LOCUS AJ438952 6864 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for additional sex combs-like 1 protein (ASXL1
gene).
ACCESSION AJ438952
VERSION AJ438952.2
KEYWORDS additional sex combs-like 1 protein; ASXL1 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Brock H.W.
JOURNAL Submitted (12-MAR-2002) to the INSDC. Brock H.W., Zoology,
University of British Columbia, 6270 University Boulevard, British
Columbia, V6T 1Z4, CANADA.
REMARK revised by [3]
REFERENCE 2
AUTHORS Fisher C.L.
TITLE The human homologue of Additional sex combs, ADDITIONAL SEX
COMBS-LIKE 1 (ASX1L) maps to chromosome 20q11
JOURNAL Unpublished.
REFERENCE 3 (bases 1 to 6864)
AUTHORS Brock H.W.
JOURNAL Submitted (08-JAN-2003) to the INSDC. Brock H.W., Zoology,
University of British Columbia, 6270 University Boulevard, British
Columbia, V6T 1Z4, CANADA.
FEATURES Location/Qualifiers
source 1..6864
/db_xref="H-InvDB:HIT000248050"
/organism="Homo sapiens"
/chromosome="20"
/map="20q11"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR 1..258
/gene="ASXL1"
CDS 259..4884
/gene="ASXL1"
/product="additional sex combs-like 1 protein"
/db_xref="GOA:Q8IXJ9"
/db_xref="H-InvDB:HIT000248050.14"
/db_xref="HGNC:HGNC:18318"
/db_xref="InterPro:IPR007759"
/db_xref="InterPro:IPR024811"
/db_xref="InterPro:IPR024815"
/db_xref="InterPro:IPR026905"
/db_xref="InterPro:IPR028020"
/db_xref="UniProtKB/Swiss-Prot:Q8IXJ9"
/protein_id="CAD27708.1"
/translation="MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLK
EMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDALQWSRHPATVEGEEP
EDTADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANK
QKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIR
GQAEVTQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHAL
PSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFFTHAAQSWRERLADGEFTHEMQ
VRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGES
VRIQRGPATRQRDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYK
DGETKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAEPDNLARASASPDRIP
SLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEE
PKVPPIRIQLSRIKPPWVVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQV
RGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACGHPEPRGGPS
TPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLT
DGLGDASQLPVAPTGDQPCQALPLLSSQTSVAERLVEQPQLHPDVRTECESGTTSWES
DDEEQGPTVPADNGPIPSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSPTDC
LQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPE
SREHIPSVEPQVGEEWEKAAPTPPALPGDLTAEEGLDPLDSLTSLWTVPSRGGSDSNG
SYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVD
KDEKPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQ
PRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLPPAHDDSMSESPQVPLTKDQSHGS
LRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNC
KAVPSFDSLHPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKS
PGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKKLFGSGNVAATLQRPRPA
DPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPL
KANAENRKATGHSPLELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSI
KQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSASLSLQMFT
DSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR"
polyA_site 4882
/gene="ASXL1"
3'UTR 4885..6864
/gene="ASXL1"
polyA_site 5935
/gene="ASXL1"
polyA_site 6844
/gene="ASXL1"
BASE COUNT 1655 a 1833 c 1807 g 1569 t
ORIGIN
1 gggcagccgc cgctgccgcc gtgggcgact gacgcagcgc gggcgcgtgg agccgccgcc
61 gcccctcccc caccgccgct ctcgcgccag ccggtccccg cgtgcccgcc ccttctcccc
121 ggccgcaccc gagacctcgc gcgccgccgc tgccacgcgc cccccccacc gccgccgccg
181 ccccagcccc gcgccaccgc cccagcccgc ccagcccgga ggtcccgcgt ggagctgccg
241 ccgccgccgg ggagaaggat gaaggacaaa cagaagaaga agaaggagcg cacgtgggcc
301 gaggccgcgc gcctggtatt agaaaactac tcggatgctc caatgacacc aaaacagatt
361 ctgcaggtca tagaggcaga aggactaaag gaaatgagaa gtgggacttc ccctctcgca
421 tgcctcaatg ctatgctaca ttccaattca agaggaggag aggggttgtt ttataaactg
481 cctggccgaa tcagcctttt cacgctcaag aaggatgccc tgcagtggtc tcgccatcca
541 gctacagtgg agggagagga gccagaggac acggctgatg tggagagctg tgggtctaat
601 gaagccagca ctgtgagtgg tgaaaacgat gtatctcttg atgaaacatc ttcgaacgca
661 tcctgttcta cagaatctca gagtcgacct ctttccaatc ccagggacag ctacagagct
721 tcctcacagg cgaacaaaca aaagaaaaag actggggtga tgctgcctcg agttgtcctg
781 actcctctga aggtaaacgg ggcccacgtg gaatctgcat cagggttctc gggctgccac
841 gccgatggcg agagcggcag cccgtccagc agcagcagcg gctctctggc cctgggcagc
901 gctgctattc gtggccaggc cgaggtcacc caggaccctg ccccgctcct gagaggcttc
961 cggaagccag ccacaggtca aatgaagcgc aacagagggg aagaaataga ttttgagaca
1021 cctgggtcca ttcttgtcaa caccaacctc cgtgccctga tcaactctcg gaccttccat
1081 gccttaccat cacacttcca gcagcagctc ctcttcctcc tgcctgaagt agacagacag
1141 gtggggacgg atggcctgtt gcgtctcagc agcagtgcac taaataacga gttttttacc
1201 catgcggctc agagctggcg ggagcgcctg gctgatggtg aatttactca tgagatgcaa
1261 gtcaggatac gacaggaaat ggagaaggaa aagaaggtgg aacaatggaa agaaaagttc
1321 tttgaagact actatggaca gaagctgggt ttgaccaaag aagagtcatt gcagcagaac
1381 gtgggccagg aggaggctga aatcaaaagt ggcttgtgtg tcccaggaga atcagtgcgt
1441 atacagcgtg gtccagccac ccgacagcga gatgggcatt ttaagaaacg ctctcggcca
1501 gatctccgaa ccagagccag aaggaatctg tacaaaaaac aggagtcaga acaagcaggg
1561 gttgctaagg atgcaaaatc tgtggcctca gatgttcccc tctacaagga tggggagact
1621 aagactgacc cagcagggct gagcagtccc catctgccag gcacatcctc tgcagcaccc
1681 gacctggagg gtcccgaatt cccagttgag tctgtggctt ctcggatcca ggctgagcca
1741 gacaacttgg cacgtgcctc tgcatctcca gacagaattc ctagcctgcc tcaggaaact
1801 gtggatcagg aacccaagga tcagaagagg aaatcctttg agcaggcggc ctctgcatcc
1861 tttcccgaaa agaagccccg gcttgaagat cgtcagtcct ttcgtaacac aattgaaagt
1921 gttcacaccg aaaagccaca gcccactaaa gaggagccca aagtcccgcc catccggatt
1981 caactttcac gtatcaaacc accctgggtg gttaaaggtc agcccactta ccagatatgc
2041 ccccggatca tccccaccac ggagtcctcc tgccggggtt ggactggcgc caggaccctc
2101 gcagacatta aagcccgtgc tctgcaggtc cgaggggcga gaggtcacca ctgccataga
2161 gaggcggcca ccactgccat cggagggggg ggtggcccgg gtggaggtgg cggcggggcc
2221 accgatgagg gaggtggcag aggcagcagc agtggtgatg gtggtgaggc ctgtggccac
2281 cctgagccca ggggaggccc gagcacccct ggaaagtgta cgtcagatct acagcgaaca
2341 caactactgc cgccttatcc tctaaatggg gagcataccc aggccggaac tgccatgtcc
2401 agagctagga gagaggacct gccttctctg agaaaggagg aaagctgcct actacagagg
2461 gctacagttg gactcacaga tgggctagga gatgcctccc aactccccgt tgctcccact
2521 ggggaccagc catgccaggc cttgccccta ctgtcctccc aaacctcagt agctgagaga
2581 ttagtggagc agcctcagtt gcatccggat gttagaactg aatgtgagtc tggcaccact
2641 tcctgggaaa gtgatgatga ggagcaagga cccaccgttc ctgcagacaa tggtcccatt
2701 ccgtctctag tgggagatga tacattagag aaaggaactg gccaagctct tgacagtcat
2761 cccactatga aggatcctgt aaatgtgacc cccagttcca cacctgaatc ctcaccgact
2821 gattgcctgc agaacagagc atttgatgac gaattagggc ttggtggctc atgccctcct
2881 atgagggaaa gtgatactag acaagaaaac ttgaaaacca aggctctcgt ttctaacagt
2941 tctttgcatt ggatacccat cccatcgaat gatgaggtag tgaaacagcc caaaccagaa
3001 tccagagaac acataccatc tgttgagccc caggttggag aggagtggga gaaagctgct
3061 cccacccctc ctgcattgcc tggggatttg acagctgagg agggtctaga tcctcttgac
3121 agccttactt cactctggac tgtgccatct cgaggaggca gtgacagcaa tggcagttac
3181 tgtcaacagg tggacattga aaagctgaaa atcaacggag actctgaagc actgagtcct
3241 cacggtgagt ccacggatac agcctctgac tttgaaggtc acctcacgga ggacagcagt
3301 gaggctgaca ctagagaagc tgcagtgaca aagggatctt cggtggacaa ggatgagaaa
3361 cccaattgga accaatctgc cccactgtcc aaggtgaatg gtgacatgcg tctggttaca
3421 aggacagatg ggatggttgc tcctcagagc tgggtgtctc gagtatgtgc ggtccgccaa
3481 aagatcccag attccctact gctggccagt actgagtacc agccaagagc cgtgtgcctg
3541 tccatgcctg ggtcctcagt ggaggccact aacccacttg tgatgcagtt gctgcagggt
3601 agcttgcccc tagagaaggt tcttccacca gcccacgatg acagcatgtc agaatcccca
3661 caagtaccac ttacaaaaga ccagagccat ggctcgctac gcatgggatc tttacatggt
3721 cttggaaaaa acagtggcat ggttgatgga agcagcccca gttctttaag ggctttgaag
3781 gagcctcttc tgccagatag ctgtgaaaca ggcactggtc ttgccaggat tgaggccacc
3841 caggctcctg gagcacccca aaagaattgc aaggcagtcc caagttttga ctccctccat
3901 ccagtgacaa atcccattac atcctctagg aaactggaag aaatggattc caaagagcag
3961 ttctcttcct ttagttgtga agatcagaag gaagtccgtg ctatgtcaca ggacagcaat
4021 tcaaatgctg ctccaggaaa gagcccagga gatcttacta cctcgagaac acctcgtttc
4081 tcatctccaa atgtgatctc ctttggtcca gagcagacag gtcgggccct gggtgatcag
4141 agcaatgtta caggccaagg gaagaagctt tttggctctg ggaatgtggc tgcaaccctt
4201 cagcgcccca ggcctgcgga cccgatgcct cttcctgctg agatccctcc agtttttccc
4261 agtgggaagt tgggaccaag cacaaactcc atgtctggtg gggtacagac tccaagggaa
4321 gactgggctc caaagccaca tgcctttgtt ggcagcgtca agaatgagaa gacttttgtg
4381 gggggtcctc ttaaggcaaa tgccgagaac aggaaagcta ctgggcatag tcccctggaa
4441 ctggtgggtc acttggaagg gatgcccttt gtcatggact tgcccttctg gaaattaccc
4501 cgagagccag ggaaggggct cagtgagcct ctggagcctt cttctctccc ctcccaactc
4561 agcatcaagc aggcatttta tgggaagctt tctaaactcc aactgagttc caccagcttt
4621 aattattcct ctagctctcc cacctttccc aaaggccttg ctggaagtgt ggtgcagctg
4681 agccacaaag caaactttgg tgcgagccac agtgcatcac tttccttgca aatgttcact
4741 gacagcagca cggtggaaag catctcgctc cagtgtgcgt gcagcctgaa agccatgatc
4801 atgtgccaag gctgcggtgc gttctgtcac gatgactgta ttggaccctc aaagctctgt
4861 gtattgtgcc ttgtggtgag ataataaatt atggccatgg gaaacgttgt atatttagtg
4921 tgtgtatttt gataatgatt gatcttaaat ctgtatacag aatatcattg atacaatact
4981 ctttaggcag gagcactctt gccttccccc aaaatttaca ctgctaaagc cctctgtcac
5041 ttggcgaccc ttctggtctt gctggagggg tttcctgggt ataacccatt gggctgccca
5101 aggccagcca gcctgagctc tcctgcaaga cagagcctga tgtggcacgg agtggggttg
5161 cggggggtgg ggggactgcc tgactcccag agggacttga aactgaagca agaaggttgc
5221 attctccacc aagggagtta acctacctga actaagtaga aatgccagtc ttccactacc
5281 ccctccctgc catcttttct tctgctactt tggggagttg atggccagga aagaagccag
5341 cacagggtta aagtaactcc tggcattgcc caccaggggg ctggtgcacc tgctgacctc
5401 agggtcacag ttgagtcatt tgccagttga cggagcaagt ttgaccttgg ttctgttgct
5461 gaagcaaatt tggaactttt ctgtctcagt gtgatccact aacccacagg atcatttgga
5521 accttgaata gctctgcttg gacaatgggg ttggggaata gggttgtctt tcctatgaaa
5581 atgccatctg tagaccttgt gagtcagccg tccagatgtt tgcaggtgaa ttcctctgct
5641 tgacatcctc cctgtcactt tggaccctat gggagtgggc atctccacgc acctgtgtat
5701 gtgaaagtca ttttacattt caaagcagtg tgtgtttctt atttttatat ttttaactct
5761 ttattcttgg atgtataaag tgaacttttt ggcttctgta agtatgctct atgcacctct
5821 aatgttttat catgtattta tatgttgtac acagtactgg ctgattctgt aaatggatgt
5881 attgtacaga gaacatgaac gtctcttcct aattttacat cttcagcatc attgcattaa
5941 agtggtgtaa tctccttctc tacatctgtt gtcagagcca ctgagtgctg tgctgctcga
6001 cgtgagggtg aaatgattga cttgtgacct gccaggttgc ccgatgccct gttgggtcac
6061 cggctggacc tgctgcagcc tgcagagcca cagtcagcct gcccacatgc caccgagcaa
6121 acgcatcttg cttttcacat ctctcctcct acagccttaa tggctgcttg ctgccatatg
6181 tgacaaatca ccaccaccag tgttaagtgc ttctggattc atgggtgagt tccctgggca
6241 gcccccagga aggccttcca gatctggctc cagggtcacc acctgtcaca gcaatacctg
6301 ggaccatgct ctcctgggac tgtgaggctc cttttgacgt acttttgaca tcaggcaggt
6361 ttgggaagaa acaaagccat gcctgctcct gcctctctcc caacatgttt ccagcaagta
6421 gatgcccctg tgtgtgtttt cccttgcctt gtttcctgcc ttatatcttg tatttcgact
6481 tattacagag ttgagggttc ttgcttaatt tagatcaagt ataaaatttg tatgacttca
6541 agtctcattt tatctgaaag gtttttttct catttaatct gatgtggcat tttcgtcatc
6601 tgaagcatga gtgacaagtt gggaatgatg tggtgattta gaatgcagta ttggccaagt
6661 ccaagttgtc aacttaagcg tctgtttacc aaagaccggg aacaggggcc caaacatgtc
6721 cagtcctctt cttccctctg ctggaacctt tggggacact caagggtaca gtttgacact
6781 gatctggtcc atgaggctgc ccagagaaag cactgcttct gtatgtctct tgtggtattg
6841 gaacaataaa cccgtacaac ctgc
//