LOCUS AJ409065 1856 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for liver-expressed antimicrobial peptide 2,
alternative promotor region.
ACCESSION AJ409065
VERSION AJ409065.1
KEYWORDS alternative splicing; LEAP-2 gene; liver-expressed antimicrobial
peptide 2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1856)
AUTHORS Krause A.
JOURNAL Submitted (20-FEB-2001) to the INSDC. Krause A., Molecular Biology,
IPF PharmaCeuticals GmbH, Feodor-Lynen-Str.31, Hannover, Lower
Saxony, D-30625, GERMANY.
REFERENCE 2
AUTHORS Krause A., Sillard R., Kleemier B., Kluver E., Maronde E.,
Conejo-Garcia J.R., Forssman W.G., Schulz-Knappe P., Nehls M.C.,
Wattler F., Wattler F., Adermann K.
TITLE Isolation and biochemical characterization of LEAP-2, a novel blood
peptide expressed in the liver
JOURNAL Protein Sci. 12(1), 143-152(2003).
PUBMED 12493837
FEATURES Location/Qualifiers
source 1..1856
/db_xref="H-InvDB:HIT000247548"
/organism="Homo sapiens"
/chromosome="5"
/map="5q31"
/mol_type="mRNA"
/dev_stage="adult"
/tissue_type="lung"
/db_xref="taxon:9606"
5'UTR 1..1373
/gene="LEAP-2"
/note="alternative"
CDS 1374..1607
/gene="LEAP-2"
/product="liver-expressed antimicrobial peptide 2"
/note="alternative"
/db_xref="GOA:Q969E1"
/db_xref="H-InvDB:HIT000247548.15"
/db_xref="HGNC:HGNC:29571"
/db_xref="InterPro:IPR009955"
/db_xref="PDB:2L1Q"
/db_xref="UniProtKB/Swiss-Prot:Q969E1"
/protein_id="CAC51516.1"
/translation="MWHLKLCAVLMIFLLLLGQIDGSPIPEVSSAKRRPRRMTPFWRG
VSLRPIGASCRDDSECITRLCRKRRCSLSVAQE"
mat_peptide 1485..1604
/gene="LEAP-2"
/product="liver-expressed antimicrobial peptide 2"
/note="alternative"
/experiment="experimental evidence, no additional details
recorded"
3'UTR 1608..1856
/gene="LEAP-2"
regulatory 1839..1844
/gene="LEAP-2"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 516 a 432 c 398 g 510 t
ORIGIN
1 aggactagaa tcaggacagt cagatctgtg gtcacatcct gcccaattcc agctctgagg
61 tccatcaaac catctgcttc tcccttggca agaagctccc tctgtctgac tggcagcagg
121 gtcagtggcc atccttttct accttcagct gttgcgcatc tcctccacgt tttcctggag
181 taaaggaaca agcaggttct tatccaaata cccaacctgt gaagatgaga cggcccttgg
241 gaagaggtat tagccaagtt ttcagtatga tgcccggcag aaagaatttg ttgtctttgt
301 cttaagctta ttatcctccc aggtcatagg aagatctaaa gtccaatcaa tctccttact
361 cagaattcac agctttcccc tcaaacttaa aatgcccatg tcatttcacg agtacccata
421 actacccatc gtttagatac atgtcctccc ttggactaga aatctgcagc agttcctact
481 taaactgatg gatgctttgg gctttggagg tatctcatcc ctatgcctgt tgccctgaag
541 ctgccggaag gaaaggcccc actcaactac tgggaagaaa gcccataatt caaggctttt
601 aatacagtca ctacacaagc tctccctctg atttaggaga tcttgttacc tcctcatcta
661 catgtgctta aaaacaaaaa gaaacctata attattcaat tcacctgtgg tccaaataag
721 tctcacatcc agccattccc ctgagagggc aggaggccag actttgaact ttccacagct
781 gggtcttcat tttactagtg agataaagag gtgcagatta gggtgacagt ccatctaagc
841 aagtggacga tctggggaac tgtaggcctt gctgaagcat cctcccacag aaaggagata
901 agggccttat ccaattggct gtacacaata gatcagtgct tctttcctag acaaggctga
961 aaggggccaa cattatttct gaagacttca ttattggaat tctatgggag tgatctcact
1021 gagctatttt ggaatagaaa tgtggctagt tgcctgacct ccctcaatgg tttcacgtgg
1081 ctttcaaagg gaaggaaggg cagtgctgac ttttggtaaa atgggcgaaa gggtccatgc
1141 cagcaacaca atcactcaaa gtccagatga gggatcagta aatacaacgt gcctgaaagg
1201 tggcccttga gcacattcct ccggtagaca ttaacttatt aaattgattc tgattacaaa
1261 tataaacttt gcccccatct cacccagtaa caatgcaaga gttgatgtca gtctataaaa
1321 ggaagtagga actgtccctg gctttcaggc tccaacatcc tccccctgtc aagatgtggc
1381 acctcaaact ttgtgcagtc ctcatgatct tcctgttgct gttgggccag atagatggct
1441 ccccaatacc agaagtgagt tcggcaaaga gaaggccacg gagaatgacc ccattttgga
1501 gaggggtttc cctcaggcct attggagcct cctgccggga tgattctgag tgtatcacaa
1561 ggctatgcag aaaaagacgc tgttccttaa gtgtggccca ggaatgatgt acataccagg
1621 gaaagaaagg acagcagtca cctccgacaa tgctccgttc tatggaatat tgattaactg
1681 cattttggct ggagacaccc aagtgaagca atcttgtatt tttaatattt aaaggcagat
1741 gtacgcttta aattggtctc catttcttct tagaatgttg atatatggat aagcataact
1801 aaacttgtca atttagagtt tatttttcta tggatactat taaatgtctc aaattg
//