LOCUS AY017168 2247 bp mRNA linear HUM 25-SEP-2002
DEFINITION Homo sapiens ABC transporter ABCG2 (ABCG2) mRNA, complete cds.
ACCESSION AY017168
VERSION AY017168.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2247)
AUTHORS Zhou,S., Schuetz,J.D., Bunting,K.D., Colapietro,A.M., Sampath,J.,
Morris,J.J., Lagutina,I., Grosveld,G.C., Osawa,M., Nakauchi,H. and
Sorrentino,B.P.
TITLE The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of
stem cells and is a molecular determinant of the side-population
phenotype
JOURNAL Nat. Med. 7 (9), 1028-1034 (2001)
PUBMED 11533706
REFERENCE 2 (bases 1 to 2247)
AUTHORS Schuetz,J.D., Wall,A.M., Sampath,J., Sorrentino,B. and Du,G.
TITLE The Human ABC Transporter, ABCG2, Transports Hoechst 33342 and
Requires an Intact Walker A Motif
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 2247)
AUTHORS Schuetz,J.D., Wall,A.M., Sampath,J., Sorrentino,B. and Du,G.
TITLE Direct Submission
JOURNAL Submitted (02-JAN-2001) Pharmaceutical Sciences, St. Jude
Children's Research Hospital, 332 North Lauderdale, Memphis, TN
38105, USA
FEATURES Location/Qualifiers
source 1..2247
/db_xref="H-InvDB:HIT000083213"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q22"
gene 1..2247
/gene="ABCG2"
CDS 194..2161
/gene="ABCG2"
/codon_start=1
/product="ABC transporter ABCG2"
/protein_id="AAG52982.1"
/translation="MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICY
RVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGL
SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER
INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDS
STANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGY
FESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAE
IYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNP
QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVV
EKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKAKADAFFV
MMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLS
WLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPW
GLWKNHVALACMIVIFLTIAYLKLLFLKKYS"
BASE COUNT 646 a 471 c 483 g 647 t
ORIGIN
1 accgtgcaca tgcttggtgg tcttgttaag tggaaactgc tgctttagag tttgtttgga
61 aggtccgggt gactcatccc aacatttaca tccttaattg ttaaagcgct gcctccgagc
121 gcacgcatcc tgagatcctg agcctttggt taagaccgag ctctattaag ctgaaaagat
181 aaaaactctc cagatgtctt ccagtaatgt cgaagttttt atcccagtgt cacaaggaaa
241 caccaatggc ttccccgcga cagcttccaa tgacctgaag gcatttactg aaggagctgt
301 gttaagtttt cataacatct gctatcgagt aaaactgaag agtggctttc taccttgtcg
361 aaaaccagtt gagaaagaaa tattatcgaa tatcaatggg atcatgaaac ctggtctcaa
421 cgccatcctg ggacccacag gtggaggcaa atcttcgtta ttagatgtct tagctgcaag
481 gaaagatcca agtggattat ctggagatgt tctgataaat ggagcaccgc gacctgccaa
541 tttcaaatgt aattcaggtt acgtggtaca agatgatgtt gtgatgggca ctctgacggt
601 gagagaaaac ttacagttct cagcagctct tcggcttgca acaactatga cgaatcatga
661 aaaaaacgaa cggattaaca gggtcattca agagttaggt ctggataaag tggcagactc
721 caaggttgga actcagttta tccgtggtgt gtctggagga gaaagaaaaa ggactagtat
781 aggaatggag cttatcactg atccttccat cttgttcttg gatgagccta caactggctt
841 agactcaagc acagcaaatg ctgtcctttt gctcctgaaa aggatgtcta agcagggacg
901 aacaatcatc ttctccattc atcagcctcg atattccatc ttcaagttgt ttgatagcct
961 caccttattg gcctcaggaa gacttatgtt ccacgggcct gctcaggagg ccttgggata
1021 ctttgaatca gctggttatc actgtgaggc ctataataac cctgcagact tcttcttgga
1081 catcattaat ggagattcca ctgctgtggc attaaacaga gaagaagact ttaaagccac
1141 agagatcata gagccttcca agcaggataa gccactcata gaaaaattag cggagattta
1201 tgtcaactcc tccttctaca aagagacaaa agctgaatta catcaacttt ccgggggtga
1261 gaagaagaag aagatcacag tcttcaagga gatcagctac accacctcct tctgtcatca
1321 actcagatgg gtttccaagc gttcattcaa aaacttgctg ggtaatcccc aggcctctat
1381 agctcagatc attgtcacag tcgtactggg actggttata ggtgccattt actttgggct
1441 aaaaaatgat tctactggaa tccagaacag agctggggtt ctcttcttcc tgacgaccaa
1501 ccagtgtttc agcagtgttt cagccgtgga actctttgtg gtagagaaga agctcttcat
1561 acatgaatac atcagcggat actacagagt gtcatcttat ttccttggaa aactgttatc
1621 tgatttatta cccatgagga tgttaccaag tattatattt acctgtatag tgtacttcat
1681 gttaggattg aaggcaaagg cagatgcctt cttcgttatg atgtttaccc ttatgatggt
1741 ggcttattca gccagttcca tggcactggc catagcagca ggtcagagtg tggtttctgt
1801 agcaacactt ctcatgacca tctgttttgt gtttatgatg attttttcag gtctgttggt
1861 caatctcaca accattgcat cttggctgtc atggcttcag tacttcagca ttccacgata
1921 tggatttacg gctttgcagc ataatgaatt tttgggacaa aacttctgcc caggactcaa
1981 tgcaacagga aacaatcctt gtaactatgc aacatgtact ggcgaagaat atttggtaaa
2041 gcagggcatc gatctctcac cctggggctt gtggaagaat cacgtggcct tggcttgtat
2101 gattgttatt ttcctcacaa ttgcctacct gaaattgtta tttcttaaaa aatattctta
2161 aatttcccct taattcagta tgatttatcc tcacataaaa aagaagcact ttgattgaag
2221 tattcaaaaa aaaaaaaaaa aaaaaaa
//