LOCUS AY028896 3949 bp mRNA linear HUM 11-JUN-2001
DEFINITION Homo sapiens caspase recruitment domain protein 10 mRNA, complete
cds.
ACCESSION AY028896
VERSION AY028896.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3949)
AUTHORS Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
Bertin,J.
TITLE Card10 is a novel caspase recruitment domain/membrane-associated
guanylate kinase family member that interacts with BCL10 and
activates NF-kappa B
JOURNAL J. Biol. Chem. 276 (24), 21405-21409 (2001)
PUBMED 11259443
REFERENCE 2 (bases 1 to 3949)
AUTHORS Wang,L., Guo,Y., Nir,W.-J., Poyet,J.-L., Manji,G.A., Merriam,S.,
Glucksmann,A., DiStefano,P.S., Alnemri,E.S. and Bertin,J.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-2001) Neurobiology, Millennium Pharmaceuticals
Inc., 640 Memorial Drive, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..3949
/db_xref="H-InvDB:HIT000083300"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 41..3139
/note="CARD10; CARD/MAGUK family member; binds to Bcl10
and activates NF-kappaB"
/codon_start=1
/product="caspase recruitment domain protein 10"
/protein_id="AAK26165.1"
/translation="MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNP
AKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEF
YYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQAR
GRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSE
EKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDN
VDLVSELRAENQQLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQE
LCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIE
KERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQ
LQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEE
ATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGL
SSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFY
GDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSL
MDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYK
RRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALD
QLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLA
PRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQES
VGKKHCLLELGARGVRERVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQC
RGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSS
EA"
misc_feature 131..391
/note="Region: CARD domain"
misc_feature 452..1408
/note="Region: coiled-coil domain"
misc_feature 1859..2080
/note="Region: PDZ domain"
misc_feature 2150..2356
/note="Region: SH3 domain"
misc_feature 2537..3094
/note="Region: GUK domain"
BASE COUNT 724 a 1222 c 1319 g 684 t
ORIGIN
1 ccccgtgcgc ctcttgcccg cagaccctga ggacacggcc atgccgggcc gggcggaggc
61 gggggaggcc gaggaggagg ccggggccgg ctcggggtct gaggcggagg aggacgcgct
121 gtgggagcga atcgagggcg tccggcatcg gctggctcgc gccctgaacc cggccaagct
181 cacgccgtat ctgcgccagt gccgggtcat cgacgagcag gacgaggagg aggtgctgag
241 cacctaccgc ttcccgtgcc gcgtcaaccg caccgggcgc ctgatggaca tcttgcgctg
301 ccgtggcaag aggggctatg aggccttcct ggaagccctg gagttctact accccgaaca
361 cttcacgctg ctcacgggcc aggaacccgc ccagcgctgc tccatgatcc tcgatgagga
421 ggggcctgag ggcctgaccc aattcttgat gacagaggtg cgacggctgc gggaagctcg
481 caagagccag ctgcagcggg agcagcaact gcaggcccgg ggccgggtgc tcgaggagga
541 gcgggcaggg ctggagcagc ggctgcggga ccagcagcag gctcaggagc gctgtcaacg
601 gctgcgggag gactgggagg cgggcagcct ggagctgctg cggctcaagg atgagaacta
661 catgatcgcc atgcgcctgg cacagctcag tgaggagaag aactcggctg tacttcgcag
721 ccgtgacctg cagctggcgg tggatcagct caagctcaaa gtgagtcggc tggaggaaga
781 gtgtgcactg cttcgaaggg ccaggggccc gccccctggg gcagaggaga aggagaagga
841 gaaggagaag gagaaggagc cagacaatgt ggaccttgtc tctgagctgc gtgctgagaa
901 ccagcagctg acggcgtcac tgcgggagtt gcaggagggc ctgcagcagg aggcgagccg
961 gccgggggcc ccgggctccg agcgcatcct gctggacatc ctagagcatg actggcggga
1021 ggcgcaggac agcaggcagg agctgtgcca gaagctgcat gccgtgcagg gggagctgca
1081 gtgggccgag gagctgcgcg accagtacct gcaggagatg gaagacctgc ggctcaagca
1141 ccgcacgctg cagaaggact gtgacctgta caagcaccgc atggccactg tcctggccca
1201 actggaggag attgagaagg agcgagacca ggccatccag agccgtgacc ggatccagtt
1261 gcagtactca cagagcctca tcgagaagga ccagtaccgc aagcaggtgc ggggcctgga
1321 ggcggagcgg gatgagctgc tgacaacgct caccagcctg gagggcacca aggctctgct
1381 ggaggttcag ctgcagcggg cccagggtgg cacctgcctc aaggcctgtg cctcctccca
1441 ttccctgtgc tccaacctca gcagcacttg gagcctgagc gagttcccct cccctctggg
1501 aggcccagaa gcaactgggg aggcagctgt catgggggga cctgagcctc acaactcgga
1561 ggaagccaca gacagtgaaa aggagatcaa tcggctctcc atcctgccct tcccccccag
1621 tgccggctcc atcctccgcc ggcagcgtga ggaagacccc gcacccccta agagatcctt
1681 cagcagcatg tcagacatca cagggagtgt gacacttaag ccctggtccc ctggcctctc
1741 ttcgtcctca tcctctgaca gcgtgtggcc tttgggaaag ccggaaggcc tcctggctcg
1801 gggctgtggc ctggacttcc tcaacaggtc tctggctatt cgggtgtctg gccggagccc
1861 cccagggggc ccagagccgc aggacaaggg accagatgga ctgtcgtttt atggggacag
1921 atggtctggg gctgtggtgc gcagggtgct gtctgggcct gggtccgcca ggatggaacc
1981 aagagagcaa agggtggaag ctgctggtct ggagggggcg tgcctggaag ccgaggccca
2041 gcagagaacc ttgctctgga atcaggggtc cacactcccc tccctgatgg actcgaaggc
2101 ctgccagtcc ttccacgagg ccctagaagc ctgggcaaag ggaccaggtg ccgagccctt
2161 ctacattcgt gccaacctca ccttgcctga gagggcagat ccccatgccc tttgcgtgaa
2221 agcccaagag atccttcgac tggtggactc ggcatacaag cggaggcagg aatggttctg
2281 cacccgggtt gaccccctca ctctgcggga cctggaccgg ggcaccgtgc ccaattatca
2341 gagagcccag cagctcctag aagttcagga gaaatgcctg ccctccagcc ggcaccgagg
2401 cccccgcagt aatctgaaga agagagccct ggaccagctg cggctggtga ggcccaagcc
2461 cgtgggggcg cctgcagggg actccccgga tcagctgctg ctggagccct gtgcagagcc
2521 ggagcggagc ctcagaccct acagtttggt gcggccgcta ctggtgtctg ccctgcggcc
2581 cgtggtgctg ttgcctgagt gcctggcgcc ccggctcatc cgtaacctgc tagacctgcc
2641 cagctcccgg ctggacttcc aagtgtgccc agcggaaagc ctctctgggg aggaactgtg
2701 cccatcctca gcgcctggag cccccaaggc tcagcctgcc acccctgggc taggcagcag
2761 gatccgggcc atccaggagt ctgttgggaa gaagcactgc ctgctggagc tgggtgctcg
2821 gggtgtgcgg gagcgggtgc agaacgagat ctaccccatc gtcatccacg tggaggtgac
2881 tgagaagaat gtccgggaag tcaggggtct gctgggccgg ccgggctggc gggactcaga
2941 gctgctgcgg cagtgccgtg gctcagagca ggtgctctgg gggctgccct gctcctgggt
3001 gcaggtgccc gcccatgagt ggggacacgc agaggagctg gccaaggtgg tgcgcggccg
3061 catcctgcag gagcaggccc gcctcgtgtg ggtggagtgc ggcagcagca gaggctgccc
3121 cagcagcagt gaggcctgag gctcatctga tacctgcacc ttctccccaa gccagcgtgg
3181 accctggtgt ctatggtgaa gctgggccct cccaccctga gccttcctag acccttggac
3241 tctcagatgc agggcccttg gctctggcct ctcaccccca aggctgtctc tggccctgcc
3301 gagcctatgg gagtcccggg acagagtgcc cactcccctc tacttgctgc tctgggcctc
3361 cccacctttc ctggggtctc cacattccca ctagtgggtc ttatgtgtgt ctgtgtcttc
3421 tccttaaaca ctcgccctgg agtctgttct cacacctgtg cgcaggtttg cacactcaag
3481 ttctcatggg caggctcagg tctgtcccgc tgccctgggc acgaggtctc ctgaggacct
3541 gggcctgttc tgctcctagg agacctgagc ccgttaccgc gtgactccca ccatccagct
3601 cgcgctcctc gtggattcag ccatgcatgg actggggtgt tccctggccc atggtcacct
3661 gtgcccctcg tgtctcctca catgggtgtc tgtggttctc tcctgtgtaa atgtcacgcc
3721 ccacccctgt ttcatgtggg cactaacacg tgtgcgttcc tggcgggcac acacaggacc
3781 gtgcctcaca gggcccactc cctgcctatg cctccctctt ggggggccga ggagggcggc
3841 tgctctgtca tgagaatgta cggcccgtgg atgattaacg ggcctttttc acttagaagc
3901 tgcacattat ggagcattaa acacttttgt cataaaaaaa aaaaaaaaa
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