LOCUS AJ878416 4581 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for transient receptor potential cation channel,
subfamily M, member 2 (TRPM2 gene).
ACCESSION AJ878416
VERSION AJ878416.1
KEYWORDS transient receptor potential cation channel, subfamily M, member 2;
TRPM2 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4581)
AUTHORS Kelsell R.E.
JOURNAL Submitted (27-JAN-2005) to the INSDC. Kelsell R.E., Bioinformatics,
GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park
(North), Third Avenue, Harlow, Essex, CM19 5AW, UNITED KINGDOM.
REFERENCE 2
AUTHORS Hill K., Tigue N.J., Kelsell R.E., Benham C.D., McNulty S.,
Schaefer M., Randall A.D.
TITLE Characterisation of recombinant rat TRPM2 and a TRPM2-like
conductance in cultured rat striatal neurones
JOURNAL Neuropharmacology 50(1), 89-97(2006).
PUBMED 16260005
REFERENCE 3
AUTHORS Hayes P.D.
TITLE Cloning of the human TRPM2
JOURNAL Unpublished.
FEATURES Location/Qualifiers
source 1..4581
/db_xref="H-InvDB:HIT000330168"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 64..4575
/gene="TRPM2"
/product="transient receptor potential cation channel,
subfamily M, member 2"
/db_xref="GOA:O94759"
/db_xref="H-InvDB:HIT000330168.10"
/db_xref="HGNC:HGNC:12339"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR029594"
/db_xref="InterPro:IPR041491"
/db_xref="PDB:6MIX"
/db_xref="PDB:6MIZ"
/db_xref="PDB:6MJ2"
/db_xref="UniProtKB/Swiss-Prot:O94759"
/protein_id="CAI47593.1"
/translation="MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSW
RLQCPFGNNDKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEA
TKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQ
HWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQV
GEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC
LDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGP
GTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFE
TFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHE
NWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGV
QLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLR
ELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRD
LLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEY
EHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLT
KVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVV
FHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGL
MKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMHIF
TISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVY
HSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLC
LYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLS
HLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQ
KIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFS
SEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNEKV
PWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ
AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVK
LPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTD
NAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQK
AAAEFGAHY"
BASE COUNT 950 a 1408 c 1402 g 821 t
ORIGIN
1 agctggagag aggactgtcc tgagggcagc aggcctggtt gcagctggcg tgggggtctc
61 agaatggagc cctcagccct gaggaaagct ggctcggagc aggaggaggg ctttgagggg
121 ctgcccagaa gggtcactga cctggggatg gtctccaatc tccggcgcag caacagcagc
181 ctcttcaaga gctggaggct acagtgcccc ttcggcaaca atgacaagca agaaagcctc
241 agttcgtgga ttcctgaaaa catcaagaag aaagaatgcg tgtattttgt ggaaagttcc
301 aaactgtctg atgctgggaa ggtggtgtgt cagtgtggct acacgcatga gcagcacttg
361 gaggaggcta ccaagcccca caccttccag ggcacacagt gggacccaaa gaaacatgtc
421 caggagatgc caaccgatgc ctttggcgac atcgtcttca cgggcctgag ccagaaggtg
481 aaaaagtacg tccgagtctc ccaggacacg ccctccagcg tgatctacca cctcatgacc
541 cagcactggg ggctggacgt ccccaatctc ttgatctcgg tgaccggggg ggccaagaac
601 ttcaacatga agccgcggct gaagagcatt ttccgcagag gcctggtcaa ggtggctcag
661 accacagggg cctggatcat cacagggggg tcccacaccg gcgtcatgaa gcaggtaggc
721 gaggcggtgc gggacttcag cctgagcagc agctacaagg aaggcgagct catcaccatc
781 ggagtcgcca cctggggcac tgtccaccgc cgcgagggcc tgatccatcc cacgggcagc
841 ttccccgccg agtacatact ggatgaggat ggccaaggga acctgacctg cctagacagc
901 aaccactctc acttcatcct cgtggacgac gggacccacg gccagtacgg ggtggagatt
961 cctctgagga ccaggctgga gaagttcata tcggagcaga ccaaggaaag aggaggtgtg
1021 gccatcaaga tccccatcgt gtgcgtggtg ctggagggcg gcccgggcac gttgcacacc
1081 atcgacaacg ccaccaccaa cggcaccccc tgtgtggttg tggagggctc gggccgcgtg
1141 gccgacgtca ttgcccaggt ggccaacctg cctgtctcgg acatcactat ctccctgatc
1201 cagcagaaac tgagcgtgtt cttccaggag atgtttgaga ccttcacgga aagcaggatt
1261 gtcgagtgga ccaaaaagat ccaagatatc gtccggaggc ggcagctgct gactgtcttc
1321 cgggaaggca aggatggtca gcaggacgtg gatgtggcca tcttgcaggc cttgctgaaa
1381 gcctcacgga gccaagacca ctttggccac gagaactggg accaccagct gaaactggca
1441 gtggcatgga atcgcgtgga cattgcccgc agtgagatct tcatggatga gtggcagtgg
1501 aagccttcag atctgcaccc cacgatgaca gctgcactca tctccaacaa gcctgagttt
1561 gtgaagctct tcctggagaa cggggtgcag ctgaaggagt ttgtcacctg ggacaccttg
1621 ctctacctgt acgagaacct ggacccctcc tgcctgttcc acagcaagct gcagaaggtg
1681 ctggtggagg atcccgagcg cccggcttgc gcgcccgcgg cgccccgcct gcagatgcac
1741 cacgtggccc aggtgctgcg ggagctgctg ggggacttca cgcagccgct ttatccccgg
1801 ccccggcaca acgaccggct gcggctcctg ctgcccgttc cccacgtcaa gctcaacgtg
1861 cagggagtga gcctccggtc cctctacaag cgttcctcag gccatgtgac cttcaccatg
1921 gaccccatcc gtgaccttct catttgggcc attgtccaga accgtcggga gctggcagga
1981 atcatctggg ctcagagcca ggactgcatc gcagcggcct tggcctgcag caagatcctg
2041 aaggaactgt ccaaggagga ggaggacacg gacagctcgg aggagatgct ggcgctggcg
2101 gaggagtatg agcacagagc catcggggtc ttcaccgagt gctaccggaa ggacgaagag
2161 agagcccaga aactgctcac ccgcgtgtcc gaggcctggg ggaagaccac ctgcctgcag
2221 ctcgccctgg aggccaagga catgaagttt gtgtctcacg ggggcatcca ggccttcctg
2281 accaaggtgt ggtggggcca gctctccgtg gacaatgggc tgtggcgtgt gaccctgtgc
2341 atgctggcct tcccgctgct cctcaccggc ctcatctcct tcagggagaa gaggctgcag
2401 gatgtgggca cccccgcggc ccgcgcccgt gccttcttca ccgcacccgt ggtggtcttc
2461 cacctgaaca tcctctccta cttcgccttc ctctgcctgt tcgcctacgt gctcatggtg
2521 gacttccagc ctgtgccctc ctggtgcgag tgtgccatct acctctggct cttctccttg
2581 gtgtgcgagg agatgcggca gctcttctat gaccctgacg agtgcgggct gatgaagaag
2641 gcagccttgt acttcagtga cttctggaat aagctggacg tcggcgcaat cttgctcttc
2701 gtggcagggc tgacctgcag gctcatcccg gcgacgctgt accccgggcg cgtcatcctc
2761 tctctggact tcatcctgtt ctgcctccgg ctcatgcaca tttttaccat cagtaagacg
2821 ctggggccca agatcatcat tgtgaagcgg atgatgaagg acgtcttctt cttcctcttc
2881 ctgctggctg tgtgggtggt gtccttcggg gtggccaagc aggccatcct catccacaac
2941 gagcgccggg tggactggct gttccgaggg gccgtctacc actcctacct caccatcttc
3001 gggcagatcc cgggctacat cgacggtgtg aacttcaacc cggagcactg cagccccaat
3061 ggcaccgacc cctacaagcc taagtgcccc gagagcgacg cgacgcagca gaggccggcc
3121 ttccctgagt ggctgacggt cctcctactc tgcctctacc tgctcttcac caacatcctg
3181 ctgctcaacc tcctcatcgc catgttcaac tacaccttcc agcaggtgca ggagcacacg
3241 gaccagattt ggaagttcca gcgccatgac ctgatcgagg agtaccacgg ccgccccgcc
3301 gcgccgcccc ccttcatcct cctcagccac ctgcagctct tcatcaagag ggtggtcctg
3361 aagactccgg ccaagaggca caagcagctc aagaacaagc tggagaagaa cgaggaggcg
3421 gccctgctat cctgggagat ctacctgaag gagaactacc tccagaaccg acagttccag
3481 caaaagcagc ggcccgagca gaagatcgag gacatcagca ataaggttga cgccatggtg
3541 gacctgctgg acctggaccc actgaagagg tcgggctcca tggagcagag gttggcctcc
3601 ctggaggagc aggtggccca gacagcccga gccctgcact ggatcgtgag gacgctgcgg
3661 gccagcggct tcagctcgga ggcggacgtc cccactctgg cctcccagaa ggccgcggag
3721 gagccggatg ctgagccggg aggcaggaag aagacggagg agccgggcga cagctaccac
3781 gtgaatgccc ggcacctcct ctaccccaac tgccctgtca cgcgcttccc cgtgcccaac
3841 gagaaggtgc cctgggagac ggagttcctg atctatgacc caccctttta cacggcagag
3901 aggaaggacg cggccgccat ggaccccatg ggagacaccc tggagccact gtccacgatc
3961 cagtacaacg tggtggatgg cctgagggac cgccggagct tccacgggcc gtacacagtg
4021 caggccgggt tgcccctgaa ccccatgggc cgcacaggac tgcgtgggcg cgggagcctc
4081 agctgcttcg gacccaacca cacgctgtac cccatggtca cgcggtggag gcggaacgag
4141 gatggagcca tctgcaggaa gagcataaag aagatgctgg aagtgctggt ggtgaagctc
4201 cctctctccg agcactgggc cctgcctggg ggctcccggg agccagggga gatgctacct
4261 cggaagctga agcggatcct ccggcaggag cactggccgt cttttgaaaa cttgctgaag
4321 tgcggcatgg aggtgtacaa aggctacatg gatgacccga ggaacacgga caatgcctgg
4381 atcgagacgg tggccgtcag cgtccacttc caggaccaga atgacgtgga gctgaacagg
4441 ctgaactcta acctgcacgc ctgcgactcg ggggcctcca tccgatggca ggtggtggac
4501 aggcgcatcc cactctatgc gaaccacaag accctcctcc agaaggcagc cgctgagttc
4561 ggggctcact actgactgtg c
//