LOCUS AY013249 3874 bp mRNA linear HUM 16-JAN-2001
DEFINITION Homo sapiens hUPF2 mRNA, complete cds.
ACCESSION AY013249
VERSION AY013249.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3874)
AUTHORS Lykke-Andersen,J., Shu,M.D. and Steitz,J.A.
TITLE Human Upf proteins target an mRNA for nonsense-mediated decay when
bound downstream of a termination codon
JOURNAL Cell 103 (7), 1121-1131 (2000)
PUBMED 11163187
REFERENCE 2 (bases 1 to 3874)
AUTHORS Lykke-Andersen,J., Shu,M.-D. and Steitz,J.A.
TITLE Direct Submission
JOURNAL Submitted (07-NOV-2000) Molecular Biochemistry and Biophysics, Yale
University School of Medicine, 295 Congress Avenue, New Haven, CT
06536, USA
FEATURES Location/Qualifiers
source 1..3874
/db_xref="H-InvDB:HIT000083176"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 25..3843
/function="involved in nonsense-mediated mRNA decay"
/note="similar to yeast Upf2"
/codon_start=1
/product="hUPF2"
/protein_id="AAG48509.1"
/translation="MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLT
AKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEER
KKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENF
FSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISD
VNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVG
IFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKF
NLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELS
EDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPG
EYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKE
NKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKL
IVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYAR
LVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKN
DTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHL
DARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKL
PWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIQVVDGVLEDIRLG
MEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPE
HLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDI
DYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLE
EDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENET
DEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHL
KSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQA
EQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNAD
LIFKTGGRRR"
BASE COUNT 1365 a 707 c 891 g 911 t
ORIGIN
1 ttacagattg tcctgggtca cataatgcca gctgagcgta aaaagccagc aagtatggaa
61 gaaaaagact ctttaccaaa caacaaggaa aaagactgca gtgaaaggcg gacagtgagc
121 agcaaggaga ggccaaaaga cgatatcaag ctcactgcca agaaggaggt cagcaaggcc
181 cctgaagaca agaagaagag actggaagat gataagagaa aaaaggaaga caaggaacgc
241 aagaaaaaag acgaagaaaa ggtgaaggca gaggaagaat caaagaaaaa agaagaggaa
301 gaaaaaaaga aacatcaaga ggaagagaga aagaagcaag aagagcaggc caaacgtcag
361 caagaagaag aagcagctgc tcagatgaaa gaaaaagaag aatccattca gcttcatcag
421 gaagcttggg aacgacatca tttaagaaag gaacttcgta gcaaaaacca aaatgctccg
481 gacagccgac cagaggaaaa cttcttcagc cgcctcgact caagtttgaa gaaaaatact
541 gcttttgtca agaaactaaa aactattaca gaacaacaga gagactcctt gtcccatgat
601 tttaatggcc taaatttaag caaatacatt gcagaagctg tagcttccat cgtggaagca
661 aaactaaaaa tctctgatgt gaactgtgct gtgcacctct gctctctctt tcaccagcgt
721 tatgctgact ttgccccatc acttcttcag gtctggaaaa aacattttga agcaaggaaa
781 gaggagaaaa cacctaacat caccaagtta agaactgatt tgcgttttat tgcagaattg
841 acaatagttg ggattttcac tgacaaggaa ggtctttcct taatctatga acagctaaaa
901 aatattatta atgctgatcg ggagtcccac actcatgtct ctgtagtgat tagtttctgt
961 cgacattgtg gagatgatat tgctggactt gtaccaagga aagtaaagag tgctgcagag
1021 aagtttaatt tgagttttcc tcctagtgag ataattagtc cagagaaaca acagcccttc
1081 cagaatcttt taaaagagta ctttacgtct ttgaccaaac acctgaaaag ggaccacagg
1141 gagctccaga atactgagag acaaaacagg cgcattctac attctaaagg ggagctcagt
1201 gaagatagac ataaacagta tgaggaattt gctatgtctt accagaagct gctggcaaat
1261 tctcaatcct tagcagacct tttggatgaa aatatgccag atcttcctca agacaaacca
1321 acaccagaag aacatgggcc tggaattgat atattcacac ctggtaaacc tggagaatat
1381 gacttggaag gtggtatatg ggaagatgaa gatgctcgga atttttatga gaacctcatt
1441 gatttgaagg cttttgtccc agccatcttg tttaaagaca atgaaaaaag ttgtcagaat
1501 aaagagtcca acaaagatga taccaaagag gcaaaagaat ctaaggagaa taaggaggta
1561 tcaagtcccg atgatttgga acttgagttg gagaatctag aaattaatga tgacacctta
1621 gaattagagg gtggagatga agctgaagat cttacaaaga aacttcttga tgaacaagaa
1681 caagaagatg aggaagccag cactggatct catctcaagc tcatagtaga tgctttccta
1741 cagcagttac ccaactgtgt caaccgagat ctgatagaca aggcagcaat ggatttttgc
1801 atgaacatga acacaaaagc aaacaggaag aagttggtac gggcactctt catagttcct
1861 agacaaaggt tggatttgct accattttat gcaagattgg ttgctacatt gcatccctgc
1921 atgtctgatg tagcagagga tctttgttcc atgctgaggg gggatttcag atttcatgta
1981 cggaaaaagg accagatcaa tattgaaaca aagaataaaa ctgttcgttt tataggagaa
2041 ctaactaagt ttaagatgtt caccaaaaat gacacactgc attgtttaaa gatgcttctg
2101 tcagacttct ctcatcacca tattgaaatg gcatgcaccc tgctggagac atgtggacgg
2161 tttcttttca gatctccaga atctcacctg aggaccagtg tacttttgga gcaaatgatg
2221 agaaagaagc aagcaatgca tcttgatgcg agatacgtca caatggtaga gaatgcatat
2281 tactactgca acccacctcc agctgaaaaa accgtgaaaa agaaacgtcc tcctctccag
2341 gaatatgtcc ggaaactttt gtacaaggat ctctctaagg ttaccaccga gaaggttttg
2401 agacagatgc gaaagctgcc ctggcaggac caagaagtga aagactatgt tatttgttgt
2461 atgataaaca tctggaatgt gaaatataat agtattcatt gtgtagccaa cctcttagca
2521 ggactagtgc tctaccaaga ggatgttggg atccaagttg tggatggagt gttagaagat
2581 attcgattag gaatggaggt taatcaacct aaatttaatc agaggcgcat cagcagtgcc
2641 aagttcttag gagaacttta caattaccga atggtggaat cagctgttat tttcagaact
2701 ctgtattctt ttacctcatt tggtgttaat cctgatggct ctccaagttc cctggaccca
2761 cctgagcatc ttttcagaat tagactcgta tgcactattc tggacacatg tggccagtac
2821 tttgacagag gttccagtaa acgaaaactt gattgtttcc ttgtatattt tcagcgttat
2881 gtttggtgga agaaaagttt ggaggtttgg acaaaagacc atccatttcc tattgatata
2941 gattacatga tcagtgatac actagaactg ctaagaccaa agatcaaact ctgtaattct
3001 ctggaagaat ccatcaggca ggtacaagac ttggaacgag aattcttaat aaaactaggc
3061 ctagtaaatg acaaagactc aaaagattct atgacagaag gagaaaatct tgaagaggat
3121 gaagaagaag aagaaggtgg ggctgaaaca gaagaacaat ctggaaatga aagtgaagta
3181 aatgagccag aagaagagga gggttctgat aatgatgatg atgagggaga agaagaggag
3241 gaagagaata cagattacct tacagattcc aataaggaaa atgaaaccga tgaagagaat
3301 actgaggtaa tgattaaagg cggtggactt aagcatgtac cttgtgtaga agatgaggac
3361 ttcattcaag ctctggataa aatgatgcta gaaaatctac agcaacgaag tggtgaatct
3421 gttaaagtgc accaactaga tgttgccatt cctttgcatc tcaaaagcca gctgaggaaa
3481 gggcccccac tgggaggtgg ggaaggagag gctgagtctg cagacacaat gccgtttgtc
3541 atgttaacaa gaaaaggcaa taaacagcag tttaagatcc ttaatgtacc catgtcctct
3601 caacttgctg caaatcactg gaaccagcaa caggcagaac aagaagagag gatgagaatg
3661 aaaaagctca cactagatat caatgaacgg caagaacaag aagattatca agaaatgttg
3721 cagtctcttg cacagcgccc agctccagca aacaccaatc gtgagaggcg gcctcgctac
3781 caacatccga agggagcacc taatgcagat ctaatcttta agactggtgg gaggagacgt
3841 tgatccagca gcacgtgtca tttattaggt cctg
//