LOCUS AJ505014 2550 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for sirtuin type 2 (SIRT2 gene), transcript
variant 3.
ACCESSION AJ505014
VERSION AJ505014.1
KEYWORDS SIRT2 gene; sirtuin type 2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2550)
AUTHORS Lennerz V.
JOURNAL Submitted (06-AUG-2002) to the INSDC. Lennerz V., III. Medizinische
Klinik, Johannes Gutenberg-University of Mainz, Langenbeckstrasse
1, 55101 Mainz, GERMANY.
REFERENCE 3
AUTHORS Frye R.A.
TITLE Characterization of five human cDNAs with homology to the yeast
SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
have protein ADP-ribosyltransferase activity
JOURNAL Biochem. Biophys. Res. Commun. 260(1), 273-279(1999).
PUBMED 10381378
REFERENCE 4
AUTHORS Lennerz V., Fatho M., Gentilini C., Frye R.A., Lifke A., Ferel D.,
Woelfel C., Huber C., Woelfel T.
TITLE The response of autologous T cells to a human melanoma is dominated
by mutated neoantigens
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102(44), 16013-16018(2005).
PUBMED 16247014
COMMENT related sequencs: AF083107
FEATURES Location/Qualifiers
source 1..2550
/db_xref="H-InvDB:HIT000248308"
/organism="Homo sapiens"
/mol_type="mRNA"
/country="Germany"
/sex="female"
/cell_line="MZ7-MEL"
/cell_type="melanoma"
/db_xref="taxon:9606"
CDS 832..1941
/gene="SIRT2"
/product="sirtuin type 2"
/note="trancript variant 3, mutant allele"
/db_xref="GOA:Q8IXJ6"
/db_xref="H-InvDB:HIT000248308.12"
/db_xref="HGNC:HGNC:10886"
/db_xref="InterPro:IPR003000"
/db_xref="InterPro:IPR017328"
/db_xref="InterPro:IPR026590"
/db_xref="InterPro:IPR026591"
/db_xref="InterPro:IPR029035"
/db_xref="PDB:1J8F"
/db_xref="PDB:3ZGO"
/db_xref="PDB:3ZGV"
/db_xref="PDB:4L3O"
/db_xref="PDB:4R8M"
/db_xref="PDB:4RMG"
/db_xref="PDB:4RMH"
/db_xref="PDB:4RMI"
/db_xref="PDB:4RMJ"
/db_xref="PDB:4X3O"
/db_xref="PDB:4X3P"
/db_xref="PDB:4Y6L"
/db_xref="PDB:4Y6O"
/db_xref="PDB:4Y6Q"
/db_xref="PDB:5D7O"
/db_xref="PDB:5D7P"
/db_xref="PDB:5D7Q"
/db_xref="PDB:5DY4"
/db_xref="PDB:5DY5"
/db_xref="PDB:5FYQ"
/db_xref="PDB:5G4C"
/db_xref="PDB:5MAR"
/db_xref="PDB:5MAT"
/db_xref="PDB:5Y0Z"
/db_xref="PDB:5Y5N"
/db_xref="PDB:5YQL"
/db_xref="PDB:5YQM"
/db_xref="PDB:5YQN"
/db_xref="PDB:5YQO"
/db_xref="UniProtKB/Swiss-Prot:Q8IXJ6"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAD43717.1"
/translation="MPLAECPSCRCLSSFRSVDFLRNLFSQTLSLGSQKERLLDELTL
EGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEIS
YFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTLKCEDCQSLVKPDIVFFGES
LPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPF
LGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDA
QSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ"
variation 1427
/replace="c"
/citation=[3]
BASE COUNT 568 a 802 c 698 g 482 t
ORIGIN
1 cgaccaagca cagtggctca cgcctgtgat cccggcactt tgggaggccg aggcaggaga
61 cttgcttgag cccaggagtt caagaccacc ctgggcaaca gaggaagacc tcgtctctac
121 aaagcaaaca aacaaacaaa caaaaaatga gcctggcatg gtggcacgtg cctgtggtcc
181 cagctacttg ggaggctgag gtgggaggat cccttgagct tgggaggttg aggctgcagc
241 aagctgtgac tgcaccagtg cactccagcc tgggcaacag agcgagacac tgtctcaaaa
301 aagaaaagca aagcaaagcc actcacatga ggtcttgctc ctggggacgg gcatggccag
361 gactccaacc ccggcagcct gtcccagagc cctggagcta gccccagtgc agtctctcca
421 ccaccccgca cttcctcagg ccaccttcct gccacagcct tttccccaaa cctggtatca
481 ccccctctcc tccctcccta atcccacctc tcgggcctgg ccactccacc ccaccccttc
541 caggactcag attcagactc tgagggagga gccgctggtg gagaagcaga cagtgagtat
601 cttcctggag ggacagggag cagggttctg gggggcgggg ggatttcagg gcaggggtgt
661 gggtgatacc tcctcaactc catcaggagt gacatccaaa gtatgtagca gtgggttggg
721 taccagtgcc agagcaggct cctggaggcc gctggctggg ccgggccttg tgcctttaga
781 tgtgggaggc cgggaacccc agggctgggt gccagggtgc cggagacatc catgcccctg
841 gctgaatgcc cgtcctgccg ctgtctctct tctttccggt cagtggactt cctgcggaac
901 ttattctccc agacgctcag cctgggcagc cagaaggagc gtctgctgga cgagctgacc
961 ttggaagggg tggcccggta catgcagagc gaacgctgtc gcagagtcat ctgtttggtg
1021 ggagctggaa tctccacatc cgcaggcatc cccgactttc gctctccatc caccggcctc
1081 tatgacaacc tagagaagta ccatcttccc tacccagagg ccatctttga gatcagctat
1141 ttcaagaaac atccggaacc cttcttcgcc ctcgccaagg aactctatcc tgggcagttc
1201 aagccaacca tctgtcacta cttcatgcgc ctgctgaagg acaaggggct actcctgcgc
1261 tgctacacgc agaacataga taccctggag cgaatagccg ggctggaaca ggaggacttg
1321 gtggaggcgc acggcacctt ctacacatca cactgcgtca gcgccagctg ccggcacgaa
1381 tacccgctaa gctggatgaa agagaagatc ttctctgagg tgacgctcaa gtgtgaagac
1441 tgtcagagcc tggtgaagcc tgatatcgtc ttttttggtg agagcctccc agcgcgtttc
1501 ttctcctgta tgcagtcaga cttcctgaag gtggacctcc tcctggtcat gggtacctcc
1561 ttgcaggtgc agccctttgc ctccctcatc agcaaggcac ccctctccac ccctcgcctg
1621 ctcatcaaca aggagaaagc tggccagtcg gaccctttcc tggggatgat tatgggcctc
1681 ggaggaggca tggactttga ctccaagaag gcctacaggg acgtggcctg gctgggtgaa
1741 tgcgaccagg gctgcctggc ccttgctgag ctccttggat ggaagaagga gctggaggac
1801 cttgtccgga gggagcacgc cagcatagat gcccagtcgg gggcgggggt ccccaacccc
1861 agcacttcag cttcccccaa gaagtccccg ccacctgcca aggacgaggc caggacaaca
1921 gagagggaga aaccccagtg acagctgcat ctcccaggcg ggatgccgag ctcctcaggg
1981 acagctgagc cccaaccggg cctggccccc tcttaaccag cagttcttgt ctggggagct
2041 cagaacatcc cccaatctct tacagctccc tccccaaaac tggggtccca gcaaccctgg
2101 gcccccaacc ccagcaaatc tctaacacct cctagaggcc aaggcttaaa caggcatctc
2161 taccagcccc actgtctcta accactcctg ggctaaggag taacctccct catctctaac
2221 tgcccccacg gggccagggc taccccagaa cttttaactc ttccaggaca gggagcttcg
2281 ggcccccact ctgtctcctg cccccggggg cctgtggcta agtaaaccat acctaaccta
2341 ccccagtgtg ggtgtgggcc tctgaatata acccacaccc agcgtagggg gagtctgagc
2401 cgggagggct cccgagtctc tgccttcagc tcccaaagtg ggtggtgggc ccccttcacg
2461 tgggacccac ttcccatgct ggatgggcag aagacattgc ttattggaga caaattaaaa
2521 acaaaaacaa ctaaaaaaaa aaaaaaaaaa
//