LOCUS       AJ276171                2681 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for ASPIC (acidic secreted protein in cartilage)
            (ASPIC1 gene).
ACCESSION   AJ276171
VERSION     AJ276171.1
KEYWORDS    acidic secreted protein in cartilage; ASPIC1 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Bolton M.C.
  JOURNAL   Submitted (17-JUL-2000) to the INSDC. Bolton M.C., Cell signalling,
            Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith,
            London W6 8LH, UNITED KINGDOM.
REFERENCE   2
  AUTHORS   Bolton M.C., Wait R., Saklatvala J.
  TITLE     Cloning of ASPIC, a novel protein secreted by human normal and
            osteoarthritic cartilage, identified by 2D electrophoresis and mass
            spectrometry
  JOURNAL   Unpublished.
FEATURES             Location/Qualifiers
     source          1..2681
                     /db_xref="H-InvDB:HIT000246286"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_type="chondrocyte"
                     /tissue_type="cartilage"
                     /db_xref="taxon:9606"
     5'UTR           1..149
                     /gene="ASPIC1"
                     /note="A second transcription start site at +31"
                     /experiment="experimental evidence, no additional details
                     recorded"
     CDS             150..2135
                     /gene="ASPIC1"
                     /standard_name="acidic secreted protein in cartilage"
                     /product="ASPIC"
                     /db_xref="GOA:Q9NQ79"
                     /db_xref="H-InvDB:HIT000246286.14"
                     /db_xref="HGNC:HGNC:14882"
                     /db_xref="InterPro:IPR001881"
                     /db_xref="InterPro:IPR011519"
                     /db_xref="InterPro:IPR018097"
                     /db_xref="InterPro:IPR027039"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NQ79"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB98267.1"
                     /translation="MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLP
                     PDYDSNPTQLNYGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSS
                     PYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDI
                     LSDEVNVARGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDL
                     SRGILALRDVAAEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTF
                     VDAAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDI
                     ASPKFSMPSPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEEL
                     NPGDALEPEGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVP
                     RTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWP
                     DGKMVSRNVASGEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQF
                     PFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAA
                     ATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPSC"
     sig_peptide     150..230
                     /gene="ASPIC1"
     CDS             174..2135
                     /gene="ASPIC1"
                     /standard_name="acidic secreted protein in cartilage"
                     /product="ASPIC"
                     /note="putative alternative start, less identity to the
                     Kozak rule"
                     /db_xref="GOA:Q9NQ79"
                     /db_xref="HGNC:HGNC:14882"
                     /db_xref="InterPro:IPR001881"
                     /db_xref="InterPro:IPR011519"
                     /db_xref="InterPro:IPR018097"
                     /db_xref="InterPro:IPR027039"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NQ79"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB98268.1"
                     /translation="MSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPT
                     QLNYGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDR
                     QGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVA
                     RGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALR
                     DVAAEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAG
                     VDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMP
                     SPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEP
                     EGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFA
                     RGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRN
                     VASGEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQFPFVCPRDK
                     PVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAAATAAAAAA
                     AGAATAAPVLVDGDLNLGSVVKESCEPSC"
     sig_peptide     174..230
                     /gene="ASPIC1"
                     /note="putative alternative start, less identity to the
                     Kozak rule"
     CDS             183..2135
                     /gene="ASPIC1"
                     /standard_name="acidic secreted protein in cartilage"
                     /product="ASPIC"
                     /note="putative alternative start, less identity to the
                     Kozak rule"
                     /db_xref="GOA:Q9NQ79"
                     /db_xref="HGNC:HGNC:14882"
                     /db_xref="InterPro:IPR001881"
                     /db_xref="InterPro:IPR011519"
                     /db_xref="InterPro:IPR018097"
                     /db_xref="InterPro:IPR027039"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NQ79"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB98269.1"
                     /translation="MLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLN
                     YGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGN
                     AIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVARGV
                     ASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVA
                     AEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDD
                     PHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMPSPV
                     RTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGR
                     GTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGA
                     KVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRNVAS
                     GEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQFPFVCPRDKPVC
                     VNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGA
                     ATAAPVLVDGDLNLGSVVKESCEPSC"
     sig_peptide     183..230
                     /gene="ASPIC1"
                     /note="putative alternative start, less identity to the
                     Kozak rule"
     mat_peptide     231..2132
                     /gene="ASPIC1"
                     /standard_name="acidic secreted protein in cartilage"
                     /product="ASPIC"
     3'UTR           2136..2681
                     /gene="ASPIC1"
     regulatory      2642..2647
                     /gene="ASPIC1"
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          571 a          767 c          826 g          517 t
ORIGIN      
        1 gtataaagcg agcgcgcggc gtcggggcgg gaggctcgag gccagcccgg gaccggggct
       61 gggagcaagc aggcggcggc gccggcggca gaggcggcag cgagcgcccg cttcccacgc
      121 ccctaggcgg cggggccgag agcgggagga tggctccgag cgctgacccc ggcatgtcca
      181 ggatgttacc gttcctgctg ctgctctggt ttctgcccat cactgagggg tcccagcggg
      241 ctgaacccat gttcactgca gtcaccaact cagttctgcc tcctgactat gacagtaatc
      301 ccacccagct caactatggt gtggcagtta ctgatgtgga ccatgatggg gactttgaga
      361 tcgtcgtggc ggggtacaat ggacccaacc tggttctgaa gtatgaccgg gcccagaagc
      421 ggctggtgaa catcgcggtc gatgagcgca gctcacccta ctacgcgctg cgggaccggc
      481 aggggaacgc catcggggtc acagcctgcg acatcgacgg ggacggccgg gaggagatct
      541 acttcctcaa caccaataat gccttctcgg gggtggccac gtacaccgac aagttgttca
      601 agttccgcaa taaccggtgg gaagacatcc tgagcgatga ggtcaacgtg gcccgtggtg
      661 tggccagcct ctttgccgga cgctctgtgg cctgtgtgga cagaaagggc tctggacgct
      721 actctatcta cattgccaat tacgcctacg gtaatgtggg ccctgatgcc ctcattgaaa
      781 tggaccctga ggccagtgac ctctcccggg gcattctggc gctcagagat gtggctgctg
      841 aggctggggt cagcaaatat acagggggcc gaggcgtcag cgtgggcccc atcctcagca
      901 gcagtgcctc ggatatcttc tgcgacaatg agaatgggcc taacttcctt ttccacaacc
      961 ggggcgatgg cacctttgtg gacgctgcgg ccagtgctgg tgtggacgac ccccaccagc
     1021 atgggcgagg tgtcgccctg gctgacttca accgtgatgg caaagtggac atcgtctatg
     1081 gcaactggaa tggcccccac cgcctctatc tgcaaatgag cacccatggg aaggtccgct
     1141 tccgggacat cgcctcaccc aagttctcca tgccctcccc tgtccgcacg gtcatcaccg
     1201 ccgactttga caatgaccag gagctggaga tcttcttcaa caacattgcc taccgcagct
     1261 cctcagccaa ccgcctcttc cgcgtcatcc gtagagagca cggagacccc ctcatcgagg
     1321 agctcaatcc cggcgacgcc ttggagcctg agggccgggg cacagggggt gtggtgaccg
     1381 acttcgacgg agacgggatg ctggacctca tcttgtccca tggagagtcc atggctcagc
     1441 cgctgtccgt cttccggggc aatcagggct tcaacaacaa ctggctgcga gtggtgccac
     1501 gcacccggtt tggggccttt gccaggggag ctaaggtcgt gctctacacc aagaagagtg
     1561 gggcccacct gaggatcatc gacgggggct caggctacct gtgtgagatg gagcccgtgg
     1621 cacactttgg cctggggaag gatgaagcca gcagtgtgga ggtgacgtgg ccagatggca
     1681 agatggtgag ccggaacgtg gccagcgggg agatgaactc agtgctggag atcctctacc
     1741 cccgggatga ggacacactt caggacccag ccccactgga gtgtggccaa ggattctccc
     1801 agcaggaaaa tggccattgc atggacacca atgaatgcat ccagttccca ttcgtgtgcc
     1861 ctcgagacaa gcccgtatgt gtcaacacct atggaagcta caggtgccgg accaacaaga
     1921 agtgcagtcg gggctacgag cccaacgagg atggcacagc ctgcgtgggg actctcggcc
     1981 agtcaccggg cccccgcccc accaccccca ccgctgctgc tgccactgcc gctgctgctg
     2041 ccgctgctgg agctgccact gctgcaccgg tcctcgtaga tggagatctc aatctggggt
     2101 cggtggttaa ggagagctgc gagcccagct gctgagcagg ggtgggacat gaaccagcgg
     2161 atggagtcca gcaggggagt gggaaagtgg gcttgtgctg ctgcctagac agtagggatg
     2221 taaaggcctg ggagctagac cctccccaag cccatccatg cacattactt agctaacaat
     2281 tagggagact cgtaaggcca ggccctgtgc tgggcacata gctgtgatca cagcagacag
     2341 ggtcgctgcc ctgatggcgc ttacattcca gtgggtctaa tgaccatatc ttaggacaca
     2401 gatgtgccca gggaggtggt gtcactgcac aggaagtatg aggactttag tgtcctgagt
     2461 tcaaatcctg attcaggaac tcacaaagct atgtgacctt acaccagtca cttaacttgt
     2521 tagccatcca ttatcgcatc tgcaaaatgg ggattaagaa tagaatcttg gggttagtgt
     2581 ggagattaga ttaaatgtat gtaagacact tggcacaaaa cctggcacat agtaaaggct
     2641 caataaaaac aagtgcctct cactgggctt tgtcaacacg t
//