LOCUS AJ250460 1968 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for neutral sphingomyelinase II (nSMase2 gene).
ACCESSION AJ250460
VERSION AJ250460.1
KEYWORDS neutral sphingomyelinase II; nSMase2 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1968)
AUTHORS Hofmann K.
JOURNAL Submitted (20-OCT-1999) to the INSDC. Hofmann K., Bioinformatics
Group, MEMOREC Stoffel GmbH, Stoeckheimer Weg 1, D-50829 Koeln,
GERMANY.
REFERENCE 3
AUTHORS Hofmann K., Tomiuk S., Wolff G., Stoffel W.
TITLE Cloning and characterization of the mammalian brain-specific,
Mg2+-dependent neutral sphingomyelinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97(11), 5895-5900(2000).
PUBMED 10823942
FEATURES Location/Qualifiers
source 1..1968
/db_xref="H-InvDB:HIT000245970"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..1968
/gene="nSMase2"
/product="neutral sphingomyelinase II"
/function="lipid metabolism"
/EC_number="3.1.4.12"
/db_xref="GOA:Q9NY59"
/db_xref="H-InvDB:HIT000245970.12"
/db_xref="HGNC:HGNC:14240"
/db_xref="InterPro:IPR036691"
/db_xref="PDB:5UVG"
/db_xref="UniProtKB/Swiss-Prot:Q9NY59"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAB92964.1"
/translation="MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYE
KRQRADDPCCLQLLCTALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRLED
KGLAGGAALLSEWKGTGPGKSFCFATANVCLLPDSLARVNNLFNTQARAKEIGQRIRN
GAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGVARAVPGSIKRTASVEYKGDGGR
HPGDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPPEADDPVPGGQARNGAGGGPR
GQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANSKLLYKASVVKKAA
ARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVY
GCQGCCSFKCLNSGLLFASRYPIMDVAYHCYPNKCNDDALASKGALFLKVQVGSTPQD
QRIVGYIACTHLHAPQEDSAIRCGQLDLLQDWLADFRKSTSSSSAANPEELVAFDVVC
GDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPD
NLQKVLESEEGRREYLAFPTSKSSGQKGRKELLKGNGRRIDYMLHAEEGLCPDWKAEV
EEFSFITQLSGLTDHLPVAMRLMVSSGEEEA"
BASE COUNT 381 a 631 c 607 g 349 t
ORIGIN
1 atggttttgt acacgacccc ctttcctaac agctgtctgt ccgccctgca ctgtgtgtcc
61 tgggccctta tctttccatg ctactggctg gtggaccggc tcgctgcctc cttcataccc
121 accacctacg agaagcgcca gcgggcagac gacccgtgct gcctgcagct gctctgcact
181 gccctcttca cgcccatcta cctggccctc ctggtggcct cgctgccctt tgcgtttctc
241 ggctttctct tctggtcccc actgcagtcg gcccgccggc cctacatcta ttcacggctg
301 gaagacaagg gcctggccgg tggggcagcc ctgctcagtg aatggaaggg cacggggcct
361 ggcaaaagct tctgctttgc cactgccaac gtctgcctcc tgcccgactc actcgccagg
421 gtcaacaacc tttttaacac ccaagcgcgg gccaaggaga tcgggcagag aatccgcaat
481 ggggccgccc ggccccagat caaaatttac atcgactccc ccaccaatac ctccatcagc
541 gccgctagct tcagcagcct ggtgtcacca cagggcggcg atggggtggc ccgggccgtc
601 cccgggagca ttaagaggac agcctctgtg gagtacaagg gtgacggtgg gcggcacccc
661 ggtgacgagg ctgccaacgg cccagcctct ggggaccctg tcgacagcag cagcccggag
721 gatgcctgca tcgtgcgcat cggtggcgag gagggcggcc ggccacctga agctgacgac
781 cctgtgcctg ggggccaggc caggaacgga gctggcgggg gcccaagggg ccagacgccc
841 aaccataatc agcaggacgg ggattcaggg agcctgggca gcccctcggc ctcccgggag
901 tccctggtga aggggcgagc tgggccagac accagtgcca gcggggagcc aggtgccaac
961 agcaagctcc tgtacaaggc ctcggtggtg aagaaggcgg ctgcacgcag gaggcggcac
1021 cccgacgagg ccttcgacca tgaggtctcc gccttcttcc ccgccaacct ggacttcctg
1081 tgcctgcagg aggtgtttga caagcgagca gccaccaaat tgaaagagca gctgcacggc
1141 tacttcgagt acatcctgta cgacgtcggg gtctacggct gccagggctg ctgcagcttc
1201 aagtgtctca acagcggcct cctctttgcc agccgctacc ccatcatgga cgtggcctat
1261 cactgttacc ccaacaagtg taacgacgat gccctggcct ctaagggagc tctgtttctc
1321 aaggtgcagg tgggaagcac acctcaggac caaagaatcg tcgggtacat cgcctgcaca
1381 cacctgcatg ccccacaaga ggacagcgcc atccggtgtg ggcagctgga cctgcttcag
1441 gactggctgg ctgatttccg aaaatctacc tcctcgtcca gcgcagccaa ccccgaggag
1501 ctggtggcat ttgacgtcgt ctgtggagat ttcaactttg ataactgctc ctctgacgac
1561 aagctggagc agcaacactc cctgttcacc cactacaggg acccctgccg cctggggcct
1621 ggtgaggaga agccgtgggc catcggtact ctgctggaca cgaacggcct gtacgatgag
1681 gatgtgtgca cccccgacaa cctgcagaag gtcctggaga gtgaggaggg ccgcagggag
1741 tacctggcgt ttcccaccag caagagctcg ggccagaagg ggcggaagga gctgctgaag
1801 ggcaacggcc ggcgcatcga ctacatgctg catgcagagg aggggctgtg cccagactgg
1861 aaggccgagg tggaagaatt cagttttatc acccagctgt ccggcctgac ggaccacctg
1921 ccagtagcca tgcgactgat ggtgtcttcg ggggaggagg aggcatag
//