LOCUS AJ250014 5371 bp mRNA linear HUM 07-OCT-2008 DEFINITION Homo sapiens mRNA for Familial Cylindromatosis cyld gene. ACCESSION AJ250014 VERSION AJ250014.1 KEYWORDS cyld gene; Familial Cylindromatosis. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5371) AUTHORS Stratton M.R. JOURNAL Submitted (29-NOV-1999) to the INSDC. Stratton M.R., Cancer Genetics, Institute of Cancer Research, 15 Cotswold Rd, Sutton,, Surrey. SM2 5NG., UNITED KINGDOM. REFERENCE 2 AUTHORS Bignell G.R., Brown C., Biggs P.J., Lakhani S.R., Jones C., Hansen J., Blair E., Hofmann B., Siebert R., Turner G., Evans D.G., Schrander-Stumpel C., Beemer F.A., Van Den Ouweland A., Halley D., Delpech B., Cleveland M.G., Leigh I., Leisti J., Rasmussen S., Wallace M.R., Fenske C., Banerjee P., Oiso N., Chaggar R., Merrett S., Leonard N., Huber M., Hohl D., Chapman P., Burn J., Swift S., Smith A., Ashworth A., Stratton M.R. TITLE Identification of the familial cylindromatosis tumour-suppressor gene JOURNAL Nat Genet 25(2), 160-165(2000). PUBMED 10835629 FEATURES Location/Qualifiers source 1..5371 /db_xref="H-InvDB:HIT000245961" /organism="Homo sapiens" /chromosome="16" /map="16q12 - q13" /mol_type="mRNA" /db_xref="taxon:9606" CDS 392..3262 /gene="cyld" /function="tumour suppressor/recessive oncogene" /note="Familial Cylindromatosis Gene" /db_xref="GOA:Q9NQC7" /db_xref="H-InvDB:HIT000245961.14" /db_xref="HGNC:HGNC:2584" /db_xref="InterPro:IPR000938" /db_xref="InterPro:IPR001394" /db_xref="InterPro:IPR018200" /db_xref="InterPro:IPR028889" /db_xref="InterPro:IPR036859" /db_xref="InterPro:IPR038765" /db_xref="PDB:1IXD" /db_xref="PDB:1WHL" /db_xref="PDB:1WHM" /db_xref="PDB:2VHF" /db_xref="UniProtKB/Swiss-Prot:Q9NQC7" /experiment="experimental evidence, no additional details recorded" /protein_id="CAB93533.1" /translation="MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKG SIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLA ITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSG IFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAG PGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNW DGRFDGVQLCSFACVESTILLHINDIIPALSESVTQERRPPKLAFMSRGVGDKGSSSH NKPKATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEVAEDPAKSLTEIS TDFDRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSVMEELN TAPVQESPPLAMPPGNSHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELED ECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGY LSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRP KEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDP EEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFIN SNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYE CRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPC QNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGE YLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK" BASE COUNT 1600 a 950 c 1183 g 1638 t ORIGIN 1 gggggcgggc ccaggtagca ggtttggctg cgcgggggcc gcgcgtcgga gtttccccct 61 ttctagggtg aggatggttc tacacagcca cccggagttc cttagttgaa aggtgcgccc 121 tgctgtgaca gaatgtggta attgtaatct ttaacatttt catgtaaaac atatttcctg 181 atcatctttc cattgtcttc atggaaaatt gataaatatt tgtgccttcc aactctcgtc 241 ttggttgaat gacttcatct taatacaaca tggacaccac gttgctgaaa acatgctttg 301 ggactgccac tgaatttatc ttttgcggtt ttatgacaaa gttattagta gtttcccttt 361 tttgaattag tattttgaag ttaatatcac aatgagttca ggcttatgga gccaagaaaa 421 agtcacttca ccctactggg aagagcggat tttttacttg cttcttcaag aatgcagcgt 481 tacagacaaa caaacacaaa agctccttaa agtaccgaag ggaagtatag gacagtatat 541 tcaagatcgt tctgtggggc attcaaggat tccttctgca aaaggcaaga aaaatcagat 601 tggattaaaa attctagagc aacctcatgc agttctcttt gttgatgaaa aggatgttgt 661 agagataaat gaaaagttca cagagttact tttggcaatt accaattgtg aggagaggtt 721 cagcctgttt aaaaacagaa acagactaag taaaggcctc caaatagacg tgggctgtcc 781 tgtgaaagta cagctgagat ctggggaaga aaaatttcct ggagttgtac gcttcagagg 841 acccctgtta gcagagagga cagtctccgg aatattcttt ggagttgaat tgctggaaga 901 aggtcgtggt caaggtttca ctgacggggt gtaccaaggg aaacagcttt ttcagtgtga 961 tgaagattgt ggcgtgtttg ttgcattgga caagctagaa ctcatagaag atgatgacac 1021 tgcattggaa agtgattacg caggtcctgg ggacacaatg caggtcgaac ttcctccttt 1081 ggaaataaac tccagagttt ctttgaaggt tggagaaaca atagaatctg gaacagttat 1141 attctgtgat gttttgccag gaaaagaaag cttaggatat tttgttggtg tggacatgga 1201 taaccctatt ggcaactggg atggaagatt tgatggagtg cagctttgta gttttgcgtg 1261 tgttgaaagt acaattctat tgcacatcaa tgatatcatc ccagctttat cagagagtgt 1321 gacgcaggaa aggaggcctc ccaaacttgc ctttatgtca agaggtgttg gggacaaagg 1381 ttcatccagt cataataaac caaaggctac aggatctacc tcagaccctg gaaatagaaa 1441 cagatctgaa ttattttata ccttaaatgg gtcttctgtt gactcacaac cacaatccaa 1501 atcaaaaaat acatggtaca ttgatgaagt tgcagaagac cctgcaaaat ctcttacaga 1561 gatatctaca gactttgacc gttcttcacc accactccag cctcctcctg tgaactcact 1621 gaccaccgag aacagattcc actctttacc attcagtctc accaagatgc ccaataccaa 1681 tggaagtatt ggccacagtc cactttctct gtcagcccag tctgtaatgg aagagctaaa 1741 cactgcaccc gtccaagaga gtccaccctt ggccatgcct cctgggaact cacatggtct 1801 agaagtgggc tcattggctg aagttaagga gaaccctcct ttctatgggg taatccgttg 1861 gatcggtcag ccaccaggac tgaatgaagt gctcgctgga ctggaactgg aagatgagtg 1921 tgcaggctgt acggatggaa ccttcagagg cactcggtat ttcacctgtg ccctgaagaa 1981 ggcgctgttt gtgaaactga agagctgcag gcctgactct aggtttgcat cattgcagcc 2041 ggtttccaat cagattgagc gctgtaactc tttagcattt ggaggctact taagtgaagt 2101 agtagaagaa aatactccac caaaaatgga aaaagaaggc ttggagataa tgattgggaa 2161 gaagaaaggc atccagggtc attacaattc ttgttactta gactcaacct tattctgctt 2221 atttgctttt agttctgttc tggacactgt gttacttaga cccaaagaaa agaacgatgt 2281 agaatattat agtgaaaccc aagagctact gaggacagaa attgttaatc ctctgagaat 2341 atatggatat gtgtgtgcca caaaaattat gaaactgagg aaaatacttg aaaaggtgga 2401 ggctgcatca ggatttacct ctgaagaaaa agatcctgag gaattcttga atattctgtt 2461 tcatcatatt ttaagggtag aacctttgct aaaaataaga tcagcaggtc aaaaggtaca 2521 agattgttac ttctatcaaa tttttatgga aaaaaatgag aaagttggcg ttcccacaat 2581 tcagcagttg ttagaatggt cttttatcaa cagtaacctg aaatttgcag aggcaccatc 2641 atgtctgatt attcagatgc ctcgatttgg aaaagacttt aaactattta aaaaaatttt 2701 tccttctctg gaattaaata taacagattt acttgaagac actcccagac agtgccggat 2761 atgtggaggg cttgcaatgt atgagtgtag agaatgctac gacgatccgg acatctcagc 2821 tggaaaaatc aagcagtttt gtaaaacctg caacactcaa gtccaccttc atccgaagag 2881 gctgaatcat aaatataacc cagtgtcact tcccaaagac ttacccgact gggactggag 2941 acacggctgc atcccttgcc agaatatgga gttatttgct gttctctgca tagaaacaag 3001 ccactatgtt gcttttgtga agtatgggaa ggacgattct gcctggctct tctttgacag 3061 catggccgat cgggatggtg gtcagaatgg cttcaacatt cctcaagtca ccccatgccc 3121 agaagtagga gagtacttga agatgtctct ggaagacctg cattccttgg actccaggag 3181 aatccaaggc tgtgcacgaa gactgctttg tgatgcatat atgtgcatgt accagagtcc 3241 aacaatgagt ttgtacaaat aactggggtc atcgggaaag gcaaagaaac tgaaggcaga 3301 gtcctaacgt tgcatcttat tcgagctggc agttctgttc acgtccattg ccggcaatgg 3361 atgtctttgt ggtgatgatc cttcagaaaa ggatgcctct gtttaaaaac aaattgcttt 3421 tgtgtccctg aagtatttaa taagaagcat tttgcactct agaaagtatg tttgtgttgg 3481 ttttttaaga agtctaaatg aagttattaa tacctgaagc tttaagttaa gtgcattgat 3541 catatgatat ttttggaagc atacaatttt aattgtggaa gtttaaagcc tcttttagtc 3601 cattgagaat gtaaataaat gtgtcttctt tatggaccaa ggatatgaaa tcatttttct 3661 tttgtagcta acggttgcct tgaggaagaa ataatttggt tttattaaga gtctactctc 3721 aatccagtta ttagagatgt actgagtttg atttgttaat cctttctata tactgctgat 3781 cttgcatgtc tacaatctgc tcagtttttc tgtgtttctg caatagtggt cagaaaaata 3841 cttaaattcc cttaatggtg ttgttttcta tttgttctgg ttttgagata aatgagtgat 3901 tctgtcccca aatgtccatt tttgaagtga ttttcctgga ggattagggt atttagcagt 3961 tgaagctctt cattcatagt agttactgtc agctaacagg ttttttaagg cttttaacta 4021 ttaatatttt atggaatggg gcaaagtaaa ttgatgaaag aattggagtg ataatagtcc 4081 tttacaaaca tacagtccat aagaaaatga atttggcata tagaattatt acaatttcct 4141 gggagagatg gatatttaaa cctctattat tttagacaag actgtctaga acttaagttt 4201 gatctgtcag ccagtactcc cattaaattc agtgtagttt cacttgatag aatcagatat 4261 gttatcgaaa tgttagcagc agcttcatcc tccttctgat taaagtaagt agaaatggga 4321 tgttttgttt aataacagcc atagtgtgtg tttagaccac agcggatgtt gtagaccagg 4381 accatagatg atacatgtca gtgctgtgga atgtgcattc tctgagtgtt gttttgtggt 4441 atcattgtct ttcctgaatg actttctaac tgtgcagaaa ggcagaaaag tcatcatatg 4501 tatatgtcat atgactttat aaaatattta atgtgacaaa aagtggaaag aatctttaca 4561 aaccctgcaa ttactttttt aaaggcactt ttactctttg gttttatcat tccattttgc 4621 taatatttac tagctttata aattacagta aggtacaaaa actcatcttg taatattttc 4681 atttttgaag tgaaaaagta catatatttt gcacaaggtt ttatactgct aagtgcttgg 4741 ttggggtggt gagatgatga ttagatcagg ggtgaggctg agagactctg ggtttagggc 4801 tagccctgcc tccatctccc ttgggtaaaa tgaagggtgt ggggtaaaag atgcataagg 4861 ccttttctag ctctgacagc ctagaagtcc aatcaccctg taataaatat gtgttgaatg 4921 aagaaatggg tgaatgagct tgtcaatgtg attttaaaaa attgactacc tggaggaatg 4981 attaggaatc taaatgaagc cagccctcgg tatctgcagg tttctcatcc atggattcaa 5041 ccaactgcaa atggaaaata cgattttttt taaaaaaagg atggttacat ccgtattgaa 5101 catgtacaga cttttttctt gtcattattc tctgaacaat acaagaactc tttatgtagc 5161 atttacattt attaggtatt ataagtaatc tagagattat ttaattaaaa tatacaggag 5221 gatgtgtgtt tatatgccag aaattctgta ccattttgta tcagggaatt gagcatcttc 5281 agatgttggt atctgcaggg atcctggaac caaacccctg cagatactaa gggctgacga 5341 tctaggtaag actggattta acagttggaa a //