LOCUS AY024365 1422 bp mRNA linear HUM 22-MAR-2001
DEFINITION Homo sapiens integrin-linked kinase-associated serine/threonine
phosphatase 2C mRNA, complete cds.
ACCESSION AY024365
VERSION AY024365.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1422)
AUTHORS Leung-Hagesteijn,C., Mahendra,A., Naruszewicz,I. and Hannigan,G.E.
TITLE Modulation of integrin signal transduction by ILKAP, a protein
phosphatase 2C associating with the integrin-linked kinase, ILK1
JOURNAL EMBO J. 20 (9), 2160-2170 (2001)
PUBMED 11331582
REFERENCE 2 (bases 1 to 1422)
AUTHORS Leung-Hagesteijn,C. and Hannigan,G.E.
TITLE Direct Submission
JOURNAL Submitted (25-JAN-2001) Research Institute, Hospital for Sick
Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
FEATURES Location/Qualifiers
source 1..1422
/db_xref="H-InvDB:HIT000083220"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="isolated by two-hybrid screen for ILK1-interacting
proteins"
CDS 102..1280
/function="negative regulator of ILK1 kinase activity and
signaling"
/note="ILKAP; similar to Rattus norvegicus PP2C"
/codon_start=1
/product="integrin-linked kinase-associated
serine/threonine phosphatase 2C"
/protein_id="AAK07736.1"
/translation="MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGG
PLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASS
VIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRAS
KFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGST
ATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGG
NVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTP
EEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
"
BASE COUNT 343 a 348 c 411 g 320 t
ORIGIN
1 ggcaccaggc ccgctgctgc cgcccgcccg gggtgtggag cccggccgct gctcgcgggc
61 tgagtgtctg tcgctgctgc cgcctccacc cagcctccgc catggacctc ttcggggacc
121 tgccggagcc cgagcgctcg ccgcgcccgg ctgccgggaa agaagctcag aaaggacccc
181 tgctctttga tgacctccct ccggccagca gtactgactc aggatcaggg ggacctttgc
241 tttttgatga tctcccaccc gctagcagtg gcgattcagg ttctcttgcc acatcaatat
301 cccagatggt aaagactgaa gggaaaggag caaagagaaa aacctccgag gaagagaaga
361 atggcagtga agagcttgtg gaaaagaaag tttgtaaagc ctcttcggtg atctttggtc
421 tgaagggcta tgtggctgag cggaagggtg agagggagga gatgcaggat gcccacgtca
481 tcctgaacga catcaccgag gagtgtaggc ccccatcgtc cctcattact cgggtttcat
541 attttgctgt ttttgatgga catggaggaa ttcgagcctc aaaatttgct gcacagaatt
601 tgcatcaaaa cttaatcaga aaatttccta aaggagatgt aatcagtgta gagaaaaccg
661 tgaagagatg ccttttggac actttcaagc atactgatga agagttcctt aaacaagctt
721 ccagccagaa gcctgcctgg aaagatgggt ccactgccac gtgtgttctg gctgtagaca
781 acattcttta tattgccaac ctcggagata gtcgggcaat cttgtgtcgt tataatgagg
841 agagtcaaaa acatgcagcc ttaagcctca gcaaagagca taatccaact cagtatgaag
901 agcggatgag gatacagaag gctggaggaa acgtcaggga tgggcgtgtt ttgggcgtgc
961 tagaggtgtc acgctccatt ggggacgggc agtacaagcg ctgcggtgtc acctctgtgc
1021 ccgacatcag acgctgccag ctgaccccca atgacaggtt cattttgttg gcctgtgatg
1081 ggctcttcaa ggtctttacc ccagaagaag ccgtgaactt catcttgtcc tgtctcgagg
1141 atgaaaagat ccagacccgg gaagggaagt ccgcagccga cgcccgctac gaagcagcct
1201 gcaacaggct ggccaacaag gcggtgcagc ggggctcggc cgacaacgtc actgtgatgg
1261 tggtgcggat agggcactga ggggtggcgc gcggccagga gcacgcatgg tattgactta
1321 aaaggttcat tttgtgtgtg tgcacattgt gtgttttgtg tactcctgtg ggactcccat
1381 ggttgtaaat aaaggtttct cttttttttc ctaaaaaaaa aa
//