LOCUS       AJ250014                5371 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for Familial Cylindromatosis cyld gene.
ACCESSION   AJ250014
VERSION     AJ250014.1
KEYWORDS    cyld gene; Familial Cylindromatosis.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5371)
  AUTHORS   Stratton M.R.
  JOURNAL   Submitted (29-NOV-1999) to the INSDC. Stratton M.R., Cancer
            Genetics, Institute of Cancer Research, 15 Cotswold Rd, Sutton,,
            Surrey. SM2 5NG., UNITED KINGDOM.
REFERENCE   2
  AUTHORS   Bignell G.R., Brown C., Biggs P.J., Lakhani S.R., Jones C.,
            Hansen J., Blair E., Hofmann B., Siebert R., Turner G., Evans D.G.,
            Schrander-Stumpel C., Beemer F.A., Van Den Ouweland A., Halley D.,
            Delpech B., Cleveland M.G., Leigh I., Leisti J., Rasmussen S.,
            Wallace M.R., Fenske C., Banerjee P., Oiso N., Chaggar R.,
            Merrett S., Leonard N., Huber M., Hohl D., Chapman P., Burn J.,
            Swift S., Smith A., Ashworth A., Stratton M.R.
  TITLE     Identification of the familial cylindromatosis tumour-suppressor
            gene
  JOURNAL   Nat Genet 25(2), 160-165(2000).
   PUBMED   10835629
FEATURES             Location/Qualifiers
     source          1..5371
                     /db_xref="H-InvDB:HIT000245961"
                     /organism="Homo sapiens"
                     /chromosome="16"
                     /map="16q12 - q13"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             392..3262
                     /gene="cyld"
                     /function="tumour suppressor/recessive oncogene"
                     /note="Familial Cylindromatosis Gene"
                     /db_xref="GOA:Q9NQC7"
                     /db_xref="H-InvDB:HIT000245961.14"
                     /db_xref="HGNC:HGNC:2584"
                     /db_xref="InterPro:IPR000938"
                     /db_xref="InterPro:IPR001394"
                     /db_xref="InterPro:IPR018200"
                     /db_xref="InterPro:IPR028889"
                     /db_xref="InterPro:IPR036859"
                     /db_xref="InterPro:IPR038765"
                     /db_xref="PDB:1IXD"
                     /db_xref="PDB:1WHL"
                     /db_xref="PDB:1WHM"
                     /db_xref="PDB:2VHF"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NQC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB93533.1"
                     /translation="MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKG
                     SIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLA
                     ITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSG
                     IFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAG
                     PGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNW
                     DGRFDGVQLCSFACVESTILLHINDIIPALSESVTQERRPPKLAFMSRGVGDKGSSSH
                     NKPKATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEVAEDPAKSLTEIS
                     TDFDRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSVMEELN
                     TAPVQESPPLAMPPGNSHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELED
                     ECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGY
                     LSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRP
                     KEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDP
                     EEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFIN
                     SNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYE
                     CRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPC
                     QNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGE
                     YLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK"
BASE COUNT         1600 a          950 c         1183 g         1638 t
ORIGIN      
        1 gggggcgggc ccaggtagca ggtttggctg cgcgggggcc gcgcgtcgga gtttccccct
       61 ttctagggtg aggatggttc tacacagcca cccggagttc cttagttgaa aggtgcgccc
      121 tgctgtgaca gaatgtggta attgtaatct ttaacatttt catgtaaaac atatttcctg
      181 atcatctttc cattgtcttc atggaaaatt gataaatatt tgtgccttcc aactctcgtc
      241 ttggttgaat gacttcatct taatacaaca tggacaccac gttgctgaaa acatgctttg
      301 ggactgccac tgaatttatc ttttgcggtt ttatgacaaa gttattagta gtttcccttt
      361 tttgaattag tattttgaag ttaatatcac aatgagttca ggcttatgga gccaagaaaa
      421 agtcacttca ccctactggg aagagcggat tttttacttg cttcttcaag aatgcagcgt
      481 tacagacaaa caaacacaaa agctccttaa agtaccgaag ggaagtatag gacagtatat
      541 tcaagatcgt tctgtggggc attcaaggat tccttctgca aaaggcaaga aaaatcagat
      601 tggattaaaa attctagagc aacctcatgc agttctcttt gttgatgaaa aggatgttgt
      661 agagataaat gaaaagttca cagagttact tttggcaatt accaattgtg aggagaggtt
      721 cagcctgttt aaaaacagaa acagactaag taaaggcctc caaatagacg tgggctgtcc
      781 tgtgaaagta cagctgagat ctggggaaga aaaatttcct ggagttgtac gcttcagagg
      841 acccctgtta gcagagagga cagtctccgg aatattcttt ggagttgaat tgctggaaga
      901 aggtcgtggt caaggtttca ctgacggggt gtaccaaggg aaacagcttt ttcagtgtga
      961 tgaagattgt ggcgtgtttg ttgcattgga caagctagaa ctcatagaag atgatgacac
     1021 tgcattggaa agtgattacg caggtcctgg ggacacaatg caggtcgaac ttcctccttt
     1081 ggaaataaac tccagagttt ctttgaaggt tggagaaaca atagaatctg gaacagttat
     1141 attctgtgat gttttgccag gaaaagaaag cttaggatat tttgttggtg tggacatgga
     1201 taaccctatt ggcaactggg atggaagatt tgatggagtg cagctttgta gttttgcgtg
     1261 tgttgaaagt acaattctat tgcacatcaa tgatatcatc ccagctttat cagagagtgt
     1321 gacgcaggaa aggaggcctc ccaaacttgc ctttatgtca agaggtgttg gggacaaagg
     1381 ttcatccagt cataataaac caaaggctac aggatctacc tcagaccctg gaaatagaaa
     1441 cagatctgaa ttattttata ccttaaatgg gtcttctgtt gactcacaac cacaatccaa
     1501 atcaaaaaat acatggtaca ttgatgaagt tgcagaagac cctgcaaaat ctcttacaga
     1561 gatatctaca gactttgacc gttcttcacc accactccag cctcctcctg tgaactcact
     1621 gaccaccgag aacagattcc actctttacc attcagtctc accaagatgc ccaataccaa
     1681 tggaagtatt ggccacagtc cactttctct gtcagcccag tctgtaatgg aagagctaaa
     1741 cactgcaccc gtccaagaga gtccaccctt ggccatgcct cctgggaact cacatggtct
     1801 agaagtgggc tcattggctg aagttaagga gaaccctcct ttctatgggg taatccgttg
     1861 gatcggtcag ccaccaggac tgaatgaagt gctcgctgga ctggaactgg aagatgagtg
     1921 tgcaggctgt acggatggaa ccttcagagg cactcggtat ttcacctgtg ccctgaagaa
     1981 ggcgctgttt gtgaaactga agagctgcag gcctgactct aggtttgcat cattgcagcc
     2041 ggtttccaat cagattgagc gctgtaactc tttagcattt ggaggctact taagtgaagt
     2101 agtagaagaa aatactccac caaaaatgga aaaagaaggc ttggagataa tgattgggaa
     2161 gaagaaaggc atccagggtc attacaattc ttgttactta gactcaacct tattctgctt
     2221 atttgctttt agttctgttc tggacactgt gttacttaga cccaaagaaa agaacgatgt
     2281 agaatattat agtgaaaccc aagagctact gaggacagaa attgttaatc ctctgagaat
     2341 atatggatat gtgtgtgcca caaaaattat gaaactgagg aaaatacttg aaaaggtgga
     2401 ggctgcatca ggatttacct ctgaagaaaa agatcctgag gaattcttga atattctgtt
     2461 tcatcatatt ttaagggtag aacctttgct aaaaataaga tcagcaggtc aaaaggtaca
     2521 agattgttac ttctatcaaa tttttatgga aaaaaatgag aaagttggcg ttcccacaat
     2581 tcagcagttg ttagaatggt cttttatcaa cagtaacctg aaatttgcag aggcaccatc
     2641 atgtctgatt attcagatgc ctcgatttgg aaaagacttt aaactattta aaaaaatttt
     2701 tccttctctg gaattaaata taacagattt acttgaagac actcccagac agtgccggat
     2761 atgtggaggg cttgcaatgt atgagtgtag agaatgctac gacgatccgg acatctcagc
     2821 tggaaaaatc aagcagtttt gtaaaacctg caacactcaa gtccaccttc atccgaagag
     2881 gctgaatcat aaatataacc cagtgtcact tcccaaagac ttacccgact gggactggag
     2941 acacggctgc atcccttgcc agaatatgga gttatttgct gttctctgca tagaaacaag
     3001 ccactatgtt gcttttgtga agtatgggaa ggacgattct gcctggctct tctttgacag
     3061 catggccgat cgggatggtg gtcagaatgg cttcaacatt cctcaagtca ccccatgccc
     3121 agaagtagga gagtacttga agatgtctct ggaagacctg cattccttgg actccaggag
     3181 aatccaaggc tgtgcacgaa gactgctttg tgatgcatat atgtgcatgt accagagtcc
     3241 aacaatgagt ttgtacaaat aactggggtc atcgggaaag gcaaagaaac tgaaggcaga
     3301 gtcctaacgt tgcatcttat tcgagctggc agttctgttc acgtccattg ccggcaatgg
     3361 atgtctttgt ggtgatgatc cttcagaaaa ggatgcctct gtttaaaaac aaattgcttt
     3421 tgtgtccctg aagtatttaa taagaagcat tttgcactct agaaagtatg tttgtgttgg
     3481 ttttttaaga agtctaaatg aagttattaa tacctgaagc tttaagttaa gtgcattgat
     3541 catatgatat ttttggaagc atacaatttt aattgtggaa gtttaaagcc tcttttagtc
     3601 cattgagaat gtaaataaat gtgtcttctt tatggaccaa ggatatgaaa tcatttttct
     3661 tttgtagcta acggttgcct tgaggaagaa ataatttggt tttattaaga gtctactctc
     3721 aatccagtta ttagagatgt actgagtttg atttgttaat cctttctata tactgctgat
     3781 cttgcatgtc tacaatctgc tcagtttttc tgtgtttctg caatagtggt cagaaaaata
     3841 cttaaattcc cttaatggtg ttgttttcta tttgttctgg ttttgagata aatgagtgat
     3901 tctgtcccca aatgtccatt tttgaagtga ttttcctgga ggattagggt atttagcagt
     3961 tgaagctctt cattcatagt agttactgtc agctaacagg ttttttaagg cttttaacta
     4021 ttaatatttt atggaatggg gcaaagtaaa ttgatgaaag aattggagtg ataatagtcc
     4081 tttacaaaca tacagtccat aagaaaatga atttggcata tagaattatt acaatttcct
     4141 gggagagatg gatatttaaa cctctattat tttagacaag actgtctaga acttaagttt
     4201 gatctgtcag ccagtactcc cattaaattc agtgtagttt cacttgatag aatcagatat
     4261 gttatcgaaa tgttagcagc agcttcatcc tccttctgat taaagtaagt agaaatggga
     4321 tgttttgttt aataacagcc atagtgtgtg tttagaccac agcggatgtt gtagaccagg
     4381 accatagatg atacatgtca gtgctgtgga atgtgcattc tctgagtgtt gttttgtggt
     4441 atcattgtct ttcctgaatg actttctaac tgtgcagaaa ggcagaaaag tcatcatatg
     4501 tatatgtcat atgactttat aaaatattta atgtgacaaa aagtggaaag aatctttaca
     4561 aaccctgcaa ttactttttt aaaggcactt ttactctttg gttttatcat tccattttgc
     4621 taatatttac tagctttata aattacagta aggtacaaaa actcatcttg taatattttc
     4681 atttttgaag tgaaaaagta catatatttt gcacaaggtt ttatactgct aagtgcttgg
     4741 ttggggtggt gagatgatga ttagatcagg ggtgaggctg agagactctg ggtttagggc
     4801 tagccctgcc tccatctccc ttgggtaaaa tgaagggtgt ggggtaaaag atgcataagg
     4861 ccttttctag ctctgacagc ctagaagtcc aatcaccctg taataaatat gtgttgaatg
     4921 aagaaatggg tgaatgagct tgtcaatgtg attttaaaaa attgactacc tggaggaatg
     4981 attaggaatc taaatgaagc cagccctcgg tatctgcagg tttctcatcc atggattcaa
     5041 ccaactgcaa atggaaaata cgattttttt taaaaaaagg atggttacat ccgtattgaa
     5101 catgtacaga cttttttctt gtcattattc tctgaacaat acaagaactc tttatgtagc
     5161 atttacattt attaggtatt ataagtaatc tagagattat ttaattaaaa tatacaggag
     5221 gatgtgtgtt tatatgccag aaattctgta ccattttgta tcagggaatt gagcatcttc
     5281 agatgttggt atctgcaggg atcctggaac caaacccctg cagatactaa gggctgacga
     5341 tctaggtaag actggattta acagttggaa a
//