LOCUS AJ409088 5232 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens partial mRNA for protein kinase WNK3 (PRKWNK3 gene).
ACCESSION AJ409088
VERSION AJ409088.2
KEYWORDS PRKWNK3 gene; protein kinase WNK3.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Jordan P.
JOURNAL Submitted (20-FEB-2001) to the INSDC. Jordan P., Centro de Genetica
Humana, Instituto Nacional de Saude "Dr. Ricardo Jorge", Avenida
Padre Cruz, Lisboa, 1649-016, PORTUGAL.
REMARK revised by [4]
REFERENCE 3
AUTHORS Verissimo F., Jordan P.
TITLE WNK kinases, a novel protein kinase subfamily in multi-cellular
organisms
JOURNAL Oncogene 20(39), 5562-5569(2001).
PUBMED 11571656
REFERENCE 4 (bases 1 to 5232)
AUTHORS Jordan P.
JOURNAL Submitted (18-JAN-2002) to the INSDC. Jordan P., Centro de Genetica
Humana, Instituto Nacional de Saude "Dr. Ricardo Jorge", Avenida
Padre Cruz, Lisboa, 1649-016, PORTUGAL.
REFERENCE 5
AUTHORS Verassimo F., Silva E., Morris J.D., Pepperkok R., Jordan P.
TITLE Protein kinase WNK3 increases cell survival in a caspase
3-dependent pathway
JOURNAL Oncogene 25, 4172-4182(2006).
FEATURES Location/Qualifiers
source 1..5232
/db_xref="H-InvDB:HIT000247549"
/organism="Homo sapiens"
/chromosome="X"
/map="Xp11.21-23"
/mol_type="mRNA"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 1..5232
/gene="PRKWNK3"
/product="protein kinase WNK3"
/db_xref="GOA:Q9BYP7"
/db_xref="H-InvDB:HIT000247549.13"
/db_xref="HGNC:HGNC:14543"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR024678"
/db_xref="PDB:5NKP"
/db_xref="PDB:5O1V"
/db_xref="PDB:5O21"
/db_xref="PDB:5O23"
/db_xref="PDB:5O26"
/db_xref="PDB:5O2B"
/db_xref="PDB:5O2C"
/db_xref="UniProtKB/Swiss-Prot:Q9BYP7"
/protein_id="CAC32455.2"
/translation="MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNS
TFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQ
EVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKT
VYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILK
GKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDL
KCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAF
GMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSE
RLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEF
SFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRD
SQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGD
NLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHY
QQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVS
QPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEK
GTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLES
EKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQ
TSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEI
SRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAP
VTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGN
SLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQ
PTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFS
SSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDL
NVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPDPI
PLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAA
CETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSG
KSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLR
EKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSR
PQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLI
KPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLP
SFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQA
FPTSSVQNPATIPPGPK"
exon <1..537
/gene="PRKWNK3"
/number=1
exon 538..710
/gene="PRKWNK3"
/number=2
exon 711..931
/gene="PRKWNK3"
/number=3
exon 932..1089
/gene="PRKWNK3"
/number=4
exon 1090..1178
/gene="PRKWNK3"
/number=5
exon 1179..1398
/gene="PRKWNK3"
/number=6
exon 1399..1693
/gene="PRKWNK3"
/number=7
exon 1694..1887
/gene="PRKWNK3"
/number=8
exon 1888..2037
/gene="PRKWNK3"
/number=9
exon 2038..2102
/gene="PRKWNK3"
/number=10
exon 2103..2250
/gene="PRKWNK3"
/number=11
exon 2251..2367
/gene="PRKWNK3"
/number=12
exon 2368..2523
/gene="PRKWNK3"
/number=13
exon 2524..2575
/gene="PRKWNK3"
/number=14
exon 2576..2713
/gene="PRKWNK3"
/number=15
exon 2714..3651
/gene="PRKWNK3"
/number=16
exon 3652..3742
/gene="PRKWNK3"
/number=17
exon 3743..3873
/gene="PRKWNK3"
/number=18
exon 3874..4487
/gene="PRKWNK3"
/number=19
exon 4488..4699
/gene="PRKWNK3"
/number=20
exon 4700..4902
/gene="PRKWNK3"
/number=21
exon 4903..>5232
/gene="PRKWNK3"
/number=22
BASE COUNT 1668 a 1137 c 1143 g 1284 t
ORIGIN
1 atggccactg attcagggga tccagccagc acagaagatt ctgagaaacc tgatggaatt
61 tcatttgaaa acagagttcc ccaggtcgct gcaactttga cagtagaagc tagactaaag
121 gagaaaaaca gtaccttctc tgcttctggg gaaactgtag aaaggaagag atttttccga
181 aagagtgttg aaatgacgga agatgacaaa gttgccgaat catcccccaa agatgagaga
241 attaaggctg caatgaatat tccaagagta gataagcttc cttcaaatgt gttgagaggt
301 ggacaagaag ttaaatatga acagtgttca aagtcaacct cagaaatctc aaaagattgt
361 ttcaaggaga aaaatgaaaa ggaaatggaa gaagaagcag aaatgaaggc tgtagctact
421 tctcctagtg gcagattcct gaaatttgac atagaactag gaagaggagc atttaaaaca
481 gtatataaag gactggacac tgaaacatgg gttgaggttg cttggtgtga gctgcaggac
541 cgaaagttaa ccaaagctga gcagcaaaga ttcaaggaag aagcagagat gttgaagggt
601 ctccagcacc ccaatatagt tcgattttat gattcctggg aatctatatt aaaaggaaag
661 aaatgtattg tattagtgac tgaactaatg acatctggga ccttaaagac gtacttaaaa
721 cgatttaaag tcatgaaacc aaaggtctta aggagctggt gcaggcaaat tttaaagggg
781 ttgcagttct tgcacactag gactcctcct attattcacc gggatctgaa gtgtgacaat
841 attttcatca cgggacccac tggatctgtg aagattggtg atctaggatt agccacctta
901 atgcgtacct catttgctaa gagtgtcatt ggaactcctg agtttatggc tccagagatg
961 tatgaagaac actatgatga atccgtagat gtttatgctt ttggaatgtg tatgctggaa
1021 atggccacat cggagtatcc ttattctgag tgtcagaatg cagctcaaat ataccggaaa
1081 gtaactagtg gcataaaacc agccagcttc aataaagtca ctgatcctga agtcaaagaa
1141 atcattgaag gatgtattcg tcaaaacaaa tctgaaaggt tgtctatcag ggacctatta
1201 aaccatgcat tttttgctga ggatacagga ctgagggtgg agttagcaga agaagatgat
1261 tgctcaaatt catcccttgc tttaagactc tgggttgaag accctaaaaa attgaaaggc
1321 aaacacaaag acaatgaagc tattgaattt agtttcaact tagaaacaga tacacctgag
1381 gaagtagcat atgaaatggt caagtctggg ttcttccatg aaagtgattc caaagctgtt
1441 gctaaatcca ttagagaccg ggtgacgcca ataaagaaga caagagagaa gaagcctgct
1501 ggctgtttgg aagaacgcag ggattctcag tgcaagtcta tggggaatgt attccctcag
1561 ccccagaata caactttacc ccttgctccc gctcagcaaa ctggggctga atgtgaagaa
1621 actgaagttg atcaacatgt tagacaacag cttctacaaa gaaaaccaca gcagcactgc
1681 tcctctgtta caggtgacaa tttgtctgag gcaggagctg catcagttat acattcagat
1741 acttcaagtc agcccagtgt agcctattcc tcaaatcaaa cgatgggctc tcaaatggtt
1801 tctaatatcc cgcaggctga agtaaatgtt ccagggcaaa tttattcatc tcagcaacta
1861 gtaggacatt accagcaagt ttcagggtta cagaagcatt caaagctgac tcagccgcag
1921 attttgcctt tggttcaagg tcagtccact gttttacctg tacatgtcct tggaccgaca
1981 gttgtttcac aaccccaggt ttccccatta actgttcaga aggtcccaca gataaagcct
2041 gtatcccaac cagttggagc tgaacaacaa gcagctcttc taaaaccaga tttagttcga
2101 agcttgaatc aagatgtggc aactacgaag gaaaacgtca gtagccctga taacccaagt
2161 ggaaatggca aacaggatcg gatcaaacag agaagagctt cctgtccccg accagagaag
2221 gggactaaat ttcagcttac cgtccttcag gtatcaacct ctggagataa catggtagag
2281 tgtcagctgg agacacacaa caacaagatg gtcaccttca agtttgatgt tgatggtgat
2341 gcgccagagg atattgcaga ctatatggtt gaagataact ttgtgctgga aagtgagaaa
2401 gaaaaatttg tagaagaatt gagagctatt gtaggtcaag cccaggagat ccttcatgtc
2461 cactttgcca cagaaagagc cactggagtt gattctatta ctgtggactc caacagtagc
2521 cagacagggt catctgaaca agtacagata aattctacat ctactcaaac cagcaatgaa
2581 tctgctcctc agtcatcccc agttggtcgg tggcgattct gtatcaatca gacgataaga
2641 aaccgtgaga ctcagtctcc tccttctctt cagcattcca tgtctgcggt tcctggccga
2701 catccacttc ctagtccaaa aaacacaagt aataaggaaa tatcacggga cacattgctc
2761 actatagaaa ataatccatg ccaccgtgca cttttcacct ccaaatcaga acacaaggat
2821 gtggttgatg gtaagatttc tgaatgtgct agtgtagaaa ccaagcagcc agctatactt
2881 tatcaagtgg aagataacag gcagataatg gcaccagtta ctaatagttc cagttactct
2941 actacttcag ttcgtgcagt tccagctgaa tgtgagggac tcaccaaaca agcaagcata
3001 ttcatacctg tgtatccatg tcaccaaact gccagtcagg ctgatgcact tatgtcccat
3061 cctggcgaat caactcagac ttctggtaac tctcttacaa ctctggcatt tgatcaaaag
3121 cctcaaacct tatcagtaca gcagccagct atggatgcag agtttatttc tcaagaagga
3181 gaaactacag tgaacactga agcaagttct cctaagacag tcattcccac tcagacccct
3241 ggccttgaac caactaccct tcaacccact actgtcctgg aatcagatgg agaaagacct
3301 ccaaaactgg agtttgcaga caaccgaatt aaaactctgg atgaaaaatt aagaaacttg
3361 ctctatcagg agcacagcat ctctagcatc tatcccgaga gtcagaagga tacccaaagc
3421 atagactctc cattttcttc ctctgctgaa gataccctct cctgtccagt gacagaagtc
3481 atagccatca gtcactgtgg aattaaagat agccctgtac aatcccctaa tttccaacag
3541 acaggctcta agcttctgtc caatgtggct gcaagtcagc ctgctaatat atcagtgttc
3601 aaaagggacc tgaatgtgat aacttctgta cccagcgaat tgtgtttaca tgagatgtcc
3661 tcagatgctt cacttccagg ggatccagag gcctatcctg ctgctgtgtc aagcggtgga
3721 gccattcatc tgcagacagg agtggaaaca gaagagatga gatcagcaat tgctcctgat
3781 cccattcctc tgacacggga gtccacagct gatactaggg ctttgaatag atgtaaagcg
3841 atgagtggat catttcagcg gggtcggttc caggtgatta caattcctca gcagcagtca
3901 gcaaaaatga catcttttgg aatagaacac atatcagtgt tcagtgagac aaaccattct
3961 agtgaagaag cctttattaa aacagcaaag tctcagttgg tagaaataga acctgccaca
4021 caaaatccaa aaacttcgtt ttcttatgag aagttacaag ctcttcagga aacctgtaaa
4081 gaaaataaag gagttcccaa acaaggtgac aacttcttat ctttcagcgc agcttgtgag
4141 actgatgtat cttcagtgac cccagaaaag gaatttgaag aaacttcagc cacaggaagt
4201 agcatgcagt ctggatctga actgttgctt aaagagagag agatattgac tgctgggaaa
4261 cagcctagct ctgatagtga attttcagcc agtcttgctg gcagtggaaa gtcagtggca
4321 aagactggtc cagagagtaa tcagtgctta ccacaccacg aagaacaagc ttatgctcaa
4381 acacagagtt cactcttcta ttcgccatct tccccaatga gcagtgatga tgaatcagaa
4441 atagaggatg aggacttgaa ggtggagctt caaagattac gagaaaaaca cattcaggag
4501 gtggtaaatc ttcaaaccca gcagaataag gagctgcagg agctctatga acgccttcgg
4561 tcaattaaag atagcaaaac ccaatctact gagattcctt tgccacctgc atcaccacgt
4621 cgaccaagat ctttcaaaag caaacttcga agccgccccc agtccttgac acatgtggac
4681 aatggcatag ttgctacaga tccactgtgt gtggagagta atgcagcatc atgccaacag
4741 tctccagcca gtaaaaaagg gatgttcaca gatgacttac acaagctggt ggatgactgg
4801 acaaaggaag cagtaggaaa ttctcttatt aagccaagtt taaaccaact taaacaaagt
4861 caacacaaac tagagacaga aaactggaat aaagtatctg aaaatactcc gtctactatg
4921 ggctacacat caacatggat ttcttctctg tcccaaatcc gtggagctgt cccaacttcc
4981 ttgccacaag gactctcact cccttcattt cctgggccat tatcatcata tggaatgcct
5041 cacgtttgtc agtataatgc tgtggcgggg gcggggtatc cagtacagtg ggtaggaatt
5101 tcaggaacaa cacaacaatc tgtagtaatt cccgcccaat ctgggggacc attccagcca
5161 gggatgaata tgcaggcatt tccaacttca tcagtgcaga atcctgccac aatccctcct
5221 ggtcctaaat ga
//