LOCUS AJ428203 2087 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens partial mRNA for mitochondrial glutamate carrier (GC2
gene), isoform 2.
ACCESSION AJ428203
VERSION AJ428203.1
KEYWORDS GC2 gene; mitochondrial glutamate carrier.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2087)
AUTHORS Fiermonte G.
JOURNAL Submitted (16-JAN-2002) to the INSDC. Fiermonte G.,
Pharmaco-Biology, University, Via orabona 4, 70125, ITALY.
REFERENCE 2
AUTHORS Palmieri L., Pardo B., Lasorsa F.M., del Arco A., Kobayashi K.,
Iijima M., Runswick M.J., Walker J.E., Saheki T., Satrustegui J.,
Palmieri F.
TITLE Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate
transporters in mitochondria
JOURNAL EMBO J. 20(18), 5060-5069(2001).
PUBMED 11566871
REFERENCE 3
AUTHORS Fiermonte G., Palmieri L., Todisco S., Agrimi G., Palmieri F.,
Walker J.E.
TITLE Identification of the mitochondrial glutamate transporter.
Bacterial expression, reconstitution, functional characterization,
and tissue distribution of two human isoforms
JOURNAL J Biol Chem 277(22), 19289-19294(2002).
PUBMED 11897791
FEATURES Location/Qualifiers
source 1..2087
/db_xref="H-InvDB:HIT000247926"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="brain"
/db_xref="taxon:9606"
mRNA <1..>2087
/gene="GC2"
CDS 495..1442
/codon_start=1
/gene="GC2"
/product="glutamate carrier"
/function="involved in transport of glutamate across the
inner mitochondrial membrane"
/db_xref="GOA:Q9H1K4"
/db_xref="H-InvDB:HIT000247926.12"
/db_xref="HGNC:HGNC:10988"
/db_xref="InterPro:IPR002067"
/db_xref="InterPro:IPR018108"
/db_xref="InterPro:IPR023395"
/db_xref="UniProtKB/Swiss-Prot:Q9H1K4"
/protein_id="CAD21008.1"
/translation="MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAM
YKGMIDCLMKTARAEGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNL
KMEMLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSAST
HRRPSATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGK
ASFAHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEG
PSAFMKGAGCRALVIAPLFGIAQGVYFIGIGERILKCFD"
BASE COUNT 471 a 578 c 564 g 474 t
ORIGIN
1 ctggatttgg acttcattct ggacagcata tgacaaggac gaggacccct attctagcca
61 gttaaagctg gacagaattt ttaaaagcaa tgaagccagt tccttggata tatccacggg
121 ctttgctttg agaaggaact gagtaggcag tgagaagagt cgagtgaagc ctggcccgtg
181 agtgcctcaa caactgagat gaacgtcgac tcgcttgcag gcaagttgtc actcagcagc
241 gatctgaact atatcctggg ttccagaaaa ggcagaggtt cttaccgaaa gcaggggagg
301 aagccgcagc ccaaggaggt cgtcacttgc cgggaaggtg gctcgggcca ggctgcactc
361 aaaacccgtg ctctgtccac actgctacgg ggccagagcc aaggaagctt ccacttcttc
421 ccccagacag ccccaacagc ggctacccca aggagccagc agccttgtgt cctgggatcc
481 ccagcccctg cagaatgacc caccaggatc tgagcatcac agccaaactc atcaatggag
541 gtgtagcagg gctcgtgggg gtgacctgcg tgttccccat cgacttggcc aagactcgcc
601 tgcagaacca gcatgggaaa gccatgtaca aaggaatgat cgactgcctg atgaagacgg
661 ctcgggcgga gggcttcttc ggcatgtacc gaggggctgc agtgaacctc actctggtca
721 ctccagagaa ggccatcaag ctggcggcca acgacttttt ccggcggctg ctcatggaag
781 atgggatgca gcggaacctg aagatggaga tgcttgccgg gtgtggggct gggatgtgcc
841 aggtcgtggt gacctgtccc atggaaatgc tcaagattca gctgcaggat gctggacgcc
901 tggccgtcca tcatcagggc tcggcctcag caccctccac ctccaggtcc tacacaactg
961 gttcggcttc cacccacagg cgcccctctg ccaccctcat tgcctgggag ctgctccgca
1021 ctcagggcct ggctgggctc tacaggggcc tgggtgccac tctcctcaga gacattcctt
1081 tctccatcat ctacttccca ctgtttgcca accttaacaa cctggggttc aacgagctcg
1141 ccggtaaggc gtcctttgca cattccttcg tgtcaggctg tgtggcaggt tccatagctg
1201 cggtcgcagt gacgcctcta gatgttctga aaactcgaat ccaaaccctc aagaaaggcc
1261 tgggcgagga catgtacagt gggatcaccg actgtgccag gaaactctgg attcaggagg
1321 gaccatctgc cttcatgaaa ggcgctggct gccgggcact ggtcatagca cctctctttg
1381 ggattgctca aggggtctat tttattggga ttggagagcg catcttaaag tgttttgact
1441 agacagagct ggaggtcaag tccctgcgct tgccgccctc tctctagctg tttcacttag
1501 cctagagggg gcaagggcag gtggggccac tctggcctgc ctggtcctct gcgttgtagt
1561 gctacctcaa tctcgggaga aacagcccta tattctaaca agttgagcac agccttcttc
1621 cccttcgtgt ctacactcgt tttcctttgt gggcacagct accaggggct tttggaagcc
1681 cctaaccacc tacttttcaa caaaaatggt actttcgttg tattaattgc aggaccttaa
1741 caggtagtca caatagaagg gttgtttctg tattttaaca tttctatttc acagtcaaac
1801 tcggcattct tcagtcagct tgaggattta gcattgttaa tcttggactc cataacttat
1861 gagtcctagc actgattttg aggaaaagga ggatcagaag ttcaagggac cgtgaaagcc
1921 ctcagagtca gcacctagtt tgagaccaag caccctttcg aatccctgga tggctgaggg
1981 ggctgaggcc ggctctgact gggcagccca gcccctcccc cagagcccag gctcttgcac
2041 acccctccct gtaaccaagg aacactctga aataaaggtg aatggct
//