttacctggg cctggtgagc
661 ctacctgctg cctcggtggc cgggcggcag ttcgtggaga agtggtaccc ggtggtgacg
721 cccaacccca agggcggcaa gggccctgga cccatgatcc gcatcaaggc gcgctaccaa
781 accatcacca tcctgcccat ggagatgtac aaagagttcg ctgagcacat caccaaccac
841 tacctggggc tgtgtgcagc cctcgagccc atcctcagtg ccaagaccaa ggaggagatg
901 gcatctgccc tggtgcacat cctgcagagc acgggcaagg tgaaggactt cctgacagac
961 ctgatgatgt cagaggtgga ccgctgcggg gacaacgagc acctcatctt ccgggagaac
1021 acactggcca ccaaggccat tgaggagtac ctcaagctag tgggccagaa gtacctgcag
1081 gacgccctag gtgagttcat caaagcgctg tatgagtcag atgagaactg cgaagtggat
1141 cccagcaagt gctcggccgc tgacctccca gagcaccagg gcaacctcaa gatgtgctgc
1201 gagctggcct tctgcaagat catcaactcc tactgtgtct tcccacggga gttgaaagag
1261 gtgtttgcct cgtggaggca ggagtgcagc agtcgcggcc gcccggacat cagtgagcgg
1321 ctcatcagcg cctccctctt cctgcgcttc ctctgcccag ccatcatgtc gccctcactc
1381 ttcaacctgc tgcaggagta ccctgatgac cgcactgccc gcaccctcac cctcatcgcc
1441 aaggtcaccc agaacctggc caactttgcc aaatttggca gcaaggagga atacatgtcc
1501 ttcatgaacc agttcctaga gcatgagtgg accaacatgc agcgcttcct gctggagatc
1561 tccaaccccg agaccctctc caatacagcc ggcttcgagg gctacatcga cctgggccgc
1621 gagctctcca gcctgcactc actgctctgg gaggccgtca gccagctgga gcagagcata
1681 gtatccaaac tgggacccct gcctcggatc ctgagggacg tccacacagc actgagcacc
1741 ccaggtagcg ggcagctccc agggaccaat gacctggcct ccacaccggg ctctggcagc
1801 agcagcatct cagctgggct gcagaagatg gtgattgaga acgatctttc cggtctgata
1861 gatttcaccc ggttaccgtc tccaaccccc gaaaacaagg acttgttttt tgtcacaagg
1921 tcctccgggg tccagccctc acctgcccgc agctcgagtt actcggaagc caacgagcct
1981 gatcttcaga tggccaacgg tggcaagagc ctctccatgg tggacctcca ggacgcccgc
2041 acgctggatg gggaggcagg ctccccggcg ggccccgacg tcctccccac agatgggcag
2101 gccgctgcag ctcagctggt ggccgggtgg ccggcccggg caaccccagt gaacctggca
2161 gggctggcca cggtgcggcg ggcaggccag acaccaacca caccaggcac ctccgagggc
2221 gcgccaggcc ggccccagct gttggcaccg ctctccttcc agaaccctgt gtaccagatg
2281 gcggctggcc tgccgctgtc accccgtggc cttggcgact caggctctga gggccacagc
2341 tccctgagct cacacagcaa cagcgaggag ttggcggctg ctgccaagct gggaagtttc
2401 agcactgccg cggaggagct ggctcggcgg cccggtgagc tggcacggcg acagatgtca
2461 ctgactgaaa aaggcgggca gcccacggtg ccacggcaga acagtgctgg cccccagagg
2521 aggatcgacc agcctccgcc cccacccccg ccgccacctc ctgccccccg cggccggacg
2581 ccccccaacc tgctgagcac cctgcagtac ccaagaccct caagcggaac cctggcgtcg
2641 gcctcacctg attgggtggg ccccagtacc cgcctgaggc agcagtcctc ttcctccaag
2701 ggggacagcc cagaactgaa gccacgggca gtgcacaagc agggcccttc acctgtgagc
2761 cccaatgccc tggaccgcac agccgcttgg ctcttgacca tgaacgcgca gttgttagaa
2821 gacgagggcc tgggcccaga ccccccccac agggataggc taaggagtaa ggacgagctc
2881 agccaagcag aaaaggacct ggcggtgctg caggacaagc tgcgaatctc caccaagaag
2941 ctggaggagt atgagaccct gttcaagtgc caggaggaga cgacgcagaa gctggtgctg
3001 gagtaccagg cacggctgga ggagggcgag gagcggctgc ggcggcagca ggaggacaag
3061 gacatccaga tgaagggcat catcagcagg ttgatgtccg tggaggaaga actgaagaag
3121 gaccacgcag agatgcaagc ggctgtggac tccaaacaga agatcattga tgcccaggag
3181 aagcgcattg cctcgttgga tgccgccaat gcccgcctca tgagtgccct gacccagctg
3241 aaagagaggt acagcatgca agcccgtaac ggcatctccc ccaccaaccc caccaaattg
3301 cagattactg agaacggcga gttcagaaac agcagcaatt gttaacctgc ctgaggaggg
3361 aggaagctac ccaaggagag ggggactatg gtggccaagg gcagggtctc ggcctgggga
3421 ggcacccacg gttgcagccc cagcgcgggt gtcaggaggc cgagcctccc ctccctgccg
3481 ctgtccagga ggcggccgca
//