LOCUS AJ310567 5210 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for phosphoinositide-binding protein, isolate
PIP3-G/H.
ACCESSION AJ310567
VERSION AJ310567.1
KEYWORDS ARAP3 gene; phosphoinositide-binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5210)
AUTHORS Hawkins P.T.
JOURNAL Submitted (20-FEB-2001) to the INSDC. Hawkins P.T., Signalling
Programme, The Babraham Institute, Babraham Hall, Babraham,
Cambridge, CB2 4AT, UNITED KINGDOM.
REFERENCE 3
AUTHORS Krugmann S., Anderson K.E., Ridley S.H., Risso N., McGregor A.,
Coadwell J., Davidson K., Eguinoa A., Ellson C.D., Lipp P.,
Manifava M., Ktistakis N., Painter G., Thuring J.W., Cooper M.A.,
Lim Z.-Y., Holmes A.B., Dove S.K., Michell R.H., Grewal A.,
Nazarian A., Erdjument-Bromage H., Tempst P., Stephens L.R.,
Hawkins P.T.
TITLE Identification of ARAP3, a novel PI3K effector regulating both Arf
and Rho GTPases, by selective capture on phosphoinositide affinity
matrices
JOURNAL Mol. Cell 9(1), 95-108(2002).
PUBMED 11804589
FEATURES Location/Qualifiers
source 1..5210
/db_xref="H-InvDB:HIT000247062"
/organism="Homo sapiens"
/isolate="PIP3-G/H"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 29..4663
/gene="ARAP3"
/product="phosphoinositide-binding proteins"
/db_xref="GOA:Q8WWN8"
/db_xref="H-InvDB:HIT000247062.14"
/db_xref="HGNC:HGNC:24097"
/db_xref="InterPro:IPR000159"
/db_xref="InterPro:IPR000198"
/db_xref="InterPro:IPR001164"
/db_xref="InterPro:IPR001660"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR008936"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR013761"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR037278"
/db_xref="InterPro:IPR037858"
/db_xref="InterPro:IPR038508"
/db_xref="PDB:2KG5"
/db_xref="PDB:2LNW"
/db_xref="PDB:5JCP"
/db_xref="PDB:5JD0"
/db_xref="UniProtKB/Swiss-Prot:Q8WWN8"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAC83946.1"
/translation="MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEEL
KQLGISATGHRKRILRLLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVF
GGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIY
FGLDSRGRAQAAQDKAPDSSQISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPD
RRESRGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPY
ASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPL
TAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQP
PRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSR
SFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCG
SSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDR
ANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAV
ARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVVRATYSGF
LYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSPEPLSLIQPQDIVCLGV
SPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPG
LLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQE
ISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQM
SRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHF
VEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRT
LATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVF
DIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEE
LTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLL
LKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLKEK
KSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSI
LKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRT
LSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPE
NPLTSQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLIL
RKGETTAGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT"
BASE COUNT 1095 a 1566 c 1509 g 1040 t
ORIGIN
1 cgcgtagtga gcaatggcct gagcccccat ggctgcccct caggacctgg acatcgctgt
61 gtggctggcc acggtgcacc tggagcagta tgcagacacg ttccgacggc atggcctggc
121 tacagcaggt gcagcccggg gcctgggcca cgaggagttg aagcagttgg gcatcagcgc
181 cacagggcac cggaaacgca ttctacgcct gctgcagaca ggcaccgaag agggctccct
241 ggatcccaaa tcagatagtg ccatggaacc atcccccagc ccagccccgc aagcccagcc
301 ccctaagccc gtgccgaagc ccaggaccgt gtttggtgga ctcagtggcc ctgccaccac
361 tcagagacct gggctgagcc cagccctcgg gggaccagga gtgtccagga gcccagagcc
421 cagcccaagg ccccctcctc tccccacttc ctcctctgag cagtcttcag ccctaaatac
481 tgtggagatg atgcctaatt ccatctactt cggcctggac tcaagaggca gggcacaggc
541 agctcaggac aaggccccag acagctccca aatctctgcc cccacccctg ccctcaggcc
601 cacaacaggc acagtgcaca tcatggatcc tggttgcctg tactatggtg tccaacctgt
661 ggggactcca ggagcccccg acagaagaga gagcagaggt gtttgtcagg gcagggctga
721 acacaggctc agcagacagg atctggaggc acgggaggat gctggctatg ccagccttga
781 gctacctgga gactccaccc tcttatcgcc caccctggaa acagaggaga ccagtgatga
841 cctcatttca ccctatgcca gcttctcctt cacggcagac cgcctcacgc ccctgctcag
901 tggctggcta gacaagctct cccctcaggg aaactatgtc ttccagagac gctttgtgca
961 gttcaatggg aggagtctga tgtactttgg cagtgacaag gaccccttcc ctaagggtgt
1021 gatacctttg actgccattg agatgacccg cagcagcaag gacaacaagt tccaggtcat
1081 caccggccag agggtgttcg tgttccgcac agagagcgag gctcagcggg acatgtggtg
1141 ctccacgctg cagtcctgtc tgaaggagca gcgcctcctg ggccaccccc ggcccccaca
1201 accaccccga cccctccgca cgggcatgct ggagctgcgt ggacacaagg ccaaggtgtt
1261 tgctgccttg agccctggag agctggcact gtacaagagt gagcaggcct tctctctggg
1321 catcgggatc tgcttcatcg aactgcaggg ctgcagcgtc cgggagacca agagtcgaag
1381 ctttgacctg ctcacacccc atcgctgctt cagcttcaca gccgagtctg ggggtgctcg
1441 gcagagctgg gcggccgctc tgcaggaagc agtaaccgag accctgtctg actacgaggt
1501 ggctgagaag atctggtcta atcgggccaa ccggcagtgt gcggactgtg ggtcctcccg
1561 cccagattgg gctgctgtca atttgggggt ggtcatctgc aagcagtgtg caggtcagca
1621 ccgggccctg ggttctggga tctccaaggt gcagagcctg aagctggaca cgagtgtctg
1681 gagtaatgag atagtacagt tattcattgt cctgggaaat gatcgtgcca accgcttctg
1741 ggcagggacc ctacccccag gtgagggact acatccagat gcgacccctg gcccccgggg
1801 agagttcatc tcccgaaagt accgtctggg tctcttccgg aagccccacc ctcagtaccc
1861 agatcatagc cagcttctcc aggcactgtg tgcagctgtg gcaagaccca acctgctgaa
1921 gaacatgacc cagctcctct gtgttgaggc ctttgaaggc gaggagccct ggttcccccc
1981 agcccctgat ggcagctgcc ctggcctctt gccctcagac ccctcccctg gtgtgtacaa
2041 tgaggtggtg gtgcgtgcta cttacagcgg cttcctgtac tgcagtcccg tcagcaacaa
2101 agctggaccc tcaccccctc gcaggggccg ggatgctccc ccgcgccttt ggtgtgtgct
2161 gggagcagct ctggaaatgt ttgcatcgga aaacagccct gaacccctca gcctcataca
2221 gccccaggat attgtatgtc tgggtgtgag ccccccaccc actgacccag gtgacaggtt
2281 ccccttttcc tttgagctca tcctcgctgg ggggaggatc cagcattttg gcacagatgg
2341 agctgacagt ctggaggcct ggactagtgc tgtgggcaag tggttctccc cgctgagctg
2401 ccaccagctg ctgggccccg ggctgctgcg gctgggccgc ctatggctgc ggtccccctc
2461 ccatacagcc ccggcccctg gtctctggct gtcagggttt ggcctccttc gtggtgacca
2521 cctcttcctg tgctcagcgc cgggcccagg ccccccagcc cctgaggaca tggtgcatct
2581 gcggcggcta caggagatca gtgtggtttc tgcagctgac accccagata agaaagagca
2641 tttggtcctg gtggagacag gaaggaccct gtatctgcaa ggagagggcc ggctggactt
2701 cacggcatgg aacgcagcca ttgggggcgc ggctggtggg ggcggcacag ggctgcagga
2761 gcagcagatg agccggggtg acatccccat catcgtggat gcctgcatca gttttgttac
2821 ccagcatggg ctccggctgg aaggtgtata ccggaaaggg ggcgctcgtg cccgcagcct
2881 gagactcctg gctgagttcc gtcgggatgc ccggtcggtg aagctccgac caggggagca
2941 ctttgtggag gatgtcactg acacactcaa acgcttcttt cgtgagctcg atgaccctgt
3001 gacctctgca cggttgctgc ctcgctggag ggaggctgct gagctgcccc agaagaatca
3061 gcgcctggag aaatataaag atgtgattgg ctgcctgccg cgggtcaacc gccgcacact
3121 ggccaccctc attgggcatc tctatcgggt gcagaaatgt gcggctctaa accagatgtg
3181 cacgcggaac ttggctctgc tgtttgcacc cagcgtgttc cagacggatg ggcgagggga
3241 gcacgaggtg cgagtgctgc aagagctcat tgatggctac atctctgtct ttgatatcga
3301 ttctgaccag gtagctcaga ttgacttgga ggtcagtctt atcaccacct ggaaggacgt
3361 gcagctgtct caggctggag acctcatcat ggaagtttat atagagcagc agctcccaga
3421 caactgtgtc accctgaagg tgtccccaac cctgactgct gaggagctga ctaaccaggt
3481 actggagatg cgggggacag cagctgggat ggacttgtgg gtgacttttg agattcgcga
3541 gcatggggag ctggagcggc cactgcatcc caaggaaaag gtcttagagc aggctttaca
3601 atggtgccag ctcccagagc cctgctcagc ttccctgctc ttgaaaaaag tccccctggc
3661 ccaagctggc tgcctcttca caggtatccg acgtgagagc ccacgggtgg ggctgttgcg
3721 gtgtcgtgag gagccacctc gcttgctggg aagccgcttc caggagaggt tctttctgct
3781 gcgtggccgc tgcctgctgc tgctcaagga gaagaaaagc tctaaaccag aacgggagtg
3841 gcctttggaa ggtgccaagg tctacctggg aatccgcaag aagttaaagc ccccaacacc
3901 gtggggcttc acattgatac tagagaagat gcacctctac ttgtcctgca ctgacgagga
3961 tgaaatgtgg gattggacca ccagcatcct taaagcccag cacgatgacc agcagccagt
4021 ggtcttacga cgccattcct cctctgacct tgcccgtcag aagtttggca ctatgccttt
4081 gctgcctatc cgtggggatg acagtggagc caccctcctc tctgccaatc agaccctgcg
4141 gcgactacac aaccggagga ccctgtccat gttctttcca atgaagtcat cccaggggtc
4201 tgtggaggag caagaggagc tggaggagcc tgtgtacgag gagccagtgt atgaggaagt
4261 aggggccttc cctgagttga tccaggacac ttctacctcc ttctccacca cacgggagtg
4321 gacagtgaag ccagagaacc ccctcaccag ccagaagtca ttggatcaac cctttctctc
4381 caagtcaagc acccttggcc aggaggagag gccacctgag ccccctccag gccccccttc
4441 aaagagcagt ccccaggcac gggggtccct agaggaacag ctgctccagg agctcagcag
4501 cctcatcctg aggaaaggag agaccactgc aggcctggga agtccttccc agccatccag
4561 cccccaatcc cccagcccca ctggccttcc aacacagaca cctggcttcc ccacccaacc
4621 cccatgcact tccagtccac cctccagcca gcccctcaca tgaccctagg accagcagtc
4681 tgagagggta ggtaccagaa gacccagaaa ctcttatcgt ggcactgttg cagcttcctc
4741 tgccctggct ggaaagactc cagaatccag tgtggtgctg tggaaggagc actggactaa
4801 aggcttcagt ggctgcgtgt cccaggacag gtcatggccc ctctctgggc ccagcccatt
4861 tatctatacc atgaggtaac tgaagtaagg agagcagtga atgtcaaact gtgtttctta
4921 gagccataag ccccacatat tatccctgaa caagggcagc tcctgcttta tatatttgat
4981 acgtaggggt tccatgagag attttgggtt ttaaaggaat ggttttactg cattaaagaa
5041 aaaaaatgct ttggaaacca gaggcctggg tgatgttaaa gtctatcctg tcccacttcc
5101 tacattctgg gactaccgtg aagcctggag tagggagagc gagtttggga gctgggactc
5161 ggggagtcaa aaatagatga gtaattgtca ataaacctgg gaaccaaaag
//