LOCUS AJ320261 5861 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for P-Rex1 protein.
ACCESSION AJ320261
VERSION AJ320261.1
KEYWORDS P-REX1 gene; P-Rex1 protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5861)
AUTHORS Welch H.C.E.
JOURNAL Submitted (20-JUL-2001) to the INSDC. Welch H.C.E., Signalling,
Babraham, The Babraham Institute, Cambridge,, CB2 4AT, UNITED
KINGDOM.
REFERENCE 2
AUTHORS Welch H.C.E., Coadwell W.J., Ellson C.D., Ferguson G.J.,
Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T.,
Stephens L.R.
TITLE P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated
guanine-nucleotide exchange factor for Rac
JOURNAL Cell 108(6), 809-821(2002).
PUBMED 11955434
FEATURES Location/Qualifiers
source 1..5861
/db_xref="H-InvDB:HIT000247211"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 24..5003
/gene="P-rex1"
/product="P-Rex1 protein"
/function="PI3K- and GBetaGamma-regulated
guanine-nucleotide exchange factor for Rac"
/db_xref="GOA:Q8TCU6"
/db_xref="H-InvDB:HIT000247211.13"
/db_xref="HGNC:HGNC:32594"
/db_xref="InterPro:IPR000219"
/db_xref="InterPro:IPR000591"
/db_xref="InterPro:IPR001331"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR035899"
/db_xref="InterPro:IPR036034"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:3QIK"
/db_xref="PDB:4YON"
/db_xref="PDB:5D27"
/db_xref="PDB:5D3V"
/db_xref="PDB:5D3W"
/db_xref="PDB:5D3X"
/db_xref="PDB:5D3Y"
/db_xref="PDB:5FI0"
/db_xref="PDB:5FI1"
/db_xref="UniProtKB/Swiss-Prot:Q8TCU6"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAC86401.1"
/translation="MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESE
RQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSN
IEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLV
ELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHP
DHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQG
TLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTE
VMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRERE
QRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAW
LLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELE
DIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVA
LGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAK
RLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFS
EVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEA
MAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEA
RASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVV
YEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTM
PHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNC
HINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSW
KCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDV
ALKEMKQYVTQINRLLSTITEPTSGGSCDTSLAEEASSLPLVSEESEMDRSDHGGIKK
VCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDEL
PCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQ
KEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ
LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLL
HCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQA
LKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDIN
AQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHP
KPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLP
KCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL"
BASE COUNT 1300 a 1736 c 1715 g 1110 t
ORIGIN
1 cggcgccgcg cggccgcgct agaatggagg cgcccagcgg cagcgagccc ggcggcgacg
61 gggccgggga ctgcgcccac ccggaccccc gggcccctgg cgccgcggcg cccagctccg
121 gccccggccc gtgcgcggcc gcccgggagt ccgagcgcca gctgcgcctc cgcctctgcg
181 tcctcaacga gatcttgggc accgagaggg actacgtggg caccttgcgc ttcttgcagt
241 cggcattcct gcatcgcatc cggcagaacg tggccgactc agtggagaag ggcctcacgg
301 aggagaatgt caaggtcctg ttctcgaaca tcgaagacat cctggaagtt cataaggatt
361 tcttggccgc cttggagtat tgtttacacc cggagccgca gtctcagcat gaacttggga
421 atgttttctt aaaattcaag gacaagttct gcgtgtacga ggagtattgc agcaaccatg
481 agaaagccct gaggctgctg gtggagctga acaagatccc taccgtgcgc gccttccttt
541 tgagctgcat gcttctggga ggccggaaga ccacggacat ccctttggaa ggctacctgt
601 tgtctccgat ccagaggatc tgcaagtacc cgctcctcct taaggagctg gccaagagga
661 ctcccggcaa gcacccagac caccccgcgg tccagagtgc cctgcaggcc atgaagaccg
721 tttgctccaa catcaatgag accaagcggc agatggagaa gctggaagcc ctggagcagc
781 tgcagtccca catcgaaggc tgggagggtt ccaacctcac agacatctgc actcagctcc
841 tcctgcaagg gactttgtta aagatctctg cgggcaacat ccaggaaagg gccttcttcc
901 tcttcgacaa ccttctcgtc tactgcaagc ggaaatccag ggtcaccggg agcaagaagt
961 ccaccaagag gaccaaatcc atcaacggct ccctctacat cttcaggggt cgaatcaaca
1021 ctgaagtcat ggaggtggag aatgtggaag atgggacagc ggattaccat agcaatggct
1081 ataccgtcac caacggctgg aagatccaca acacggccaa gaataagtgg tttgtctgca
1141 tggccaagac ggcagaggag aagcagaagt ggctggatgc catcatccgc gagcgggagc
1201 agcgcgagag cctgaagctg ggcatggagc gtgatgccta cgtcatgatt gcggagaagg
1261 gggagaagct gtaccacatg atgatgaaca agaaggtgaa cctcatcaag gaccgccgga
1321 gaaagctgag cactgtcccc aagtgctttc ttggcaatga gttcgttgcc tggctcctag
1381 aaattggtga aatcagcaag acggaagaag gagtcaactt gggccaagcc ctgttggaga
1441 atggcatcat ccaccatgtt tccgacaagc accagttcaa gaatgagcag gtgatgtatc
1501 gcttccgcta cgacgatggc acctacaagg cccgaagtga gctggaggac atcatgtcca
1561 agggtgtgag gctttactgc cgtcttcaca gcctctacac cccggtgatc aaagaccgtg
1621 attaccacct gaagacctac aagtcagtgc ttcccgggag caagctggtg gactggctgc
1681 tggctcaggg agactgccag actcgggagg aggcagtggc gctcggcgtg ggtctgtgca
1741 acaatggctt catgcaccac gtgctggaga agagcgagtt cagggatgag tcccagtact
1801 tccgctttca tgctgacgag gagatggagg ggaccagcag caagaacaaa cagcttcgca
1861 acgacttcaa gctggtggag aacattctgg ccaagcgcct gctgatcctg ccccaggagg
1921 aggactatgg ctttgacatc gaggagaaga acaaggctgt ggtggtgaag tccgtccaga
1981 ggggctcgct ggctgaggtg gctggcctgc aggtggggag gaagatctac tccatcaatg
2041 aggacctggt gttcctgcgg ccgttttcag aggtggagtc catcctcaac cagtccttct
2101 gctcccgccg ccctctgcgc ctcctggtgg ccacgaaggc caaagagatc atcaaaatcc
2161 ccgaccagcc ggacacactg tgcttccaga ttcgtggagc tgccccaccg tacgtctatg
2221 ctgtggggag aggctctgag gccatggctg cagggctctg tgctggtcag tgcattctga
2281 aggtcaatgg cagcaacgtg atgaacgatg gtgcccctga ggtcctggag cacttccagg
2341 cattccggag tcggcgcgaa gaggccctgg gcctgtacca gtggatctac cacacccatg
2401 aggatgccca ggaagcacga gccagtcagg aggcctccac tgaggacccc agtggcgagc
2461 aggcccagga ggaagaccag gctgattcag ccttcccact gctgtccctg ggtccccggc
2521 tgagcctgtg tgaggacagc cccatggtca ccctgactgt ggacaacgtg cacctggaac
2581 acggcgtggt gtatgagtat gtgagcacgg caggcgtcag gtgccatgtg ctggagaaga
2641 tcgtggagcc ccgcggctgc ttcggcctca ccgccaagat cctcgaggcc tttgctgcca
2701 atgacagcgt cttcgtggag aactgcaggc ggctcatggc cctgagcagc gccatcgtga
2761 ccatgcccca ctttgagttc cgcaacatct gtgacaccaa gctggagagc attggccaga
2821 ggattgcctg ctaccaggag tttgcagccc aactgaagag cagggtcagc ccacccttca
2881 aacaagcccc cctggagccc cacccgctgt gtggcctgga cttctgcccc accaattgcc
2941 acatcaacct catggaagtg tcctacccca agaccacccc ctcagtgggc aggtccttca
3001 gcatccgctt tggacgcaaa ccctccctca tcggccttga cccggagcaa ggccacctga
3061 accccatgtc gtacacccag cactgcatca ccaccatggc tgctccctcc tggaagtgct
3121 tgcctgctgc agagggtgat ccccaaggcc agggtctcca tgatggcagc ttcgggccag
3181 ccagtgggac ccttggtcag gaagaccggg gcctcagctt cctactcaag caggaggacc
3241 gtgagatcca ggatgcctac ctgcagctct tcaccaagct ggatgtggcc ctgaaggaga
3301 tgaagcaata tgtcacccag atcaacaggc tgctgtccac catcacagag cccacctcgg
3361 gtgggtcctg cgacacatcc ttggctgagg aggcctcctc cctgcccctg gtcagtgaag
3421 agagcgagat ggacaggagt gaccatgggg gcatcaagaa ggtgtgcttc aaggtggccg
3481 aggaggacca ggaggactca ggccacgaca ccatgagtta tcgcgactcc tacagcgagt
3541 gtaacagcaa tcgagactcg gtcctgtcct acaccagcgt gagaagtaac agctcctact
3601 tgggcagcga cgagatgggg tctggagatg agctgccctg tgacatgcgg atcccatctg
3661 acaagcagga caagcttcat ggctgcctgg agcacctctt taaccaggtg gactccatca
3721 atgctctcct caaggggcca gtcatgagcc gggctttcga agagaccaag catttcccta
3781 tgaaccacag cttacaagag tttaaacaga aagaagagtg tacaatccgt ggccggagcc
3841 tgatccagat tagcatccag gaggacccct ggaacctccc caactccatc aagaccctgg
3901 tggacaacat tcagagatat gtggaagatg ggaagaacca gctgctcctg gccttgctga
3961 agtgcacaga cacggagctg cagctgcgca gagacgcgat cttctgccag gccctggtgg
4021 ccgccgtgtg caccttctcc gagcagctgc tggcggccct gggctaccgc tacaacaaca
4081 atggcgagta cgaggagagc agccgcgacg ccagccgcaa gtggctggag caggtggcgg
4141 ccacgggcgt cctgctgcac tgccagtccc tgctctcgcc agccacagtg aaggaggaac
4201 ggaccatgct ggaggacatc tgggtgacgc tgtcagagct ggacaatgtc accttctcct
4261 ttaagcagct ggacgagaac tatgtggcca acaccaacgt cttctaccac attgagggca
4321 gccggcaggc gctgaaggtc atcttctacc tcgacagcta ccacttctcc aagctgccct
4381 cccgcctgga gggtggggcc agcctgaggc tgcacacagc gctgttcacg aaagtgctgg
4441 agaacgtgga ggggctgcct tctccaggca gccaggccgc ggaggatttg cagcaggaca
4501 tcaacgcgca gtccctggag aaagttcagc agtattaccg caaactcagg gcattttacc
4561 tggagcggtc taacctgccc acggatgcca gcaccacggc ggtaaagata gaccagctga
4621 tccgccccat caatgccctg gatgagctct gccgcctcat gaagtccttt gtccacccaa
4681 agcctggtgc tgctgggagt gtgggcgccg gcctcatccc catctcctcg gagctctgct
4741 accgcctggg ggcctgccag atggtcatgt gtggcacagg catgcagagg agcaccctga
4801 gcgtgtccct ggagcaggcg gccatcttgg cacggagcca cgggttgctg cccaagtgca
4861 tcatgcaggc cacggacatc atgcggaagc agggcccaag ggtggagatt ctggccaaaa
4921 acctgcgagt caaggaccag atgccccagg gtgctccgcg cctctaccgc ctctgccagc
4981 cgccggtgga tggggacctc tgaacaccca aatgccccac gctgggccgc ggcctctgga
5041 gctgggattt gggaggacac agcaggcagc gctggccttc tccagggatg gcccaaggct
5101 tccgcagccg cccgttccgg gacctgccca gcgtcctccc tgcctccttc cgggacaagc
5161 ctggccaccc tcgctgtgat gacgagctgg ctgattggcc ctgggccggc ccattcttca
5221 cacgcctgcc agaagctgga ggggtgctgg agacccatag agctgatggg agcagctggt
5281 gcctggcctt cggctcctgc gtccccagaa cccaagggaa cgtcatggag gccacatggg
5341 gccacccggc tccctcggga tggctccgcc tgcacttttg aaaccccggt ttccttcaac
5401 gtccacattc caggtgacca cacgtgtctc ctcctcctca tcttagcttc caggttcacc
5461 ctaaccctgt actaacctgc ttggtggact tggaaaagac ttggctctgt cgggaaagga
5521 gagacggggc ctccatcacg cctgttacca gaggatcccc gagagccaca ccagctctgg
5581 acatcaccgc ccctggaact ggggccacca gccctgggca cgagatttgc tctgacttta
5641 tttatatggc atgaaatctc tggtttattt tgggattttt tgttgttggt gttgtcaaag
5701 tttgtttttt ctaaagttgt gtgattatat atttgacatt ttacatttca aagaaaggta
5761 tgttgtctaa caggggacca acagaaggta gtattgacaa ctgttcccgc ttctactaaa
5821 aaaaaaagag cacaaaagaa aaactaaatt attgaaaaat t
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