LOCUS AY029205 6843 bp mRNA linear HUM 24-AUG-2001
DEFINITION Homo sapiens protocadherin 15 (PCDH15) mRNA, complete cds.
ACCESSION AY029205
VERSION AY029205.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6843)
AUTHORS Alagramam,K.N., Yuan,H., Kuehn,M.H., Murcia,C.L., Wayne,S.,
Srisailpathy,C.R.S., Lowry,R.B., Knaus,R., Van Laer,L.,
Bernier,F.P., Schwartz,S., Lee,C., Morton,C.C., Mullins,R.F.,
Ramesh,A., Van Camp,G., Hagemen,G.S., Woychik,R.P. and Smith,R.J.H.
TITLE Mutations in the novel protocadherin PCDH15 cause Usher syndrome
type 1F
JOURNAL Hum. Mol. Genet. 10 (16), 1709-1718 (2001)
PUBMED 11487575
REFERENCE 2 (bases 1 to 6843)
AUTHORS Yuan,H., Alagramam,K.N., Kuehn,M., Murcia,C.L., Woychik,R.P. and
Smith,R.J.
TITLE Direct Submission
JOURNAL Submitted (03-APR-2001) Dept. of Otolaryngology, Univ. of Iowa, 200
Hawkins Drive, Iowa City, IA 52242, USA
FEATURES Location/Qualifiers
source 1..6843
/db_xref="H-InvDB:HIT000083325_02"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q11.2-q21"
gene 1..6843
/gene="PCDH15"
CDS 384..6251
/gene="PCDH15"
/codon_start=1
/product="protocadherin 15"
/protein_id="AAK31581.1"
/translation="MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIV
AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRV
LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELT
PVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK
RLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDSGPMFLPCVLVPNTRD
CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY
PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQS
PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS
VFTVTQTGITRYLTLLLPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT
FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT
IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE
ISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD
RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVK
ATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHP
RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI
RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV
IVKDMNDYPPVFSKQIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF
PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG
EIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGV
IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK
KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI
KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEK
KIEDLTEILDRYVREQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALL
ALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPP
PPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHK
SAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPF
SPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENE
NTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPH
FSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIET
ERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPP
SIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVC
ITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMY
SQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL"
BASE COUNT 2087 a 1498 c 1394 g 1864 t
ORIGIN
1 ctaatagcga cagatagagg gcagacagat tcctgctagc agcttagtgt tagttgcttg
61 tggtaactaa ggcaggtggc atacatctca gaacgtggag aatgatggta tgctttctga
121 gttaacatgt tgaactgttt tgcttttcta aaaattttcc tagtaacatt ttcttgatga
181 tatgagagtg gatatcaatg cctcacagaa acaagaggtg gaacatgtga atgaatcgtc
241 ttggaactag attatgagca ctggttcttt ttaaagggat gtgcaagagg cagccttggc
301 aagaaaactt gctgcataat cttacatgga ctaaagatga aactttaaac cgcaaatcag
361 ctttgagtga actttgacag aagatgtttc gacagtttta tctctggaca tgtttagctt
421 cagggatcat cctgggctct ctctttgaaa tctgcttggg ccagtatgat gatgattgca
481 aactagctag gggaggacca ccagctacca tagttgctat tgatgaagaa agtcggaatg
541 gtacaattct ggtggacaac atgctgatca aagggactgc tggaggacca gaccccacca
601 tagaactttc tttaaaggat aatgtggatt actgggtgtt gatggatcct gttaagcaaa
661 tgcttttcct gaacagcacc ggaagagttc tggatagaga tccaccgatg aacatacact
721 ccattgtggt gcaggtccag tgcatcaaca aaaaagtggg cactattatc taccatgaag
781 tgcgaatagt ggtgagagac aggaatgaca actcacccac tttcaagcat gaaagctact
841 atgccacagt gaatgagctc actccagttg gtaccacaat attcacagga ttttcaggag
901 acaatggagc tacagatata gatgatggac caaatggaca gatagagtat gttattcagt
961 ataatccaga tgatccgaca tccaatgaca cctttgaaat tcccctaatg ttgactggaa
1021 atatagtgtt aaggaagagg ctcaactatg aagataagac tcgctacttt gtcataatcc
1081 aagctaatga ccgtgcccaa aatctgaatg agaggcgaac caccaccacc actctcacag
1141 tggatgttct ggatggagat gactcgggtc caatgtttct tccttgtgtc cttgtgccaa
1201 acactcgtga ttgccgtcca ctcacttatc aagctgccat acctgagttg agaactccgg
1261 aagaactgaa ccccattatt gttacgccac caatccaagc cattgatcag gaccggaata
1321 ttcaaccgcc atcagatagg ccaggaatcc tctattccat ccttgttggg actcctgagg
1381 attacccacg atttttccat atgcatccta ggacagcaga acttagtctc ctggagccag
1441 taaacagaga ctttcaccag aaatttgatt tggttattaa ggctgaacaa gacaatggtc
1501 atcctcttcc tgcctttgcc ggtctacaca ttgaaatact ggatgaaaac aatcaaagtc
1561 catattttac aatgcccagt tatcaaggct atatcctgga atctgcccca gtgggagcaa
1621 ccatttcgga cagtctcaat ttgacttcac ctttaagaat agtagctctg gacaaggaca
1681 tagaagatac caaagaccca gagcttcacc tttttctgaa tgactacacc tcagtcttca
1741 ccgtcacaca gactggtatt actcgctacc tcaccttact tctaccagtg gacagggaag
1801 aacagcaaac ttacaccttt tcgataacag catttgatgg tgtacaagaa agtgagccag
1861 tcatcgtcaa tattcaagtg atggatgcaa atgataacac gccaaccttc cctgaaatat
1921 cctatgatgt gtatgtttat acagacatga gacctgggga cagtgtcata cagctcactg
1981 cagtcgacgc agacgaaggg tcaaatgggg agatcacata tgaaatcctt gttggggctc
2041 agggagactt catcatcaat aaaacaacag ggcttatcac catcgctcca ggggtggaaa
2101 tgatagtcgg gcggacttac gcactcacgg tccaagcagc ggataatgct cctcctgcag
2161 agcgaaggaa ctccatctgc actgtgtata ttgaagtgct tccaccaaat aatcaaagcc
2221 ctcctcgctt cccacagctg atgtatagcc ttgaaattag tgaagccatg agggttggtg
2281 ctgttttatt aaatctacag gcaactgatc gagagggaga ctcaataaca tatgccattg
2341 agaatggaga tcctcagaga gtttttaatc tttcagaaac cacggggatt ctaaccttag
2401 ggaaagcact ggacagggaa agcactgatc gctacattct gatcatcaca gcttcagatg
2461 gcaggccaga tgggacctca actgccacag taaacatagt ggtgacagat gtcaatgaca
2521 atgctccagt gtttgatcct tatctgccaa gaaatttatc tgtggtggaa gaagaagcca
2581 atgcctttgt gggtcaagta aaagcaacag accctgatgc tggaataaat ggtcaagtgc
2641 actacagttt gggtaacttt aataatcttt ttcgtatcac atccaatggg agcatttaca
2701 cagcagtgaa gcttaacaga gaagtcaggg actactatga acttgttgtt gtggcaacag
2761 atggagcagt acaccctcgt cattcaactc taaccttggc catcaaggtt ttggacattg
2821 atgataacag tcctgtgttc accaattcaa catacactgt ccttgttgaa gagaatttgc
2881 cagctgggac taccatcctt caaatagagg ccaaagatgt cgaccttgga gcaaatgtgt
2941 cttaccggat aagaagccca gaagtgaagc acttttttgc actacatcca tttacaggag
3001 aactatcgct tttaaggagt ttagattatg aggcatttcc agaccaagaa gcaagtatca
3061 cttttctggt agaggccttt gatatttatg gaacaatgcc acctggtatt gctactgtca
3121 cagtgattgt aaaggatatg aatgattatc ctcctgtctt tagtaaacaa atatacaaag
3181 ggatggtggc tccggatgca gtcaagggta cacctatcac aacagtttat gctgaagatg
3241 cagaccctcc tggattacct gcaagtcgtg tgaggtatag agtagatgat gtacagtttc
3301 cttaccctgc cagtattttt gaagtggaag aagattctgg aagagtaata acacgagtca
3361 atcttaatga agaacctaca acaattttta agttggtggt ggttgctttt gatgatgggg
3421 agcctgtgat gtccagcagt gccacagtga agattcttgt cttacatcct ggtgagatcc
3481 cacgcttcac acaggaggaa tatagacctc ctccagtaag tgaacttgcc accaaaggga
3541 ccatggttgg tgtaatttct gctgctgcca ttaatcaaag tattgtgtac tccattgttt
3601 caggaaatga agaagataca tttggaatta ataacatcac aggtgttatc tatgtgaatg
3661 gacctctgga ttatgagacc aggacaagct atgtacttcg agtccaagct gattccctgg
3721 aagtggtcct tgccaatctc cgagttcctt caaaaagcaa tacagctaaa gtatacattg
3781 agattcagga tgaaaataat catcccccag tgtttcagaa aaaattctac atcggaggtg
3841 tatctgaaga tgcaagaatg tttacttctg tactcagagt gaaggctact gataaagata
3901 ctggcaatta tagtgtcatg gcctacagac tcataatacc accaattaaa gagggaaaag
3961 aaggatttgt agtggaaaca tatacagggc ttatcaaaac tgctatgctc ttccataata
4021 tgaggagatc ctacttcaag tttcaagtta ttgcaactga cgactatggg aagggactga
4081 gcggcaaagc cgatgtactc gtctccgtgg tcaatcagct ggatatgcaa gtcattgttt
4141 ccaatgtgcc tcctactcta gtggaaaaaa agatagaaga tcttacagag atcttggatc
4201 gctatgttcg ggaacaaatt cctggtgcca aggtcgtagt ggagtccatt ggagctcgcc
4261 ggcatggaga tgccttttcc ctagaagatt acaccaaatg tgacttgact gtctatgcaa
4321 ttgaccccca aaccaacaga gccatcgata gaaatgagct ttttaaattt ttggatggca
4381 aactacttga tatcaataaa gactttcagc cgtattatgg ggaaggagga cgcattctgg
4441 agatccggac tccagaggca gtgaccagca ttaaaaagag aggagaaagt ctaggataca
4501 cagaaggggc cttgttggct ctggccttca tcatcatcct ctgctgcatt cctgccatct
4561 tggtggtttt ggtcagctac agacagttta aagtacgtca agctgagtgt acaaagactg
4621 cacgaattca ggccgcatta cccgcggcta aaccagcagt gccggctcct gcaccagtgg
4681 cagcgccccc gccgccgccg ccgcctccgc caggtgcgca tctctatgaa gaacttggag
4741 acagctcaat tcttttcctt ctctaccatt ttcaacaaag caggggaaat aactcagtct
4801 cagaagacag gaaacatcaa caagttgtga tgcccttttc ttccaatact attgaggctc
4861 acaagtcagc tcatgtagac ggatcactta agagcaacaa actgaagtct gcaagaaaat
4921 tcacatttct atctgatgag gatgacttaa gtgcccataa tcccctttat aaggaaaaca
4981 taagtcaagt atcaacaaat tcagacattt cacagagaac agattttgta gacccatttt
5041 cacccaaaat acaagccaag agtaagtctc tgaggggccc aagagaaaag attcagaggc
5101 tgtggagtca gtcagtcagc ttacccagga ggctgatgag gaaagttcca aatagaccag
5161 agatcataga tctgcagcag tggcaaggca ccaggcagaa agctgaaaat gaaaacactg
5221 gaatctgtac aaacaaaaga ggtagcagca atccattgct tacaactgaa gaggcaaatt
5281 tgacagagaa agaggaaata aggcaaggtg aaacactgat gatagaagga acagaacagt
5341 tgaaatctct ctcttcagac tcttcatttt gctttcccag gcctcacttc tcattctcca
5401 ctttgccaac tgtttcaaga actgtggaac tcaaatcaga acctaatgtc atcagttctc
5461 ctgctgagtg ttccttggaa ctttctcctt caaggccttg tgttttacat tcttcactct
5521 ctaggagaga gacacctatt tgtatgttac ctattgaaac cgaaagaaat atttttgaaa
5581 attttgccca tccaccaaac atctctcctt ctgcctgtcc ccttccccct cctcctccta
5641 tttctcctcc ttctcctcct cctgctcctg ctcctcttgc tcctcctcct gacatttctc
5701 ctttttctct tttttgtcct cctccctctc ctccttctat ccctcttcct cttcctcctc
5761 ctacattttt tccactttcc gtttcaacgt ctggtccccc aacaccacct cttctacctc
5821 catttccaac tcctcttcct ccaccacctc cttctattcc ttgccctcca cctccttcag
5881 cttcatttct gtccacagag tgtgtctgta taacaggtgt taaatgcacg accaacttga
5941 tgcctgccga gaaaattaag tcctctatga cacagctatc aacaacgaca gtgtgtaaaa
6001 cagaccctca gagagaacca aaaggcatcc tcagacacgt taaaaactta gcagaacttg
6061 aaaaatcagt agctaacatg tacagtcaaa tagaaaaaaa ctatctacgc acaaatgttt
6121 cagaacttca aactatgtgc ccttcagaag taacaaatat ggaaatcaca tctgaacaaa
6181 acaaggggag tttgaacaat attgtcgagg gaactgaaaa acaatctcac agtcaatcta
6241 cttcactgta atgttgcttt tcttatttta gtcgggcaaa cctcttgttg atcatagtct
6301 tcaagttgaa catcaaattt gaacgtcaaa gaagactcta ttattttacc ccaaattcaa
6361 tgaaatgcag ttttttttct cgtttttaat ttaaaaagat attaacctca tcactactaa
6421 ctcactcata taatagattt accttacttt ttaaaaacta caaagtagca taatttgttc
6481 tacatttatt tgaaaagtaa gtaattttaa tctctttttt agtgggaata tgtgggcatg
6541 aaaattagat acccaactta aaccaaaggc atgtctatca tgtggatgca gtaacattta
6601 catttagttt ttgatcgtag ttttatatga atgttccaag aaaaaagcag actgttacaa
6661 ataagttaaa actgatatga ttgataggtt ctgttttttc ttgaagccta tgtatttggt
6721 aagaagaaat actaccgaag taaaatataa tgtacctaga ttgtaggaga tgacagacat
6781 aaggtatttc aaaataaatc tcaggtgcta taacataaaa aaaaaaaaaa aaaaaaaaaa
6841 aaa
//