LOCUS AJ297407 3572 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for transcription factor II B-related factor,
isoform 3 (BRF gene).
ACCESSION AJ297407
VERSION AJ297407.1
KEYWORDS alternative splicing; BRF gene; TFIIB-related factor; transcription
factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3572)
AUTHORS Lobo-Ruppert S.M.
JOURNAL Submitted (04-JUL-2000) to the INSDC. Lobo-Ruppert S.M.,
Biochemistry and Molecular Genetics, University of Alabama at
Birmingham, 844 BBRB, 845 19th Street South, Birmingham, AL 35294,
USA.
REFERENCE 3
AUTHORS McCulloch V., Hardin P., Peng W., Ruppert J.M., Lobo-Ruppert S.M.
TITLE Alternatively spliced hBRF variants function at different RNA
polymerase III promoters
JOURNAL EMBO J. 19(15), 4134-4143(2000).
PUBMED 10921893
FEATURES Location/Qualifiers
source 1..3572
/db_xref="H-InvDB:HIT000246740"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="lambda zap express, pBKCMV"
/cell_line="MCF7, T47D, ZR75-1, MDAMB-453"
/cell_type="breast cancer"
/db_xref="taxon:9606"
CDS 892..2313
/gene="BRF"
/product="transcription factor II B-related factor"
/function="unknown"
/note="isoform 3"
/db_xref="GOA:Q92994"
/db_xref="H-InvDB:HIT000246740.12"
/db_xref="HGNC:HGNC:11551"
/db_xref="InterPro:IPR000812"
/db_xref="InterPro:IPR011665"
/db_xref="InterPro:IPR013137"
/db_xref="InterPro:IPR013150"
/db_xref="InterPro:IPR013763"
/db_xref="InterPro:IPR036915"
/db_xref="UniProtKB/Swiss-Prot:Q92994"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAC04513.1"
/translation="MTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKE
VISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQL
EQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGGLASLAKDGSTEDTASSLCGEED
TEDEELEAAASHLNKDLYRELLGGAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLG
ISDSIRECISSQSSDPKDASGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAE
YLREQREKEARIAKEKELGIYKEHKPKKSCKRREPIQASTAREAIEKMLEQKKISSKI
NYSVLRGLSSAGGGSPHREDAQPEHSASARKLSRRRTPASRSGADPVTSVGKRLRPLV
STQPAKKVATGEALLPSSPTLGAEPARPQAVLVESGPVSYHADEEADEEEPDEEDGEP
CVSALQMMGSNDYGCDGDEDDGY"
BASE COUNT 787 a 1028 c 1144 g 613 t
ORIGIN
1 ggcacgaggt ggcatggggc actggctttg ctgatgagga gaccagactt cagaggccgt
61 gtcacctggc ctgggccgca cagctggtgc atgccaagct cgcgtgcaga cgaagctcca
121 gaggcctggc tgtcaggagg gttcctcccc gaggacacac acgcaacctc ctggaccgcc
181 aggctttaga cttttaaaac ttccatatgc aggaaacccc acaggacgca gccagcatct
241 cgggtcatgg gtgcacctgt caccgcagtc ctgggctaaa cagtgaacag gagctctgtg
301 tctctgtggt cgttacagtt gtagtgaatg ttccctggga gagtcctctt cagaagatat
361 ttgcggtatt ttcaacaaag gactctccag gatggaggag caactacaag tcaggaagga
421 aaaggctgac aacccagttt tttaaaaaac gggcaaagga cgtgaacaga caccatgcaa
481 tggcccagag tgcacaaatc atcatttctc ccaggaatgg ggtgcccgag cccccaggcg
541 gctgaacttg agacttgtca cgtagtgttg gtggaatgca gagcagctgg agatcacctg
601 ctgcaggtgg gtgcgtaact ccgcacggcc aagccgtttg gaaagctgta gcatatgcat
661 gagagtccgg aaagttccga gagaaagtgt gtggatgcac ccgccaagga cacacccacc
721 gaggccacag ctgcgatttc atagtgtggg accccactgg caaagacacg ctggctgctg
781 tggccgtggt ttctgtccca gccgtctgtt tccatagaaa aagacccgtg cctgtatatt
841 ccacgctttg cgcacctgct ggaattcggg gagaagaacc acgaggtgtc catgactgcc
901 ctgaggctcc tacagaggat gaagcgggac tggatgcaca caggccggcg cccctcgggc
961 ctctgcggag cagcgctcct ggttgcagcc agaatgcatg acttcaggag gactgtgaag
1021 gaggtcatca gtgtggtcaa agtgtgtgag tccacgctgc ggaagaggct cacggaattt
1081 gaagacaccc ccaccagtca gttgaccatt gatgagttca tgaagatcga cctggaggag
1141 gagtgcgacc ccccctcgta cacagctggg cagaggaagc tgcggatgaa gcagcttgaa
1201 caagtcctgt caaaaaaact ggaggaggtt gaaggtgaaa tatccagtta ccaggatgca
1261 attgagattg aactagaaaa cagccggcca aaggccaagg ggggcctggc cagcctggca
1321 aaagatggct ccaccgagga caccgcgtcc agcttgtgtg gcgaggagga cacagaggac
1381 gaggagctgg aagccgcggc cagccacctg aacaaagact tataccggga gctccttggt
1441 ggtgcccccg gcagctcgga agcagcagga agccccgagt ggggcggcag acctccggcc
1501 ctggggtccc tgctggaccc cctccccact gcagccagcc tgggcatctc agactccatc
1561 cgcgaatgca tctcctctca gagcagcgac cccaaagatg cttcaggaga cggtgagctg
1621 gacctcagtg gcattgatga cctggagatt gacaggtaca tcctgaatga gtcggaagcc
1681 cgcgtgaagg ccgagctgtg gatgagggag aacgccgagt acctgcggga acagagggaa
1741 aaagaagcaa gaatagcgaa agagaaggag ctcggcatct acaaggaaca caagcccaag
1801 aagtcttgca agcgacggga gccaattcag gccagtaccg ccagggaggc catcgagaag
1861 atgctggagc agaagaagat ctccagcaag atcaattata gcgtgctccg gggcctcagc
1921 agcgccggcg ggggcagtcc gcacagggag gatgcacagc ccgagcatag cgccagtgcc
1981 aggaagctgt cacgaaggag gacgccggcc agcagaagtg gggctgaccc tgtgaccagt
2041 gtggggaaaa ggttgaggcc tctggtgtct acgcagccag caaagaaggt ggccacggga
2101 gaggctttgc tcccaagctc tcccaccctc ggagctgagc ctgccaggcc ccaggcggtg
2161 ctggtggaga gcgggcccgt gtcataccac gccgacgagg aggctgacga ggaggagcct
2221 gacgaggagg acggggagcc ctgcgtcagt gccctgcaga tgatgggcag caacgactat
2281 ggctgtgatg gcgatgagga cgacggctac tgaagtgtgg cctccaggca ggtgatgtcc
2341 tggcaggggg cctcgcgggt ctcctcagca tcagacgggc ttccaggacc gcagcaggca
2401 ggccccagcg ccgagactcc tggtgacagg tggcacctgt cccacagccc tcgtcccatg
2461 tggaacttac cattgggatt gtgtttctat tcagcaaggg aaaccggacc aagcgtctgc
2521 atgtgtgtga tcagatgtgg gccggtgtgt gcagggctgg gtcccgctgc ctgccgtcga
2581 ctcatccaag gaccctccaa ggctggcagt gtggtgttgc tactattaag gaaacaggct
2641 tggggcagcc ccactgctgg tccaagtgtg tggagggctg agtgtgctgg ccctgtgact
2701 caggaccagc tctggagtct ccagcccacc ctccgcaccg tcccctcctg agcagcactc
2761 ggcgccagca gcctctgcca gagtggaagc cagagccctg caggtgtccg gcgcagccgt
2821 gggagctgag gatctggcac ttgagaggca gcagctcctt gaaggtcctc tgcctccagc
2881 tgtggccctg catccagata cctgcctcgt ccgaggcaga cacccccacc cctgcctcct
2941 ccagaccccc ctccccgctg cctgcaccgc ctggagcagc atgggggtca gacccctgct
3001 ccagggccac ttgagttgtg ggcccaggag ccctgcggct gccggcaggt gaactgagtg
3061 cccgacagct gagaccggcg cccacccgtc ctgagcatag ctctgtaggc agtgcgggca
3121 gagcctgcat agtgtcctgg cgctgggagt tgcccgtgga cagagccaga gggcagtggc
3181 gctccctgtc agagctggat caggcccccc atcgaggagg gagggcagac ggaggcccga
3241 gagcctcccc aggcctcttc gtgggaggcc ccagtaccac tcgtaggagg tctcagctct
3301 ggcatggctg ccccggatgt ggccgaaggg gcttcaccct gtgtccttaa gaaggggtgg
3361 ccttgaggca gagccgtgcc tcactgaccc caggggcctc atcctcccca tggaatgggc
3421 tgtatgtcct gccccaactt ggcccgcagc aggccagacc cccctacccc cgcccagagc
3481 tcagtagcca gcctgggtcc tgccagggct tctcgagggc ttgggggaag aatagattta
3541 gtaaagcagg aagatctgtt gttacttaac ag
//