LOCUS AJ250725 5115 bp mRNA linear HUM 21-OCT-2008
DEFINITION Homo sapiens mRNA for ADAMTS12.
ACCESSION AJ250725
VERSION AJ250725.1
KEYWORDS ADAMTS12 gene; disintegrin metalloprotease; disintegrin-like;
thrombospondin type 1 motif.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5115)
AUTHORS Lopez-Otin C.
JOURNAL Submitted (29-OCT-1999) to the INSDC. Lopez-Otin C., Bioquimica y
Biologia Molecular, Universidad de Oviedo, C/Julian Claveria, s/n,
Oviedo. Asturias. 33006, SPAIN.
REFERENCE 2
AUTHORS Cal S., Arguelles J.M., Fernandez P.L., Lopez-Otin C.
TITLE Identification, characterization, and intracellular processing of
ADAM-TS12, a novel human disintegrin with a complex structural
organization involving multiple thrombospondin-1 repeats
JOURNAL J Biol Chem 276(21), 17932-17940(2001).
PUBMED 11279086
FEATURES Location/Qualifiers
source 1..5115
/db_xref="H-InvDB:HIT000245977"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 327..5108
/gene="ADAMTS12"
/product="a disintegrin-like and metalloprotease
(reprolysin type) with thrombospondin type 1 motif, 12"
/function="putative disintegrin metalloprotease"
/db_xref="GOA:P58397"
/db_xref="H-InvDB:HIT000245977.14"
/db_xref="HGNC:HGNC:14605"
/db_xref="InterPro:IPR000884"
/db_xref="InterPro:IPR001590"
/db_xref="InterPro:IPR002870"
/db_xref="InterPro:IPR010294"
/db_xref="InterPro:IPR010909"
/db_xref="InterPro:IPR013273"
/db_xref="InterPro:IPR024079"
/db_xref="InterPro:IPR036383"
/db_xref="InterPro:IPR041645"
/db_xref="UniProtKB/Swiss-Prot:P58397"
/protein_id="CAC20419.1"
/translation="MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEH
FIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDL
FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSAC
HGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQ
KQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMN
MVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDL
NPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAH
ELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGF
CLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCR
SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAE
RLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWF
PIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEI
DSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNF
LAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLL
FQVTNPGIKYEYTIQKDGLDNDVEQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRG
MVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMV
SDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK
NHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRM
LTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQ
PILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTL
TKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLS
RESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKT
ANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGN
WSECSTTCGLGAYWKRVECTTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRN
CSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSR
SCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRI
VQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLK
AMKKCSVPTVRAECCFSCPQTHITHTQRQRRQRLLQKSKEL"
BASE COUNT 1344 a 1331 c 1369 g 1071 t
ORIGIN
1 gaattccggg agcgggcggg ctgcgaggcc gcggggcatg cgggaggcgg aggggtggga
61 ccgggtggct gcgcccattc cacacccgcc gaaagcggac actgtcagct gaatcactcc
121 ccttttagga ggagggaggg ggaaaaggtg tctagctaat ttctgcttaa aaaagcacag
181 gagatcgcgg gtcagctttg cagtcgctgc cttctcgcgc ctgaccatgc acccctgcat
241 cttcctgctg ggcacaggcg agcgctttat ttctggagct gagggctaaa acttttttca
301 cttttcttct cctcaacatc tgaatcatgc catgtgccca gaggagctgg cttgcaaacc
361 tttccgtggt ggctcagctc cttaactttg gggcgctttg ctatgggaga cagcctcagc
421 caggcccggt tcgcttcccg gacaggaggc aagagcattt tatcaagggc ctgccagaat
481 accacgtggt gggtccagtc cgagtagatg ccagtgggca ttttttgtca tatggcttgc
541 actatcccat cacgagcagc aggaggaaga gagatttgga tggctcagag gactgggtgt
601 actacagaat ttctcacgag gagaaggacc tgttttttaa cttgacggtc aatcaaggat
661 ttctttccaa tagctacatc atggagaaga gatatgggaa cctctcccat gttaagatga
721 tggcttcctc tgcccccctc tgccatctca gtggcacggt tctacagcag ggcaccagag
781 ttgggacggc agccctcagt gcctgccatg gactgactgg atttttccaa ctaccacatg
841 gagacttttt cattgaaccc gtgaagaagc atccactggt tgagggaggg taccacccgc
901 acatcgttta caggaggcag aaagttccag aaaccaagga gccaacctgt ggattaaagg
961 acagtgttaa catctcccag aagcaagagc tatggcggga gaagtgggag aggcacaact
1021 tgccaagcag aagcctctct cggcgttcca tcagcaagga gagatgggtg gagacactgg
1081 tggtggccga cacaaagatg attgaatacc atgggagtga gaatgtggag tcctacatcc
1141 tcaccatcat gaacatggtc actgggttgt tccataaccc aagcattggc aatgcaattc
1201 acattgttgt ggttcggctc attctactcg aagaagaaga gcaaggactg aaaatagttc
1261 accatgcaga aaagacactg tctagcttct gcaagtggca gaagagtatc aatcccaaga
1321 gtgacctcaa tcctgttcat cacgacgtgg ctgtccttct caccagaaag gacatctgtg
1381 ctggtttcaa tcgcccctgc gagaccctgg gcctgtctca cctttcagga atgtgtcagc
1441 ctcaccgcag ttgtaacatc aatgaagatt cgggactccc tctggctttc acaattgccc
1501 atgagctagg acacagcttc ggcatccagc atgatgggaa agaaaatgac tgtgagcctg
1561 tgggcagaca tccgtacatc atgtcccgcc agctccagta cgatcccact ccgctgacat
1621 ggtccaagtg cagcgaggag tacatcaccc gcttcttgga ccgaggctgg gggttctgtc
1681 ttgatgacat acctaaaaag aaaggcttga agtccaaggt cattgccccc ggagtgatct
1741 atgatgttca ccaccagtgc cagctacaat atggacccaa tgctaccttc tgccaggaag
1801 tagaaaacgt ctgccagaca ctgtggtgct ccgtgaaggg cttttgtcgc tctaagctgg
1861 acgctgctgc agatggaact caatgtggtg agaagaagtg gtgtatggca ggcaagtgca
1921 tcacagtggg gaagaaacca gagagcattc ctggaggctg gggccgctgg tcaccctggt
1981 cccactgttc caggacctgt ggggctggag tccagagcgc agagaggctc tgcaacaacc
2041 ccgagccaaa gtttggaggg aaatattgca ctggagaaag aaaacgctat cgcttgtgca
2101 acgtccaccc ctgtcgctca gaggcaccaa catttcggca gatgcagtgc agtgaatttg
2161 acactgttcc ctacaagaat gaactctacc actggtttcc catttttaac ccagcacatc
2221 cttgtgagct ctactgccga cccatagatg gccagttttc tgagaaaatg ctggatgctg
2281 tcattgatgg taccccttgc tttgaaggcg gcaacagcag aaatgtctgt attaatggca
2341 tatgtaagat ggttggctgt gactatgaga tcgattccaa tgccaccgag gatcgctgcg
2401 gtgtgtgcct gggagatggc tcttcctgcc agactgtgag aaagatgttt aagcagaagg
2461 aaggatctgg ttatgttgac attgggctca ttccaaaagg agcaagggac ataagagtga
2521 tggaaattga gggagctgga aacttcctgg ccatcaggag tgaagatcct gaaaaatatt
2581 acctgaatgg agggtttatt atccagtgga acgggaacta taagctggca gggactgtct
2641 ttcagtatga caggaaagga gacctggaaa agctgatggc cacaggtccc accaatgagt
2701 ctgtgtggat ccagcttcta ttccaggtga ctaaccctgg catcaagtat gagtacacaa
2761 tccagaaaga tggccttgac aatgatgttg agcagatgta cttctggcag tacggccact
2821 ggacagagtg cagtgtgacc tgcgggacag gtatccgccg ccaaactgcc cattgcataa
2881 agaagggccg cgggatggtg aaagctacat tctgtgaccc agaaacacag cccaatggga
2941 gacagaagaa gtgccatgaa aaggcttgtc cacccaggtg gtgggcaggg gagtgggaag
3001 catgctcggc gacatgcggg ccccacgggg agaagaagcg aaccgtgctg tgcatccaga
3061 ccatggtctc tgacgagcag gctctcccgc ccacagactg ccagcacctg ctgaagccca
3121 agaccctcct ttcctgcaac agagacatcc tgtgcccctc ggactggaca gtgggcaact
3181 ggagtgagtg ttctgtttcc tgtggtggtg gagtgcggat tcgcagtgtc acatgtgcca
3241 agaaccatga tgaaccttgc gatgtgacaa ggaaacccaa cagccgagct ctgtgtggcc
3301 tccagcaatg cccttctagc cggagagttc tgaaaccaaa caaaggcact atttccaatg
3361 gaaaaaaccc accaacacta aagcccgtcc ctccacctac atccaggccc agaatgctga
3421 ccacacccac agggcctgag tctatgagca caagcactcc agcaatcagc agccctagtc
3481 ctaccacagc ctccaaagaa ggagacctgg gtgggaaaca gtggcaagat agctcaaccc
3541 aacctgagct gagctctcgc tatctcattt ccactggaag cacttcccag cccatcctca
3601 cttcccaatc cttgagcatt cagccaagtg aggaaaatgt ttccagttca gatactggtc
3661 ctacctcgga gggaggcctt gtagctacaa caacaagtgg ttctggcttg tcatcttccc
3721 gcaaccctat cacttggcct gtgactccat tttacaatac cttgaccaaa ggtccagaaa
3781 tggagattca cagtggctca ggggaagaaa gagaacagcc tgaggacaaa gatgaaagca
3841 atcctgtaat atggaccaag atcagagtac ctggaaatga cgctccagtg gaaagtacag
3901 aaatgccact tgcacctcca ctaacaccag atctcagcag ggagtcctgg tggccaccct
3961 tcagcacagt aatggaagga ctgctcccca gccaaaggcc cactacttcc gaaactggga
4021 cacccagagt tgaggggatg gttactgaaa agccagccaa cactctgctc cctctgggag
4081 gagaccacca gccagaaccc tcaggaaaga cggcaaaccg taaccacctg aaacttccaa
4141 acaacatgaa ccaaacaaaa agttctgaac cagtcctgac tgaggaggat gcaacaagtc
4201 tgattactga gggctttttg ctaaatgcct ccaattacaa gcagctcaca aacggccacg
4261 gctctgcaca ctggatcgtc ggaaactgga gcgagtgctc caccacatgt ggcctggggg
4321 cctactggaa aagggtggag tgcaccaccc agatggattc tgactgtgcg gccatccaga
4381 gacctgaccc tgcaaaaaga tgccacctcc gtccctgtgc tggctggaaa gtgggaaact
4441 ggagcaagtg ctccagaaac tgcagtgggg gcttcaagat acgcgagatt cagtgcgtgg
4501 acagccggga ccaccggaac ctgaggccat ttcactgcca gttcctggcc ggcattcctc
4561 ccccattgag catgagctgt aacccggagc cctgtgaggc gtggcaggtg gagccttgga
4621 gccagtgctc caggtcctgt ggaggtggag ttcaggagag aggagtgttc tgtccaggag
4681 gcctctgtga ttggacaaaa agacccacat ccaccatgtc ttgcaatgag cacctgtgct
4741 gtcactgggc cactgggaac tgggacctgt gttccacttc ctgtggaggt ggctttcaga
4801 agaggattgt ccaatgtgtg ccctcagagg gcaataaaac tgaagaccaa gaccaatgtc
4861 tatgtgatca caaacccaga cctccagaat tcaaaaaatg caaccagcag gcctgcaaga
4921 aaagtgccga tttactttgc actaaggaca aactgtcagc cagtttctgc cagacactga
4981 aagccatgaa gaaatgttct gtgcccaccg tgagggctga gtgctgcttc tcgtgtcccc
5041 agacacacat cacacacacc caaaggcaaa gaaggcaacg gttgctccaa aagtcaaaag
5101 aactctaagc ccaaa
//