LOCUS AJ242724 6894 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for putative mitogen-activated protein kinase
kinase kinase (PRKWNK2 gene), splice variant KIAA1760-related.
ACCESSION AJ242724
VERSION AJ242724.4
KEYWORDS mitogen-activated protein kinase kinase kinase; PRKWNK2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Jordan P.
JOURNAL Submitted (28-MAY-1999) to the INSDC. Jordan P., Laboratorio de
Oncobiologia-Centro de Genetica Humana, Instituto Nacional de Saude
Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, PORTUGAL.
REMARK Revised by [3]
REFERENCE 3
AUTHORS Jordan P.
JOURNAL Submitted (02-FEB-2001) to the INSDC. Jordan P., Laboratorio de
Oncobiologia-Centro de Genetica Humana, Instituto Nacional de Saude
Dr. Ricardo Jorge , Avenida Padre Cruz, 1649-016 Lisboa, PORTUGAL.
REMARK revised by [5]
REFERENCE 4
AUTHORS Verissimo F., Jordan P.
TITLE WNK kinases, a novel protein kinase subfamily in multi-cellular
organisms
JOURNAL Oncogene 20(39), 5562-5569(2001).
PUBMED 11571656
REFERENCE 5
AUTHORS Jordan P.
JOURNAL Submitted (17-MAR-2003) to the INSDC. Jordan P., Laboratorio de
Oncobiologia-Centro de Genetica Humana, Instituto Nacional de Saude
Dr. Ricardo Jorge , Avenida Padre Cruz, 1649-016 Lisboa, PORTUGAL.
REMARK revised by [6]
REFERENCE 6 (bases 1 to 6894)
AUTHORS Jordan P.
JOURNAL Submitted (04-JAN-2005) to the INSDC. Jordan P., Laboratorio de
Oncobiologia-Centro de Genetica Humana, Instituto Nacional de Saude
Dr. Ricardo Jorge , Avenida Padre Cruz, 1649-016 Lisboa, PORTUGAL.
REFERENCE 7
AUTHORS Moniz S., Verassimo F., Matos P., Brazao R., Silva E.,
Kotelevets L., Chastre E., Ge spach C., Jordan P.
TITLE Protein kinase WNK2 inhibits cell proliferation by negatively
modulating the activation of MEK1/ERK1/2
JOURNAL Oncogene 26, 6071-6081(2008).
FEATURES Location/Qualifiers
source 1..6894
/db_xref="H-InvDB:HIT000245480"
/organism="Homo sapiens"
/chromosome="9"
/map="q22.3"
/mol_type="mRNA"
/tissue_type="colon crypt epithelium"
/db_xref="taxon:9606"
CDS 1..6894
/gene="PRKWNK2"
/product="putative mitogen-activated protein kinase kinase
kinase"
/note="protein kinase, lysine deficient 2"
/note="splice variant KIAA1760-related"
/db_xref="GOA:Q9Y3S1"
/db_xref="H-InvDB:HIT000245480.13"
/db_xref="HGNC:HGNC:14542"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR024678"
/db_xref="PDB:6ELM"
/db_xref="PDB:6FBK"
/db_xref="UniProtKB/Swiss-Prot:Q9Y3S1"
/protein_id="CAB44308.5"
/translation="MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRR
SVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALV
AQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAE
AKPEPGRTRRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETW
VEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTE
LMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS
EYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSH
AFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPD
EVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKARG
PPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTV
YSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLP
VGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPL
PQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPI
PVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPL
QAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPA
AFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQP
TRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAP
YAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTA
TLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSG
KELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVEC
QLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLS
EDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE
HPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSK
QPPDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGA
APATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCT
PAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLP
SPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAG
TPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPT
RGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPT
DRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGR
FSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPV
SSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGM
KVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEA
LYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLAD
SSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARG
QGWTVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAP
GPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQ
KLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDG
ALGTARRNQVWFGLRVPPTACCGHSTQPRGGQRVGSKTASFAASDPVRS"
exon 1..681
/gene="PRKWNK2"
/number=1
exon 682..854
/gene="PRKWNK2"
/number=2
exon 855..1075
/gene="PRKWNK2"
/number=3
exon 1076..1233
/gene="PRKWNK2"
/number=4
exon 1234..1322
/gene="PRKWNK2"
/number=5
exon 1323..1542
/gene="PRKWNK2"
/number=6
exon 1543..1834
/gene="PRKWNK2"
/number=7
exon 1835..2034
/gene="PRKWNK2"
/number=8
exon 2035..2190
/gene="PRKWNK2"
/number=9
exon 2191..2382
/gene="PRKWNK2"
/number=10
exon 2383..3066
/gene="PRKWNK2"
/number=11
exon 3067..3360
/gene="PRKWNK2"
/number=12
exon 3361..3410
/gene="PRKWNK2"
/number=13
exon 3411..3579
/gene="PRKWNK2"
/number=14
exon 3580..3696
/gene="PRKWNK2"
/number=15
exon 3697..3867
/gene="PRKWNK2"
/number=16
exon 3868..3913
/gene="PRKWNK2"
/number=17
exon 3914..4033
/gene="PRKWNK2"
/number=18
exon 4034..4144
/gene="PRKWNK2"
/number=19
exon 4145..4977
/gene="PRKWNK2"
/number=20
exon 4978..5047
/gene="PRKWNK2"
/number=21
exon 5048..5136
/gene="PRKWNK2"
/number=22
exon 5137..5819
/gene="PRKWNK2"
/number=23
exon 5820..6034
/gene="PRKWNK2"
/number=24
exon 6035..6226
/gene="PRKWNK2"
/number=25
exon 6227..6325
/gene="PRKWNK2"
/number=26
exon 6326..6370
/gene="PRKWNK2"
/number=27
exon 6371..6627
/gene="PRKWNK2"
/number=28
exon 6628..6739
/gene="PRKWNK2"
/number=29
exon 6740..6894
/gene="PRKWNK2"
/number=30
BASE COUNT 1281 a 2482 c 2100 g 1031 t
ORIGIN
1 atggacggcg atggcggccg ccgagacgtc cccggcacgc tgatggagcc cgggcgcggc
61 gcggggcccg cgggcatggc ggagcctcgg gcgaaggcgg cgcggccggg gccccagcgc
121 tttctgcggc gcagcgtggt agagtcggac caggaggagc cgccgggctt ggaggcagcc
181 gaggcgccgg gcccgcagcc cccgcagccc ctgcagcgcc gggtgcttct gctctgcaag
241 acgcgccgcc tcatcgcgga gcgcgcccgc ggacgccccg ccgcccccgc gcccgcagcg
301 ctggtagcgc agccgggagc ccccggagcc cccgcggacg ccggccccga gcccgtgggc
361 acgcaggagc ccggcccgga ccccatcgca gccgctgtcg aaaccgcgcc tgcccccgac
421 ggcggcccca gggaggaggc ggcggcgacc gtgaggaagg aggatgaggg ggcggccgag
481 gcgaagcctg agcccgggcg cactcgccgg gacgagcccg aagaggagga ggacgacgag
541 gacgacctca aggccgtggc cacctctctg gacggccgct tcctcaagtt cgacatcgag
601 ctgggccgcg gttccttcaa gacggtctac aaggggctgg acacggagac ctgggtggag
661 gtggcctggt gtgagctgca ggaccggaag ctcaccaagc tggagcggca gcggttcaag
721 gaagaggctg agatgctgaa aggcctgcag caccccaaca tcgtgcgctt ctacgacttc
781 tgggagtcca gcgccaaggg caagcggtgc attgtgctgg tgacggagct gatgacctca
841 gggacgctga agacatacct gaagcggttc aaggtgatga agcccaaggt tctccgcagc
901 tggtgccggc agatcctgaa gggcctgctg ttcctgcaca caaggacgcc acccatcatc
961 caccgagacc tgaaatgtga caatattttc atcaccggac caactgggtc tgtgaagatt
1021 ggcgacttgg gcctggccac tctgaaaaga gcgtcatttg ccaaaagtgt gataggtact
1081 cccgagttca tggcgcccga gatgtacgag gagcactacg atgagtccgt ggacgtctat
1141 gcctttggga tgtgcatgct ggagatggcc acctcggagt acccctactc ggagtgccag
1201 aatgcggccc agatctaccg caaggtcacc tgtggtatca agccggccag ctttgagaaa
1261 gtgcacgatc ctgaaatcaa ggagattatt ggggagtgta tctgcaaaaa caaggaggaa
1321 aggtacgaga tcaaagacct gctgagccac gccttcttcg cagaggacac aggcgtgagg
1381 gtggagctcg cggaggagga ccacggcagg aagtccacca tcgccctgag gctctgggtg
1441 gaagacccca agaaactgaa gggaaagccc aaggacaatg gagccataga gttcaccttc
1501 gacctggaga aggagacgcc ggatgaggtg gcccaagaga tgattgagtc tggattcttc
1561 cacgagagtg acgtcaagat cgtggccaag tccatccgtg accgcgtggc cttgatccag
1621 tggcggcggg agaggatctg gcccgcgctg cagcccaagg agcagcagga tgtgggcagc
1681 ccggacaagg ccaggggtcc gccggtgccc ctgcaggtcc aggtgaccta ccatgcacag
1741 gctgggcagc ccgggccacc agagcccgag gagccggagg ccgaccagca cctcctgcca
1801 cctacgttgc cgaccagcgc cacctccctg gcctcggaca gcaccttcga cagcggccag
1861 ggctctaccg tgtactcaga ctcgcagagc agccagcaga gcgtgatgct tggctccctt
1921 gccgacgcag cgccgtcccc ggcccagtgt gtgtgcagcc cccctgtgag cgaggggccc
1981 gtcctgccgc agagcctgcc ctcgctgggg gcctaccagc agcccacggc tgcacctggc
2041 ttgccggtgg gctctgtccc ggcccccgcc tgccctccgt ccctccagca gcacttcccg
2101 gatccggcca tgagcttcgc ccccgtgctg ccgccgccca gcacccccat gcccacgggc
2161 ccaggccagc cagcaccccc cggccagcag cctcctccgc tggcccagcc gacacccctg
2221 ccgcaggtcc tggccccaca gcccgtggtc cccctccagc cggttccccc ccacctgcca
2281 ccgtacctgg ctccagcctc ccaggtgggg gcccccgctc agctgaagcc cctccagatg
2341 ccacaggcgc ccctgcagcc gcttgctcaa gtccctccgc agatgccccc gattcctgtt
2401 gtgcccccca tcacgcccct ggcgggaatc gacggcctcc ctccggccct cccagacctg
2461 ccgaccgcga ctgtgcctcc cgtgccacca cctcagtatt tctctccagc cgtgatcttg
2521 ccgagcctcg ctgccccact cccccctgcg tccccagcct tgcctctgca ggctgtgaag
2581 ctgccccacc cccctggggc gcccctggcc atgccctgcc ggaccattgt gccaaatgca
2641 ccggccacta tccccctgct ggccgtagcc ccaccgggcg tggctgccct gtccattcat
2701 tctgccgtgg cccagctccc aggccaacct gtgtacccag cggccttccc acagatggcg
2761 cctactgacg tccctccttc cccccatcac acggtgcaga atatgagggc cacccctcca
2821 cagccggcac tgcctccaca acccacactg cccccacaac ccgtgctgcc cccgcaaccc
2881 acgctgcccc ctcaacctgt gttgcccccg caacccacac ggccccctca acctgtgctg
2941 cccccgcaac ccatgctgcc cccacaacct gtgctgcccc cgcagccggc actgcctgtg
3001 cgccctgagc ccctccagcc ccaccttcct gaacaagctg ctccagctgc tacaccaggg
3061 agccagattc tgcttggcca cccagctccc tatgctgtgg acgtcgccgc tcaggtcccc
3121 accgtgcctg tgccaccggc tgcggtcctc tcgccgcctc tgccggaagt gctgctgcct
3181 gccgcccctg agctcctgcc tcagttcccc agctccctgg ccacggtgtc tgcctctgtg
3241 cagagtgtgc ccacccagac tgccacactt ctgccaccag caaacccacc gctgcctggc
3301 gggcccggga tcgccagccc ttgcccaact gtccagctga cggtggaacc agtccaagag
3361 gagcaggcct cacaggacaa gccgcccggc ctcccgcaga gctgtgagag ctatggaggt
3421 tctgatgtca cttctggaaa agagctgagt gacagctgtg aaggcgcctt tggagggggc
3481 aggctggagg gcagggcagc ccgaaaacac caccgcaggt ccacgcgtgc gcgctcccgg
3541 caggagaggg ccagccggcc ccggcttacc atcttgaacg tgtgcaacac tggggacaag
3601 atggtggagt gccagctgga gacgcacaac cacaagatgg tgaccttcaa gttcgacttg
3661 gacggggacg cacccgatga aattgccacg tatatggtgg agcatgactt tatcctgcag
3721 gccgagcggg aaacgttcat cgagcagatg aaggatgtca tggacaaggc agaggacatg
3781 ctcagcgagg acacagacgc cgaccgtggc tccgacccag ggaccagccc gccacacctc
3841 agcacctgcg gcctgggcac cggggaggag agccgacaat cccaagccaa cgcccccgtg
3901 tatcagcaga acgtcctgca caccgggaag aggtggttca tcatctgtcc ggtggctgag
3961 caccccgccc ccgaggcccc tgaatcttcg cccccacttc ctctaagctc cctgccgcca
4021 gaagccagcc aaggtccatg cagggggctc accctgccct gtctcccatg gcgcagagca
4081 gcctgtgggg ctgtgttcct atccttgttt tctgctgaat cagctcagtc aaagcagcct
4141 ccagattcag cgccctataa agaccagctg tcctcgaagg aacaacccag ctttctagcc
4201 agtcagcagc tcctgagcca ggcgggcccc agcaaccctc ctggggcacc cccagcccct
4261 ttggccccct cctcccctcc tgtgactgct ctgccccaag atggagcagc tccagccacc
4321 agcaccatgc cagagccagc gtcaggaact gccagccagg cagggggtcc agggacacct
4381 caggggctga ccagtgagct cgagacgtct cagccactag cggagactca cgaggccccg
4441 cttgctgtgc agcccctcgt ggtgggccta gcaccttgca ctccagctcc agaggctgcc
4501 tcaaccaggg acgccagtgc cccaagggag cccctgccac ctcctgcacc tgagcccagc
4561 ccccacagcg ggaccccaca gcccgccttg ggtcaacctg ctcccctgct tcctgccgca
4621 gtgggggccg tcagcctggc cacctcccag ctcccaagcc cacccctggg gcccaccgtc
4681 cccccacagc caccctcggc cctggagtcg gatggggaag ggccgccccc cagggtgggc
4741 tttgtggaca gcaccatcaa gagcctggac gagaagctgc ggactctgct ctaccaggag
4801 cacgtgccca cctcctcagc ctcagctggg acccctgtgg aggtgggcga cagagacttc
4861 accctggagc ccctgagagg ggaccagccc cgctcagagg tctgcggggg ggacctggcc
4921 ctgcccccag tgcctaagga ggcggtctca gggcgtgtcc agctgcccca gcccttggtg
4981 gagaagtcag aactggcccc cactcgaggg gccgtgatgg agcagggcac gtcctcgtca
5041 atgacagcag agtcgtctcc caggagtatg ctaggctatg acagagatgg aaggcaggtg
5101 gcctcagact cccatgtggt ccccagcgtc ccccaggatg tacctgcttt tgtgagacct
5161 gcacgtgtgg agcccacaga cagggatggt ggagaagctg gagaaagctc ggcagagccc
5221 ccgccgagtg acatgggcac agtggggggc caggctagcc acccccagac actcggcgct
5281 cgagctttgg ggtcccctcg gaaacgtcca gagcagcagg atgtcagctc accagccaag
5341 actgtgggcc gtttctcggt ggtcagcact caggacgagt ggaccctggc ctccccccac
5401 agcctgagat actctgcccc acccgacgtc tacctggacg aggccccctc cagccccgac
5461 gtgaagctgg cagtgcggcg ggcgcagacg gcctcctcca tcgaggtcgg cgtgggcgag
5521 cccgtgtcca gcgactctgg ggacgagggc cctcgggcga gacccccggt gcagaagcag
5581 gcgtccctgc ccgtgagtgg cagcgtggct ggcgacttcg tgaagaaggc caccgccttc
5641 ctgcagaggc cttctcgggc cggctcgctg ggccccgaga cacccagcag ggtgggcatg
5701 aaggtcccca cgatcagcgt gacctccttc cattcccagt cgtcctacat cagcagcgac
5761 aatgattcgg agctcgagga tgctgacata aagaaggagc tgcagagtct gcgggagaag
5821 cacctgaagg agatctcgga gctgcagagc cagcagaagc aggagatcga agctctgtac
5881 cgccgcctgg gcaagccact gccccccaac gtgggcttct tccacacggc accccccact
5941 ggccgccgga gaaaaaccag caagagcaag ctgaaggcag gcaagctgct aaatcccctg
6001 gtgcggcagc tcaaggtcgt ggcctccagc acaggtcact tggctgactc cagcagaggc
6061 cctcccgcta aggaccctgc ccaagccagt gtggggctca ctgcagacag cacgggcctg
6121 agcgggaagg cagtgcagac ccagcagccc tgctccgtcc gggcctccct gtcttcggac
6181 atctgctccg gcttagccag tgatggaggc ggagcgcgtg gccaaggctg gacggtttac
6241 cacccaacgt ctgagagagt gacctataag tctagtagca aacctcgtgc tcgattcctc
6301 agtggacccg tatctgtgtc catctggtct gccctgaagc gtctctgcct aggcaaagaa
6361 cacagcagta ggtcctccac cagcagcctg gccccaggcc ctgagccagg cccccagccc
6421 gccctgcacg tccaggcgca ggtgaacaac agcaacaaca agaagggtac cttcacggac
6481 gacctgcaca agctggtgga cgagtggacg agcaagacgg tgggggccgc gcagctgaag
6541 cccacgctca accagctgaa gcagacccag aagctgcaag acatggaggc ccaggcaggc
6601 tgggctgccc ctggcgaggc gcgggctatg accgcacctc gagcaggagt ggggatgcca
6661 cgtctgcccc cagcgcccgg ccctctgtcc accacggtca ttcccggagc cgccccgacc
6721 ctgtccgtgc ccacaccaga tggcgccctc ggaaccgccc ggagaaacca ggtgtggttt
6781 ggcctccgag tcccccccac cgcctgctgt gggcacagca ctcagccgcg agggggacag
6841 cgggtgggca gcaagactgc ttcctttgcg gcttcagacc ctgttcgctc ctag
//