LOCUS AJ584699 9604 bp mRNA linear HUM 21-OCT-2008
DEFINITION Homo sapiens mRNA for RAPH1 protein.
ACCESSION AJ584699
VERSION AJ584699.1
KEYWORDS RAPH1 gene; Ras association (RalGDS/AF-6) and pleckstrin homology
domains 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9604)
AUTHORS Edgar D.
JOURNAL Submitted (02-OCT-2003) to the INSDC. Edgar D., Discovery, metaGen
Pharmaceuticals GmbH, Oudenarder Str. 16, 13347 Berlin, GERMANY.
REFERENCE 2
AUTHORS Dahl E., Sadr-Nabavi A., Klopocki E., Betz B., Grube S.,
Kreutzfeld N., Himmelfarb M., Gelling S., Klaman I., Hinzmann B.,
Kristiansen G., Gruetzmann R., Kuner R., Petschke B., Rhiem K.,
Wiechen K., Wiestler O., Hoefler H., Naehrig J., Dietel M.,
Schaefer R., Rosenthal A., Schmutzler R., Duerst M., Meindl A.,
Niederacher D.
TITLE Systematic identification and molecular characterization of genes
differentially expressed in breast and ovarian cancer
JOURNAL Unpublished.
FEATURES Location/Qualifiers
source 1..9604
/db_xref="H-InvDB:HIT000249159"
/organism="Homo sapiens"
/chromosome="2"
/map="204,5-204,6 Mb"
/map="2q33.2"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR <1..219
/gene="RAPH1"
CDS 220..3972
/gene="RAPH1"
/product="RAPH1 protein"
/note="Ras association (RalGDS/AF-6) and pleckstrin
homology domains 1"
/note="splice variant containing two additional exons and
coding for 1302aa is supported by only one clone
(accession number: AB053311)"
/db_xref="GOA:Q70E73"
/db_xref="H-InvDB:HIT000249159.14"
/db_xref="HGNC:HGNC:14436"
/db_xref="InterPro:IPR000159"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR039664"
/db_xref="InterPro:IPR039665"
/db_xref="PDB:4GMV"
/db_xref="PDB:4GN1"
/db_xref="UniProtKB/Swiss-Prot:Q70E73"
/protein_id="CAE48361.1"
/translation="MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDS
DKPMEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSS
IGSGNSKRQITETKATQKLPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQL
EQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASS
MDSLDIDKVTRPQELDLTHQGQPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVH
MSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLV
ENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS
SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNV
YYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQ
LYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGH
VRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQP
SPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGA
LFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQF
SAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVV
TQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLS
PVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP
DFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPP
PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKL
NLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETDLPLPPIE
IPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMAT
VVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPP
PPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW"
3'UTR 3973..>9604
/gene="RAPH1"
BASE COUNT 2732 a 2226 c 1927 g 2719 t
ORIGIN
1 cgcccccgct cccgccgccg cccgccagtc agtcagtcag tcagtcagtc agtcagtcag
61 tcagtcagtc actgagcgcg cggcgcggga gctgctggca gtcgctgcgt ctctggcgag
121 ggagcgccgc gcctggggag gaggcggagg cagcggctgg aggagcgcga gcggcggttt
181 ccttgcccgg ggccgcggga aggccgaccg actgccgcga tggagcagct atcagatgaa
241 gaaattgatc atggtgctga agaagacagt gacaaggaag atcaggacct ggacaaaatg
301 tttggagcct ggcttggaga actagacaaa ctcactcaga gtttggattc tgacaagccc
361 atggaaccag taaaaagatc tcctcttcgc caggaaacaa acatggccaa cttttcttac
421 cgcttctcca tatacaactt gaatgaagct ctgaatcagg gagagactgt ggatctggat
481 gccttgatgg ctgatctttg ctctatagag caggagctca gcagcattgg ttcaggaaac
541 agtaagcgtc aaatcacaga aacgaaagct actcagaaat tgcctgttag ccgacataca
601 ttgaaacatg gcaccttgaa aggattatct tcttcatcta ataggatagc taaaccttcc
661 catgccagct actccttgga cgacgtcact gcacagttag aacaggcctc tttgagtatg
721 gatgaggctg ctcagcaatc tgtactagaa gatactaaac ccttagtaac taatcagcac
781 agaagaaccg cgtcagcagg cacagtgagt gatgctgaag tacactctat tagtaattcc
841 tcccattcca gcatcacttc cgcagcctcc agcatggact ctttggatat tgataaagta
901 acacgccctc aagagctgga tttgacacat caagggcagc caattactga ggaagaacag
961 gcagcaaaat tgaaagctga gaagatcaga gttgccctag agaaaattaa agaggcacaa
1021 gtgaaaaagc tggtgatcag agtccacatg tctgatgaca gttctaaaac aatgatggtg
1081 gatgagaggc agacagtaag acaagtactg gataacctga tggacaaatc ccactgcggt
1141 tatagtttag actggtcact ggtagaaacc gtttctgaat tacaaatgga gagaatcttt
1201 gaagaccatg aaaacttggt tgaaaatctt cttaattgga caagagatag ccaaaacaag
1261 cttatattta tggagcgtat agaaaaatat gcacttttca aaaacccaca gaattatctt
1321 ttggggaaaa aagaaacagc tgagatggca gatagaaaca aagaagtcct cttggaggaa
1381 tgtttttgtg gaagttctgt aactgtacca gaaattgaag gagtcctttg gttgaaggat
1441 gatggcaaga agtcctggaa aaagcgttat tttctcttgc gagcatctgg tatctactat
1501 gttcccaaag gaaaagcaaa ggtctctcgg gatctggtgt gctttctcca gctggatcat
1561 gtcaacgttt attatggcca ggactatcgg aacaaataca aagcacctac agactattgt
1621 ctggtgctga agcatccaca aatccagaag aaatctcaat atatcaaata cctttgttgt
1681 gatgatgtga ggacactgca tcagtgggtc aatgggatcc gcattgcaaa gtatgggaag
1741 cagctctata tgaactacca agaagccttg aagaggacag agtcagccta tgattggact
1801 tccttatcca gctccagcat taaatcggga tccagttctt ccagcatccc agagtctcag
1861 tcaaaccact ccaatcagtc tgatagcgga gtttctgaca cccagccagc aggacacgtc
1921 cgttcccaga gcattgtgag ctccgtattc tctgaagcct ggaaacgagg cactcagttg
1981 gaagagtcca gcaaggccag aatggagtct atgaatcggc cctacacttc acttgtgccc
2041 cctttatccc cgcaacctaa gatagtcacc ccctacactg cttcacagcc ttcaccacct
2101 ctacctcctc cgccaccccc acctcctcct ccaccacccc ctccaccacc ccctcctccc
2161 ccactcccca gccagtctgc accttctgca ggctcagcag ccccaatgtt cgtcaagtac
2221 agcacaataa cacggctaca gaatgcgtct cagcattcag gggccctgtt taagccgcca
2281 acacccccag tgatgcagtc acagtcagtg aagcctcaga tcctggtacc ccccaatgga
2341 gttgttccac caccccctcc ccctcctcca cccccaaccc caggctctgc catggcccag
2401 ctaaagcctg caccgtgtgc cccatccctt ccacagttca gtgccccgcc tcctccactg
2461 aagatccatc aagttcagca tattactcag gtggctcccc caacaccccc cccacctcct
2521 cctatccctg cacccctccc tccccaagct cccccaaaac cccttgtgac catccccgca
2581 ccaaccagca ccaagactgt ggcacctgtt gtgactcaag ctgcaccacc cacacctact
2641 cctccagtgc ccccagcaaa aaagcagcca gctttccctg cttcttacat tccaccctct
2701 ccccctaccc ctcctgttcc agtacccccg ccaacattac ccaagcaaca gagcttctgt
2761 gcaaaacccc ctccctctcc actgtcaccg gtgccctcgg tcgtgaagca gatagccagc
2821 cagtttccac cccctccaac tccccctgcc atggaatctc agcccttaaa gcctgtccca
2881 gcaaatgtag ctccacagtc ccctcctgca gtaaaagcaa agcccaagtg gcagcccagc
2941 tccatcccag tcccttctcc ggacttccct cctccccctc ctgaaagcag cctggtgttt
3001 cctcctccac ccccatcacc tgtcccagcc ccaccaccgc cacctccacc cacagcttct
3061 cctacccctg acaaaagtgg atctccaggc aaaaagacca gtaagacgtc cagccctggg
3121 ggaaagaaac cacccccaac cccacagcgc aactccagca ttaaatccag cagtggtgca
3181 gagcaccccg agcccaagag accctcggtg gacagtctag tcagcaagtt tacaccgcca
3241 gcagaatcag ggtctcccag caaggagacc ctaccacctc ctgcagcacc ccccaagcct
3301 ggaaaactca atctttctgg agtcaacctt cctggagttc tccaacaagg gtgtgtgtca
3361 gcaaaagccc ctgttctgag tgggcgtgga aaggactccg tggtggaatt tccttctcct
3421 ccatccgatt ctgattttcc accccctcca cctgaaacag accttcctct gccccccatt
3481 gagattccag cagttttctc gggaaacacc tctccaaaag tggcagtcgt taatcctcaa
3541 ccacaacaat ggtctaaaat gtcagtgaag aaggcccctc cacccacacg acccaaacgg
3601 aatgatagca cccgcctcac tcaagctgag atttctgagc agccaacaat ggccacagtt
3661 gtgccacaag tgcccacctc tcccaaatcc agccttagtg tccagcctgg attcctggct
3721 gacctcaaca ggacactgca acgaaagtcc atcactcggc acggctcact ctcctcccgc
3781 atgtccagag cagaaccaac agccaccatg gatgatatgg cattgcctcc accaccccct
3841 gaactgctgt ctgatcaaca gaaggctggt tacggaggca gtcatatatc aggctatgca
3901 acgttgcgga gaggaccccc tcctgctccc cccaaaagag accagaacac caagctctcc
3961 agagactggt agccaccata ggactttatt ttcatgatat ctgtaatcac tgctacaatc
4021 agctcacctg atcatctgtg aattcaggtg ttcagagcct cctggtatga tgttattcag
4081 gtagtgtcca gctatatgtg tatgtgtgtg tgtacacgtg catgtacaca cagctgtaca
4141 gtgtgtgtat atatgtatac atatatgtat gtgtatgtgt atatagagag agagctgaga
4201 gttattctat ttattccttt tctctcctaa tctgaaaatg ggtgttctgt attttgggtg
4261 gaagaggcat agaaggggat gtgtgttgtc tcttaagatt tctatatcat gtggattgga
4321 ccaaaaactt ctaatcactt atttagaagg tatttataag tgtctgtcca tgtgtagcct
4381 attcgtgcat gttgtgtatt atataactaa ggaatagatg tagaatgtgc tatttctggt
4441 tgagaaaaat caccagaatg tttggtgtat ctataaggct tttgtgtttg tttttcccca
4501 gttggctgaa gttagaattg cttgactgac acttcattgc tatacatgaa ggggcacttt
4561 aaatcaggaa aatctctcag cttcatagaa cgggtaacta gtgcaggatg gggaaatgtt
4621 cacagacatc atctgtatgt ggttgtgcat agaaagtaaa tacatggcgt aattaactca
4681 gctgttctag ctgcagtact gctgcagtga tccacccaca tttaggatgt gctgacagat
4741 aagctctttg cctacaatac atggataatt agtgctataa ttctggatag ttccttttta
4801 gtactgtttt atgaagcttt atcaacttgg cttcatgatc ctcactttga ttgattttaa
4861 gaggatggat aacacagtta tctctgtaat gttctgtccc agtatgtctt tgggtcacca
4921 gttaccttct taaaatatgt gctttaggta ggtgttatta catatctgta gacaattggt
4981 atatgaaata tacacatcct gtgccccaat atggtgcatt atgaaaaaca aaatcatttt
5041 ctaaaatgca ttttttgagc attgctctat agaagggaag ggtgatgaga gaacagaact
5101 ggcccctgta caggtgtcat taatctggtt gtatatgggt tataatatgt aatacaaaaa
5161 gctcattaag tatgggacta catggagagg gaagacagtt tcatttatag ctactggggc
5221 taccaggacc cttgctgact gcagcctggt tgtgattagt tcaggttact aggtgttctg
5281 atggagtggg acagtccaag tccagtaact gacattacgt tttatgcgtg tgcagtttgg
5341 tataacgtgg agtcagtgct ctaacgacac actatacttc tatatgcttt tttctgtgaa
5401 ttttccttgg tacatgagag aaataagtac tctcatcaac ttatgataaa ttggactatt
5461 aggaataaaa caatctcaga gcagctccta aacaagagaa taaaaatggg ccatcccagc
5521 acttataagg ggagcacatc ttgtaatgaa agtctgtgcc tattgttaat gattaccaat
5581 gcaaactgca gaaatcagtt gacattgtcc cacaaggaaa aagtgatgcc agtaaagtgg
5641 gggaagagat ggtaaataat tctagaatga gcaaaagtgc ttaattagta cagtatactc
5701 aaggtcttgc ataacccaca ctccacgaaa accgcatcgt aaacagagag tgaacagcac
5761 ctctccattg ctacatctcc agaatattgt tcggttatgt tcatgtggtt atggagcaat
5821 aagaatatat accattaatt tttaggtctt tcaaattgtt caccaagttt tgtgtttgat
5881 atttatgaag tgatctttaa cacatctgca ttgttaattt aagcatgcac agaaatttgg
5941 gtaatgtttg agtagattgc caagcgctac tgtgattcat gaatgaattt ctcatagtct
6001 tctgcctgca gttttatagt ttgaggggca cccatatttg tgggttagag ttagtaagaa
6061 tatgaatcca gttatcaaag tattcatccc tgaggttttg agttttattg tggtggtgat
6121 tttctcatga gaaggtagac aacacttcag tttttcttga gggggaaaaa aatgtacccg
6181 ctaacctttt ttcacccatg atttgagccc taaaacaaca gcctttatgt tttcagtgca
6241 ggatttcttg gaatttcttg cttgtatcaa tcctgatgat agccatcctg aacagatgct
6301 tctggtctgt tttcctggaa tagcagacat ccttttgaac actaatgatg ccaggaagag
6361 agtaaggcta gaggaggaga ctgtcatttt aaccccagtc cagtggcttg tccgacaaca
6421 ggccatttcc ctttacattc ctccacagac agaaatggct attaaaaatg ttttaacctc
6481 atgtatgaac tgaatttaaa aaaccactaa agtgatactt tatacttctg ttttactccc
6541 tagtgggttt tctttaattt ggatttttgt tgggatgtag cttttcctag actgtatttc
6601 tgtagctctt tttctctggt gtattcatgg aaagcatcta ctgccgcacg acactagtac
6661 tgtgccttct ttcactgccc tctgctctgc agctctcacc cagcttggct gcttcaagtc
6721 tgtgcagttg acttggctgt actgaaaagt gaacagcatg gattaactca tcctgctgct
6781 gagggcagtg caaacaggtg cttattagag gtagtgactt gcttaattag tgacactcct
6841 aatttctact atggataatt tcaaagtaga atcactctat gcttagagtt ttggcaccaa
6901 tgctgtaggg cagcagaatc tattctcagt aaaataactt atggtttatt agatattctg
6961 tattggattt taccagcttg acttttactg ctcagatgct ttctttcccc cccttagacg
7021 ctgtaattct cttgggaaga gtaactattc ttaaggtttt tacagatacc caccttagtt
7081 gtaaattgga tagtttatat ttctgggact ttttaaatga aaatgtggaa tgttaagtta
7141 caaaagactt ttcatcagaa aatttcaaac aaagtaaaca tggcgtttta tagtcctcta
7201 aaatctaggt gctcccaccc accaaaggca tatcctgcaa agggctgtga actatcttgg
7261 tgaactgtct tgggtcccct ttccatgtat gttttcttgt cactgaaaac aaacaacgct
7321 gagtttatca agaaaattta aattggggga tcataataat tccaaccaag tgacaactct
7381 gacatcaagg ttattaggag ctgtacatcc aattcaagtt ttatttgctg ctattctggg
7441 agaataaact tgtatatgga gaataaacta ataaacttgt atcgaggaaa tccataaagt
7501 tataaattag cctgaaaaat atttcaggta atggtgtgga ttggcctgct ttgactctca
7561 gccaccaaca gaaatctttg tcacctttgt tcctcagcta aaagtaattt tgttataaac
7621 acaaagtgac tttaaacagg taaaaaaccc attcctattt ttgtacatta ccaaaagttt
7681 ttcatatacc tacagagcta actaattaca actgatttaa tccactcaag tttagaccag
7741 ttaaacccat aggatcctgt atggttatca atgtgatgcc ttgcttttca taaaataggt
7801 ataattgggt catacacttg acgagagggt gactgtttct aggggaagaa aaccctttag
7861 attgcaggta actttcactt tttttttttt aaatatacac tttacatttg tataaattat
7921 gcagggtact cctaaccctg tagaaatgta tgacctctca caaagttgag atttgatcca
7981 aagagaaatg caagtataaa agaattagat acttattatc ttttaaggtt tttttttttt
8041 tttggtagag atgggggtct cactgtgttg cccaggctgg tctcaaactc ctggccacaa
8101 gtgatcttcc tgcctcagcc tcccaaaatg ctgagattac aggcatgagc cactgtaccc
8161 agcctttcct tataaaattc aaagagaaaa tttctacacc tttatccctc aaataaaaca
8221 agtgctcagt tcttaccgtg cccttgcaag gtctatatgt aaaagaaatc tgaaatttag
8281 ctgtagaata aaacttgata aataaaaaga aaaaacatac atttctccag ttggtttgct
8341 ctttgcttgt tgaagtaata aaccgtttta aagagaaaat acttgctgta aacccccagt
8401 gccttcaact cttttggcag aatattttta aagaaatcca gcaagcaaac tttgaggtgc
8461 taatgaaagt aaaggaaggt ggtatttcta gttttggcag aaatgaaaag tgtctcacaa
8521 gagacatcac tacccacgtg gggtctggct gctttctacc aaagacattt agagaagaag
8581 tgaattgagt cagggtgatg gtgaacacta catattttat agatggttaa gttgagaatt
8641 aattatgttt atcatggatg gctactaata ccaagctcat gattgttgca gcctcaacgt
8701 cttaggcagt aaaacttgtc tgcagcacta aagggggaga aacccttata ttttgcaaac
8761 tgtccattcg ttaaatttat tgtaacctaa taccaaaaac tgccgttttt catattattt
8821 ccccacctcc tacttttttt tttttttttt gctacttgta aaataacccc ttctagaaaa
8881 taagcattaa ctggaatgtt tcaaacaatt ttgcttcatt ttactatcag ccactagtga
8941 actcttacag agatgtacat ttaagataaa attagcttgt gctaagtgtt ttaaaaacat
9001 tgtttactgt taaaggggaa ttgcacatta tatttaactg ggattgctcc ctccctcagt
9061 tctttaaaaa acaagagtca aggctcacac caacttgtag gctgtgggag ctttgccata
9121 ggtagataca atgtagaagt atactttttt aaagcatgaa gaagacaagg aacttcatta
9181 taatgtacca ggtagaggac attattattc aaaggattat gcacagctca gtgaagatga
9241 agttacaatt tttctcgcag ctttgttgct attattttct tctgcataaa tgtatgctca
9301 tttcattatg tgccttgctc cctgattgtg caaagctata tatatatata tatatatata
9361 gatagataga tagatagata tatgagagag atatattcag tactactgag gatgtttttc
9421 tgaggatgtt tttgttctgc tggattaagt tattttccaa gttactcttg ccagttatgt
9481 cagtaaacta ttgtaatggc ttagcacact agtcgtacag tcagtgtaaa tgtttttcat
9541 ttacatgttt tcattatatc agcttatcaa atccttaata aaaaaaattc atagatttca
9601 ttta
//