LOCUS AJ417076 5284 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for putative TRP cation channel (KNP3 gene).
ACCESSION AJ417076
VERSION AJ417076.1
KEYWORDS KNP3 gene; TRP cation channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5284)
AUTHORS Wehage E.
JOURNAL Submitted (19-OCT-2001) to the INSDC. Wehage E., Institute of
Physiology, Medical Faculty, RWTH Aachen, Pauwelsstr. 30, 52074
Aachen, GERMANY.
REFERENCE 2
AUTHORS Wehage E., Eisfeld J., Heiner I., Juengling E., Zitt C.,
Lueckhoff A.
TITLE Activation of the cation channel long transient receptor potential
channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a
mode of activation independent of ADP-ribose
JOURNAL J Biol Chem 277(26), 23150-23156(2002).
PUBMED 11960981
FEATURES Location/Qualifiers
source 1..5284
/db_xref="H-InvDB:HIT000247673"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="HL-60 cells"
/cell_type="leukemia, acute promyelocytic"
/db_xref="taxon:9606"
CDS 14..4363
/gene="KNP3"
/product="putative TRP cation channel"
/db_xref="GOA:O94759"
/db_xref="H-InvDB:HIT000247673.13"
/db_xref="HGNC:HGNC:12339"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR029594"
/db_xref="InterPro:IPR041491"
/db_xref="PDB:6MIX"
/db_xref="PDB:6MIZ"
/db_xref="PDB:6MJ2"
/db_xref="UniProtKB/Swiss-Prot:O94759"
/protein_id="CAD01139.1"
/translation="MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSW
RLQCPFGNNDKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEA
TKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQ
HWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQV
GEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC
LDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGP
GTLHTIDNATTNGTPCVVVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFE
TFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHE
NWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGV
QLKEFVTWDTLLYLYENLDPSCLFHSKLQMHHVAQVLRELLGDFTQPLYPRPRHNDRL
RLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQ
SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQ
KLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCM
LAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLM
VDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAI
LLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDV
FFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFN
PEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNY
TFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLNHLQLFIKRVVLKTPAKRHKQ
LKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDP
LKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFSSEADVPTLASQKAAEEPDAE
PGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTAERKD
AAAMDPMGENPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEV
LVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDP
RNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKT
LLQKAAAEFGAHY"
BASE COUNT 1089 a 1622 c 1614 g 959 t
ORIGIN
1 tgggggtctc agaatggagc cctcagccct gaggaaagct ggctcggagc aggaggaggg
61 ctttgagggg ctgcccagaa gggtcactga cctggggatg gtctccaatc tccggcgcag
121 caacagcagc ctcttcaaga gctggaggct acagtgcccc ttcggcaaca atgacaagca
181 agaaagcctc agttcgtgga ttcctgaaaa catcaagaag aaagaatgcg tgtattttgt
241 ggaaagttcc aaactgtctg atgctgggaa ggtggtgtgt cagtgtggct acacgcatga
301 gcagcacttg gaggaggcta ccaagcccca caccttccag ggcacacagt gggacccaaa
361 gaaacatgtc caggagatgc caaccgatgc ctttggcgac atcgtcttca cgggcctgag
421 ccagaaggtg aaaaagtacg tccgagtctc ccaggacacg ccctccagcg tgatctacca
481 cctcatgacc cagcactggg ggctggacgt ccccaatctc ttgatctcgg tgaccggggg
541 ggccaagaac ttcaacatga agccgcggct gaagagcatt ttccgcagag gcctggtcaa
601 ggtggctcag accacagggg cctggatcat cacagggggg tcccacaccg gcgtcatgaa
661 gcaggtaggc gaggcggtgc gggacttcag cctgagcagc agctacaagg aaggcgagct
721 catcaccatc ggagtcgcca cctggggcac tgtccaccgc cgcgagggcc tgatccatcc
781 cacgggcagc ttccccgccg agtacatact ggatgaggat ggccaaggga acctgacctg
841 cctagacagc aaccactctc acttcatcct cgtggacgac gggacccacg gccagtacgg
901 ggtggagatt cctctgagga ccaggctgga gaagttcata tcggagcaga ccaaggaaag
961 aggaggtgtg gccatcaaga tccccatcgt gtgcgtggtg ctggagggcg gcccgggcac
1021 gttgcacacc atcgacaacg ccaccaccaa cggcaccccc tgtgtggttg tggagggctc
1081 gggccgcgtg gccgacgtca ttgcccaggt ggccaacctg cctgtctcgg acatcactat
1141 ctccctgatc cagcagaaac tgagcgtgtt cttccaggag atgtttgaga ccttcacgga
1201 aagcaggatt gtcgagtgga ccaaaaagat ccaagatatc gtccggaggc ggcagctgct
1261 gactgtcttc cgggaaggca aggatggtca gcaggacgtg gatgtggcca tcttgcaggc
1321 cttgctgaaa gcctcacgga gccaagacca ctttggccac gagaactggg accaccagct
1381 gaaactggca gtggcatgga atcgcgtgga cattgcccgc agtgagatct tcatggatga
1441 gtggcagtgg aagccttcag atctgcaccc cacgatgaca gctgcactca tctccaacaa
1501 gcctgagttt gtgaagctct tcctggagaa cggggtgcag ctgaaggagt ttgtcacctg
1561 ggacaccttg ctctacctgt acgagaacct ggacccctcc tgcctgttcc acagcaagct
1621 gcagatgcac cacgtggccc aggtgctgcg ggagctgctg ggggacttca cgcagccgct
1681 ttatccccgg ccccggcaca acgaccggct gcggctcctg ctgcccgttc cccacgtcaa
1741 gctcaacgtg cagggagtga gcctccggtc cctctacaag cgttcctcag gccatgtgac
1801 cttcaccatg gaccccatcc gtgaccttct catttgggcc attgtccaga accgtcggga
1861 gctggcagga atcatctggg ctcagagcca ggactgcatc gcagcggcct tggcctgcag
1921 caagatcctg aaggaactgt ccaaggagga ggaggacacg gacagctcgg aggagatgct
1981 ggcgctggcg gaggagtatg agcacagagc catcggggtc ttcaccgagt gctaccggaa
2041 ggacgaagag agagcccaga aactgctcac ccgcgtgtcc gaggcctggg ggaagaccac
2101 ctgcctgcag ctcgccctgg aggccaagga catgaagttt gtgtctcacg ggggcatcca
2161 ggccttcctg accaaggtgt ggtggggcca gctctccgtg gacaatgggc tgtggcgtgt
2221 gaccctgtgc atgctggcct tcccgctgct cctcaccggc ctcatctcct tcagggagaa
2281 gaggctgcag gatgtgggca cccccgcggc ccgcgcccgt gccttcttca ccgcacccgt
2341 ggtggtcttc cacctgaaca tcctctccta cttcgccttc ctctgcctgt tcgcctacgt
2401 gctcatggtg gacttccagc ctgtgccctc ctggtgcgag tgtgccatct acctctggct
2461 cttctccttg gtgtgcgagg agatgcggca gctcttctat gaccctgacg agtgcgggct
2521 gatgaagaag gcagccttgt acttcagtga cttctggaat aagctggacg tcggcgcaat
2581 cttgctcttc gtggcagggc tgacctgcag gctcatcccg gcgacgctgt accccgggcg
2641 cgtcatcctc tctctggact tcatcctgtt ctgcctccgg ctcatgcaca tttttaccat
2701 cagtaagacg ctggggccca agatcatcat tgtgaagcgg atgatgaagg acgtcttctt
2761 cttcctcttc ctgctggctg tgtgggtggt gtccttcggg gtggccaagc aggccatcct
2821 catccacaac gagcgccggg tggactggct gttccgaggg gccgtctacc actcctacct
2881 caccatcttc gggcagatcc cgggctacat cgacggtgtg aacttcaacc cggagcactg
2941 cagccccaat ggcaccgacc cctacaagcc taagtgcccc gagagcgacg cgacgcagca
3001 gaggccggcc ttccctgagt ggctgacggt cctcctactc tgcctctacc tgctcttcac
3061 caacatcctg ctgctcaacc tcctcatcgc catgttcaac tacaccttcc agcaggtgca
3121 ggagcacacg gaccagattt ggaagttcca gcgccatgac ctgatcgagg agtaccacgg
3181 ccgccccgcc gcgccgcccc ccttcatcct cctcaaccac ctgcagctct tcatcaagag
3241 ggtggtcctg aagactccgg ccaagaggca caagcagctc aagaacaagc tggagaagaa
3301 cgaggaggcg gccctgctat cctgggagat ctacctgaag gagaactacc tccagaaccg
3361 acagttccag caaaagcagc ggcccgagca gaagatcgag gacatcagca ataaggttga
3421 cgccatggtg gacctgctgg acctggaccc actgaagagg tcgggctcca tggagcagag
3481 gttggcctcc ctggaggagc aggtggccca gacagcccga gccctgcact ggatcgtgag
3541 gacgctgcgg gccagcggct tcagctcgga ggcggacgtc cccactctgg cctcccagaa
3601 ggccgcggag gagccggatg ctgagccggg aggcaggaag aagacggagg agccgggcga
3661 cagctaccac gtgaatgccc ggcacctcct ctaccccaac tgccctgtca cgcgcttccc
3721 cgtgcccaac gagaaggtgc cctgggagac ggagttcctg atctatgacc caccctttta
3781 cacggcagag aggaaggacg cggccgccat ggaccccatg ggagagaacc ccatgggccg
3841 cacaggactg cgtgggcgcg ggagcctcag ctgcttcgga cccaaccaca cgctgtaccc
3901 catggtcacg cggtggaggc ggaacgagga tggagccatc tgcaggaaga gcataaagaa
3961 gatgctggaa gtgctggtgg tgaagctccc tctctccgag cactgggccc tgcctggggg
4021 ctcccgggag ccaggggaga tgctacctcg gaagctgaag cggatcctcc ggcaggagca
4081 ctggccgtct tttgaaaact tgctgaagtg cggcatggag gtgtacaaag gctacatgga
4141 tgacccgagg aacacggaca atgcctggat cgagacggtg gccgtcagcg tccacttcca
4201 ggaccagaat gacgtggagc tgaacaggct gaactctaac ctgcacgcct gcgactcggg
4261 ggcctccatc cgatggcagg tggtggacag gcgcatccca ctctatgcga accacaagac
4321 cctcctccag aaggcagccg ctgagttcgg ggctcactac tgactgtgcc ctcaggctgg
4381 gcggctccag tccatagacg ttccccccag aaaccagggc ttctctctcc tgagcctggc
4441 caggactcag gccgttcctg ggccctgcac atgatggggt ttggtggacc cagtgcccct
4501 cacggctgcc gcaagtctgc tgcagatgac ctcatgaact ggaaggggtc aaggtgaccc
4561 gggaggagag ctcaagacag ggcacaggct actcagagct gaggggcccc tgggaccctt
4621 ggccatcagg cgaggggctg ggcctgtgca gctgggccct tggccagagt ccactccctt
4681 cctggctgtg tcaccccgag cagctcatcc accatggagg tcattggcct gaggcaagtt
4741 ccccggagag tcgggatccc ctgtggcccc ctcaggcata tgtctgtgag gaaggggccc
4801 tgccactctc cccaagaggg cctccatgtt tcgaggtgcc tcaacatgga gccttgcctg
4861 gcctgggcta ggggcactgt ctgaactcct gactgtcagg ataaactccg tggggataca
4921 ggagcccaga caaagcccag gcctgtcaag agacgcagag ggcccctgcc agggttggcc
4981 ccagggaccc tgggacgagg ctgcagaagc tctccctccc tactccctgg gagccacgtg
5041 ctggccatgt ggccagggac ggcatgagca ggaggcgggg acgtgggggc cttctggttt
5101 ggtgtcaaca gctcacagga gcgtgaacca tgagggccct caggagggga acgtggtaaa
5161 acccaagaca ttaaatctgc catctcaggc ctggctggct cttctgtgct ttccacaaat
5221 aaagttcctg acacgtccag ggccaggggc tgtgtgacgg ctgcctgaag ttctcctcga
5281 tccc
//