LOCUS       AY026038                 549 bp    mRNA    linear   HUM 11-NOV-2001
DEFINITION  Homo sapiens K-Cl cotransporter (SLC12A4) mRNA, partial cds.
ACCESSION   AY026038
VERSION     AY026038.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Casula,S., Shmukler,B.E., Wilhelm,S., Stuart-Tilley,A.K., Su,W.,
            Chernova,M.N., Brugnara,C. and Alper,S.L.
  TITLE     A dominant negative mutant of the KCC1 K-Cl cotransporter: both N-
            and C-terminal cytoplasmic domains are required for K-Cl
            cotransport activity
  JOURNAL   J. Biol. Chem. 276 (45), 41870-41878 (2001)
   PUBMED   11551954
REFERENCE   2  (bases 1 to 549)
  AUTHORS   Shmukler,B.E., Wilhelm,S. and Alper,S.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2001) Molecular Medicine Unit, Beth Israel
            Deaconless Medical Center, 330 Brookline Ave., RW-663, Boston, MA
            02215, USA
FEATURES             Location/Qualifiers
     source          1..549
                     /db_xref="H-InvDB:HIT000083221"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
                     /cell_line="293T"
     gene            <1..549
                     /gene="SLC12A4"
                     /gene_synonym="KCC1"
     CDS             <1..294
                     /gene="SLC12A4"
                     /gene_synonym="KCC1"
                     /note="cotransporter; exon 18 deletion terminates product
                     inside exon 19"
                     /codon_start=1
                     /product="K-Cl cotransporter"
                     /protein_id="AAK01946.1"
                     /translation="PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIV
                     GSVIQGSFLESYGEAQAAEQTPCAALRLPTWPCSCPRTSPSTPATTSATWRAT"
BASE COUNT          111 a          168 c          163 g          107 t
ORIGIN      
        1 cctcctcaca ccaagaactg gcggccgcag ctgctggtgc tgctgaagct ggacgaggac
       61 ctccacgtga agtacccgcg gctcctcacc ttcgcctccc agctcaaggc tggcaagggc
      121 ctgaccattg ttggttctgt catccagggg agcttcttgg agagctatgg cgaggctcag
      181 gccgccgagc agacaccgtg cgctgcacta cggctgccca cctggccctg ctcgtgccca
      241 agaacatcgc cttctacccc agcaaccacg agcgctacct ggagggccac atagacgtgt
      301 ggtggatcgt gcacgatggt ggcatgctca tgcttctgcc cttcctgctg cgccagcata
      361 aggtctggag gaagtgccgg atgcgcatct tcacagtggc ccagatggat gacaacagca
      421 tccagatgaa gaaggacctg gctgtctttc tgtaccatct gcgccttgag gccgaggtgg
      481 aggtggtgga gatgcataac agtgacatct ctgcatacac ctacgagcgg acactgatga
      541 tggagcagc
//