LOCUS       AJ242972                1178 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for TOLLIP protein.
ACCESSION   AJ242972
VERSION     AJ242972.1
KEYWORDS    TOLLIP protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Volpe F.
  JOURNAL   Submitted (09-JUN-1999) to the INSDC. Volpe F., Cell Biology, Glaxo
            Wellcome R&D, Gunnels Wood Road Stevenage, SG1 2NY, UNITED KINGDOM.
REFERENCE   3
  AUTHORS   Volpe F., Clatworthy J., Kaptein A., Maschera B., Griffin A.M.,
            Ray K.
  TITLE     The IL1 receptor accessory protein is responsible for the
            recruitment of the interleukin-1 receptor associated kinase to the
            IL1/IL1 receptor I complex
  JOURNAL   FEBS Lett. 419(1), 41-44(1997).
   PUBMED   9426216
REFERENCE   4
  AUTHORS   Burns K., Clatworthy J., Martin L., Martinon F., Plumpton C.,
            Maschera B., Lewis A., Ray K., Tschopp J., Volpe F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat. Cell Biol. 2(6), 346-351(2000).
   PUBMED   10854325
FEATURES             Location/Qualifiers
     source          1..1178
                     /db_xref="H-InvDB:HIT000245492"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     misc_feature    53..175
                     /note="C2 domain"
     CDS             114..935
                     /gene="tollip"
                     /product="TOLLIP protein"
                     /function="IL-1 signalling, responsible for IRAK
                     recruitment to the IL-1R complex"
                     /note="alternative name AcPIP protein"
                     /db_xref="GOA:Q9H0E2"
                     /db_xref="H-InvDB:HIT000245492.12"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="InterPro:IPR000008"
                     /db_xref="InterPro:IPR003892"
                     /db_xref="InterPro:IPR009060"
                     /db_xref="InterPro:IPR035892"
                     /db_xref="InterPro:IPR037301"
                     /db_xref="InterPro:IPR041799"
                     /db_xref="PDB:1WGL"
                     /db_xref="PDB:2N31"
                     /db_xref="UniProtKB/Swiss-Prot:Q9H0E2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB58118.1"
                     /translation="MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAQQLQY
                     GGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKV
                     IHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDD
                     KEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALP
                     PAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP"
BASE COUNT          214 a          397 c          370 g          196 t
ORIGIN      
        1 ggcaggcgcc ntcgaggtga caacttgtct ccgtcgcagg ctccggcggg ggcgcaggag
       61 gtcgcccggc gcgtcactgt cgggtcggcg agccacgggg gccgcgcagc accatggcga
      121 ccaccgtcag cactcagcgc gggccggtgt acatcggtga gctcccgcag gacttcctcc
      181 gcatcacgcc cacacagcag cagcgtcagg tccagctgga cgcccaggcg cagcagctgc
      241 agtacggagg cgcagtgggc accgtgggcc gactgaacat cacggtggta caggcaaagt
      301 tggccaagaa ttacggcatg acccgcatgg acccctactg ccgactgcgc ctgggctacg
      361 cggtgtacga gacgcccacg gcacacaatg gcgccaagaa tccccgctgg aataaggtca
      421 tccactgcac ggtgccccca ggcgtggact ctttctatct cgagatcttc gatgagagag
      481 ccttctccat ggacgaccgc attgcctgga cccacatcac catcccggag tccctgaggc
      541 agggcaaggt ggaggacaag tggtacagcc tgagcgggag gcagggggac gacaaggagg
      601 gcatgatcaa cctcgtcatg tcctacgcgc tgcttccagc tgccatggtg atgccacccc
      661 agcccgtggt cctgatgcca acagtgtacc agcagggcgt tggctatgtg cccatcacag
      721 ggatgcccgc tgtctgtagc cccggcatgg tgcccgtggc cctgcccccg gccgccgtga
      781 acgcccagcc ccgctgtagc gaggaggacc tgaaagccat ccaggacatg ttccccaaca
      841 tggaccagga ggtgatccgc tccgtgctgg aagcccagcg agggaacaag gatgccgcca
      901 tcaactccct gctgcagatg ggggaggagc catagagcct ctgcctcgat gccttttgcc
      961 cccgctcttt ggacacgccg acccggcatc cccaaggaat gctgtcccaa caagattccc
     1021 gtgaaagagc acccgtgtcg ccccctcccg tggacttctg tgccgccccg tccacacctg
     1081 ttcttgggtg caatgtgggt tttcggttcc tggcggtcca ggacggggcg ggggctccct
     1141 cccatctcgt gctgggaggt ctcagcgcgc tctcctgt
//